Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters.

abstract：:As demonstrated in previous studies, the phosphorylated form of 4E‑binding protein 1 (p‑4E‑BP1) may be a suitable tumor biomarker. The aim of the current study was to examine the expression status of p‑4E‑BP1 in colorectal cancer (CRC), in order to determine its clinical significance. The present study enrolled 89 pat...

journal_title：Molecular medicine reports

authors： Miao Y,Chen L,Shi C,Fan R,Chen P,Liu H,Xia A,Qian H

更新日期：2017-05-01 00:00:00

abstract：:A polymorphism within the 3'-UTR 8473T↷C of the cyclooxygenase-2 (COX-2) gene, which plays a role in gastrointestinal cancer development, has been associated with susceptibility to malignant disease. Here, we report on the interaction between the COX-2 3'-UTR T↷C polymorphism and gastric cancer development. DNA from 1...

journal_title：Molecular medicine reports

authors： Shibata T,Arisawa T,Tahara T,Hirata I,Nakano H

更新日期：2008-07-01 00:00:00

abstract：:The cell cycle is tightly regulated by the family of cyclin-dependent kinases (CDKs). CDKs act as regulatory factors on serine and threonine residues by phosphorylating their substrates and cyclins. CDK‑targeting drugs have previously demonstrated promising effects as cancer therapeutics both in vitro and in vivo. Ros...

journal_title：Molecular medicine reports

authors： Coker-Gurkan A,Arisan ED,Obakan P,Ozfiliz P,Kose B,Bickici G,Palavan-Unsal N

更新日期：2015-03-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is highly prevalent worldwide, and the outcome of HNSCC is still difficult to predict due to the lack of appropriate prognostic markers. In the present study, a prognostic model based on a miRNA panel was established to better predict the survival of HNSCC patients. miRNA ...

journal_title：Molecular medicine reports

authors： Lu L,Wu Y,Feng M,Xue X,Fan Y

更新日期：2019-11-01 00:00:00

abstract：:Calcium oxalate stones account for >80% of urinary stones, however the mechanisms underlying their formation remains to be elucidated. Hyperoxaluria serves an important role in the pathophysiological process of stone formation. In the present study, differences in the miRNA expression profiles between experimental hyp...

journal_title：Molecular medicine reports

authors： Liu Z,Jiang H,Yang J,Wang T,Ding Y,Liu J,Wang S,Ye Z

更新日期：2016-11-01 00:00:00

abstract：:The cooperation and communication between different cell signaling transduction pathways are considered critical in the development of various types of cancer as well as drug resistance. There is evidence of crosstalk between the G protein-coupled receptor 30 (GPR30), the newly discovered estrogen receptor (ER), and t...

journal_title：Molecular medicine reports

authors： Ruan SQ,Wang SW,Wang ZH,Zhang SZ

更新日期：2012-07-01 00:00:00

abstract：:Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence, metastasis, and chemo‑, radio‑ and immuno‑resistance. Understanding the mechanism of CSC self‑renewal and proliferation may help overcome the limitations of clinical treatment. The microenvironment of tumor growth consists of a lack...

journal_title：Molecular medicine reports

authors： Zhang Q,Han Z,Zhu Y,Chen J,Li W

更新日期：2021-01-01 00:00:00

abstract：:Although Frey syndrome is not life-threatening, it is identified as the most serious and widely recognized sequela of parotidectomy and has significant potential negative social and psychological implications. Several studies have investigated whether AlloDerm® implants prevent Frey syndrome effectively and safely, ho...

journal_title：Molecular medicine reports

authors： Zeng XT,Tang XJ,Wang XJ,Li MZ,Guo Y,Huang W,Niu YM,Leng WD

更新日期：2012-04-01 00:00:00

abstract：:Saikosaponin‑d (SSd), a triterpene saponin compound derived from Bupleurum radix, has been shown to have a cytotoxic effect on various cancer cell lines. However, its effect on prostate cancer cells has remained unexplored. The present study reports the apoptosis‑inducing effect of SSd on the DU145 human prostate carc...

journal_title：Molecular medicine reports

authors： Yao M,Yang J,Cao L,Zhang L,Qu S,Gao H

更新日期：2014-07-01 00:00:00

abstract：:Dengue virus (DENV) causes self‑limiting dengue fever (DF), severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). It is generally considered that cytokine storm leads to the increased plasma leakage characteristic of DHF/DSS. In the present study, peripheral blood m...

journal_title：Molecular medicine reports

authors： Qi Y,Li Y,Zhang L,Huang J

更新日期：2013-03-01 00:00:00

abstract：:Human mucin 1 (MUC1) is a target for immunotherapy. The major problem associated with MUC1‑based cancer vaccines is the weakness of the immunogenicity of MUC1. The present study aimed to develop an efficient cancer vaccine through generating a recombinant fusion protein consisting of MUC1 and maltose‑binding protein (...

journal_title：Molecular medicine reports

authors： Fang F,Ma J,Ni W,Wang F,Sun X,Li Y,Li Q,Xie F,Wang J,Zhai R,Liu Z,Gao S,Tai G

更新日期：2014-08-01 00:00:00

abstract：:Cardiac fibrosis is one of the pathological characteristics of diabetic cardiomyopathy (DbCM). Matrine treatment has proven to be effective in cases of organ fibrosis and cardiovascular diseases. In the present study, the anti-fibrosis-associated cardioprotective effects of matrine on DbCM were investigated. Rats with...

journal_title：Molecular medicine reports

authors： Zhang Y,Cui L,Guan G,Wang J,Qiu C,Yang T,Guo Y,Liu Z

更新日期：2018-01-01 00:00:00

abstract：:The aim of the present study was to investigate the changes of retinal microvascular network in patients with central serous chorioretinopathy (CSCR). A total of fifteen patients (right eye) with CSCR and 15 normal controls (right eye) were recruited. We used optical coherence tomography angiography to scan 6x6 mm mac...

journal_title：Molecular medicine reports

authors： Yu L,Shao Y,Chai Y,Ye LH,Yang QC,Ye L,Yuan Q,Jiang N,Yi JL

更新日期：2018-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs), which can be isolated from umbilical cords and induced to differentiate into multiple cell types in vitro, represent an ideal source for cell and gene therapy. MSCs are typically expanded in culture prior to their therapeutic application. However, similar to other types of stem cell, MSC...

journal_title：Molecular medicine reports

authors： Gu Y,Li T,Ding Y,Sun L,Tu T,Zhu W,Hu J,Sun X

更新日期：2016-06-01 00:00:00

abstract：:Toll-like receptor (TLR) family members are pattern recognition receptors that are essential in the activation of innate and adaptive immune responses. Submandibular gland epithelial cells (SMGCs) may recognize microbial components through TLRs and be involved in the development of inflammatory reactions in the subman...

journal_title：Molecular medicine reports

authors： Ohta K,Ishida Y,Fukui A,Mizuta K,Nishi H,Takechi M,Kamata N

更新日期：2014-11-01 00:00:00

abstract：:More than 60 years after their isolation and characterization, aminoglycoside (AG) antibiotics remain powerful agents in the treatment of severe gram-negative, enterococcal or mycobacterial infections. However, the clinical use of AGs is hampered by nephrotoxicity and ototoxicity, which often develop as a consequence ...

journal_title：Molecular medicine reports

authors： Perletti G,Vral A,Patrosso MC,Marras E,Ceriani I,Willems P,Fasano M,Magri V

更新日期：2008-01-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a highly metastatic malignancy, which is highly prevalent in Southeast Asia and North Africa. Recent studies implicated the critical role of nemo‑like kinase (NLK) in tumor biology. However, the functional role of NLK in NPC has yet to be elucidated. In the present study, the signific...

journal_title：Molecular medicine reports

authors： Chen S,Ma Z,Chen X,Zhang J

更新日期：2014-07-01 00:00:00

abstract：:Serious diabetic complications affect millions of patients worldwide. Skeletal muscle represents the largest insulin-regulated glucose sink in the body, making insulin resistance and abnormal glucose disposal in muscle fibres a critical aspect of diabetes mellitus. Advances in the biomedical analysis of the molecular ...

journal_title：Molecular medicine reports

authors： Mulvey C,Mullen E,Ohlendieck K

更新日期：2008-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate biogenesis and disease development by targeting numerous mRNAs. miRNA (miR)‑124 and its direct target, inhibitor of apoptosis‑stimulating protein of p53 (iASPP), may be involved in tumor development and progression. The aim of the present study was to explore the role of miR‑124‑targeted iA...

journal_title：Molecular medicine reports

authors： Liu X,Kang J,Sun S,Luo Y,Ji X,Zeng X,Zhao S

更新日期：2018-01-01 00:00:00

abstract：:The present study aimed to investigate the protective effects of ghrelin against oxidative stress, inducible nitric oxide synthase (iNOS) and inflammation in a mouse model of myocardial ischemia/reperfusion injury (MIRI). In addition, the study aimed to determine its underlying mechanisms. A mouse model of MIRI was us...

journal_title：Molecular medicine reports

authors： Sun N,Wang H,Wang L

更新日期：2016-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancer types worldwide. The signal transducer and activator of transcription 3 (STAT3) protein is a member of the STAT transcription factor family. Oncogenesis, invasion, and metastasis of HCC are associated with activation of STAT3. However, whether aberrant ex...

journal_title：Molecular medicine reports

authors： Wang X,Xin W,Zhang H,Zhang F,Gao M,Yuan L,Xu X,Hu X,Zhao M

更新日期：2014-11-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a common liver disease that currently has no standard treatment. The present study aimed to evaluate the effects of Lycium ruthenicum extract (LRE) on high‑fat diet (HFD)-induced NAFLD, and elucidate the underlying molecular mechanisms. To determine the hepatoprotective effe...

journal_title：Molecular medicine reports

authors： Lin J,Zhang Y,Wang X,Wang W

更新日期：2015-09-01 00:00:00

abstract：:Bone cancer pain (BCP) is a severe complication of advanced bone cancer. Although cannabinoid receptor 2 (CB2) agonists may have an analgesic effect, the underlying mechanism remains unclear. CB2 serves a protective role in various pathological states through the activation of autophagy. Therefore, the present study a...

journal_title：Molecular medicine reports

authors： Mao Y,Huang Y,Zhang Y,Wang C,Wu H,Tian X,Liu Y,Hou B,Liang Y,Rong H,Gu X,Ma Z

更新日期：2019-12-01 00:00:00

abstract：:The overexpression and hypersecretion of mucus is a hallmark of several chronic pulmonary inflammatory diseases, including chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis. Mucin 5ac (MUC5AC) is a major component of airway mucus. Annexin II (ANXII) has been reported to be expressed in various c...

journal_title：Molecular medicine reports

authors： Xu R,Li Q,Zhou X,Perelman JM,Kolosov VP

更新日期：2014-01-01 00:00:00

abstract：:In the present study, a novel monoclonal antibody (MAb) specific for icariin (ICA) was prepared and characterized. A hybridoma‑secreting MAb against icariin was produced by fusing splenocytes immunized with an ICA‑bovine serum albumin conjugate with a hypoxanthine‑aminopterin‑thymidine‑sensitive mouse myeloma SP2/0 ce...

journal_title：Molecular medicine reports

authors： Cheng J,Zhang Y,Liu S,Qu B,Zhang M,Liu X,Zhao Y,Qu H

更新日期：2017-01-01 00:00:00

abstract：:The aims of the current study were to systematically analyze the regulation of the expression of NALP3 by the P2X7 receptor in P388D1 murine macrophage‑like cells, and to investigate the association between the P2X7 receptor and the NALP3 at the molecular level. Cell culture, RNA transfection, adenosine triphosphate (...

journal_title：Molecular medicine reports

authors： Chen Z,Jin H,Hou Y,Wang B,Chen C,Yang Z,Ding D,Zuo Y,Ren S

更新日期：2015-02-01 00:00:00

abstract：:Heme oxygenase‑1 (HO‑1), as an inducible and cytoprotective enzyme, has a protective effect against cellular oxidative stress. In the present study, cholesterol was used to induce lipid overload and increase reactive oxygen species (ROS), leading to oxidative stress in EA.hy926 cells. In the present study, western blo...

journal_title：Molecular medicine reports

authors： Jin X,Xu Z,Fan R,Wang C,Ji W,Ma Y,Cai W,Zhang Y,Yang N,Zou S,Zhou X,Li Y

更新日期：2017-09-01 00:00:00

abstract：:Hypertensive nephrosclerosis (HNS) is a major risk factor for end-stage renal disease. However, the underlying pathogenesis of HNS remains to be fully determined. The gene expression profile of GSE20602, which consists of 14 glomeruli samples from patients with HNS and 4 normal glomeruli control samples, was obtained ...

journal_title：Molecular medicine reports

authors： Liu T,Liu M,Shang P,Jin X,Liu W,Zhang Y,Li X,Ding Y,Li Y,Wen A

更新日期：2018-03-01 00:00:00

abstract：:The association of the peripheral lymphocyte‑to‑monocyte ratio (LMR) with α‑fetoprotein (AFP) status in patients with AFP‑positive and AFP‑negative hepatocellular carcinoma (HCC) has not been investigated in detail. The aim of the present study was to examine the association between the LMR and AFP status in these pat...

journal_title：Molecular medicine reports

authors： Wang H,Xiang Y,Li X,Liu S,Liu L

更新日期：2020-10-01 00:00:00

abstract：:Numerous studies have indicated that the human endothelial nitric oxide synthase (eNOS) gene Glu298Asp polymorphism is associated with coronary heart disease (CHD) susceptibility, however, their conclusions are inconsistent. The present meta‑analysis aimed to evaluate the precise result by searching the PubMed databas...

journal_title：Molecular medicine reports

authors： Tian GX,Zeng XT,Wang XB,Zhang L,Zhang W,Wei WL

更新日期：2013-04-01 00:00:00