Association between CLOCK, PER3 and CCRN4L with non‑small cell lung cancer in Brazilian patients.

abstract：:Human interferon α (IFN-α) and erythropoietin (EPO) have been used for a variety of purposes in clinical medicine. Human IFN-α has been used to treat several types of viral infection and cancer, as well as renal anemia, via stimulation of erythrocyte formation in the bone marrow. Transgenic cattle are excellent candid...

journal_title：Molecular medicine reports

authors： Jung EM,An BS,Kim YK,Hwang I,Lee JY,Shin TY,Hyun SH,Hwang WS,Jeung EB

更新日期：2013-02-01 00:00:00

abstract：:The present study investigated the synergic effects and potential mechanisms of action of Astragalus polysaccharides (APS) combined with Crataegus flavonoids (CF) in the treatment of type 1 diabetes. Diabetes was induced by intraperitoneal injection of 100 mg/kg streptozotocin in mice. Normal and untreated diabetic co...

journal_title：Molecular medicine reports

authors： Cui K,Zhang S,Jiang X,Xie W

更新日期：2016-06-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) affect atherosclerosis by regulating the physiological and pathological processes of endothelial cells; however, the role of lncRNA WEE2 antisense RNA 1 (WEE2‑AS1) in arteriosclerosis obliterans (ASO) is not completely understood. The present study aimed to explore the function of lncRNA...

journal_title：Molecular medicine reports

authors： Jiang B,Wang R,Lin Z,Ma J,Cui J,Wang M,Liu R,Wu W,Zhang C,Li W,Wang S

更新日期：2020-12-01 00:00:00

abstract：:Glioma is the most common primary brain tumor in adults and the second most common malignant tumor in children. Aberrant expression of signal transducer and activator of transcription 1 (STAT‑1) and p53 are known to affect the occurrence and progression of malignant tumors. The aim of the present study was to investig...

journal_title：Molecular medicine reports

authors： Yang W,Wang H,Ju H,Dou C

更新日期：2018-06-01 00:00:00

abstract：:Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates T-cell activation and Th1/Th2 cytokine production and is involved in the immune response against Hepatitis B virus (HBV) infection. To detect the association of the CTLA-4 gene polymorphisms with susceptibility to HBV infection a hospital-based case-contro...

journal_title：Molecular medicine reports

authors： Chen M,Chang Y,Tang F,Xie QH,Li J,Yang H,He XX,Lin JS

更新日期：2014-02-01 00:00:00

abstract：:Mechanical allodynia, which develops in patients of diabetes mellitus as a neuropathic manifestation, remains without an effective treatment. The aim of the present study was to investigate the effects and potential mechanisms underlying resveratrol (RES) in a rat model of streptozocin (STZ)‑induced diabetic mechanica...

journal_title：Molecular medicine reports

authors： Cui Y,Li Y,Ning J,Mi Y,Wang X,Qiu Z,Li L,Gou X

更新日期：2020-08-01 00:00:00

abstract：:It has previously been demonstrated that phosphatidylinositol-3-kinase (PI3K)/Akt and cleaved caspase-3 serve critical roles in the apoptosis of cardiac myocytes following ischemia/reperfusion injury. Epigallocatechin-3-gallate (EGCG), the predominant catechin component of green tea, has been reported to have potentia...

journal_title：Molecular medicine reports

authors： Zeng X,Tan X

更新日期：2015-08-01 00:00:00

abstract：:Physical exercise is beneficial for the functional recovery of neurons after stroke. It has been suggested that exercise regulates proliferation and differentiation of endogenous neural stem cells (NSCs); however, the underlying molecular mechanisms are still largely unknown. In the present study, the aim was to inves...

journal_title：Molecular medicine reports

authors： Liu W,Wu W,Lin G,Cheng J,Zeng Y,Shi Y

更新日期：2018-08-01 00:00:00

abstract：:Cholelithiasis is a common medical condition whose incidence rate is increasing yearly, while its pathogenesis has yet to be elucidated. The present study assessed the expression of Rho-kinase (ROCK) in gallbladder smooth muscles and its effect on the contractile function of gallbladder smooth muscles during gallstone...

journal_title：Molecular medicine reports

authors： Wang B,Ding YM,Wang CT,Wang WX

更新日期：2015-08-01 00:00:00

abstract：:Erythropoietin (EPO) has been shown to be neuroprotective in various models of neuronal injury. The aim of the present study was to investigate the beneficial effect of recombinant human EPO (rhEPO) following intracerebral hemorrhage (ICH) and the underlying molecular and cellular mechanisms. ICH was induced using aut...

journal_title：Molecular medicine reports

authors： Yu Z,Tang L,Chen L,Li J,Wu W,Hu C

更新日期：2013-11-01 00:00:00

abstract：:Endothelial dysfunction and impaired endothelial regenerative capacity are key contributors to the high incidence of cardiovascular disease in patients with chronic kidney disease (CKD). Uremic toxins are associated with this pathogenesis. Previous studies have revealed that a uremic toxin, para‑cresol (p‑cresol), exe...

journal_title：Molecular medicine reports

authors： Pan L,Ye X,Ding J,Zhou Y

更新日期：2017-04-01 00:00:00

abstract：:Infantile hemangioma (IH) is one of the most common vascular tumors that occurs during childhood, but its pathogenesis is currently not completely understood. Even though lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) plays vital roles in tumorigenesis of malignant tumors, its roles in IH remain unclear. The...

journal_title：Molecular medicine reports

authors： Yu L,Shu H,Xing L,Lv MX,Li L,Xie YC,Zhang Z,Zhang L,Xie YY

更新日期：2020-10-01 00:00:00

abstract：:β-elemene, a plant-derived drug extracted from Curcuma wenyujin, has demonstrated marked antiproliferative effects on glioblastoma, while toxicity remains low. However, the underlying molecular mechanisms of the antitumor activity of β-elemene remain to be elucidated. Previously, it was identified that the glia matura...

journal_title：Molecular medicine reports

authors： Zhu TZ,Li XM,Luo LH,Xu YH,Cao P,Liu Y,Liang GB

更新日期：2014-08-01 00:00:00

abstract：:The aim of the present study was to evaluate the protective effect and mechanism of Astragaloside IV (ASIV) on myocardial injury induced by type 2 diabetes, with a focus on energy metabolism. Blood glucose, the hemodynamic index, left ventricular weight/heart weight (LVW/HW), the left ventricular systolic pressure (LV...

journal_title：Molecular medicine reports

authors： Zhang Z,Wang J,Zhu Y,Zhang H,Wang H

更新日期：2019-11-01 00:00:00

abstract：:The present study investigated the function of oncostatin M (OSM), which may be associated with monocyte chemotactic protein‑1 (MCP‑1), on mouse MC3T3‑E1 osteoblast development and bone remodeling. Levels of MCP‑1, macrophage inflammatory protein 1α (MIP1α) and regulated upon activation normal T cell expressed and sec...

journal_title：Molecular medicine reports

authors： Zheng W,Guan J

更新日期：2018-09-01 00:00:00

abstract：:Cinobufacini is widely used in the treatment of advanced cancers. It has been previously reported that microRNA (miR)‑494 was upregulated in cinobufacini‑treated gastric cancer cells; however, the detailed role of miR‑494 in the anti‑tumor activity of cinobufacini is unclear. The present study aimed to clarify the fun...

journal_title：Molecular medicine reports

authors： Shen Z,Li Y,Zhao C,Wang F,Zhou R,Chen G

更新日期：2018-05-01 00:00:00

abstract：:Breast cancer ranks as the second most common cause of cancer death among women in the United States. Anticancer agents are an important component of breast cancer therapy. Drugs frequently used to treat breast cancer include methotrexate, 5-fluorouracil (5-FU), cyclophosphamide, anthracyclines, taxanes, trastuzumab, ...

journal_title：Molecular medicine reports

authors： Steelman LS,Navolanic PM,Franklin RA,Bonati A,Libra M,Stivala F,Martelli AM,McCubrey JA

更新日期：2008-03-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been reported to serve a key role in a variety of cardiovascular diseases, including in cardiac fibrosis. The present study aimed to investigate the biological role and underlying mechanisms of the induction of cardiac fibroblasts by the lncRNA, RNA component of mitochondrial RNA pr...

journal_title：Molecular medicine reports

authors： Zhang SY,Huang SH,Gao SX,Wang YB,Jin P,Lu FJ

更新日期：2019-10-01 00:00:00

abstract：:Findings of previous studies have revealed that intestinal mucosal mast cells (IMMCs) are involved in small intestinal ischemia‑reperfusion injury (IIRI). However, time-course changes of mast cell counts and mast cell function in this process remain unclear. The present study aimed to observe the number of IMMCs and t...

journal_title：Molecular medicine reports

authors： Ge M,Gan X,Liu D,Zhang W,Gao W,Huang P,Hei Z

更新日期：2013-08-01 00:00:00

abstract：:Glaucoma is a group of progressive optic neuropathies that have in common characteristic optic nerve head changes, loss of retinal ganglion cells and visual field defects. Among the large family of glaucomas, primary open‑angle glaucoma (POAG) is the most common type, a complex and heterogeneous disorder with environm...

journal_title：Molecular medicine reports

authors： Trivli A,Zervou MI,Goulielmos GN,Spandidos DA,Detorakis ET

更新日期：2020-08-01 00:00:00

abstract：:Subsequent to the publication of the above paper, the authors have realized that there were errors in Fig. 1 on page 902; essentially, the experimental data described as being 'Preterm' and 'Infected preterm' should have been labelled as 'Full‑term without labor' and 'Preterm', respectively. Note that these errors in ...

journal_title：Molecular medicine reports

authors： Chen J,Zheng D,Cui H,Liu S,Zhang L,Liu C

更新日期：2018-04-01 00:00:00

abstract：:Human glucose-6-phosphate dehydrogenase (G6PD) is a crucial enzyme in the pentose phosphate pathway, and serves an important role in biosynthesis and the redox balance. G6PD deficiency is a major cause of neonatal jaundice and acute hemolyticanemia, and recently, G6PD has been associated with diseases including inflam...

journal_title：Molecular medicine reports

authors： Chen L,Zhang C,Wang Y,Li Y,Han Q,Yang H,Zhu Y

更新日期：2017-08-01 00:00:00

abstract：:Interleukin (IL)-33, is a novel member of the IL-1 superfamily, and act as a dual-function molecule as a nuclear factor and cytokine. The expression of IL-33 can be detected in several tissues and cells in humans and in mice. In addition to the conventional secretion approach for cytokines, full-length IL-33 can also ...

journal_title：Molecular medicine reports

authors： Yang F,Zhu P,Duan L,Yang L,Wang J

更新日期：2016-01-01 00:00:00

abstract：:Bone mesenchymal stem cells (BMSCs) have been an area of interest in biomedical research and tissue engineering due to their diverse differentiation abilities. In osteogenesis, bone morphogenetic proteins (BMPs), particularly BMP‑2, are important. However, the effect of BMP‑2 on the osteogenetic capacity of BMSCs rema...

journal_title：Molecular medicine reports

authors： Sun J,Li J,Li C,Yu Y

更新日期：2015-09-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) is considered to have a critical role in the occurrence and development of atherosclerosis in atherosclerosis-prone mice; however, it remains uncertain whether treatment with a TLR4 inhibitor may attenuate atherosclerosis. The present study aimed to determine the vascular protective effects...

journal_title：Molecular medicine reports

authors： Wang XQ,Wan HQ,Wei XJ,Zhang Y,Qu P

更新日期：2016-07-01 00:00:00

abstract：:As one of main active ingredients of salvia miltiorrhizae, which is a traditional Chinese medicine, tanshinone IIA is the basis of its pharmacological activities. In the present study, the effect of tanshinone IIA on weakening spastic cerebral palsy (SCP) in neonatal rats was investigated. Radial arm water maze and ho...

journal_title：Molecular medicine reports

authors： Zhang WL,Cao YA,Xia J,Tian L,Yang L,Peng CS

更新日期：2018-01-01 00:00:00

abstract：:Numerous studies have demonstrated that microRNAs (miRNAs) are upregulated or downregulated in retinoblastoma (RB), and that this phenomenon is associated with the modulation of various malignant behaviours during RB occurrence and development. Therefore, the mechanisms that associate deregulated miRNAs with RB initia...

journal_title：Molecular medicine reports

authors： Sun Z,Zhang A,Zhang L

更新日期：2019-03-01 00:00:00

abstract：:Apoptosis and necroptosis occur in renal tubular epithelial cell (RTEC) death in acute kidney injury (AKI), and may be regulated by several methods. The present study identified a protective effect of necrostatin‑1 (Nec‑1) on RTECs via a flow-control-like effect. The results established a hypoxic‑ischemic injury model...

journal_title：Molecular medicine reports

authors： Luo J,Tao Y,Liang X,Chen Y,Zhang L,Jiang F,Liu S,Ye Z,Li Z,Shi W

更新日期：2017-07-01 00:00:00

abstract：:G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-bound estrogen receptor that is involved in the mediation of non-genomic estradiol signalling. In this study, we demonstrated that male, but not female, GPR30-deficient mice suffer from impaired left‑ventricular cardiac function. Left ventric...

journal_title：Molecular medicine reports

authors： Delbeck M,Golz S,Vonk R,Janssen W,Hucho T,Isensee J,Schäfer S,Otto C

更新日期：2011-01-01 00:00:00

abstract：:The activation of the (pro)renin receptor (PRR) may be potentially active in the development of atherosclerotic plaques independent of angiotensin II. Our previous studies demonstrated that high glucose was able to induce the activation of PRR. The present study was designed to determine the function of oxidized low‑d...

journal_title：Molecular medicine reports

authors： Cheng Y,Liu X,Zhang L,Zhang Y,Liu Y,Lu Y,Jiang Y

更新日期：2015-06-01 00:00:00