Role of bone morphogenetic protein-2 in osteogenic differentiation of mesenchymal stem cells.

abstract：:Calcium is an important second messenger and it is widely recognized that acute lung injury (ALI) is often caused by oscillations of cytosolic free Ca2+. Previous studies have indicated that the activation of transient receptor potential‑vanilloid (TRPV) channels and subsequent Ca2+ entry initiates an acute calcium‑de...

journal_title：Molecular medicine reports

authors： Li C,Bo L,Liu Q,Liu W,Chen X,Xu D,Jin F

更新日期：2016-03-01 00:00:00

abstract：:Eurycoma (E.) longifolia Jack (Tongkat Ali) is a widely applied medicine that has been reported to boost serum testosterone and increase muscle mass. However, its actual biological targets and effects on an in vitro level remain poorly understood. Therefore, the present study aimed to investigate the effects of a stan...

journal_title：Molecular medicine reports

authors： Khurshid Ahmed NA,Lim SK,Pandian GN,Sugiyama H,Lee CY,Khoo BY,Chan KL

更新日期：2020-11-01 00:00:00

abstract：:microRNA 21 (miRNA‑21) promotes the development of cardiac fibrosis, hypertrophy and heart failure. However, whether it can be used as a biomarker for the diagnosis and prognosis of heart failure remains unclear. The current study assessed circulating miRNA‑21 as a viable indicator for diagnosis and prognosis of heart...

journal_title：Molecular medicine reports

authors： Zhang J,Xing Q,Zhou X,Li J,Li Y,Zhang L,Zhou Q,Tang B

更新日期：2017-11-01 00:00:00

abstract：:Prostate cancer (PCa) poses a high risk to older men and it is the second most common type of male malignant tumor in western developed countries. Additionally, there is a lack of effective therapies for PCa at advanced stages. Novel treatment strategies such as adenovirus‑mediated gene therapy and virotherapy involve...

journal_title：Molecular medicine reports

authors： Cai Z,Lv H,Cao W,Zhou C,Liu Q,Li H,Zhou F

更新日期：2017-11-01 00:00:00

abstract：:A total of 60 breast cancer (BC) tissues and adjacent healthy tissues from patients who underwent surgery in Renmin Hospital of Wuhan University were collected for analysis in the present study. Results from reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) demonstrated that, compared with the adj...

journal_title：Molecular medicine reports

authors： Xu W,Wang W

更新日期：2018-06-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is a signaling gasotransmitter, involved in various physiological and pathological processes. H2S-donating drugs have been tested to conjugate the beneficial effects of H2S with other pharmaceutical properties. It has been shown that the endogenous cystathionine-γ-lyase (CSE)/H2S pathway partici...

journal_title：Molecular medicine reports

authors： Xie YH,Zhang N,Li LF,Zhang QZ,Xie LJ,Jiang H,Li LP,Hao N,Zhang JX

更新日期：2014-10-01 00:00:00

abstract：:The development of pharmaceutical agents possessing anti‑invasive and anti‑metastatic abilities, as well as apoptotic activity, is important in decreasing the incidence and recurrence of oral cancer. Cancer cells are known to acquire invasiveness not only through epigenetic changes, but also from inflammatory stimuli ...

journal_title：Molecular medicine reports

authors： Cho BH,Jung YH,Kim DJ,Woo BH,Jung JE,Lee JH,Choi YW,Park HR

更新日期：2018-02-01 00:00:00

abstract：:The present study aimed to investigate the effects of electrical stimulation (ES) on cell activity, cell cycle and apoptosis in injured rat dorsal root ganglion (DRG) cells induced by cyclic mechanical stretching (CMS). The present study also investigated whether the Wnt/β‑catenin pathway is involved in this process. ...

journal_title：Molecular medicine reports

authors： Hu M,Hong L,He S,Huang G,Cheng Y,Chen Q

更新日期：2020-06-01 00:00:00

abstract：:Obesity is marked by deposition of collagen I in adipose tissue. Toll like receptor (TLR)2 is involved in lipid metabolism, however the association between TLR2 and collagen I remains unclear. The present study was designed to investigate the effect of TLR2 knockout on collagen I in adipose tissue in obese mice. TLR2 ...

journal_title：Molecular medicine reports

authors： Song B,Zhang H,Zhang S

更新日期：2018-04-01 00:00:00

abstract：:Induction of cardiomyocyte proliferation, the most promising approach to reverse myocardial attrition, has been gaining importance as a therapy for cardiovascular disease. Hypoxia and macrophages were previously independently reported to promote cardiomyocyte proliferation in mice. However, whether hypoxia promotes ca...

journal_title：Molecular medicine reports

authors： Liu B,Zhang HG,Zhu Y,Jiang YH,Luo GP,Tang FQ,Jian Z,Xiao YB

更新日期：2017-06-01 00:00:00

abstract：:Oxidative stress serves important roles in cardiac injury during the process of ischemia/reperfusion (I/R). Y‑box protein 1 (YB1), a member of the highly conserved Y‑box protein family, is closely associated with inflammation and stress responses by regulating gene transcription, RNA splicing and mRNA translation. How...

journal_title：Molecular medicine reports

authors： Wang S,He F,Li Z,Hu Y,Huangfu N,Chen X

更新日期：2019-06-01 00:00:00

abstract：:Chronic constipation (CC) is a highly prevalent heterogeneous disorder. Although CC is not known to be associated with the development of serious disease or with excess mortality, it considerably reduces the patients quality of life. In addition, it represents an economic burden to patients and society. The majority o...

journal_title：Molecular medicine reports

authors： El-Salhy M,Svensen R,Hatlebakk JG,Gilja OH,Hausken T

更新日期：2014-01-01 00:00:00

abstract：:A limited number of studies have revealed that adding kidneys to liver perfusion may maintain an improved physiological balance; however, the underlying mechanism remains to be elucidated. The preset study confirmed the protective role of this new model and investigated the underlying mechanisms. Methods: A total of 1...

journal_title：Molecular medicine reports

authors： Li J,Jia J,He N,Jiang L,Yu H,Li H,Peng Y,Xie H,Zhou L,Zheng S

更新日期：2019-08-01 00:00:00

abstract：:Thymidylate synthase, as a rate-limiting step in DNA synthesis, catalyses the conversion of dUMP into dTMP using 5,10-methylenotetrahydrofolate as the methyl donor. Two polymorphisms have been described in this gene: a repeat polymorphism in the 5' promoter enhancer region (3R versus 2R) and a 6 bp deletion in the 3' ...

journal_title：Molecular medicine reports

authors： Carmona B,Guerreiro C,Cravo M,Nobre-Leitão C,Brito M

更新日期：2008-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) has been ranked the second leading cause of cancer‑associated mortality in China and the third leading cause of cancer‑associated mortality worldwide. A number of previous studies investigating SLC44A5 have revealed important biological insight and disease‑specific functions. Therefore, ...

journal_title：Molecular medicine reports

authors： Peng GZ,Ye QF,Wang R,Li MX,Yang ZX

更新日期：2016-06-01 00:00:00

abstract：:The overexpression and hypersecretion of mucus is a hallmark of chronic pulmonary inflammatory disease. Mucin5AC (MUC5AC) is a major component of airway gel‑forming mucin. Members of the Unc13 (Munc13) protein family act as important activators of granule exocytosis from various types of mammalian cells. The present s...

journal_title：Molecular medicine reports

authors： Xu R,Zhou J,Zhou XD,Li Q,Perelman JM,Kolosov VP

更新日期：2018-07-01 00:00:00

abstract：:The aim of the present study was to investigate Fas expression in tumor samples from patients with gastric cancer, in order to determine the involvement of the Fas signaling pathway. The protein expression levels of Fas, caspase-8, caspase‑3 and poly (adenosine diphosphate‑ribose) polymerase 1 (PARP1) were examined in...

journal_title：Molecular medicine reports

authors： Wang X,Fu Z,Chen Y,Liu L

更新日期：2017-02-01 00:00:00

abstract：:In contrast with mature brain‑derived neurotrophic factor (mBDNF), proBDNF induces cell apoptosis. However, the function of proBDNF in oligodendrocytes remains unclear. In the present study, the OLN‑93 oligodendroglia cell line was utilized as an in vitro model to analyse the functions of proBDNF in oligodendroglia. p...

journal_title：Molecular medicine reports

authors： Liu S,Guo W,Zhou H,Tang L,Feng S,Zhong JH,Zhou XF

更新日期：2018-10-01 00:00:00

abstract：:Vitamin A deficiency (VAD) caused by malnutrition and certain intestinal diseases induces visual impairments, including night blindness and photoreceptor cell dysfunction as indicated by reduced a‑ and b‑waves in an electroretinogram (ERG). The effects of VAD on the inner retinal layer cells, including amacrine and ga...

journal_title：Molecular medicine reports

authors： Kakiuchi D,Uehara T,Shiotani M,Nakano-Ito K,Suganuma A,Aoki T,Tsukidate K,Sawada K

更新日期：2015-02-01 00:00:00

abstract：:In the pathophysiology of osteoarthritis (OA), articular cartilage degeneration exhibits a significant role. Vascular endothelial growth factor (VEGF) is considered to be an effective angiogenic factor and a crucial regulator of articular cartilage degeneration in the development of OA. Therefore, the present study ai...

journal_title：Molecular medicine reports

authors： Deng S,Zhou JL,Peng H,Fang HS,Liu F,Weng JQ

更新日期：2018-05-01 00:00:00

abstract：:Previous studies revealed that Kanglaite (KLT) exhibits antitumor and immunomodulatory activities. In the present study, we show that KLT treatment stimulated the immune response by increasing the number of T cells and natural killer (NK) cells in the blood of hepatocellular carcinoma (HCC) patients. Experiments in tu...

journal_title：Molecular medicine reports

authors： Huang X,Qin J,Lu S

更新日期：2014-10-01 00:00:00

abstract：:Several studies have noted benign thecoma‑fibroma tumors with positive F‑18 fluorodeoxyglucose (FDG) accumulation mimicking malignant ovarian tumors following F‑18 FDG positron emission tomography (PET). The present study analyzed four cases with false‑positive F‑18 FDG PET/computed tomography (CT) diagnoses of thecom...

journal_title：Molecular medicine reports

authors： Seino H,Ono S,Miura H,Morohashi S,Wu Y,Tsushima F,Takai Y,Kijima H

更新日期：2016-05-01 00:00:00

abstract：:Ras‑GTPase‑activating protein SH3 domain‑binding protein 1 (G3BP1) has been reported to be of importance in the occurrence and development of colon cancer. However, the underlying mechanisms remain largely unknown. Therefore, the aim of the present study was to investigate the role of Wnt/β‑catenin signaling in G3BP1‑...

journal_title：Molecular medicine reports

authors： Li Y,Wang J,Zhong S,Li J,Du W

更新日期：2020-11-01 00:00:00

abstract：:The pro-apoptotic and anti-proliferative effects of 3,3'-diindolylmethane (DIM) in various tumor cell types have been widely investigated. The underlying mechanisms were suggested to include cell cycle arrest, cell signaling inhibition and downregulation of the androgen receptor. The present study demonstrated that DI...

journal_title：Molecular medicine reports

authors： Li F,Xu Y,Chen C,Chen SM,Xiao BK,Tao ZZ

更新日期：2015-09-01 00:00:00

abstract：:The chondrogenic differentiation of synovial mesenchymal stem cells (SMSCs) is regulated by essential transcription factors and signaling cascades. However, the precise mechanisms involved in this process remain unclear. MicroRNAs (miRs/miRNAs) are undersized non‑coding RNAs responsible for the post‑transcriptional re...

journal_title：Molecular medicine reports

authors： Cong R,Tao K,Fu P,Lou L,Zhu Y,Chen S,Cai X,Mao L

更新日期：2017-12-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD), common in elderly patients, refers to a decline in cognitive function following surgery, which may persist or even evolve into Alzheimer's disease (AD). Despite great efforts, the mechanism of POCD remains unclear. In the present study, we tested the hypothesis that Toll-lik...

journal_title：Molecular medicine reports

authors： Wang Y,He H,Li D,Zhu W,Duan K,Le Y,Liao Y,Ou Y

更新日期：2013-04-01 00:00:00

abstract：:Tumor necrosis factor‑related apoptosis-inducing ligand (TRAIL) is well known as a transmembrane cytokine and has been proposed as one of the most effective anti‑cancer therapeutic agents, owing to its efficiency to selectively induce cell death in a variety of tumor cells. Suppression of autophagy flux has been incre...

journal_title：Molecular medicine reports

authors： Nazim UM,Yin H,Park SY

更新日期：2019-02-01 00:00:00

abstract：:Ovarian cancer (OC) is the gynecological malignancy with the highest rate of mortality, and lymphatic metastasis is a critical factor in disease recurrence and prognosis. In the current study, the SKOV-3/LN403 cell line, which has high potential for lymph node metastasis was established as a result of four rounds of s...

journal_title：Molecular medicine reports

authors： Kang Y,Pu T,Cai Q,Hong S,Zhang M,Li G,Zhu Z,Xu C

更新日期：2015-08-01 00:00:00

abstract：:The aim of the present study was to evaluate the effect of astragalosides (ASTs) on angiogenesis, as well as the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) following myocardial infarction (MI). MI was induced in rats by ligation of the left coronary artery. Twenty...

journal_title：Molecular medicine reports

authors： Yu JM,Zhang XB,Jiang W,Wang HD,Zhang YN

更新日期：2015-11-01 00:00:00

abstract：:The renal allograft survival rates of patients with immunoglobulin A nephropathy (IgAN), and patients with or without other glomerular diseases, have yet to be fully elucidated. In this study, the clinicopathological factors associated with long-term allograft survival for the prognosis of renal allograft recipients w...

journal_title：Molecular medicine reports

authors： Guo JQ,Song BL,Wu ZX,Wu WZ,Luo LT,Chen XW,He FQ,Zheng ZY,Yang SL,Tan JM

更新日期：2014-04-01 00:00:00