Antiproliferation effect of the uremic toxin para‑cresol on endothelial progenitor cells is related to its antioxidant activity.

abstract：:Intimal hyperplasia appears to differ after implanting a drug-eluting stent (DES) with a biodegradable or a permanent polymer. The aim of the present study was to compare biodegradable with permanent polymer DES, since the available data are limited. One hundred patients with de novo coronary artery stenosis were incl...

journal_title：Molecular medicine reports

authors： Tian F,Chen Y,Liu C,Jin Q,Chen L,Sun Z,Liu H,Guo J,Gai L

更新日期：2013-04-01 00:00:00

abstract：:Ovarian cancer (OC) is associated with a poor prognosis due to difficulties in early detection. The aims of the present study were to construct a recurrence risk prediction model and to reveal important OC genes or pathways. RNA sequencing data was obtained for 307 OC samples, and the corresponding clinical data were ...

journal_title：Molecular medicine reports

authors： Cheng L,Li L,Wang L,Li X,Xing H,Zhou J

更新日期：2018-09-01 00:00:00

abstract：:The pathogenesis and therapy of hypertrophic scars (HS) have not yet been established. The aim of the present study was to investigate the potential effect of naringenin on HS and its underlying mechanisms. The mouse model of HS was prepared by a mechanical stretch device and then treated with naringenin at various co...

journal_title：Molecular medicine reports

authors： Shan S,Zhang Y,Wu M,Yi B,Wang J,Li Q

更新日期：2017-10-01 00:00:00

abstract：:The use of non‑steroidal anti‑inflammatory drugs (NSAIDs) has been associated with a reduced risk of various types of cancer, including esophageal cancer. However, the mechanisms underlying the antineoplastic effects of NSAIDs in esophageal cancer remain to be elucidated. In the present study, a significant inhibition...

journal_title：Molecular medicine reports

authors： Qin S,Xu C,Li S,Yang C,Sun X,Wang X,Tang SC,Ren H

更新日期：2015-06-01 00:00:00

abstract：:Acute lung injury (ALI) is a common complication following intestinal ischemia/reperfusion (I/R) and is a major contributing factor to its high mortality rate. Sirtuin 1 (SIRT1), a NAD+-dependent deacetylase, has been reported to have an important role in apoptosis inhibition, oxidative stress resistance and cell life...

journal_title：Molecular medicine reports

authors： Zhang F,Li ZL,Xu XM,Hu Y,Yao JH,Xu W,Jing HR,Wang S,Ning SL,Tian XF

更新日期：2015-01-01 00:00:00

abstract：:Osteosarcoma is the most common malignant bone tumour and the second leading cause of cancer‑related death in children and adolescents. Microwave ablation has an excellent therapeutic effect on bone tumours by instantaneously increasing the temperature in the tumour; however, there is a risk of damaging the surroundin...

journal_title：Molecular medicine reports

authors： Chen L,Wang M,Lin Z,Yao M,Wang W,Cheng S,Li B,Zhang Y,Yin Q

更新日期：2020-08-01 00:00:00

abstract：:Artemisinin, the active ingredient of the Chinese medicinal herb Artemisia annua L., and its derivatives (ARTs) are currently widely used as anti-malarial drugs around the world. In this study, we found that dihydroartemisinin (DHA), one of the main active metabolites of ARTs, inhibited the proliferation of human hepa...

journal_title：Molecular medicine reports

authors： Lu JJ,Yang Z,Lu DZ,Wo XD,Shi JJ,Lin TQ,Wang MM,Li Y,Tang LH

更新日期：2012-08-01 00:00:00

abstract：:The differentiation of pluripotent mesenchymal stem cells to mature osteoblasts is crucial for the maintenance of the adult skeleton. In rheumatic arthritis, osteoblast differentiation is impaired by the overproduction of cytokine tumor necrosis factor (TNF)‑α. It has been demonstrated that TNF-α is able to inhibit os...

journal_title：Molecular medicine reports

authors： Wang G,Zhang X,Yu B,Ren K

更新日期：2015-07-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a life‑threatening disease induced by the excessive proliferation and reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs). Formononetin (FMN) is a natural isoflavone with numerous cardioprotective properties, which can inhibit the proliferation and induce the apo...

journal_title：Molecular medicine reports

authors： Cai C,Xiang Y,Wu Y,Zhu N,Zhao H,Xu J,Lin W,Zeng C

更新日期：2019-12-01 00:00:00

abstract：:Inflammatory responses are vital in lung injury diseases, particularly acute respiratory distress syndrome (ARDS). Recombinant human brain natriuretic peptide (rhBNP) has been shown to exhibit anti‑inflammatory effects in vivo in our previous studies. The present study aimed to investigate the mechanisms underlying th...

journal_title：Molecular medicine reports

authors： Song Z,Zhao X,Liu M,Jin H,Cui Y,Hou M,Gao Y

更新日期：2016-08-01 00:00:00

abstract：:Transcription intermediary factor 1γ (Tif1γ), a ubiquitous nuclear protein, is a regulator of transforming growth factor‑β (TGF‑β)/Smad signaling. Tif1γ can function as an oncogene and as a tumor suppressor. In the present study, Tif1γ levels were measured in the plasma of patients with breast cancer in order to inves...

journal_title：Molecular medicine reports

authors： Cai F,Cai L,Zhou Z,Pan X,Wang M,Chen S,Luis MAF,Cen C,Biskup E

更新日期：2019-05-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is a signaling gasotransmitter, involved in various physiological and pathological processes. H2S-donating drugs have been tested to conjugate the beneficial effects of H2S with other pharmaceutical properties. It has been shown that the endogenous cystathionine-γ-lyase (CSE)/H2S pathway partici...

journal_title：Molecular medicine reports

authors： Xie YH,Zhang N,Li LF,Zhang QZ,Xie LJ,Jiang H,Li LP,Hao N,Zhang JX

更新日期：2014-10-01 00:00:00

abstract：:In the present study, mutL homolog 1 (MLH1) small interfering (si)RNA, KU‑55933, an ataxia‑telangiectasia mutated (ATM) inhibitor, and compound C, an adenosine monophosphate‑activated protein kinase (AMPK) inhibitor, were used to investigate the mechanisms underlying temozolomide (TMZ)‑induced autophagy and to determi...

journal_title：Molecular medicine reports

authors： Zou Y,Wang Q,Wang W

更新日期：2015-06-01 00:00:00

abstract：:Obesity has a negative effect on ovarian functions, which is reported to increase the risk of infertility. The mechanism underlying obesity‑induced infertility is not yet clear. The present study established a high‑fat diet (HFD)‑induced obesity mouse model to elucidate the mechanisms underlying the effect of HFD‑indu...

journal_title：Molecular medicine reports

authors： Wu Y,Zhang Z,Liao X,Qi L,Liu Y,Wang Z

更新日期：2016-10-01 00:00:00

abstract：:Resistin, an adipocytokine secreted by fat tissues, has been shown to be associated with increased local and systemic complications in acute pancreatitis (AP). However, the mechanism underlying the effect of resistin in the aggravation of AP remains to be elucidated. The aim of the present study was to investigate the...

journal_title：Molecular medicine reports

authors： Jiang CY,Wang W

更新日期：2017-01-01 00:00:00

abstract：:Benign thyroid nodules are among the most common endocrine disorders. Recent advances in diagnostic imaging and pathology have significantly contributed to better risk stratification of thyroid nodules. However, current treatment options, beyond surgical approaches are limited. The following placebo-controlled study p...

journal_title：Molecular medicine reports

authors： Stancioiu F,Mihai D,Papadakis GZ,Tsatsakis A,Spandidos DA,Badiu C

更新日期：2019-09-01 00:00:00

abstract：:In the present study, the expression of microRNA (miR)‑671‑3p in non‑small‑cell lung cancer (NSCLC) was detected via reverse transcription‑quantitative polymerase chain reaction analysis, and its role in cell proliferation, apoptosis, migration and invasion was investigated via Cell Counting Kit‑8, colony formation, f...

journal_title：Molecular medicine reports

authors： Li ZY,Zhang ZZ,Bi H,Zhang QD,Zhang SJ,Zhou L,Zhu XQ,Zhou J

更新日期：2019-10-01 00:00:00

abstract：:Histone deacetylase inhibitor (HDACi) has been a major target of anticancer agents. Quisinostat (JNJ‑26481585), a novel second‑generation HDACi, has previously demonstrated antiproliferative activity against non‑small cell lung cancer; however, the function of quisinostat in hepatocellular carcinoma (HCC) remains to b...

journal_title：Molecular medicine reports

authors： Li F,Wang T,Wang Z,Chen X,Liu R

更新日期：2017-11-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the primary causes of cancer‑associated mortality worldwide. However, the potential molecular mechanism of CRC progression remains unknown. Long non‑coding RNA small nucleolar RNA host gene 20 (SNHG20) has been demonstrated to be involved in the development and progression of a variet...

journal_title：Molecular medicine reports

authors： Wang Y,Fu J,Yang L,Liang Z

更新日期：2021-01-01 00:00:00

abstract：:Clear-cell renal cell carcinoma (CCRCC) is the most frequent primary malignancy in the adult kidney. Most patients with advanced CCRCC have poor prognosis as CCRCC remains resistant to chemotherapy. The present study explored the possible mechanism underlying CCRCC resistance to chemotherapy and found that loss of PTE...

journal_title：Molecular medicine reports

authors： Chen J,Zhu H,Zhang Y,Cui MH,Han LY,Jia ZH,Wang L,Teng H,Miao LN

更新日期：2015-08-01 00:00:00

abstract：:In adults, bone hematopoietic cells are responsible for the lifelong production of all blood cells. It is affected in aging, with progressive loss of physiological integrity leading to impaired function by cellular intrinsic and extrinsic factors. However, intervention measures, which directly inhibit the aging of hem...

journal_title：Molecular medicine reports

authors： Zhou Y,Liu J,Cai S,Liu D,Jiang R,Wang Y

更新日期：2015-09-01 00:00:00

abstract：:To determine the effect of the down-regulation of osteopontin (OPN) expression on the sensitivity of breast cancer cells to doxorubicin, a chemotherapeutic drug, OPN shRNA was used to transfect the OPN-positive breast cancer cell line MDA-MB-231. The expression of OPN mRNA and protein was analyzed by RT-PCR and Wester...

journal_title：Molecular medicine reports

authors： Yang L,Wei L,Zhao W,Wang X,Zheng G,Zheng M,Song X,Zuo W

更新日期：2012-02-01 00:00:00

abstract：:Molecular biologists have identified a number of genes and microRNAs (miRs) associated with chronic myelogenous leukemia (CML). However, their underlying mechanisms in CML remain unclear. In the present study, three regulatory networks of genes and miRs were constructed to elucidate the underlying mechanisms of CML. T...

journal_title：Molecular medicine reports

authors： Wang K,Xu Z,Wang N,Tian Y,Sun X,Ma Y

更新日期：2016-01-01 00:00:00

abstract：:The present study aimed to investigate the protective effects of ghrelin against oxidative stress, inducible nitric oxide synthase (iNOS) and inflammation in a mouse model of myocardial ischemia/reperfusion injury (MIRI). In addition, the study aimed to determine its underlying mechanisms. A mouse model of MIRI was us...

journal_title：Molecular medicine reports

authors： Sun N,Wang H,Wang L

更新日期：2016-09-01 00:00:00

abstract：:Previous studies have demonstrated that microRNAs (miRNAs), a class of single‑stranded RNA molecules that are 18‑27 nucleotides in length, serve a critical function in tumorigenesis, including in the development of colon cancer. In the current study, miR‑100 levels were demonstrated to be reduced in colon cancer tissu...

journal_title：Molecular medicine reports

authors： Zhou MK,Liu XJ,Zhao ZG,Cheng YM

更新日期：2015-04-01 00:00:00

abstract：:The present study aimed to evaluate the effects of Krüppel‑like factor 2 (KLF2) on the differentiation of endothelial progenitor cells (EPCs) to endothelial cells (ECs) induced by shear stress, and to investigate the corresponding mechanisms. Cultured rat late EPCs were exposed to shear stress (12 dyn/cm2) for differe...

journal_title：Molecular medicine reports

authors： Chu HR,Sun YC,Gao Y,Guan XM,Yan H,Cui XD,Zhang XY,Li X,Li H,Cheng M

更新日期：2019-03-01 00:00:00

abstract：:Autophagy is a highly conserved pathway that permits recycling of nutrients within the cell and is rapidly upregulated during starvation or cell stress. Autophagy has been implicated in the pathophysiological process of warm ischemia‑reperfusion injury in the rat lung. Cold ischemia (CI) preservation for lung transpla...

journal_title：Molecular medicine reports

authors： Chen X,Wu JX,You XJ,Zhu HW,Wei JL,Xu MY

更新日期：2015-04-01 00:00:00

abstract：:A disintegrin and metalloproteinases (ADAMs), a family of transmembrane glycoproteins, are expressed in numerous tissues and organs, and have been implicated in a variety of physiological and pathological processes. ADAM15 is unique among the ADAMs in having an Arg-Gly-Asp motif in its disintegrin domain. In the prese...

journal_title：Molecular medicine reports

authors： Hou Y,Chu M,Cai Y,Lei J,Chen Y,Zhu R,Gong X,Ma X,Jin J

更新日期：2015-08-01 00:00:00

abstract：:MicroRNAs (miRs) can lead to mRNA degradation or inhibit protein translation through directly binding to the 3'‑untranslational region (UTR) of their target mRNAs. Deregulation of miR‑10b has been reported to be associated with chondrosarcoma. However, the role of miR‑10b in chondrosarcoma cell migration and invasion,...

journal_title：Molecular medicine reports

authors： Aili A,Chen Y,Zhang H

更新日期：2016-01-01 00:00:00

abstract：:Lung cancer is a leading cause of cancer mortality worldwide and patients occasionally develop local recurrence or distant metastasis soon after curative resection. Reports of new therapeutic strategies for lung squamous cell carcinoma (SqCC) are extremely rare, while selective anti...

journal_title：Molecular medicine reports

authors： Masuda R,Kijima H,Imamura N,Aruga N,Nakamura Y,Masuda D,Takeichi H,Kato N,Nakagawa T,Tanaka M,Inokuchi S,Iwazaki M

更新日期：2012-11-01 00:00:00