Abstract:
:Cochlear progenitor cells are considered as one of the best candidates for hair cell regeneration, thus, the regulation of cochlear progenitor cell proliferation has become a focus in this field. Several genes expressed in the inner ear during postnatal development have been demonstrated to be involved in maintaining the proliferative potential of progenitor cells, but the mechanism for regulating the proliferation and differentiation of cochlear progenitor cells remains poorly understood. Telomerase reverse transcriptase (TERT) has rate limiting telomerase activity and the overexpression of TERT has been shown to promote cell proliferation in series of cell lines. The aim of the present study was to evaluate the expression of TERT in the postnatal development of the cochlea and progenitor cells. The results demonstrated that TERT was expressed in the basilar membranes during the first postnatal week. In vitro, TERT expression in progenitor cells reached a maximum at day 4 after culture and decreased as the culture time prolonged or the cell passage number increased. These results led us to hypothesize that TERT may be involved in the development of the cochlea and in maintaining the proliferation ability of progenitor cells.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Song YL,Tian KY,Mi WJ,Ding ZJ,Qiu Y,Chen FQ,Zha DJ,Qiu JHdoi
10.3892/mmr.2018.8565subject
Has Abstractpub_date
2018-04-01 00:00:00pages
6077-6083issue
4eissn
1791-2997issn
1791-3004journal_volume
17pub_type
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