MicroRNA‑409 may function as a tumor suppressor in endometrial carcinoma cells by targeting Smad2.

abstract：:A total of 60 breast cancer (BC) tissues and adjacent healthy tissues from patients who underwent surgery in Renmin Hospital of Wuhan University were collected for analysis in the present study. Results from reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) demonstrated that, compared with the adj...

journal_title：Molecular medicine reports

authors： Xu W,Wang W

更新日期：2018-06-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease. MicroRNAs (miRNAs) are a group of endogenous small non‑coding RNAs that regulate target genes, and play a critical role in many biological processes. However, the underlying mechanism of specific miRNA, miR‑130a‑3p, in AS remains largely unknown....

journal_title：Molecular medicine reports

authors： Li F,Si D,Guo X,Guo N,Li D,Zhang L,Jian X,Ma J

更新日期：2019-10-01 00:00:00

abstract：:Malignant glioma is the most common type of cancer in the central nervous system, with highly invasive characteristics. The Rho-associated protein kinase (ROCK1) has been found to act as key regulator of actin cytoskeleton reorganization, a process closely associated with cancer cell invasion. microRNA-145 (miRNA-145)...

journal_title：Molecular medicine reports

authors： Wan X,Cheng Q,Peng R,Ma Z,Chen Z,Cao Y,Jiang B

更新日期：2014-05-01 00:00:00

abstract：:The aim of the current study was to investigate the role of phospholipase C (PLC)γ/protein kinase C (PKC)/C‑kinase‑activated protein phosphatase‑1 (CPI‑17) signaling pathways in uterine smooth muscle during parturition. Samples of uterine tissue were collected from pregnant patients who underwent a caesarean section f...

journal_title：Molecular medicine reports

authors： Chen J,Zheng D,Cui H,Liu S,Zhang L,Liu C

更新日期：2018-01-01 00:00:00

abstract：:Arctigenin is a natural lignan that is found in burdock with anti‑viral, ‑oxidative, ‑inflammatory and anti‑tumor activities. In the current study, the effect of arctigenin on metastatic potential was examined in 4T‑1 mouse triple‑negative breast cancer cells. The results indicated that arctigenin inhibited cell motil...

journal_title：Molecular medicine reports

authors： Lee MG,Lee KS,Nam KS

更新日期：2020-03-01 00:00:00

abstract：:Identification of novel risk factors that are critical to the initiation of lung cancer will be key for its prevention. Recently, it has been reported that glycine dehydrogenase (GLDC) can drive the formation of lung cancer initiating cells. However, there have been no perspective studies on the association between ci...

journal_title：Molecular medicine reports

authors： Wei HY,Feng R,Shao H,Feng B,Liu HQ,Men JL,Zou W

更新日期：2018-08-01 00:00:00

abstract：:The replication of hepatitis B virus (HBV) may be modulated by a variety of cell signaling pathways, including the phosphatidylinositol 3‑kinase (PI3K)‑RAC‑α serine/threonine‑protein kinase (AKT)‑serine/threonine‑protein kinase mTOR (mTOR) pathway. The aim of the present study was to determine the regulatory effects o...

journal_title：Molecular medicine reports

authors： Xiang K,Wang B

更新日期：2018-03-01 00:00:00

abstract：:The present study investigated the immunopathological effect of Echinococcus multilocularis (Em) using cytokine detection. Expression of the T‑helper (Th) 17‑cytokine, interleukin 17 (IL‑17), was observed using immunohistochemical staining, and levels of cytokines, including IL‑17, transforming growth factor β1 (TGF‑β...

journal_title：Molecular medicine reports

authors： Ma X,Wang L,Zhao H,Pang N,Zhang F,Jiang T,Liu X,Mamuti W,Wen H,Ding J

更新日期：2014-07-01 00:00:00

abstract：:Cnidium monnieri (L.) Cusson is a frequently used traditional Chinese medicine that treats gynecological diseases and carbuncles. However, the mechanism of action of C. monnieri remains to be fully elucidated. The present study examined the cell cycle arrest and apoptotic effects resulting from ethanol extract of C. m...

journal_title：Molecular medicine reports

authors： Lim EG,Kim GT,Kim BM,Kim EJ,Kim SY,Kim YM

更新日期：2018-02-01 00:00:00

abstract：:Chloride intracellular channel 1 (CLIC1) has been demonstrated to be overexpressed in gastric cancer, and elevated CLIC1 expression levels are markedly associated with the processes of tumor cell migration and invasion. However, the regulatory mechanism and signaling pathway underlying these processes have remained to...

journal_title：Molecular medicine reports

authors： Zhao W,Lu M,Zhang Q

更新日期：2015-12-01 00:00:00

abstract：:Osteosarcoma is the most common primary malignant bone tumor among children and young people and is associated with poor prognosis. Punicalagin is an antioxidant ellagitannin found in pomegranate juice with known antiproliferation and anti‑angiogenesis properties. However, the antitumor effect of punicalagin on osteos...

journal_title：Molecular medicine reports

authors： Huang T,Zhang X,Wang H

更新日期：2020-09-01 00:00:00

abstract：:The existence of cancer stem cells (CSCs) is considered to be the main reason for chemoresistance, metastasis and the ultimate failure of treatment in hepatocellular carcinoma (HCC). However, there are a few chemical agents that may inhibit CSCs. The present study identified that 4,4'‑bond secalonic acid D (4,4'‑SAD),...

journal_title：Molecular medicine reports

authors： Chen L,Cheng MM,Li YP,Lin SF,Zheng QH,Liu QY

更新日期：2020-06-01 00:00:00

abstract：:Cervical cancer (CC) is a frequently occurring cancer in women with a high mortality rate. Despite improvements to therapeutic strategies, the survival outcome for patients with CC remains poor. Therefore, the present study aimed to investigate the molecular mechanism underlying CC inhibition involving microRNA (miR)‑...

journal_title：Molecular medicine reports

authors： Guo Y,Luo S

更新日期：2020-12-01 00:00:00

abstract：:Post‑cardiac arrest myocardial dysfunction (PAMD) is a leading cause of death in patients undergoing resuscitation patients following cardiac arrest (CA). Although prostaglandin E1 (PGE1) is a clinical drug used to mitigate ischemia injury, its effect on PAMD remains unknown. In the present study, the protective effec...

journal_title：Molecular medicine reports

authors： Su C,Fan X,Xu F,Wang J,Chen Y

更新日期：2021-02-01 00:00:00

abstract：:Cip1-interacting zinc finger protein 1 (CIZ1) is a nuclear protein that was observed to bind to p21Cip1/Waf1. p21Cip1/Waf1 regulates the cell cycle and is associated with colorectal cancer (CRC) progression. However, the effect of CIZ1 on CRC cells remains unclear. In the present study, CIZ1 was observed to be highly ...

journal_title：Molecular medicine reports

authors： Yin J,Wang C,Tang X,Sun H,Shao Q,Yang X,Qu X

更新日期：2013-12-01 00:00:00

abstract：:Nuclear respiratory factor 1 (NRF-1) has important roles in the regulation of several key metabolic genes required for cellular growth and respiration. A previous study by our group indicated that NRF‑1 is involved in mitochondrial dysfunction induced by the environmental pollutant benzo[a]pyrene in the 16HBE human br...

journal_title：Molecular medicine reports

authors： Wu J,Wang Y,Wo D,Zhang L,Li J

更新日期：2016-05-01 00:00:00

abstract：:Lung cancer is the most common cancer worldwide, and morbidity and mortality associated with lung cancer has been increasing annually in recent decades. MicroRNAs (miRNAs), which are short non‑coding RNA sequences that are involved in the regulation of gene expression, have been previously demonstrated to be key regul...

journal_title：Molecular medicine reports

authors： Li J,Jin H,Yu H,Wang B,Tang J

更新日期：2017-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancer types, and chemotherapy plays an important role in treatment of HCC. However, long‑term treatment with chemotherapeutic drugs such as 5‑fluorouracil (5‑FU) often results in chemoresistance, and the underlying mechanisms remain unclear. In this study, we s...

journal_title：Molecular medicine reports

authors： Wang C,Guo Y,Wang J,Min Z

更新日期：2015-03-01 00:00:00

abstract：:Heme oxygenase‑1 (HO‑1), as an inducible and cytoprotective enzyme, has a protective effect against cellular oxidative stress. In the present study, cholesterol was used to induce lipid overload and increase reactive oxygen species (ROS), leading to oxidative stress in EA.hy926 cells. In the present study, western blo...

journal_title：Molecular medicine reports

authors： Jin X,Xu Z,Fan R,Wang C,Ji W,Ma Y,Cai W,Zhang Y,Yang N,Zou S,Zhou X,Li Y

更新日期：2017-09-01 00:00:00

abstract：:Branchio‑otic (BO) syndrome is a clinically and genetically heterogeneous disorder that presents with variable branchial arch and otic anomalies. Dominant mutations in the human homologues of the Drosophila eyes absent (EYA1) gene, and the Drosophila sine oculis homeobox 1 and 5 (SIX1 and SIX5, respectively) genes hav...

journal_title：Molecular medicine reports

authors： Kause F,Reutter H,Marsch F,Thiele H,Altmüller J,Ludwig M,Zhang R

更新日期：2018-02-01 00:00:00

abstract：:Chronic microglial activation endangers neuronal survival through the release of various pro-inflammatory and neurotoxic factors. As such, negative regulators of microglial activation have been considered as potential therapeutic candidates to reduce the risk of neurodegeneration associated with inflammation. Uncaria ...

journal_title：Molecular medicine reports

authors： Jung HY,Nam KN,Woo BC,Kim KP,Kim SO,Lee EH

更新日期：2013-01-01 00:00:00

abstract：:The β1‑adrenergic receptor (AR) is the primary β‑AR subtype in the heart and is the target of metoprolol (Met), which is commonly used to treat angina and hypertension. Previous studies have revealed a positive correlation between the methylation levels of the adrenoreceptor β1 gene (Adrb1) promoter in the myocardium ...

journal_title：Molecular medicine reports

authors： Huang Y,Liu XL,Wen J,Huang LH,Lu Y,Miao RJ,Liu X,Li Y,Xing XW,Yuan H

更新日期：2017-02-01 00:00:00

abstract：:Tubeimoside-1 (TBMS1), a traditional Chinese herb extracted from Bolbostemma paniculatum (Maxim.), induces apoptosis in a number of human cancer cell lines. TBMS1 has been reported to induce apoptosis in human glioma cells, however the mechanism remains to be elucidated. The present study explored TBMS1‑induced PI3K/A...

journal_title：Molecular medicine reports

authors： Cao LJ,Xie HT,Chu ZX,Ma Y,Wang MM,Shi Z

更新日期：2020-08-01 00:00:00

abstract：:Triple‑negative breast cancer (TNBC) is a heterogeneous disease characterized by an aggressive phenotype and reduced survival. The aim of the present study was to investigate the molecular mechanisms involved in the carcinogenesis of TNBC and to identify novel target molecules for therapy. The differentially expressed...

journal_title：Molecular medicine reports

authors： Peng C,Ma W,Xia W,Zheng W

更新日期：2017-03-01 00:00:00

abstract：:Diabetic cardiomyopathy (DCM) is a major cause of mortality in patients with diabetes, particularly those with type 2 diabetes. Long non‑coding RNAs (lncRNAs), including terminal differentiation‑induced lncRNA (TINCR), myocardial infarction‑associated transcript (MIAT) and H19, serve a key role in the regulation of DC...

journal_title：Molecular medicine reports

authors： Chen K,Ma Y,Wu S,Zhuang Y,Liu X,Lv L,Zhang G

更新日期：2019-08-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL), the most frequently occurring type of lymphoid malignancy, has been demonstrated to be associated with mutations of Ten‑Eleven Translocation (TET). In order to explore the association between DLBCL and TET mutations, the present study analyzed the gene expression and methylation ...

journal_title：Molecular medicine reports

authors： Liu P,Jiang W,Zhao J,Zhang H

更新日期：2017-10-01 00:00:00

abstract：:The present study investigated the function of oncostatin M (OSM), which may be associated with monocyte chemotactic protein‑1 (MCP‑1), on mouse MC3T3‑E1 osteoblast development and bone remodeling. Levels of MCP‑1, macrophage inflammatory protein 1α (MIP1α) and regulated upon activation normal T cell expressed and sec...

journal_title：Molecular medicine reports

authors： Zheng W,Guan J

更新日期：2018-09-01 00:00:00

abstract：:Cisplatin is a first generation platinum‑based chemotherapeutic agent, however, the extensive application of cisplatin inevitably results in drug resistance, which is a major obstacle in cancer chemotherapy. The aim of the present study was to investigate the efficiency of reversing cisplatin‑resistance with the use o...

journal_title：Molecular medicine reports

authors： Ma S,Tan W,Du B,Liu W,Li W,Che D,Zhang G

更新日期：2016-04-01 00:00:00

abstract：:Neuroinflammation and microglial activation are two important hallmarks of neurodegenerative diseases. Continuous microglial activation may cause the release of several cytotoxic molecules, including many cytokines that are involved in the inflammatory process. Therefore, attenuating inflammation caused by activated m...

journal_title：Molecular medicine reports

authors： Mendonca P,Taka E,Soliman KFA

更新日期：2019-08-01 00:00:00

abstract：:Breast cancer (BC) is the most common cancer among women worldwide. However, there is insufficient research that focuses on the expression and molecular mechanisms of microRNA (miR)‑204‑5p in BC. In the current study, data were downloaded from the Cancer Genome Atlas (TCGA), the Gene Expression Omnibus (GEO) and the U...

journal_title：Molecular medicine reports

authors： Cai KT,Liu AG,Wang ZF,Jiang HW,Zeng JJ,He RQ,Ma J,Chen G,Zhong JC

更新日期：2019-02-01 00:00:00