Inhibition of microRNA‑492 attenuates cell proliferation and invasion in retinoblastoma via directly targeting LATS2.

abstract：:A polymorphism within the 3'-UTR 8473T↷C of the cyclooxygenase-2 (COX-2) gene, which plays a role in gastrointestinal cancer development, has been associated with susceptibility to malignant disease. Here, we report on the interaction between the COX-2 3'-UTR T↷C polymorphism and gastric cancer development. DNA from 1...

journal_title：Molecular medicine reports

authors： Shibata T,Arisawa T,Tahara T,Hirata I,Nakano H

更新日期：2008-07-01 00:00:00

abstract：:Growing evidence suggests that the elevation of free fatty acids, including palmitic acid (PA), are associated with inflammation and oxidative stress, which may be involved in endothelial dysfunction, characterized by the reduced bioavailability of nitric oxide (NO) synthesized from endothelial NO synthase (eNOS). Hem...

journal_title：Molecular medicine reports

authors： Jeong SO,Son Y,Lee JH,Cheong YK,Park SH,Chung HT,Pae HO

更新日期：2015-07-01 00:00:00

abstract：:Anti-tumor therapies based on anti-inflammatory effects have been considered in cancer treatment. Survival, proliferation and, resultantly, invasion and metastasis of tumor cells are regulated by local inflammatory mediators. Primary inflammatory cytokines, such as tumor necrosis factor (TNF), are targets for anticanc...

journal_title：Molecular medicine reports

authors： Dexheimer GM,Becker Delving LKO,de Oliveira HS,Biolchi V,Goettert MI,Pozzobon A

更新日期：2017-05-01 00:00:00

abstract：:Molecular biologists have identified a number of genes and microRNAs (miRs) associated with chronic myelogenous leukemia (CML). However, their underlying mechanisms in CML remain unclear. In the present study, three regulatory networks of genes and miRs were constructed to elucidate the underlying mechanisms of CML. T...

journal_title：Molecular medicine reports

authors： Wang K,Xu Z,Wang N,Tian Y,Sun X,Ma Y

更新日期：2016-01-01 00:00:00

abstract：:B cells are critically important for the pathogenesis of IgA nephropathy (IgAN). The present study aimed to investigate the abundance of B cell activating factor (BAFF), which belongs to the tumor necrosis factor superfamily, in the peripheral blood of patients with IgAN. The different forms of BAFF in peripheral bloo...

journal_title：Molecular medicine reports

authors： Zheng N,Fan J,Wang B,Wang D,Feng P,Yang Q,Yu X

更新日期：2017-04-01 00:00:00

abstract：:Acute lung injury (ALI) is a common, costly and potentially lethal disease with characteristics of alveolar‑capillary membrane disruption, pulmonary edema and impaired gas exchange due to increased apoptosis and pulmonary inflammation. There is no effective and specific therapy for ALI; however, mesenchymal stem cells...

journal_title：Molecular medicine reports

authors： Chen XX,Tang L,Han ZH,Wang WJ,Meng JG

更新日期：2019-03-01 00:00:00

abstract：:Trefoil factor 3 (TFF3) serves an important role in intestinal mucosal damage and healing, and contributes to the pathogenesis and treatment of inflammatory bowel disease (IBD). The aim of the present study was to determine the association between TFF3 and microRNA‑7‑5p (miR‑7‑5p) in IBD. Tissue immunohistochemistry w...

journal_title：Molecular medicine reports

authors： Guo J,Sun M,Teng X,Xu L

更新日期：2017-08-01 00:00:00

abstract：:Biglycan is an important component of the extracellular matrix, and it is also a member of small leucine-rich proteoglycan family. Previous studies indicated that the expression of biglycan was increased in a variety of tumor tissues, including colon cancer. However, the mechanisms underlying its effects in colon canc...

journal_title：Molecular medicine reports

authors： Xing X,Gu X,Ma T

更新日期：2015-11-01 00:00:00

abstract：:Runt-related transcription factor 2 (RUNX2) is a vital regulatory factor that controls osteoblast-specific gene expression; however, RUNX2‑regulated genes in human mesenchymal stem cells (hMSCs) remain to be fully elucidated. In the present study, chromatin immunoprecipitation (ChIP)-on-chip analysis of RUNX2 in hMSCs...

journal_title：Molecular medicine reports

authors： Xiong J,Hu Z,Wang T,Xu X,Liu J,Wu P,Che X,Li W

更新日期：2016-08-01 00:00:00

abstract：:The present study presented a protocol that can be used to obtain rapidly a high purity of proliferating rat Schwann cells from freshly dissociated rat peripheral nerves. The sciatic nerves of newborn rats (1‑3 day old) were dissociated, and the Schwann cells (SCs) were purified using fluorescence‑activated cell sorti...

journal_title：Molecular medicine reports

authors： Shen M,Tang W,Cao Z,Cao X,Ding F

更新日期：2017-08-01 00:00:00

abstract：:Hyperbaric oxygen (HBO) therapy is an effective therapy for ischemia/reperfusion (I/R) injury of the brain, small intestine, testes and liver. However, the detailed molecular mechanisms underlying the effect of HBO therapy remain undetermined. In the current study, the hypothesis that preconditioning rats with HBO pro...

journal_title：Molecular medicine reports

authors： Kang N,Hai Y,Liang F,Gao CJ,Liu XH

更新日期：2014-06-01 00:00:00

abstract：:Cholelithiasis is a common medical condition whose incidence rate is increasing yearly, while its pathogenesis has yet to be elucidated. The present study assessed the expression of Rho-kinase (ROCK) in gallbladder smooth muscles and its effect on the contractile function of gallbladder smooth muscles during gallstone...

journal_title：Molecular medicine reports

authors： Wang B,Ding YM,Wang CT,Wang WX

更新日期：2015-08-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) and collagen type I (Col-1) serve a critical role in the development and progression of hypertrophic scarring (HS). The present study hypothesized that a post‑translational mechanism of microRNAs (miR) regulated the expression of TGF‑β1 and Col‑1 in HS fibroblasts (HSFBs). A coll...

journal_title：Molecular medicine reports

authors： Xiao K,Luo X,Wang X,Gao Z

更新日期：2017-04-01 00:00:00

abstract：:Alzheimer's disease is one of the most common age‑associated diseases that frequently leads to memory disorders, cognitive decline and dementia. Evidence suggests that nicergoline serves an important role in the apoptosis of hippocampal cells, memory recovery, cognitive function and neuronal survival. However, the sig...

journal_title：Molecular medicine reports

authors： Zang G,Fang L,Chen L,Wang C

更新日期：2018-05-01 00:00:00

abstract：:Previous studies have shown that long non‑coding RNAs (lncRNAs) serve important roles in necrotizing enterocolitis (NEC). However, the underlying mechanisms remain largely unknown. In order to examine the potential role of lncRNAs in NEC, the present study investigated lncRNA and mRNA expression profiles in NEC lesion...

journal_title：Molecular medicine reports

authors： Chen W,Yan X,Tian T,Yan R,Wang X,Yu Z,Li Y,Zhang L,Han S

更新日期：2020-07-01 00:00:00

abstract：:Pancreatic cancer (PC) is the fourth most common cause of cancer‑related mortality worldwide and is characterized by high invasiveness and early metastasis. To identify novel diagnostic markers, the present study aimed to understand the mechanism underlying PC progression. The present study demonstrated that exosomes ...

journal_title：Molecular medicine reports

authors： Wei Q,Wei L,Zhang J,Li Z,Feng H,Ren L

更新日期：2020-10-01 00:00:00

abstract：:Following the publication of the above article, an interested reader drew to the authors' attention that a pair of the data panels shown in Fig. 4 contained overlapping data. After having consulted their original data, the authors realized that a total of three panels featured in Figs. 4 and 6 had been erroneously sel...

journal_title：Molecular medicine reports

authors： Xu F,Wu H,Zhang K,Lv P,Zheng L,Zhao J

更新日期：2020-09-01 00:00:00

abstract：:Circular RNAs (circRNAs) are class of endogenous RNAs that have a role in the regulation of gene expression. The present study aimed to investigate the diagnostic value and role of circRNA in the pathogenesis of leukoaraiosis (LA). The present study performed Arraystar Human circRNA Array analysis of 6 samples from LA...

journal_title：Molecular medicine reports

authors： Mi T,Luo C,Hu Y,Qu C,Wang X,Guo S,Du Y

更新日期：2017-09-01 00:00:00

abstract：:Owing to an oversight during the proof checking stage, the above article has been published with the incorrect author listed for correspondence. The first author, Chao Huang, is listed as the corresponding author, although he was only intended to have been temporarily assigned to handle queries during the pre-press st...

journal_title：Molecular medicine reports

authors： Huang C,Liu H,Gong X,Wen B,Chen D,Liu J,Hu F

更新日期：2016-12-01 00:00:00

abstract：:MicroRNAs (miRs) are considered to be effective, post‑transcriptional regulators in the pathophysiology of type 2 diabetes (T2D) and promising treatment targets. However, the function of miR‑141 remains to be elucidated. In the present study, upregulation of miR‑141 was demonstrated in diabetic mice and elderly diabet...

journal_title：Molecular medicine reports

authors： Yu X,Zhong L

更新日期：2018-06-01 00:00:00

abstract：:Multipotent differentiation ability, low expression of co‑stimulatory molecules and immunosuppressive effects render mesenchymal stem cells (MSCs) the best candidate for use in cell‑based therapy. At present, MSCs are widely used in clinical trials, which have, however, failed to demonstrate any long‑term therapeutic ...

journal_title：Molecular medicine reports

authors： Li Q,Ma Y,Li L,Bao J,Zhang L

更新日期：2015-11-01 00:00:00

abstract：:Toll-like receptors (TLRs) are critical in the induction of the immune response in tumor development. TLR7 has previously been demonstrated to be associated with the development of pancreatic cancer, and the release of cytokines and chemokines from other types of cancer cell; however, the specific expression induced b...

journal_title：Molecular medicine reports

authors： Wang F,Jin R,Zou BB,Li L,Cheng FW,Luo X,Geng X,Zhang SQ

更新日期：2016-02-01 00:00:00

abstract：:Peripheral arterial disease (PAD) is the third leading cause of cardiovascular morbidity worldwide, after coronary artery disease and stroke. As endogenous regulators of gene expression, microRNAs (miRs) are implicated in the development and progression of various diseases, including types of cancer, autoimmune diseas...

journal_title：Molecular medicine reports

authors： Shi Y,Xu X,Luan P,Kou W,Li M,Yu Q,Zhuang J,Xu Y,Peng W,Jian W

更新日期：2020-12-01 00:00:00

abstract：:To explore the restraining effect of baicalein and the mitogen-activation protein kinase kinase inhibitor, U0126, on human cervical cell line HeLa proliferation, apoptosis and migration. HeLa cells were treated by different concentrations of baicalein or U0126. A Cell Counting Kit (CCK)‑8 assay was applied to examine ...

journal_title：Molecular medicine reports

authors： Ye H,Zhang Y,Wang Y,Xia J,Mao X,Yu X

更新日期：2017-07-01 00:00:00

abstract：:It has been confirmed that bone morphogenetic protein-9 (BMP-9) promotes the differentiation of osteoblasts. However, the ways in which BMP‑9 exerts its effects on the differentiation of osteoclasts and bone resorption remain to be elucidated. The present study was designed to investigate the roles and the molecular m...

journal_title：Molecular medicine reports

authors： Li H,Zhao D,Wang S,Ding J,Zhao L

更新日期：2016-11-01 00:00:00

abstract：:Methylglyoxal (MGO)-induced carbonyl stress and pro-inflammatory responses have been suggested to contribute to endothelial dysfunction. Curcumin (Cur), a polyphenolic compound from Curcuma longa L., may protect endothelial cells against carbonyl stress-induced damage by trapping dicarbonyl compounds such as MGO. Howe...

journal_title：Molecular medicine reports

authors： Sun YP,Gu JF,Tan XB,Wang CF,Jia XB,Feng L,Liu JP

更新日期：2016-02-01 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most important causes of end‑stage renal disease. Astragaloside IV (AS-IV) is a saponin isolated from Astragalus membranaceus, which possesses various pharmacological activities. AS‑IV prevents podocyte apoptosis and ameliorates renal injury in DN; however, few studies have focu...

journal_title：Molecular medicine reports

authors： Yao XM,Liu YJ,Wang YM,Wang H,Zhu BB,Liang YP,Yao WG,Yu H,Wang NS,Zhang XM,Peng W

更新日期：2016-06-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effect of puerarin on pelvic organ prolapse (POP) and the underlying mechanisms that regulate the metabolism of human parametrial ligament fibroblasts (HPLFs). HPLFs obtained from the pelvic tissue of patients with (n=10) or without (n=8) POP during hyster...

journal_title：Molecular medicine reports

authors： Li Y,Hong L,Liu C,Min J,Hong S,Hu M,Zhao Y,Yang Q,Tang J,He S

更新日期：2018-02-01 00:00:00

abstract：:Kashin-Beck disease (KBD) is a degenerative osteoarticular disease of unknown etiology. The management of KBD would benefit from the identification of the biomarkers related to this disease. In this study, mass spectrometry (MS)-based proteomic profiling was used to identify potential biomarkers of the disease. One hu...

journal_title：Molecular medicine reports

authors： Du J,Wu X,Zhang H,Wang S,Tan W,Guo X

更新日期：2010-09-01 00:00:00

abstract：:The present study aimed to investigate the mechanism underlying the effects of minocycline on diabetic retinopathy‑associated cellular apoptosis. A total of 40 Sprague Dawley (SD) rats were used as a diabetic retinopathy model following injection with streptozotocin. Among the 34 rats in which the diabetes model was s...

journal_title：Molecular medicine reports

authors： Wu Y,Chen Y,Wu Q,Jia L,Du X

更新日期：2015-10-01 00:00:00