Abstract:
:An abundance of studies has demonstrated that disruption of circadian rhythms is one of the factors that may contribute to the initiation and development of human colorectal carcinomas (CRCs). Recently, microRNA‑124 has been demonstrated to suppress tumor growth or metastasis of CRCs. However, the mechanisms of cross‑talk between microRNA‑124 (miR‑124) and circadian rhythms in the regulation of CRCs are poorly understood. The present study demonstrated that the protein expression levels of human circadian locomoter output cycles protein kaput (hCLOCK) is significantly increased, while miR‑124 is attenuated in high‑grade human CRC tissues and in the more invasive colorectal cancer cell lines SW620 and LOVO. It was further demonstrated that hCLOCK is a direct target of miR‑124. Upregulation of miR‑124 significantly inhibited hCLOCK expression in LOVO cells, and consequently inhibited its promoting effects on the proliferation and migration of LOVO cells. In conclusion, these data revealed that hCLOCK serves an enhancing role, whereas mir‑124 serves a suppressive role, in human CRC. Attenuation of miR‑124, of which hCLOCK is a direct target, leads to increased hCLOCK expression and disruption of circadian rhythms in CRC.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Yu JZ,Sun N,Bei YB,Li XB,Lu C,Hua LCdoi
10.3892/mmr.2017.7596subject
Has Abstractpub_date
2017-09-25 00:00:00eissn
1791-2997issn
1791-3004pub_type
杂志文章abstract::There is a distinct lack of knowledge on the prevalence of skin disorders in Tuvalu. The aim of the current study was to assess the prevalence of cutaneous diseases and to evaluate access dermatological care in Tuvalu. Cutaneous disorders in the people of Tuvalu between 2009 and 2012 were examined. The most common ski...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2015.3806
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
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journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2017.6165
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular medicine reports
pub_type: 杂志文章,meta分析
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更新日期:2017-11-01 00:00:00
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pub_type: 杂志文章
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