Reprogramming human adipose tissue stem cells using epidermal keratinocyte extracts.

abstract：:Histone deacetylases (HDACs) are important in chromatin remodeling and epigenetic regulation of gene expression. Histone deacetylase inhibitors (HDACi) have highly effective anti-metastatic and anti-angiogenic activity in various types of cancer, while the molecular mechanisms involved in this process are not fully un...

journal_title：Molecular medicine reports

authors： Lu HG,Zhan W,Yan L,Qin RY,Yan YP,Yang ZJ,Liu GC,Li GQ,Wang HF,Li XL,Li Z,Gao L,Chen GQ

更新日期：2014-11-01 00:00:00

abstract：:The present study aimed to investigate the mechanism underlying the effects of minocycline on diabetic retinopathy‑associated cellular apoptosis. A total of 40 Sprague Dawley (SD) rats were used as a diabetic retinopathy model following injection with streptozotocin. Among the 34 rats in which the diabetes model was s...

journal_title：Molecular medicine reports

authors： Wu Y,Chen Y,Wu Q,Jia L,Du X

更新日期：2015-10-01 00:00:00

abstract：:Obesity may induce end‑organ damage through metabolic syndrome, and autophagy serves a vital role in the pathogenesis of metabolic syndrome. The purpose of the present study was to define the roles of autophagy and mitophagy in high fat diet (HFD)‑induced cardiomyopathy. Male, 8 week‑old C57BL/6 mice were fed either a...

journal_title：Molecular medicine reports

authors： Che Y,Wang ZP,Yuan Y,Zhang N,Jin YG,Wan CX,Tang QZ

更新日期：2018-09-01 00:00:00

abstract：:Many studies have reported that lutein may exert its biological activities, including anti‑inflammation, anti‑oxidase and anti‑apoptosis, through effects on reactive oxygen species (ROS). Thus, lutein may prevent the damaging activities of ROS in cells. The current study investigated the effect of lutein against sever...

journal_title：Molecular medicine reports

authors： Tan D,Yu X,Chen M,Chen J,Xu J

更新日期：2017-10-01 00:00:00

abstract：:Skeletal myogenesis is a highly ordered and complex biological process that is mediated by numerous regulatory factors. In previous studies, it has been demonstrated that microRNAs (miRs) and long non‑coding RNAs (lncRNAs) serve key roles in skeletal myogenesis. The present study showed that the expression levels of m...

journal_title：Molecular medicine reports

authors： Zhao X,Gu H,Wang L,Zhang P,Du J,Shen L,Jiang D,Wang J,Li X,Zhang S,Li M,Zhu L

更新日期：2020-11-01 00:00:00

abstract：:The development of acute lung injury (ALI) during sepsis almost doubles the mortality rate of patients. The efficacy of current treatment strategies is low as treatment is usually initiated following the onset of symptoms. Inflammation is one of the main mechanisms of autoimmune disorders and is a common feature of se...

journal_title：Molecular medicine reports

authors： Li T,Zhang J,Feng J,Li Q,Wu L,Ye Q,Sun J,Lin Y,Zhang M,Huang R,Cheng J,Cao Y,Xiang G,Zhang J,Wu Q

更新日期：2013-06-01 00:00:00

abstract：:The sonic hedgehog (SHH) morphogen regulates cell differentiation and controls a number of genes during renal morphogenesis. To date, the effects of SHH on fibroblast growth factors (Fgfs) in embryonic kidney development remain unclear. In the present study, explants of BALB/c mouse embryonic kidney tissues were used ...

journal_title：Molecular medicine reports

authors： Chen X,Hou XM,Fan YF,Jin YT,Wang YL

更新日期：2016-10-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effect of puerarin on pelvic organ prolapse (POP) and the underlying mechanisms that regulate the metabolism of human parametrial ligament fibroblasts (HPLFs). HPLFs obtained from the pelvic tissue of patients with (n=10) or without (n=8) POP during hyster...

journal_title：Molecular medicine reports

authors： Li Y,Hong L,Liu C,Min J,Hong S,Hu M,Zhao Y,Yang Q,Tang J,He S

更新日期：2018-02-01 00:00:00

abstract：:Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is a rare autosomal dominant disease, which has been divided into two types according to whether it involves premature ovarian failure (POF). Mutations in forkhead box L2 (FOXL2) have been identified in the majority of patients with BPES. The present study ai...

journal_title：Molecular medicine reports

authors： Yang L,Li T,Xing Y

更新日期：2017-10-01 00:00:00

abstract：:Metadherin (MTDH), also known as astrocyte-elevated gene-1, was first cloned in 2002 and has been confirmed as an oncogene in numerous types of cancer by previous studies. Overexpression of MTDH has been observed in multiple types of cancer, including breast, esophageal, prostate, cervical and non-small-cell lung canc...

journal_title：Molecular medicine reports

authors： Wei YB,Guo Q,Gao YL,Yan B,Wang Z,Yang JR,Liu W

更新日期：2015-07-01 00:00:00

abstract：:In the present study, the expression of microRNA (miR)‑671‑3p in non‑small‑cell lung cancer (NSCLC) was detected via reverse transcription‑quantitative polymerase chain reaction analysis, and its role in cell proliferation, apoptosis, migration and invasion was investigated via Cell Counting Kit‑8, colony formation, f...

journal_title：Molecular medicine reports

authors： Li ZY,Zhang ZZ,Bi H,Zhang QD,Zhang SJ,Zhou L,Zhu XQ,Zhou J

更新日期：2019-10-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effects of camel milk on hepatic pathogenicity induced by experimental infection with Escherichia (E. coli) and Staphylococcus aureus (S. aureus) in Wistar rats. The rats were divided into six groups: The control and camel milk groups received water and ca...

journal_title：Molecular medicine reports

authors： Soliman MM,Hassan MY,Mostafa SA,Ali HA,Saleh OM

更新日期：2015-12-01 00:00:00

abstract：:The development of pharmaceutical agents possessing anti‑invasive and anti‑metastatic abilities, as well as apoptotic activity, is important in decreasing the incidence and recurrence of oral cancer. Cancer cells are known to acquire invasiveness not only through epigenetic changes, but also from inflammatory stimuli ...

journal_title：Molecular medicine reports

authors： Cho BH,Jung YH,Kim DJ,Woo BH,Jung JE,Lee JH,Choi YW,Park HR

更新日期：2018-02-01 00:00:00

abstract：:Oxidative stress is known to play a key role in the progression of liver disease, including non-alcoholic steatohepatitis (NASH), which is often accompanied by hyperglycemia. This study examined the influence of high glucose on oxidative stress-induced hepatic cell death. Hc cells, a normal human hepatocyte-derived ce...

journal_title：Molecular medicine reports

authors： Shibata H,Ichikawa T,Nakao K,Miyaaki H,Takeshita S,Akiyama M,Fujimoto M,Miuma S,Kanda S,Yamasaki H,Eguchi K

更新日期：2008-05-01 00:00:00

abstract：:It has been confirmed that bone morphogenetic protein-9 (BMP-9) promotes the differentiation of osteoblasts. However, the ways in which BMP‑9 exerts its effects on the differentiation of osteoclasts and bone resorption remain to be elucidated. The present study was designed to investigate the roles and the molecular m...

journal_title：Molecular medicine reports

authors： Li H,Zhao D,Wang S,Ding J,Zhao L

更新日期：2016-11-01 00:00:00

abstract：:Postmenopausal osteoporosis (OPM) is a common type of osteoporosis in females. It is a systemic, chronic bone disease that presents as microstructure degradation of osseous tissue, decreased bone mineral density and increased osteopsathyrosis caused by hypoovarianism and reduced estrogen levels in the body following m...

journal_title：Molecular medicine reports

authors： Qiu J,Huang G,Na N,Chen L

更新日期：2018-05-01 00:00:00

abstract：:Integrin‑linked kinase (ILK) is overexpressed in ovarian cancer (OC), and ILK gene silencing results in apoptosis in OC cells. In the present study, the mechanism by which ILK induces apoptosis was explored from the perspective of microRNA (miRNA) expression. Alterations in the global miRNA expression profile were det...

journal_title：Molecular medicine reports

authors： Yuan D,Zhao Y,Wang Y,Che J,Tan W,Jin Y,Wang F,Li P,Fu S,Liu Q,Zhu W

更新日期：2017-11-01 00:00:00

abstract：:The purpose of the present study was to evaluate distinct metabolic features of meningiomas to distinguish them from other brain lesions using proton magnetic resonance spectroscopy. The study was performed on 17 meningiomas, 24 high-grade gliomas and 9 metastases. Elevated signal intensity at 3.8 ppm observed in low ...

journal_title：Molecular medicine reports

authors： Kousi E,Tsougos I,Fountas K,Theodorou K,Tsolaki E,Fezoulidis I,Kapsalaki E

更新日期：2012-04-01 00:00:00

abstract：:Previously, we demonstrated that 8-methoxypsoralen (methoxsalen), a potent human cytochrome P450 2A6 (CYP2A6) inhibitor, strongly suppresses lung adenoma induction by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice. In the present study, we examined the inhibitory effects of methoxsalen on the ...

journal_title：Molecular medicine reports

authors： Takeuchi H,Saoo K,Matsuda Y,Yokohira M,Yamakawa K,Zeng Y,Kuno T,Kamataki T,Imaida K

更新日期：2009-07-01 00:00:00

abstract：:As one of main active ingredients of salvia miltiorrhizae, which is a traditional Chinese medicine, tanshinone IIA is the basis of its pharmacological activities. In the present study, the effect of tanshinone IIA on weakening spastic cerebral palsy (SCP) in neonatal rats was investigated. Radial arm water maze and ho...

journal_title：Molecular medicine reports

authors： Zhang WL,Cao YA,Xia J,Tian L,Yang L,Peng CS

更新日期：2018-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder, which is characterized by the selective and progressive death of dopaminergic (DA) neurons in the substantia nigra. Increasing evidence suggests that inflammation is important in the degeneration of DA neurons. The purinergic receptor subtype P2X7 recept...

journal_title：Molecular medicine reports

authors： Wang XH,Xie X,Luo XG,Shang H,He ZY

更新日期：2017-02-01 00:00:00

abstract：:The pathogenesis of Graves' ophthalmopathy (GO) remains to be entirely elucidated. The present study aimed to determine the association between phenotypic expression of the MTHFR gene and susceptibility to GO in patients with Graves' disease (GD). A prospective case‑controlled study was conducted with 122 patients wit...

journal_title：Molecular medicine reports

authors： Lee JY,Kim NK,Cho YW,Lew H

更新日期：2016-09-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been reported to serve a key role in a variety of cardiovascular diseases, including in cardiac fibrosis. The present study aimed to investigate the biological role and underlying mechanisms of the induction of cardiac fibroblasts by the lncRNA, RNA component of mitochondrial RNA pr...

journal_title：Molecular medicine reports

authors： Zhang SY,Huang SH,Gao SX,Wang YB,Jin P,Lu FJ

更新日期：2019-10-01 00:00:00

abstract：:The differentiation of pluripotent mesenchymal stem cells to mature osteoblasts is crucial for the maintenance of the adult skeleton. In rheumatic arthritis, osteoblast differentiation is impaired by the overproduction of cytokine tumor necrosis factor (TNF)‑α. It has been demonstrated that TNF-α is able to inhibit os...

journal_title：Molecular medicine reports

authors： Wang G,Zhang X,Yu B,Ren K

更新日期：2015-07-01 00:00:00

abstract：:To investigate the genotype-phenotype correlation in Chinese familial and sporadic hypertrophic cardiomyopathy, specific exons of the myosin binding protein-c gene (MYBPC3) were screened in six families with hypertrophic cardiomyopathy (HCM; FHCM) and in 20 patients with sporadic HCM (SHCM) from the Anhui Province reg...

journal_title：Molecular medicine reports

authors： Wang AL,Kong DH,Chen DX,Wan J,Yu YX

更新日期：2010-09-01 00:00:00

abstract：:The aim of the present study was to identify key genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis (JSA). The gene expression profile dataset GSE58667, including data from 15 human whole blood samples collected from 11 patients with JSA and four healthy controls, was analyzed ...

journal_title：Molecular medicine reports

authors： Wang Z,Han Y,Zhang Z,Jia C,Zhao Q,Song W,Chen T,Zhang Y,Wang X

更新日期：2018-08-01 00:00:00

abstract：:The effects of acetylpuerarin treatment following oxygen-glucose deprivation/reperfusion (OGD/R) were examined in rat hippocampal neurons in vitro and compared with the effects of acetylpuerarin in normoxic cells to confirm acetylpuerarin's potential neuroprotective effects, including apoptosis inhibition. Wistar rat ...

journal_title：Molecular medicine reports

authors： Liu DM,Wang ZH,Liu L,Zhang XM,Lou FL

更新日期：2013-11-01 00:00:00

abstract：:Cervical cancer (CC) is a frequently occurring cancer in women with a high mortality rate. Despite improvements to therapeutic strategies, the survival outcome for patients with CC remains poor. Therefore, the present study aimed to investigate the molecular mechanism underlying CC inhibition involving microRNA (miR)‑...

journal_title：Molecular medicine reports

authors： Guo Y,Luo S

更新日期：2020-12-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) often develops drug resistance following radiotherapy. The molecular basis of radiotherapy-related multidrug resistance (MDR) remains unclear. In the present study, we investigated the effect of fractionated irradiation on the expression of the MDR-1 gene and the MDR-associated protein P...

journal_title：Molecular medicine reports

authors： Ji XN,Yang F,Sui XM,Wang FG,Ge RG,Quan XL,Zhao T,Gao BW,Wang RY

更新日期：2013-01-01 00:00:00

abstract：:Nestin, a type-VI intermediate filament protein, serves as a marker for neural stem cells, and is also known to be expressed in follicle stem cells. Hair follicles go through repeated cycles of anagen (growth), catagen (regression) and telogen (quiescence) throughout the life of mammals following morphogenesis. In the...

journal_title：Molecular medicine reports

authors： Chen R,Miao Y,Hu Z

更新日期：2019-01-01 00:00:00