Fine particulate matter aggravates allergic airway inflammation through thymic stromal lymphopoietin activation in mice.

abstract：:Diabetic infected foot is the outcome of progressive vascular and neurological damage caused by persistent chronic hyperglycemia. Due to acute hypoxia and infection, the tissues develop extensive necrosis and gangrene, which often require amputation. The decision regarding the level of amputation relies mainly on the ...

journal_title：Molecular medicine reports

authors： Bekker-Méndez C,Guzmán-Aguilar RM,Hernández-Cueto MA,Huerta-Yepez S,Jarillo-Luna RA,González-Veyrand E,González-Bonilla CR

更新日期：2012-02-01 00:00:00

abstract：:In recent years hydrogen sulfide (H2S) has demonstrated vasculoprotective effects against cell death, which suggests its promising therapeutic potential for numerous types of disease. Additionally, a protective effect of exogenous H2S in HG‑induced injuries in HUVECs was demonstrated, suggesting a potential protective...

journal_title：Molecular medicine reports

authors： Lin J,Li X,Lin Y,Huang Z,Wu W

更新日期：2021-01-01 00:00:00

abstract：:The present study aimed to investigate changes at the transcript level that are associated with spontaneous astrocytoma progression, and further, to discover novel targets for glioma diagnosis and therapy. GSE4290 microarray data downloaded from Gene Expression Omnibus were used to identify the differentially expresse...

journal_title：Molecular medicine reports

authors： Hu G,Wei B,Wang L,Wang L,Kong D,Jin Y,Sun Z

更新日期：2015-08-01 00:00:00

abstract：:Nestin, a type-VI intermediate filament protein, serves as a marker for neural stem cells, and is also known to be expressed in follicle stem cells. Hair follicles go through repeated cycles of anagen (growth), catagen (regression) and telogen (quiescence) throughout the life of mammals following morphogenesis. In the...

journal_title：Molecular medicine reports

authors： Chen R,Miao Y,Hu Z

更新日期：2019-01-01 00:00:00

abstract：:Glaucoma is the leading cause of irreversible blindness globally. It is known that the incidence of glaucoma is closely associated with inheritance. A large number of studies have suggested that genetic factors are involved in the occurrence and development of glaucoma, and even affect the drug sensitivity and prognos...

journal_title：Molecular medicine reports

authors： Wang HW,Sun P,Chen Y,Jiang LP,Wu HP,Zhang W,Gao F

更新日期：2018-07-01 00:00:00

abstract：:OLIG1 is an oligodendrocyte (OL) transcription factor, which can contribute to the proliferation and differentiation of OLs, and the maturation of myelin. The aim of this study was to clarify the role of OLIG1 in neonatal Sprague Dawley rats with periventricular leukomalacia (PVL), induced by hypoxia‑ischemia (HI). Ne...

journal_title：Molecular medicine reports

authors： Cheng T,Xue X,Fu J

更新日期：2015-04-01 00:00:00

abstract：:The costs of spinal cord injury and its complications are high in personal, social and financial terms. Complications include bladder cancer, for which the risk is 16-28 times higher than that of the general population, There is currently little consensus regarding the cause of this discrepancy. As microRNAs are stabl...

journal_title：Molecular medicine reports

authors： Wang T,Liu Y,Yuan W,Zhang L,Zhang Y,Wang Z,Zhou X,Zhou H,Chu T,Hao Y,Liu B,Zhao X,Lu L,Feng S,Kong X

更新日期：2015-08-01 00:00:00

abstract：:Hypoxia‑inducible factor‑1α (HIF‑1α) is key in tumor progression and aggressiveness as it regulates a series of genes involved in angiogenesis and anaerobic metabolism. Previous studies have shown that the transcriptional levels of HIF‑1α may be downregulated by endostatin. However, the molecular mechanism by which en...

journal_title：Molecular medicine reports

authors： Guo L,Chen Y,He T,Qi F,Liu G,Fu Y,Rao C,Wang J,Luo Y

更新日期：2015-05-01 00:00:00

abstract：:In the pathophysiology of osteoarthritis (OA), articular cartilage degeneration exhibits a significant role. Vascular endothelial growth factor (VEGF) is considered to be an effective angiogenic factor and a crucial regulator of articular cartilage degeneration in the development of OA. Therefore, the present study ai...

journal_title：Molecular medicine reports

authors： Deng S,Zhou JL,Peng H,Fang HS,Liu F,Weng JQ

更新日期：2018-05-01 00:00:00

abstract：:The pro-apoptotic and anti-proliferative effects of 3,3'-diindolylmethane (DIM) in various tumor cell types have been widely investigated. The underlying mechanisms were suggested to include cell cycle arrest, cell signaling inhibition and downregulation of the androgen receptor. The present study demonstrated that DI...

journal_title：Molecular medicine reports

authors： Li F,Xu Y,Chen C,Chen SM,Xiao BK,Tao ZZ

更新日期：2015-09-01 00:00:00

abstract：:In this study, we aimed to explore the radio-sensitization of the SHG44 glioma cell line by Aidi injection and the possible mechanisms involved. The growth curve, cloning efficiency and divisional index of the SHG44 cell line were observed. The inhibition ratio was determined by MTT assay, the change in the cell cycle...

journal_title：Molecular medicine reports

authors： Xu XT,Song Y,Qin S,Wang LL,Zhou JY

更新日期：2012-06-01 00:00:00

abstract：:The present study aimed to investigate the expression and function of aquaporin (AQP)9 in the intestinal tract of acute liver injury rat models. A total of 20 Sprague Dawley rats were randomly divided into four groups: Normal control (NC) group and acute liver injury groups (24, 48 and 72 h). Acute liver injury rat mo...

journal_title：Molecular medicine reports

authors： Xiang T,Ge S,Wen J,Xie J,Yang L,Wu X,Cheng N

更新日期：2018-12-01 00:00:00

abstract：:Abnormal expression of matrix metalloproteinase 9 (MMP9) is correlated with podocyte epithelial-to---mesenchymal transition (EMT) in diabetic nephropathy (DN). However, the mechanisms underlying this process are not well defined. Site‑specific demethylation may sustain high expression levels of target genes. In the pr...

journal_title：Molecular medicine reports

authors： Ling L,Chen L,Zhang C,Gui S,Zhao H,Li Z

更新日期：2018-04-01 00:00:00

abstract：:The purpose of the present study was to investigate the effect of bufadienolides on the A‑375 melanoma cell line, and to delineate the underlying mechanism. A Cell Counting Kit‑8 assay was used to determine the viability of the cells, and flow cytometry was used to evaluate apoptosis. Western blot analysis was used to...

journal_title：Molecular medicine reports

authors： Li H,Cao X,Chen X,Yi X,Xia J,Chen J,Yang L

更新日期：2019-09-01 00:00:00

abstract：:Hypothermia is an effective neuroprotective treatment for brain injury caused by intracerebral hemorrhage (ICH). It is reported to reduce brain edema and neuronal cell death. Thrombin, a coagulation protease released from blood clots, is critical in brain edema formation following ICH. Protease activated receptor‑1 (P...

journal_title：Molecular medicine reports

authors： Gao D,Ding F,Lei G,Luan G,Zhang S,Li K,Wang D,Zhang L,Dai D

更新日期：2015-04-01 00:00:00

abstract：:The pathogenesis of Graves' ophthalmopathy (GO) remains to be entirely elucidated. The present study aimed to determine the association between phenotypic expression of the MTHFR gene and susceptibility to GO in patients with Graves' disease (GD). A prospective case‑controlled study was conducted with 122 patients wit...

journal_title：Molecular medicine reports

authors： Lee JY,Kim NK,Cho YW,Lew H

更新日期：2016-09-01 00:00:00

abstract：:Hypertension affects one billion people worldwide and is an independent risk factor for death after acute coronary syndrome (ACS). The aim of this study was to examine the prevalence and medical treatment of hypertension among 1,301 ACS patients enrolled into the Chinese registry of acute coronary events (CRACE) trial...

journal_title：Molecular medicine reports

authors： Lin Y,Pan W,Ning S,Song X,Jin Z,Lv S

更新日期：2013-07-01 00:00:00

abstract：:De novo sequence variants, including truncating and splicing variants, in the additional sex‑combs like 3 gene (ASXL3) have been described as the cause of Bainbridge‑Ropers syndrome (BRS). This pathology is characterized by delayed psychomotor development, severe intellectual disability, growth delay, hypotonia and fa...

journal_title：Molecular medicine reports

authors： Wayhelova M,Oppelt J,Smetana J,Hladilkova E,Filkova H,Makaturova E,Nikolova P,Beharka R,Gaillyova R,Kuglik P

更新日期：2019-07-01 00:00:00

abstract：:The aim of the present study was to investigate the changes of retinal microvascular network in patients with central serous chorioretinopathy (CSCR). A total of fifteen patients (right eye) with CSCR and 15 normal controls (right eye) were recruited. We used optical coherence tomography angiography to scan 6x6 mm mac...

journal_title：Molecular medicine reports

authors： Yu L,Shao Y,Chai Y,Ye LH,Yang QC,Ye L,Yuan Q,Jiang N,Yi JL

更新日期：2018-02-01 00:00:00

abstract：:G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-bound estrogen receptor that is involved in the mediation of non-genomic estradiol signalling. In this study, we demonstrated that male, but not female, GPR30-deficient mice suffer from impaired left‑ventricular cardiac function. Left ventric...

journal_title：Molecular medicine reports

authors： Delbeck M,Golz S,Vonk R,Janssen W,Hucho T,Isensee J,Schäfer S,Otto C

更新日期：2011-01-01 00:00:00

abstract：:Ephrin type‑A receptor 2 (EphA2) is a receptor tyrosine kinase that is associated with cancer cell metastasis. There has been little investigation into its impact on the regulation of sensitivity to paclitaxel in nasopharyngeal carcinoma (NPC). In the present study, upregulation of EphA2 expression enhanced the surviv...

journal_title：Molecular medicine reports

authors： Wang Y,Liu Y,Li G,Su Z,Ren S,Tan P,Zhang X,Qiu Y,Tian Y

更新日期：2015-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been investigated in the treatment of numerous autoimmune diseases. However, the immune properties of MSCs on the development of asthma have remained to be fully elucidated. Airway dendritic cells (DCs) have an important role in the pathogenesis of allergic asthma, and disrupting the...

journal_title：Molecular medicine reports

authors： Zeng SL,Wang LH,Li P,Wang W,Yang J

更新日期：2015-08-01 00:00:00

abstract：:Genetically modified mesenchymal stem cells have been used in attempts to increase the expression of interleukin‑1 receptor antagonist (IL‑1Ra); however, the attempts thus far have been unsuccessful. The aim of the present study was to investigate whether the lentivirus transduced IL‑1Ra gene was able to be stably exp...

journal_title：Molecular medicine reports

authors： He T,Chi G,Tian B,Tang T,Dai K

更新日期：2015-09-01 00:00:00

abstract：:Aberrant DNA methylation is the most common type of epigenetic alteration and is associated with many types of cancer. Although previous studies have provided a few novel DNA methylation markers in hepatocellular carcinoma (HCC), specific DNA methylation patterns and comparisons of the aberrant alterations in methylat...

journal_title：Molecular medicine reports

authors： Sun N,Zhang J,Zhang C,Shi Y,Zhao B,Jiao A,Chen B

更新日期：2018-11-01 00:00:00

abstract：:A coma is a serious complication, which can occur following traumatic brain injury (TBI), for which no effective treatment has been established. Previous studies have suggested that neural electrical stimulation, including median nerve stimulation (MNS), may be an effective method for treating patients in a coma, and ...

journal_title：Molecular medicine reports

authors： Zhong YJ,Feng Z,Wang L,Wei TQ

更新日期：2015-09-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) signaling transduction pathway has been implicated in multiple physiological processes. It is not clear whether the ERK1/2 pathway participates in post-traumatic stress disorder (PTSD). The aim of this study was to provide novel insights into the mechanisms of how the am...

journal_title：Molecular medicine reports

authors： Xiao B,Han F,Wang HT,Shi YX

更新日期：2011-05-01 00:00:00

abstract：:Human interferon α (IFN-α) and erythropoietin (EPO) have been used for a variety of purposes in clinical medicine. Human IFN-α has been used to treat several types of viral infection and cancer, as well as renal anemia, via stimulation of erythrocyte formation in the bone marrow. Transgenic cattle are excellent candid...

journal_title：Molecular medicine reports

authors： Jung EM,An BS,Kim YK,Hwang I,Lee JY,Shin TY,Hyun SH,Hwang WS,Jeung EB

更新日期：2013-02-01 00:00:00

abstract：:Leptomeningeal fibrosis is important in the pathogenesis of communicating hydrocephalus following subarachnoid hemorrhage; however, the underlying mechanisms of leptomeningeal fibrosis remain largely unclear. In the present study, primary meningeal mesothelial cells (MMCs) were used as a cell model to investigate the ...

journal_title：Molecular medicine reports

authors： Yue XJ,Guo Y,Yang HJ,Feng ZW,Li T,Xu YM

更新日期：2016-08-01 00:00:00

abstract：:Telomeres are DNA repeats at the ends of linear chromosomes in eukaryotic cells; they form cap-like specialized structures at chromosome ends to protect them from digestion and degradation. With each cell division, somatic cell telomeres progressively wear and shorten, leading to cell senescence. Various environmental...

journal_title：Molecular medicine reports

authors： Feng X,Wang L,Li Y

更新日期：2011-03-01 00:00:00

abstract：:Ginkgolide B is one of the components extracted from Folium Ginkgo. It is a natural antagonist of platelet‑activating factor receptor and has multiple pharmacological applications. In the present study, the effect of ginkgolide B on the proliferation of endothelial progenitor cells (EPCs) was examined, as well as its ...

journal_title：Molecular medicine reports

authors： Chang J,Xue X,Song C,Liu B,Gao L

更新日期：2017-10-01 00:00:00