Effects of clinical isolates of Streptococcus pneumoniae on THP-1 human monocytic cells.

abstract：:Paraquat (PQ) poisoning‑induced pulmonary fibrosis is one of the primary causes of mortality in patients with PQ poisoning. The potential mechanism of PQ‑induced pulmonary fibrosis was thought to be mediated by inflammation. Recently, bone marrow‑derived mesenchymal stem cells (BMSCs) have been considered as a potenti...

journal_title：Molecular medicine reports

authors： Chen J,Si L,Zhou L,Deng Y

更新日期：2019-04-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of the eukaryotic initiation factor 6 (eIF6) gene on the secretion of M2 macrophage fibrosis‑associated factors and the expression levels of key proteases during scar repair. Male eIF6 wild‑type (eIF6+/+) and knockout (eIF6+/‑) C57BL/6 mice were intraperitoneall...

journal_title：Molecular medicine reports

authors： Bai YQ,Feng JK,Zhang QF,Wu HZ,Du YR,Wei W

更新日期：2016-07-01 00:00:00

abstract：:Gastric carcinoma (GC) ranks as the second most common cause of cancer‑associated mortality worldwide. Emerging evidence has suggested a potential novel therapeutic strategy based on the ability of cancer stem cells (CSCs) to trigger tumorigenesis. MicroRNAs (miRNAs) have previously been implicated in CSC formation an...

journal_title：Molecular medicine reports

authors： Wu K,Ma L,Zhu J

更新日期：2016-10-01 00:00:00

abstract：:Quantitative polymerase chain reaction (qPCR) analysis is a commonly used method for the study of mRNA expression throughout the field of mesenchymal stem cell (MSC) research. This technology is simple and sensitive; however the results may vary significantly due to the use of various reference genes (RGs) as normaliz...

journal_title：Molecular medicine reports

authors： Li X,Yang Q,Bai J,Yang Y,Zhong L,Wang Y

更新日期：2015-02-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been reported to serve a crucial role in renal diseases; however, their role in immunoglobulin A nephropathy (IgAN) remains unclear. In the present study, peripheral blood mononuclear cells (PBMCs) were collected from both patients with IgAN and healthy controls. A microarray analys...

journal_title：Molecular medicine reports

authors： Zuo N,Li Y,Liu N,Wang L

更新日期：2017-11-01 00:00:00

abstract：:The overexpression and hypersecretion of mucus is a hallmark of several chronic pulmonary inflammatory diseases, including chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis. Mucin 5ac (MUC5AC) is a major component of airway mucus. Annexin II (ANXII) has been reported to be expressed in various c...

journal_title：Molecular medicine reports

authors： Xu R,Li Q,Zhou X,Perelman JM,Kolosov VP

更新日期：2014-01-01 00:00:00

abstract：:Cochlear progenitor cells are considered as one of the best candidates for hair cell regeneration, thus, the regulation of cochlear progenitor cell proliferation has become a focus in this field. Several genes expressed in the inner ear during postnatal development have been demonstrated to be involved in maintaining ...

journal_title：Molecular medicine reports

authors： Song YL,Tian KY,Mi WJ,Ding ZJ,Qiu Y,Chen FQ,Zha DJ,Qiu JH

更新日期：2018-04-01 00:00:00

abstract：:An abundance of studies has demonstrated that disruption of circadian rhythms is one of the factors that may contribute to the initiation and development of human colorectal carcinomas (CRCs). Recently, microRNA‑124 has been demonstrated to suppress tumor growth or metastasis of CRCs. However, the mechanisms of cross‑...

journal_title：Molecular medicine reports

authors： Yu JZ,Sun N,Bei YB,Li XB,Lu C,Hua LC

更新日期：2017-09-25 00:00:00

abstract：:Krüppel-like factors (KLFs) regulate a wide variety of cellular functions and modulate pathological processes. In the present study, a post‑translational mechanism of microRNAs (miRs) was investigated in H2O2-induced human cardiomyocyte (HCM) injury. In H2O2‑cultured HCM cells, reactive oxygen species and apoptotic ce...

journal_title：Molecular medicine reports

authors： Zhang X,Liu F,Wang Q,Geng Y

更新日期：2017-10-01 00:00:00

abstract：:MicroRNAs (miRs) exhibit oncogenic or tumor suppressive functions that contribute to the initiation and development of various types of human cancer. miR‑149‑3p has been reported to serve multiple roles in the regulation of proliferation, apoptosis and metastasis. However, the effects and detailed mechanism of miR‑149...

journal_title：Molecular medicine reports

authors： Shen Q,Zhu H,Lei Q,Chen L,Yang D,Sui W

更新日期：2021-03-01 00:00:00

abstract：:Human adipose tissue stem cells (ATSCs) can differentiate into various types of cell in response to lineage-specific induction factors. Reprogramming cells using nuclear and cytoplasmic extracts derived from another type of somatic cell is an effective method of producing specific types of differentiated cell. In the ...

journal_title：Molecular medicine reports

authors： Xie F,Tang X,Zhang Q,Deng C

更新日期：2015-01-01 00:00:00

abstract：:Glioma is the most common malignant and fatal primary tumor in the central nervous system in adults. Recent data has suggested a profound role for microRNAs (miRs) in cancer progression. The present study demonstrated, via quantitative polymerase chain reaction (qPCR) analysis, that miR-203 expression was markedly low...

journal_title：Molecular medicine reports

authors： Tang G,Wu J,Xiao G,Huo L

更新日期：2015-04-01 00:00:00

abstract：:Atherosclerosis (AS) is a progressive disease of multifactorial origin, which occurs in response to endothelial injury. Increased homocysteine (Hcy) is considered a major cause of endothelial dysfunction, oxidative stress and DNA methylation; however, the mechanisms remain to be fully elucidated. The aim of the presen...

journal_title：Molecular medicine reports

authors： Ma SC,Hao YJ,Jiao Y,Wang YH,Xu LB,Mao CY,Yang XL,Yang AN,Tian J,Zhang MH,Jin SJ,Xu H,Jiang YD,Zhang HP

更新日期：2017-12-01 00:00:00

abstract：:Colorectal cancer has become a disease with one of the highest incidence rates worldwide, and liver metastasis threatens the prognosis of colorectal cancer. MicroRNA (miR)‑200 and miR‑141 have been confirmed to be aberrantly expressed in colorectal cancer, however, whether miR‑200 and miR‑141 are involved in the progr...

journal_title：Molecular medicine reports

authors： Ding M,Zhang T,Li S,Zhang Y,Qiu Y,Zhang B

更新日期：2017-11-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most common types of cancer in the urinary system in men. Zeylenone (Zey), a naturally occurring cyclohexene oxide, has an anticancer effect. In the present study, the role and potential mechanism of Zey in PCa were examined. The proliferative, invasive and migratory capacities of D...

journal_title：Molecular medicine reports

authors： Zeng S,Zhu B,Zeng J,Wu W,Jiang C

更新日期：2018-12-01 00:00:00

abstract：:Although imatinib has demonstrated a potent effect on advanced gastrointestinal stromal tumors (GISTs) and has improved the survival of GIST patients, with its prolonged use imatinib resistance is becoming an increasing clinical problem. Mechanisms of secondary resistance are still under investigation. Our study aimed...

journal_title：Molecular medicine reports

authors： Wang CM,Fu H,Zhao GF,Zhou XY,Du CY,Dong RZ,Zhou Y,Shi YQ

更新日期：2009-05-01 00:00:00

abstract：:Interleukin (IL)-35 is the latest member of IL-12 family, which plays an important role in other autoimmune diseases. Bone marrow mononuclear cells Coombs test‑positive hemocytopenia, also termed immunorelated hemocytopenia (IRH) is a type of autoimmune-associated diseases. The present study investigated the relations...

journal_title：Molecular medicine reports

authors： Li Y,Wang Y,Liu H,Ding K,Hao S,Shao Y,Wang H,Chen J,Huang L,Shao Z,Fu R

更新日期：2018-02-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) are a novel group of non‑coding RNAs that are associated with inflammation and tumorigenesis. At present, the diagnostic efficacy of lncRNAs in inflammatory bowel disease (IBD) is unclear. The present study aimed to identify lncRNAs that may be used as potential biomarkers for IBD. The m...

journal_title：Molecular medicine reports

authors： Wang S,Hou Y,Chen W,Wang J,Xie W,Zhang X,Zeng L

更新日期：2018-02-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe disease characterized by immune hyperactivation and cytokine storm. Given the high mortality rate of HLH, there is a need for more effective diagnostic tools and treatments. The present study developed a dendrimer‑based protein biochip for rapid, sensitive ...

journal_title：Molecular medicine reports

authors： Du YX,Ye L,Song ZJ,Lv H,Liu Q,Li SG,Liu SS,Hong J,Gao Y,Schneider ME,Du WD

更新日期：2020-12-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is endemic in the southern provinces of China and Southeast Asia. It has been reported that microRNA‑122 (miR‑122) and tripartite motif‑containing protein 29 (TRIM29) serve important roles in many types of tumor. The present study aimed to evaluate the expression of miR‑122 and TRIM29, a...

journal_title：Molecular medicine reports

authors： Yang Y,Li Q,Guo L

更新日期：2018-06-01 00:00:00

abstract：:Apoptosis and necroptosis occur in renal tubular epithelial cell (RTEC) death in acute kidney injury (AKI), and may be regulated by several methods. The present study identified a protective effect of necrostatin‑1 (Nec‑1) on RTECs via a flow-control-like effect. The results established a hypoxic‑ischemic injury model...

journal_title：Molecular medicine reports

authors： Luo J,Tao Y,Liang X,Chen Y,Zhang L,Jiang F,Liu S,Ye Z,Li Z,Shi W

更新日期：2017-07-01 00:00:00

abstract：:Promoter hypermethylation is a marginal approach to inactivating tumor suppressor genes in cancer. DNA hypermethylation is a well-recognized epigenetic malfunction observed in several malignancies, most predominantly in prostate cancer. Aberrant DNA methylation patterns are considered to be the earliest somatic genome...

journal_title：Molecular medicine reports

authors： Syeed N,Syed Sameer A,Hamid A,Shah ZA,Afroze D,Rasool R,Siddiqi MA

更新日期：2010-09-01 00:00:00

abstract：:Although monitoring and diagnosis of fetal diseases in utero remains a challenge, metabolomics may provide an additional tool to study the etiology and pathophysiology of fetal diseases at a functional level. In order to explore specific markers of fetal disease, metabolites were analyzed in two separate sets of exper...

journal_title：Molecular medicine reports

authors： Huang J,Mo J,Zhao G,Lin Q,Wei G,Deng W,Chen D,Yu B

更新日期：2017-11-01 00:00:00

abstract：:Leptomeningeal fibrosis is important in the pathogenesis of communicating hydrocephalus following subarachnoid hemorrhage; however, the underlying mechanisms of leptomeningeal fibrosis remain largely unclear. In the present study, primary meningeal mesothelial cells (MMCs) were used as a cell model to investigate the ...

journal_title：Molecular medicine reports

authors： Yue XJ,Guo Y,Yang HJ,Feng ZW,Li T,Xu YM

更新日期：2016-08-01 00:00:00

abstract：:Semaphorin 6B is a member of the semaphorin family of signaling proteins, which is implicated in a variety of biological processes, such as axon guidance and muscle regeneration. PPARα is known to be a regulator of semaphorin 6B in human cancer cell lines. In this study, we examined the effect of fenofibrate as a PPAR...

journal_title：Molecular medicine reports

authors： Murad H,Kasies F,Azroony R,Alya G,Madania A

更新日期：2011-05-01 00:00:00

abstract：:The aim of the present study was to compare the phosphatidylinositol 3-kinase (PI3KCA)-AKT serine/threonine kinase (AKT) pathway in circulating tumor cells (CTCs) and corresponding cancerous tissues. Stemness‑like circulating tumor cells (slCTCs) and CTCs in epithelial-mesenchymal transition (EMT) have been implicated...

journal_title：Molecular medicine reports

authors： Bredemeier M,Kasimir-Bauer S,Kolberg HC,Herold T,Synoracki S,Hauch S,Edimiris P,Bankfalvi A,Tewes M,Kimmig R,Aktas B

更新日期：2017-05-01 00:00:00

abstract：:The aim of the present study was to determine the role of interleukin-6 (IL-6) in the epithelial-mesenchymal transition (EMT) of human intrahepatic biliary epithelial cell (HIBEC) lines in vitro. HIBECs were stimulated with IL-6 at concentrations of 0, 10, 20, 50 and 100 µg/l for 24 h. A wound healing and Transwell as...

journal_title：Molecular medicine reports

authors： Jiang GX,Cao LP,Kang PC,Zhong XY,Lin TY,Cui YF

更新日期：2016-02-01 00:00:00

abstract：:An outbreak of hepatitis C virus (HCV) infections, for which the risk factor was unknown, was previously identified in North Guangdong, China. In the present study, a total of 736 local residents were surveyed regarding their lifetime risk factors for HCV infection. Serum anti‑HCV antibodies and HCV RNA were examined ...

journal_title：Molecular medicine reports

authors： Shao X,Luo Q,Cai Q,Zhang F,Zhu J,Liu Y,Zhao Z,Gao Z,Zhang X

更新日期：2016-11-01 00:00:00

abstract：:To investigate the association between apolipo-protein E (APOE) polymorphisms and insulin resistance and Traditional Chinese Medicine (TCM) syndromes in type 2 diabetes mellitus (T2DM) with macroangiopathy, 60 patients with T2DM macroangiopathy were enrolled and divided into three groups: dryness-heat due to deficienc...

journal_title：Molecular medicine reports

authors： Xie YQ,Wang H,Wu YP,Yin DH,Wang ZS,Huang YH

更新日期：2011-11-01 00:00:00

abstract：:Adipocytes have been demonstrated to promote the progression of various tumors through modulation of cancer cell metabolism. However, their role in lung cancer progression remains undetermined. In the present study, adipocytes and lung adenocarcinoma A549 cells were cultured in a Transwell co‑culture system. Cancer ce...

journal_title：Molecular medicine reports

authors： Li FF,Zhang H,Li JJ,Cao YN,Dong X,Gao C

更新日期：2018-08-01 00:00:00