Overexpressed microRNA-506 and microRNA-124 alleviate H2O2-induced human cardiomyocyte dysfunction by targeting krüppel-like factor 4/5.

abstract：:A coma is a serious complication, which can occur following traumatic brain injury (TBI), for which no effective treatment has been established. Previous studies have suggested that neural electrical stimulation, including median nerve stimulation (MNS), may be an effective method for treating patients in a coma, and ...

journal_title：Molecular medicine reports

authors： Zhong YJ,Feng Z,Wang L,Wei TQ

更新日期：2015-09-01 00:00:00

abstract：:Ras‑GTPase‑activating protein SH3 domain‑binding protein 1 (G3BP1) has been reported to be of importance in the occurrence and development of colon cancer. However, the underlying mechanisms remain largely unknown. Therefore, the aim of the present study was to investigate the role of Wnt/β‑catenin signaling in G3BP1‑...

journal_title：Molecular medicine reports

authors： Li Y,Wang J,Zhong S,Li J,Du W

更新日期：2020-11-01 00:00:00

abstract：:The mammalian target of rapamycin/eukaryotic translation inititiation factor 4E binding protein 1 (mTOR/4E-BP1) transduction pathway is activated in a range of malignant cancers, but its role in human gastric cardiac adenocarcinoma (GCA) has not been well defined. The present study used western blotting and reverse tr...

journal_title：Molecular medicine reports

authors： Yang HY,Xue LY,Xing LX,Wang J,Wang JL,Yan X,Zhang XH

更新日期：2013-02-01 00:00:00

abstract：:Pneumonia accounts for ~1.3 million mortalities in children per year worldwide. MicroRNAs are implicated in several diseases, including cancer and pneumonia; however, the role of let7f‑5p in pneumonia is not completely understood. In the present study, lipopolysaccharide (LPS) was used to establish an in vitro pneumon...

journal_title：Molecular medicine reports

authors： Xu L,Song Q,Ouyang Z,Zhang X,Zhang C

更新日期：2021-02-01 00:00:00

abstract：:Human interferon α (IFN-α) and erythropoietin (EPO) have been used for a variety of purposes in clinical medicine. Human IFN-α has been used to treat several types of viral infection and cancer, as well as renal anemia, via stimulation of erythrocyte formation in the bone marrow. Transgenic cattle are excellent candid...

journal_title：Molecular medicine reports

authors： Jung EM,An BS,Kim YK,Hwang I,Lee JY,Shin TY,Hyun SH,Hwang WS,Jeung EB

更新日期：2013-02-01 00:00:00

abstract：:para‑Phenylenediamine (p‑PD) is a potential carcinogen, and widely used in marketed hair dye formulations. In the present study, the role of the protein tyrosine kinase (PTK)/Ras/Raf/c‑Jun N‑terminal kinase (JNK) and phosphoinositide 3‑kinase (PI3k)/protein kinase B (Akt) pathways on the growth of NRK‑52E cells was in...

journal_title：Molecular medicine reports

authors： Kasi RA,Moi CS,Kien YW,Yian KR,Chin NW,Yen NK,Ponnudurai G,Fong SH

更新日期：2015-03-01 00:00:00

abstract：:The corticotropin-releasing factor (CRF) family is involved in modulating gastrointestinal motility, sensitivity and inflammation. CRF signalling exerts an important role in inflammatory bowel disease (IBD), predominantly by activating CRF receptors. The aim of the present study was to investigate the function of CRF ...

journal_title：Molecular medicine reports

authors： Chen H,Shi H,Liu Y,Ren X,He S,Chang X,Yin Y

更新日期：2018-01-01 00:00:00

abstract：:Neutrophilic airway inflammation in chronic lung infections caused by Pseudomonas aeruginosa (PA) is associated with T helper (Th)17 responses. Suppressor of cytokine signaling 3 (SOCS3) is the major negative modulator of Th17 function through the suppression of signal transducer and activator of transcription (STAT)3...

journal_title：Molecular medicine reports

authors： Ding FM,Liao RM,Chen YQ,Xie GG,Zhang PY,Shao P,Zhang M

更新日期：2017-07-01 00:00:00

abstract：:Emerging evidence suggests that altered expression of microRNAs (miRNAs) is involved in cancer progression. However, the role of miR-125a-5p in gastric carcinogenesis remains unknown. Quantitative real-time PCR analysis revealed that the expression of miR-125a-5p was significantly decreased in >80% of gastric cancer t...

journal_title：Molecular medicine reports

authors： Xu Y,Huang Z,Liu Y

更新日期：2014-11-01 00:00:00

abstract：:NORAD (non‑coding RNA activated by DNA damage) is a long non‑coding RNA (lncRNA) that is upregulated and promotes cell progression in various human types of cancer; however, its function in non‑small cell lung cancer (NSCLC) remains unclear. The present study investigated the regulatory function and underlying mechani...

journal_title：Molecular medicine reports

authors： Gao W,Weng T,Wang L,Shi B,Meng W,Wang X,Wu Y,Jin L,Fei L

更新日期：2019-06-01 00:00:00

abstract：:The present study observed and compared the biological behaviour of HepG2 cells prior and subsequent to the overexpression of activating transcription factor 3 (ATF3). Experiments investigating the cytological function by which ATF3 affects liver cancer cells were also performed. MTT, Transwell and flow cytometry assa...

journal_title：Molecular medicine reports

authors： Li X,Zang S,Cheng H,Li J,Huang A

更新日期：2019-02-01 00:00:00

abstract：:Metabolic syndrome arises from a combination of disorders that increase the risk of cardiovascular disease and diabetes. In previous studies, it was observed that overexpression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) induced obesity and the insulin resistance that accompanies metabolic syndrome in roden...

journal_title：Molecular medicine reports

authors： Jung EM,An BS,Kim YK,Jeong YH,Hwang WS,Jeung EB

更新日期：2013-09-01 00:00:00

abstract：:Giant cell tumor (GCT) is an aggressive type of bone tumor consisting of multinucleated osteoclast-like giant cells. Imatinib is a selective inhibitor for certain type III tyrosine kinase receptor family members with a variety of beneficial effects. The purpose of the present study was to determine the therapeutic pot...

journal_title：Molecular medicine reports

authors： Liao Y,Lv G,Wang B,Kuang L,Wang X

更新日期：2016-02-01 00:00:00

abstract：:N-acetyl cysteine (NAC) has been extensively reported to exert neuroprotective effects on the central nervous system. Oxidative stress may contribute to the underlying mechanisms causing Alzheimer's disease (AD). The effect of NAC against oxidative stress injury was investigated in a cellular model of AD in the presen...

journal_title：Molecular medicine reports

authors： Wu W,Liu BH,Xie CL,Xia XD,Zhang YM

更新日期：2018-05-01 00:00:00

abstract：:The activation of the (pro)renin receptor (PRR) may be potentially active in the development of atherosclerotic plaques independent of angiotensin II. Our previous studies demonstrated that high glucose was able to induce the activation of PRR. The present study was designed to determine the function of oxidized low‑d...

journal_title：Molecular medicine reports

authors： Cheng Y,Liu X,Zhang L,Zhang Y,Liu Y,Lu Y,Jiang Y

更新日期：2015-06-01 00:00:00

abstract：:Several studies have noted benign thecoma‑fibroma tumors with positive F‑18 fluorodeoxyglucose (FDG) accumulation mimicking malignant ovarian tumors following F‑18 FDG positron emission tomography (PET). The present study analyzed four cases with false‑positive F‑18 FDG PET/computed tomography (CT) diagnoses of thecom...

journal_title：Molecular medicine reports

authors： Seino H,Ono S,Miura H,Morohashi S,Wu Y,Tsushima F,Takai Y,Kijima H

更新日期：2016-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Although numerous studies have suggested the potentially oncogenic roles of wild‑type or mutant hepatitis B virus X (HBx) protein in hepatocarcinogenesis, their exact mechanism remains unclear. Increasing evidence suggests that microRNAs ...

journal_title：Molecular medicine reports

authors： Fu X,Tan D,Hou Z,Hu Z,Liu G,Ouyang Y,Liu F

更新日期：2013-02-01 00:00:00

abstract：:Cinobufacini is widely used in the treatment of advanced cancers. It has been previously reported that microRNA (miR)‑494 was upregulated in cinobufacini‑treated gastric cancer cells; however, the detailed role of miR‑494 in the anti‑tumor activity of cinobufacini is unclear. The present study aimed to clarify the fun...

journal_title：Molecular medicine reports

authors： Shen Z,Li Y,Zhao C,Wang F,Zhou R,Chen G

更新日期：2018-05-01 00:00:00

abstract：:Accumulated evidence has demonstrated that the microenvironment of a given tumor is important in determining its drug resistance, tumorigenesis, progression and metastasis. These microenvironments, like tumor cells, are vital targets for cancer therapy. The cross-talk between tumor cells and cancer-associated fibrobla...

journal_title：Molecular medicine reports

authors： Zi F,He J,He D,Li Y,Yang L,Cai Z

更新日期：2015-05-01 00:00:00

abstract：:Numerous studies have demonstrated that microRNAs (miRNAs) are upregulated or downregulated in retinoblastoma (RB), and that this phenomenon is associated with the modulation of various malignant behaviours during RB occurrence and development. Therefore, the mechanisms that associate deregulated miRNAs with RB initia...

journal_title：Molecular medicine reports

authors： Sun Z,Zhang A,Zhang L

更新日期：2019-03-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is a signaling gasotransmitter, involved in various physiological and pathological processes. H2S-donating drugs have been tested to conjugate the beneficial effects of H2S with other pharmaceutical properties. It has been shown that the endogenous cystathionine-γ-lyase (CSE)/H2S pathway partici...

journal_title：Molecular medicine reports

authors： Xie YH,Zhang N,Li LF,Zhang QZ,Xie LJ,Jiang H,Li LP,Hao N,Zhang JX

更新日期：2014-10-01 00:00:00

abstract：:Dbl-family guanine nucleotide exchange factors (GEFs) are important activators of Rho GTPases, which are significantly associated with tumorigenesis and metastasis. The catalytic ability of the Dbl-family GEFs to activate Rho GTPases depends on their Dbl-homology domain followed by a pleckstrin-homology domain. In the...

journal_title：Molecular medicine reports

authors： Wang H,Li Y,Wang Y,Han ZG,Cai B

更新日期：2012-05-01 00:00:00

abstract：:The biochemical events involved in the upregulation of selected glucose‑responsive genes by 3‑O‑methyl‑D‑glucose (3‑MG) remain to be elucidated. The present study mainly aimed to re‑evaluate the possible role of 3‑MG phosphorylation in the upregulation of the thioredoxin interacting protein (TXNIP) and liver pyruvate ...

journal_title：Molecular medicine reports

authors： Svoboda M,Tastenoy M,Zhang Y,Gillet C,Rasschaert J,Malaisse WJ,Sener A

更新日期：2013-09-01 00:00:00

abstract：:The aim of the present study was to investigate the possible metabolic alterations in the frontal cortex and parietal white matter in patients with diabetic hypertension (DHT) using proton magnetic resonance (MR) spectroscopic imaging. A total of 33 DHT patients and 30 healthy control subjects aged between 45 and 75 w...

journal_title：Molecular medicine reports

authors： Cao Z,Ye BD,Shen ZW,Cheng XF,Yang ZX,Liu YY,Wu RH,Geng K,Xiao YY

更新日期：2015-06-01 00:00:00

abstract：:Tissue-engineered bone substitutes are frequently used to repair bone defects. Adipose-derived stem cells (ASCs) are a promising source of cells for repairing bone tissue, however, insufficient osteogenic potency remains the main obstacle for their application. The present study aimed to enhance the osteogenic potency...

journal_title：Molecular medicine reports

authors： Wang Z,Zhang D,Hu Z,Cheng J,Zhuo C,Fang X,Xing Y

更新日期：2015-09-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is endemic in the southern provinces of China and Southeast Asia. It has been reported that microRNA‑122 (miR‑122) and tripartite motif‑containing protein 29 (TRIM29) serve important roles in many types of tumor. The present study aimed to evaluate the expression of miR‑122 and TRIM29, a...

journal_title：Molecular medicine reports

authors： Yang Y,Li Q,Guo L

更新日期：2018-06-01 00:00:00

abstract：:Cerebral infarction is a cerebrovascular disease caused by local brain ischemic necrosis or softening, which is associated with diabetes, obesity, hypertension and rheumatic heart arrhythmia. Previous studies have indicated that aspirin is a potential oral anticoagulant in the treatment of cerebral ischemic stroke. Ho...

journal_title：Molecular medicine reports

authors： Wang X,Shen B,Sun D,Cui X

更新日期：2018-01-01 00:00:00

abstract：:It is a challenge for dentists to save dental pulp in patients with pulp disease without resorting to root canal therapy. Formation of tertiary dentin to maintain pulp vitality is a key odontoblast response to dental pulp injury. Vascular endothelial growth factor (VEGF) is the most potent angiogenic and vasculogenic ...

journal_title：Molecular medicine reports

authors： Zhang J,Liu X,Yu W,Zhang Y,Shi C,Ni S,Liu Q,Li X,Sun Y,Zheng C,Sun H

更新日期：2016-01-01 00:00:00

abstract：:Histone deacetylase inhibitor (HDACi) has been a major target of anticancer agents. Quisinostat (JNJ‑26481585), a novel second‑generation HDACi, has previously demonstrated antiproliferative activity against non‑small cell lung cancer; however, the function of quisinostat in hepatocellular carcinoma (HCC) remains to b...

journal_title：Molecular medicine reports

authors： Li F,Wang T,Wang Z,Chen X,Liu R

更新日期：2017-11-01 00:00:00

abstract：:Hyperbaric oxygen (HBO) therapy is an effective therapy for ischemia/reperfusion (I/R) injury of the brain, small intestine, testes and liver. However, the detailed molecular mechanisms underlying the effect of HBO therapy remain undetermined. In the current study, the hypothesis that preconditioning rats with HBO pro...

journal_title：Molecular medicine reports

authors： Kang N,Hai Y,Liang F,Gao CJ,Liu XH

更新日期：2014-06-01 00:00:00