Abstract:
:The present study investigated the immunopathological effect of Echinococcus multilocularis (Em) using cytokine detection. Expression of the T‑helper (Th) 17‑cytokine, interleukin 17 (IL‑17), was observed using immunohistochemical staining, and levels of cytokines, including IL‑17, transforming growth factor β1 (TGF‑β1), IL‑6, interferon γ (IFN‑γ) and IL‑4, were assessed using ELISA at different stages of infection. IL‑17 expression occurred in hepatic cells at 1 month post‑infection, reached a maximum at 3 months post‑infection and then decreased gradually. Compared with the uninfected control, levels of the cytokines IL‑17, TGF‑β1, IL‑6, IFN‑γ and IL‑4 exhibited different dynamic patterns when infected with Em. In the immune response during the whole infection period, Th17 cells play an important role by secreting IL‑17, which may be involved in the Th1/Th2‑cell balance during the immune response. Th17 cells are associated with immunopathology in Em infection.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Ma X,Wang L,Zhao H,Pang N,Zhang F,Jiang T,Liu X,Mamuti W,Wen H,Ding Jdoi
10.3892/mmr.2014.2170subject
Has Abstractpub_date
2014-07-01 00:00:00pages
236-40issue
1eissn
1791-2997issn
1791-3004journal_volume
10pub_type
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