Punicalagin inhibited proliferation, invasion and angiogenesis of osteosarcoma through suppression of NF‑κB signaling.

abstract：:Osteoclasts (OCs) are resorptive cells responsible for bone erosion in diseases, including osteoporosis, periodontitis and rheumatoid arthritis. Montelukast is a cysteinyl leukotriene receptor 1 (CysLTR1) antagonist clinically used for the treatment of asthma. In the present study, the role of CysLTR1 on OC formation ...

journal_title：Molecular medicine reports

authors： Kang JH,Lim H,Lee DS,Yim M

更新日期：2018-08-01 00:00:00

abstract：:Centromere protein M (CENPM), a protein required for chromosome separation, is involved in in mitosis. However, little has been reported about the roles of CENPM in various types of cancer. The present study identified that the mRNA expression levels of CENPM were significantly upregulated in 14 types of human cancer ...

journal_title：Molecular medicine reports

authors： Liu Y,Yu W,Ren P,Zhang T

更新日期：2020-11-01 00:00:00

abstract：:DNA methylation and hydroxymethylation are the most common epigenetic modifications associated with the cell cycle and the inflammatory response. The present study aimed to investigate the role of 5‑hydroxymethyl‑cytosine (5‑hmC) and ten‑eleven translocation‑2 (TET2) in keratinocytes. Following TET2 knockdown, dot blo...

journal_title：Molecular medicine reports

authors： Liu X,Wang X,Liu N,Zhu K,Zhang S,Duan X,Huang Y,Jin Z,Jaypaul H,Wu Y,Chen H

更新日期：2020-04-01 00:00:00

abstract：:In adults, bone hematopoietic cells are responsible for the lifelong production of all blood cells. It is affected in aging, with progressive loss of physiological integrity leading to impaired function by cellular intrinsic and extrinsic factors. However, intervention measures, which directly inhibit the aging of hem...

journal_title：Molecular medicine reports

authors： Zhou Y,Liu J,Cai S,Liu D,Jiang R,Wang Y

更新日期：2015-09-01 00:00:00

abstract：:In the present study, mutL homolog 1 (MLH1) small interfering (si)RNA, KU‑55933, an ataxia‑telangiectasia mutated (ATM) inhibitor, and compound C, an adenosine monophosphate‑activated protein kinase (AMPK) inhibitor, were used to investigate the mechanisms underlying temozolomide (TMZ)‑induced autophagy and to determi...

journal_title：Molecular medicine reports

authors： Zou Y,Wang Q,Wang W

更新日期：2015-06-01 00:00:00

abstract：:Pirarubicin is frequently used in chemotherapy against tumors. However, clinical use is severely limited by the development of progressive dose-dependent cardiomyopathy and acquired drug resistance. LY294002 is a commonly used pharmacologic inhibitor, which selectively inhibits the phosphoinositide 3-kinase-AKT nexus....

journal_title：Molecular medicine reports

authors： Long XH,Zhong ZH,Peng AF,Zhu LB,Wang H,Zhang GM,Liu ZL

更新日期：2014-12-01 00:00:00

abstract：:Chemokines are known to have anti-tumor effects due to their chemoattractant properties, which stimulate the accumulation of infiltrating immune cells in tumors. CCL22 (macrophage-derived chemokine, MDC) attracts killer T?cells, helper T cells and antigen-presenting cells expressing the CCL22 receptor, CCR4. Thus, CCL...

journal_title：Molecular medicine reports

authors： Cho S,Koizumi K,Takeno N,Kato S,Yamada M,Hashimoto I,Sakurai H,Tsukada K,Saiki I

更新日期：2009-09-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is a signaling gasotransmitter, involved in various physiological and pathological processes. H2S-donating drugs have been tested to conjugate the beneficial effects of H2S with other pharmaceutical properties. It has been shown that the endogenous cystathionine-γ-lyase (CSE)/H2S pathway partici...

journal_title：Molecular medicine reports

authors： Xie YH,Zhang N,Li LF,Zhang QZ,Xie LJ,Jiang H,Li LP,Hao N,Zhang JX

更新日期：2014-10-01 00:00:00

abstract：:Tumor necrosis factor α-induced protein 8 (TNFAIP8) has been associated with the tumorigenicity of various types of cancer, however, the expression of TNFAIP8 and its function in gastric cancer remain to be fully elucidated. Therefore, the present study examined the expression and biological function of TNFAIP8 in gas...

journal_title：Molecular medicine reports

authors： Li Y,Jing C,Chen Y,Wang J,Zhou M,Liu X,Sun D,Mu L,Li L,Guo X

更新日期：2015-08-01 00:00:00

abstract：:Liver-intestine cadherin (LI-cadherin), a novel member of the cadherin family, has been associated with the ability of a tumor to acquire an aggressive phenotype in several types of cancer. However, the exact function of LI-cadherin in the process of tumor invasion and metastasis remains predominantly unknown. To expl...

journal_title：Molecular medicine reports

authors： Yu Q,Shen W,Zhou H,Dong W,Gao D

更新日期：2016-05-01 00:00:00

abstract：:MicroRNA (miR)-185, which has been reported to be abnormally expressed in some types of cancer, exerts significant effects on the proliferation, apoptosis, drug resistance and metastasis of cancer cells. The present study aimed to explore the effects and underlying molecular mechanisms of miR‑185 upregulation on the a...

journal_title：Molecular medicine reports

authors： Fan L,Tan B,Li Y,Zhao Q,Yuan H,Liu Y,Wang D,Zhang Z

更新日期：2018-02-01 00:00:00

abstract：:In order to reverse the malignant characteristics of hypopharyngeal cancer, the proteasome inhibitor MG132 was introduced into FaDu/T cells and the mechanisms underlying its effects were investigated. The multi-drug resistance (MDR) sensitivities of FaDu/T and FaDu/T-MG132 cancer cells to several chemotherapeutics wer...

journal_title：Molecular medicine reports

authors： Ma J,Yu L,Tian J,Mu Y,Lv Z,Zou J,Li J,Wang H,Xu W

更新日期：2014-06-01 00:00:00

abstract：:Numerous studies have shown that N-nitrosamines and their precursors are probable etiological factors for esophageal cancer. Certain N-nitrosamines have been shown to induce esophageal cancer in animal models. However, the molecular mechanisms by which N-nitrosamines promote esophageal carcinogenesis remain poorly und...

journal_title：Molecular medicine reports

authors： Xie Y,Tang E,Ren B,Feng L

更新日期：2010-05-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) and collagen type I (Col-1) serve a critical role in the development and progression of hypertrophic scarring (HS). The present study hypothesized that a post‑translational mechanism of microRNAs (miR) regulated the expression of TGF‑β1 and Col‑1 in HS fibroblasts (HSFBs). A coll...

journal_title：Molecular medicine reports

authors： Xiao K,Luo X,Wang X,Gao Z

更新日期：2017-04-01 00:00:00

abstract：:Wound healing impairment is increasingly recognized to be a consequence of hyperglycemia‑induced dysfunction of endothelial precursor cells (EPCs) in type 2 diabetes mellitus (T2DM). Metformin exhibits potential for the improvement of endothelial function and the wound healing process. However, the underlying mechanis...

journal_title：Molecular medicine reports

authors： Han X,Tao Y,Deng Y,Yu J,Sun Y,Jiang G

更新日期：2017-12-01 00:00:00

abstract：:Circadian rhythms comprise of daily oscillations in a variety of biological processes and are regulated by an endogenous clock. Disruption of these rhythms has been associated with cancer progression, and understanding natural oscillations in cellular growth control, tumor suppression and cancer treatment, may reveal ...

journal_title：Molecular medicine reports

authors： Couto P,Miranda D,Vieira R,Vilhena A,De Marco L,Bastos-Rodrigues L

更新日期：2014-07-01 00:00:00

abstract：:Toll-like receptor (TLR) family members are pattern recognition receptors that are essential in the activation of innate and adaptive immune responses. Submandibular gland epithelial cells (SMGCs) may recognize microbial components through TLRs and be involved in the development of inflammatory reactions in the subman...

journal_title：Molecular medicine reports

authors： Ohta K,Ishida Y,Fukui A,Mizuta K,Nishi H,Takechi M,Kamata N

更新日期：2014-11-01 00:00:00

abstract：:B cells are critically important for the pathogenesis of IgA nephropathy (IgAN). The present study aimed to investigate the abundance of B cell activating factor (BAFF), which belongs to the tumor necrosis factor superfamily, in the peripheral blood of patients with IgAN. The different forms of BAFF in peripheral bloo...

journal_title：Molecular medicine reports

authors： Zheng N,Fan J,Wang B,Wang D,Feng P,Yang Q,Yu X

更新日期：2017-04-01 00:00:00

abstract：:The aim of the present study was to develop a reliable and reproducible canine model to mimic human diffuse hepatic vein obstruction (Budd‑Chiari syndrome, BCS). A total of 24 canines were divided into an experimental (n=18) and a control (n=6) group. Under the guidance of digital subtraction angiography, a balloon ca...

journal_title：Molecular medicine reports

authors： Shen B,Zhang Q,Wang X,Xu H,Zu M,Wu M,Gao Z,Wang W,Xiao J,Wang Y

更新日期：2014-02-01 00:00:00

abstract：:The aim of the current study was to investigate the role of phospholipase C (PLC)γ/protein kinase C (PKC)/C‑kinase‑activated protein phosphatase‑1 (CPI‑17) signaling pathways in uterine smooth muscle during parturition. Samples of uterine tissue were collected from pregnant patients who underwent a caesarean section f...

journal_title：Molecular medicine reports

authors： Chen J,Zheng D,Cui H,Liu S,Zhang L,Liu C

更新日期：2018-01-01 00:00:00

abstract：:Eurycoma (E.) longifolia Jack (Tongkat Ali) is a widely applied medicine that has been reported to boost serum testosterone and increase muscle mass. However, its actual biological targets and effects on an in vitro level remain poorly understood. Therefore, the present study aimed to investigate the effects of a stan...

journal_title：Molecular medicine reports

authors： Khurshid Ahmed NA,Lim SK,Pandian GN,Sugiyama H,Lee CY,Khoo BY,Chan KL

更新日期：2020-11-01 00:00:00

abstract：:The present study characterizes the effects of resveratrol (Res) on vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelial (RPE) cells. ARPE-19 cells were treated with CoCl2, a hypoxia mimetic agent. CoCl2 treatment increased protein levels of hypoxia inducible factor-1α (HIF-1α) and CXC-che...

journal_title：Molecular medicine reports

authors： Seong H,Ryu J,Jeong JY,Chung IY,Han YS,Hwang SH,Park JM,Kang SS,Seo SW

更新日期：2015-07-01 00:00:00

abstract：:Paraquat (PQ) poisoning‑induced pulmonary fibrosis is one of the primary causes of mortality in patients with PQ poisoning. The potential mechanism of PQ‑induced pulmonary fibrosis was thought to be mediated by inflammation. Recently, bone marrow‑derived mesenchymal stem cells (BMSCs) have been considered as a potenti...

journal_title：Molecular medicine reports

authors： Chen J,Si L,Zhou L,Deng Y

更新日期：2019-04-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common neurodegenerative diseases. For decades, the unilateral 6‑hydroxydopamine (6‑OHDA) rat model has been employed to investigate the pathogenesis and therapy of PD. However, the behavior and associated pathological features of the model long term have not previously been...

journal_title：Molecular medicine reports

authors： Su RJ,Zhen JL,Wang W,Zhang JL,Zheng Y,Wang XM

更新日期：2018-02-01 00:00:00

abstract：:Thyroid cancer (TC) is a frequently occurring malignant tumor with a rising steadily incidence. microRNA (miRNA/miR)‑193a‑3p is an miRNA that is associated with tumors, playing a crucial role in the genesis and progression of various cancers. However, the expression levels of miR‑193a‑3p and its molecular mechanisms i...

journal_title：Molecular medicine reports

authors： Li XJ,Wen R,Wen DY,Lin P,Pan DH,Zhang LJ,He Y,Shi L,Qin YY,Lai YH,Lai JN,Yang JL,Lai QQ,Wang J,Ma J,Yang H,Pang YY

更新日期：2020-09-01 00:00:00

abstract：:Antimycin A (AMA) is an inhibitor of the electron transport chain in mitochondria. In this study, we investigated the anti-apoptotic effects of pan-caspase inhibitor (Z-VAD), superoxide dismutase (SOD) or catalase on AMA-induced HeLa cell death in relation to the cell cycle. Treatment with Z-VAD, SOD or catalase rescu...

journal_title：Molecular medicine reports

authors： Han YH,Kim SH,Kim SZ,Park WH

更新日期：2009-03-01 00:00:00

abstract：:Prostate cancer (PCa) poses a high risk to older men and it is the second most common type of male malignant tumor in western developed countries. Additionally, there is a lack of effective therapies for PCa at advanced stages. Novel treatment strategies such as adenovirus‑mediated gene therapy and virotherapy involve...

journal_title：Molecular medicine reports

authors： Cai Z,Lv H,Cao W,Zhou C,Liu Q,Li H,Zhou F

更新日期：2017-11-01 00:00:00

abstract：:β-crystallin B2 (CRYBB2) knockout mice exhibit morphological and functional abnormalities in the ovary. Long non‑coding RNAs (lncRNAs) regulate gene transcription and translation, and epigenetic modification of genomic DNA. The present study investigated the role of lncRNAs in mediating the effects of CRYBB2 in the re...

journal_title：Molecular medicine reports

authors： Gao Q,Ren H,Chen M,Niu Z,Tao H,Jia Y,Zhang J,Li W

更新日期：2016-11-01 00:00:00

abstract：:Clara cell protein (CC16) is an anti-inflammatory protein, which is expressed in the airway epithelium. It is involved in the development of airway inflammatory diseases, including chronic obstructive pulmonary disease and asthma. However, the exact molecular mechanism underlying its anti‑inflammatory action remains t...

journal_title：Molecular medicine reports

authors： Pang M,Bai XY,Li Y,Bai JZ,Yuan LR,Ren SA,Hu XY,Zhang XR,Yu BF,Guo R,Wang HL

更新日期：2016-11-01 00:00:00

abstract：:The present study investigated the immunopathological effect of Echinococcus multilocularis (Em) using cytokine detection. Expression of the T‑helper (Th) 17‑cytokine, interleukin 17 (IL‑17), was observed using immunohistochemical staining, and levels of cytokines, including IL‑17, transforming growth factor β1 (TGF‑β...

journal_title：Molecular medicine reports

authors： Ma X,Wang L,Zhao H,Pang N,Zhang F,Jiang T,Liu X,Mamuti W,Wen H,Ding J

更新日期：2014-07-01 00:00:00