Investigation into the underlying molecular mechanisms of hypertensive nephrosclerosis using bioinformatics analyses.

abstract：:Skeletal myogenesis is a highly ordered and complex biological process that is mediated by numerous regulatory factors. In previous studies, it has been demonstrated that microRNAs (miRs) and long non‑coding RNAs (lncRNAs) serve key roles in skeletal myogenesis. The present study showed that the expression levels of m...

journal_title：Molecular medicine reports

authors： Zhao X,Gu H,Wang L,Zhang P,Du J,Shen L,Jiang D,Wang J,Li X,Zhang S,Li M,Zhu L

更新日期：2020-11-01 00:00:00

abstract：:Ras‑GTPase‑activating protein SH3 domain‑binding protein 1 (G3BP1) has been reported to be of importance in the occurrence and development of colon cancer. However, the underlying mechanisms remain largely unknown. Therefore, the aim of the present study was to investigate the role of Wnt/β‑catenin signaling in G3BP1‑...

journal_title：Molecular medicine reports

authors： Li Y,Wang J,Zhong S,Li J,Du W

更新日期：2020-11-01 00:00:00

abstract：:A coma is a serious complication, which can occur following traumatic brain injury (TBI), for which no effective treatment has been established. Previous studies have suggested that neural electrical stimulation, including median nerve stimulation (MNS), may be an effective method for treating patients in a coma, and ...

journal_title：Molecular medicine reports

authors： Zhong YJ,Feng Z,Wang L,Wei TQ

更新日期：2015-09-01 00:00:00

abstract：:Functional appliances correct dental malocclusion, partly by exerting an indirect mechanical stimulus on the condylar cartilage, initiating novel bone formation in the condyle. Angiopoietin is involved in the angiogenesis associated with novel bone formation. This study aimed to determine the expression of angiopoieti...

journal_title：Molecular medicine reports

authors： Jing Z,Gu Z,Feng J

更新日期：2013-10-01 00:00:00

abstract：:Exploring the genetic basis for idiopathic congenital nystagmus is critical for improving our understanding of its molecular pathogenesis. In the present study, direct sequencing using gene specific primers was performed in order to identify the causative mutations in two brothers from a Chinese family who had been di...

journal_title：Molecular medicine reports

authors： Xiu Y,Yao Y,Yang T,Pan M,Yang H,Fang W,Gu F,Zhao J,Zhu Y

更新日期：2018-09-01 00:00:00

abstract：:Lipopolysaccharide (LPS), the major outer surface membrane component of Gram-negative bacteria, is one of the main etiological factors in the pathogenesis of several lung diseases, such as chronic obstructive pulmonary disease. The respiratory epithelium and the macrophages comprise the dynamic interface between the o...

journal_title：Molecular medicine reports

authors： Liu X,Yin S,Chen Y,Wu Y,Zheng W,Dong H,Bai Y,Qin Y,Li J,Feng S,Zhao P

更新日期：2018-04-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) possess three characteristics critical to tissue regeneration; multipotency, low immunogenicity and an undifferentiated status, providing plasticity. However, increasing evidence has indicated that induction of an immune response in vivo can injure and reject MSC‑based tissues. Toll‑like ...

journal_title：Molecular medicine reports

authors： Yang Y,Wang Y,Li L,Bao J,Chen F,Zhang L

更新日期：2015-12-01 00:00:00

abstract：:The aim of the present study was to explore the effects of co‑culturing bone marrow‑derived mesenchymal stem cells (BM-MSCs) cultured with hepatitis B virus (HBV)‑infected lymphocytes in vitro. BM‑MSCs and lymphocytes from Brown Norway rats were obtained from the bone marrow and spleen, respectively. Rats were divided...

journal_title：Molecular medicine reports

authors： Zheng WP,Zhang BY,Shen ZY,Yin ML,Cao Y,Song HL

更新日期：2017-05-01 00:00:00

abstract：:Galectin‑3, a galactoside‑binding protein, is highly expressed in carotid plaques and plays an important role in the atherosclerotic lesions. The phenotype transformation of vascular smooth muscle cells is the basic pathological change of atherosclerosis. This study investigated the effects of exogenous galectin‑3 on ...

journal_title：Molecular medicine reports

authors： Tian L,Chen K,Cao J,Han Z,Wang Y,Gao L,Fan Y,Wang C

更新日期：2017-06-01 00:00:00

abstract：:In recent years, oncolytic viruses have attracted increasing interest due to their potent antitumor effects. Luteolin, a natural product, has additionally been observed to exhibit various pharmacological antitumor activities. Previously, a novel dual‑targeting oncolytic adenovirus, complement decay‑accelerating factor...

journal_title：Molecular medicine reports

authors： Xiao B,Qin Y,Ying C,Ma B,Wang B,Long F,Wang R,Fang L,Wang Y

更新日期：2017-12-01 00:00:00

abstract：:Thyroid stimulating hormone (TSH) consists of an α‑subunit and a unique β‑subunit. The first in‑frame TSHβ splice variant produced by the cells of immune system was identified in 2009. The TSHβ splice variant and native TSHβ exhibit different expression profiles, and research has been conducted to elucidate the role o...

journal_title：Molecular medicine reports

authors： Liu C,Miao J,Liu X,Zhao Z,Kou T,Liu J,Wang R,Li L,Dong Q

更新日期：2019-05-01 00:00:00

abstract：:Pancreatic carcinoma is one of the leading causes of cancer mortality worldwide, although the molecular mechanisms of this disease are poorly understood. The aim of this study was to examine the expression of cyclin-dependent kinase inhibitors (CDKIs) and the epigenetic modification...

journal_title：Molecular medicine reports

authors： Li G,Ji Y,Liu C,Li J,Zhou Y

更新日期：2012-04-01 00:00:00

abstract：:The present study aimed to examine whether fms‑related tyrosine kinase 3 ligand (Flt3L) protects the organs of mice with multiorgan dysfunction syndrome (MODS). Male C57BL/6 mice were randomly assigned to normal control, MODS and Flt3L treatment groups. The mouse models of MODS were established using intraperitoneal z...

journal_title：Molecular medicine reports

authors： Tian G,Lu J,Guo H,Liu Q,Wang H

更新日期：2015-06-01 00:00:00

abstract：:Numerous studies have shown that N-nitrosamines and their precursors are probable etiological factors for esophageal cancer. Certain N-nitrosamines have been shown to induce esophageal cancer in animal models. However, the molecular mechanisms by which N-nitrosamines promote esophageal carcinogenesis remain poorly und...

journal_title：Molecular medicine reports

authors： Xie Y,Tang E,Ren B,Feng L

更新日期：2010-05-01 00:00:00

abstract：:Calcium is an important second messenger and it is widely recognized that acute lung injury (ALI) is often caused by oscillations of cytosolic free Ca2+. Previous studies have indicated that the activation of transient receptor potential‑vanilloid (TRPV) channels and subsequent Ca2+ entry initiates an acute calcium‑de...

journal_title：Molecular medicine reports

authors： Li C,Bo L,Liu Q,Liu W,Chen X,Xu D,Jin F

更新日期：2016-03-01 00:00:00

abstract：:The effects of 9 calcium antagonists on ABCG2/BCRP-mediated resistance and transport were examined in HeLa and SN-38-resistant HeLa (HeLa/SN100) cells, overexpressing ABCG2/BCRP. Sensitivity to mitoxantrone, an ABCG2/BCRP substrate, in HeLa/SN100 cells was significantly reversed by ...

journal_title：Molecular medicine reports

authors： Takara K,Matsubara M,Yamamoto K,Minegaki T,Takegami S,Takahashi M,Yokoyama T,Okumura K

更新日期：2012-03-01 00:00:00

abstract：:Adenosine monophosphate-activated protein kinase (AMPK) is a principal regulator of metabolism and the conservation of energy in cells, and protects them from exposure to various stressors. AMPK activators may exhibit therapeutic potential as suppressors of cell growth; however, the molecular mechanism underlying this...

journal_title：Molecular medicine reports

authors： Zou YF,Xie CW,Yang SX,Xiong JP

更新日期：2017-02-01 00:00:00

abstract：:Lupus nephritis (LN) is a common complication of systemic lupus erythematosus. The present study aimed to elucidate the protective effect of magnolol (MG) on the progression of LN, via inhibition of key signaling pathways. The results of the present study demonstrated that administration of MG caused inhibition of the...

journal_title：Molecular medicine reports

authors： Huang F,Zhang RY,Song L

更新日期：2017-10-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis is a chronic pulmonary disease that is characterized by formation of scar tissue in lungs. Transforming growth factor-β (TGF-β) is considered an important cytokine in the pathogenesis of this disease. Hence, the antifibrotic effect of an inhibitor of the TGF-β type I receptor, namely, SB ...

journal_title：Molecular medicine reports

authors： Koh RY,Lim CL,Uhal BD,Abdullah M,Vidyadaran S,Ho CC,Seow HF

更新日期：2015-05-01 00:00:00

abstract：:Reactive oxygen species (ROS) are important in the development of diabetic testicular dysfunction. Overproduction of ROS promotes the process of apoptosis, which shows that there is a crosstalk between oxidative stress and apoptosis. Recent research has suggested that NADPH oxidase is the main source of ROS. In this s...

journal_title：Molecular medicine reports

authors： Li M,Liu Z,Zhuan L,Wang T,Guo S,Wang S,Liu J,Ye Z

更新日期：2013-01-01 00:00:00

abstract：:A limited number of studies have revealed that adding kidneys to liver perfusion may maintain an improved physiological balance; however, the underlying mechanism remains to be elucidated. The preset study confirmed the protective role of this new model and investigated the underlying mechanisms. Methods: A total of 1...

journal_title：Molecular medicine reports

authors： Li J,Jia J,He N,Jiang L,Yu H,Li H,Peng Y,Xie H,Zhou L,Zheng S

更新日期：2019-08-01 00:00:00

abstract：:Abnormal paired box 9 (PAX9) expression is associated with tumorigenesis, cancer development, invasion and metastasis. The present study investigated the prognostic significance of PAX9 in esophageal squamous cell carcinoma (ESCC) and its role in predicting radiation sensitivity. A total of 52.8% (121/229) ESCC tissue...

journal_title：Molecular medicine reports

authors： Tan B,Wang J,Song Q,Wang N,Jia Y,Wang C,Yao B,Liu Z,Zhang X,Cheng Y

更新日期：2017-07-01 00:00:00

abstract：:Misregulation of vascular endothelial growth factor A (VEGF‑A) has been implicated in numerous types of ovarian disease, such as polycystic ovarian syndrome, ovarian hyperstimulation syndrome, endometriosis and ovarian cancer. VEGF regulates blood vessel permeability and angiogenesis. In our previous study, VEGF‑regul...

journal_title：Molecular medicine reports

authors： Fang Y,Lu X,Liu L,Lin X,Sun M,Fu J,Xu S,Tan Y

更新日期：2016-06-01 00:00:00

abstract：:Aquaporins (AQPs) are known to be important in cancer progression. The present study used a cDNA microarray to demonstrate that AQP3, a member of the AQP family, was overexpressed in prostate cancer cells. In order to determine the role of AQP3 in prostate cancer, AQP3 expression was silenced by transfection with smal...

journal_title：Molecular medicine reports

authors： Chen J,Wang Z,Xu D,Liu Y,Gao Y

更新日期：2015-04-01 00:00:00

abstract：:Smoking is an important factor that causes periodontitis, which manifests as alveolar bone injury and absorption, and has a high incidence and unfavorable treatment efficacy. Nicotine causes ischemia and inflammation of the periodontium and inhibits the mineralization of alveolar bones. Previous studies have revealed ...

journal_title：Molecular medicine reports

authors： Li Y,Jin X,Mao L

更新日期：2017-12-01 00:00:00

abstract：:B7-H1, a recently described B7 family member, has been reported to negatively regulate T-cell function in most cancer cells. In this study, we sought to investigate B7-H1 expression in four uveal melanoma (UM) cells (OCM1, SP6.5, OM431 and VUP) to determine the functional significance of B7-H1 expression in T-cell imm...

journal_title：Molecular medicine reports

authors： Jia R,Jiao Z,Xu X,Wang J,Zhou Y,Song X,Ge S,Fan X

更新日期：2011-01-01 00:00:00

abstract：:Intermittent fasting has been shown to have neuroprotective effects against transient focal cerebral ischemic insults. However, the effects of intermittent fasting on transient global ischemic insult has not been studied much yet. The present study examined effects of intermittent fasting on endogenous antioxidant enz...

journal_title：Molecular medicine reports

authors： Ahn JH,Noh Y,Shin BN,Kim SS,Park JH,Lee TK,Song M,Kim H,Lee JC,Yong JH,Kang IJ,Lee YL,Won MH,Kim JD

更新日期：2018-12-01 00:00:00

abstract：:Dendritic cells, the most powerful type of antigen‑presenting cells, have the unique ability to induce primary immune responses. Connexin43 expression is upregulated to increase gap junctions when immune cells are exposed to inflammatory factors. The present study applied small‑interfering RNA (siRNA) to decrease conn...

journal_title：Molecular medicine reports

authors： Yu F,Yan H,Nie W,Zhu J

更新日期：2016-01-01 00:00:00

abstract：:In contrast with mature brain‑derived neurotrophic factor (mBDNF), proBDNF induces cell apoptosis. However, the function of proBDNF in oligodendrocytes remains unclear. In the present study, the OLN‑93 oligodendroglia cell line was utilized as an in vitro model to analyse the functions of proBDNF in oligodendroglia. p...

journal_title：Molecular medicine reports

authors： Liu S,Guo W,Zhou H,Tang L,Feng S,Zhong JH,Zhou XF

更新日期：2018-10-01 00:00:00

abstract：:Heng-Gu-Gu-Shang-Yu-He-Ji, also known as OsteoKing, is used as a herbal Traditional Chinese Medicine for the treatment of bone disease, including femoral head necrosis and osteoarthritis. However, whether OsteoKing has anti-osteoporotic properties has remained to be elucidated. The purpose of the present study was the...

journal_title：Molecular medicine reports

authors： Dai L,Wu H,Yu S,Zhao H,Xue L,Xu M,Shen Z,Hu M

更新日期：2015-07-01 00:00:00