Isolation of rat Schwann cells based on cell sorting.

abstract：:Diabetic retinopathy is one of the most common complications in patients with diabetes and affects ~75% of them within 15 years of the onset of the disease. Activation of protein kinase C (PKC) is a key feature of diabetes mellitus and may be involved in the pathogenesis of diabetic retinopathy. The present study aime...

journal_title：Molecular medicine reports

authors： Liu ZC,Yu EH,Liu W,Liu XC,Tang SB,Zhu BH

更新日期：2014-05-01 00:00:00

abstract：:Numerous mechanisms and factors have been implicated in liver damage; however, the involvement of autophagy and endoplasmic reticulum (ER) stress during early‑stage liver injury remains to be fully elucidated. The present study was conducted to determine the expression of autophagy and ER‑stress‑associated proteins in...

journal_title：Molecular medicine reports

authors： Shi T,Song W,Xu R

更新日期：2017-11-01 00:00:00

abstract：:Bacterial protection and epithelial repair are important against inflammatory bowel disease (IBD). The present study was designed to examine the effects of different bacterial components on the repair of normal and dextran sodium sulfate (DSS)‑treated colonic epithelial cells and the corresponding mechanisms. Human co...

journal_title：Molecular medicine reports

authors： Xu Z,Liao B,Zhang R,Sh R,Wang L

更新日期：2017-08-01 00:00:00

abstract：:The function of microRNAs (miRNAs) in tumorigenesis has been extensively investigated. In the present study, the aim was to investigate the expression and role of miR‑204 in B‑cell lymphoma. The present study demonstrated that miR‑204 is downregulated in B‑cell lymphoma. Using in vitro studies, overexpression of miR‑2...

journal_title：Molecular medicine reports

authors： Wu L,Li Y,Fan JM,Zhang ZM,Ouyang JL,Ni TT,Wu HX,Li H

更新日期：2015-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the primary causes of cancer‑associated mortality worldwide. However, the potential molecular mechanism of CRC progression remains unknown. Long non‑coding RNA small nucleolar RNA host gene 20 (SNHG20) has been demonstrated to be involved in the development and progression of a variet...

journal_title：Molecular medicine reports

authors： Wang Y,Fu J,Yang L,Liang Z

更新日期：2021-01-01 00:00:00

abstract：:Semaphorin 6B is a member of the semaphorin family of signaling proteins, which is implicated in a variety of biological processes, such as axon guidance and muscle regeneration. PPARα is known to be a regulator of semaphorin 6B in human cancer cell lines. In this study, we examined the effect of fenofibrate as a PPAR...

journal_title：Molecular medicine reports

authors： Murad H,Kasies F,Azroony R,Alya G,Madania A

更新日期：2011-05-01 00:00:00

abstract：:The study investigated the effects and underlying mechanisms of silent information regulation of transcription 1 (Sirt1) action on apoptosis in chondrocytes and degradation of the extracellular matrix. Cartilage tissue samples were derived from knee arthroplasty of patients with osteoarthritis (OA). The three groups w...

journal_title：Molecular medicine reports

authors： He DS,Hu XJ,Yan YQ,Liu H

更新日期：2017-07-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most common types of cancer in the urinary system in men. Zeylenone (Zey), a naturally occurring cyclohexene oxide, has an anticancer effect. In the present study, the role and potential mechanism of Zey in PCa were examined. The proliferative, invasive and migratory capacities of D...

journal_title：Molecular medicine reports

authors： Zeng S,Zhu B,Zeng J,Wu W,Jiang C

更新日期：2018-12-01 00:00:00

abstract：:An outbreak of hepatitis C virus (HCV) infections, for which the risk factor was unknown, was previously identified in North Guangdong, China. In the present study, a total of 736 local residents were surveyed regarding their lifetime risk factors for HCV infection. Serum anti‑HCV antibodies and HCV RNA were examined ...

journal_title：Molecular medicine reports

authors： Shao X,Luo Q,Cai Q,Zhang F,Zhu J,Liu Y,Zhao Z,Gao Z,Zhang X

更新日期：2016-11-01 00:00:00

abstract：:Renal ischemia/reperfusion (I/R) is a common risk factor for renal failure. Expression of endothelin‑1 (ET‑1) and its receptor ETA were also reported to be involved in the development of acute and chronic renal disease. The present study was designed to investigate the association between inflammation and ET‑1/ETA exp...

journal_title：Molecular medicine reports

authors： Niu J,Wu J,Li X,Zhang F

更新日期：2015-05-01 00:00:00

abstract：:The mammalian target of rapamycin/eukaryotic translation inititiation factor 4E binding protein 1 (mTOR/4E-BP1) transduction pathway is activated in a range of malignant cancers, but its role in human gastric cardiac adenocarcinoma (GCA) has not been well defined. The present study used western blotting and reverse tr...

journal_title：Molecular medicine reports

authors： Yang HY,Xue LY,Xing LX,Wang J,Wang JL,Yan X,Zhang XH

更新日期：2013-02-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a life-threatening type of stroke. Previous studies have reported that bone marrow mesenchymal stem cells (BMSCs) may exert beneficial effects on the treatment of ICH. However, it remains unknown whether the neuroprotection exerted by BMSCs on ICH is due to the differentiation of BMSC...

journal_title：Molecular medicine reports

authors： Cui C,Cui Y,Gao J,Li R,Jiang X,Tian Y,Wang K,Cui J

更新日期：2017-04-01 00:00:00

abstract：:Twenty‑three clinical Streptococcus pneumoniae (SP) strains were isolated from blood and sputum specimens from the Second Affiliated Hospital of Wenzhou Medical College in 2009. These strains and the ATCC 49619 standard strain were cultured and suspended in normal saline (at a turbidity of 1.0 McFarland). The producti...

journal_title：Molecular medicine reports

authors： Zhang J,Hu DK,Wang DG,Liu Y,Liu CB,Yu LH,Qu Y,Luo XH,Yang JH,Yu J,Liu SC,Li XY

更新日期：2013-11-01 00:00:00

abstract：:Dehydrocostuslactone is a sesquiterpene lactone derived from Saussurea lappa, a plant used in traditional herbal medicines. The anti-proliferative activity of dehydrocostuslactone was investigated in human breast cancer (MDA-MB-231, MDA-MB-453 and SK-BR-3) and ovarian cancer (SK-OV-3 and OVCAR3) cell lines using the m...

journal_title：Molecular medicine reports

authors： Choi EJ,Kim GH

更新日期：2010-01-01 00:00:00

abstract：:The present study aimed to identify any association between bone morphogenetic protein‑7 (BMP‑7) and the expression of the transcriptional co‑repressor Ski‑related novel protein N (SnoN), in addition to alterations in tubulointerstitial fibrosis, during the development and progression of diabetic nephropathy (DN). Str...

journal_title：Molecular medicine reports

authors： Wang Y,Xiao Y,Li S,Shi L,Liu L,Zhang Y,Shi M,Guo B

更新日期：2017-09-01 00:00:00

abstract：:Numerous studies have shown that N-nitrosamines and their precursors are probable etiological factors for esophageal cancer. Certain N-nitrosamines have been shown to induce esophageal cancer in animal models. However, the molecular mechanisms by which N-nitrosamines promote esophageal carcinogenesis remain poorly und...

journal_title：Molecular medicine reports

authors： Xie Y,Tang E,Ren B,Feng L

更新日期：2010-05-01 00:00:00

abstract：:Myocyte apoptosis and oxidative stress key critical roles in the process of doxorubicin (DOX)‑induced cardiotoxicity. However, how apoptosis and oxidative stress arise in DOX‑induced heart injury remains largely unknown. Cathepsin B (CTSB) is a typical lysosomal cysteine protease that is associated with apoptosis, inf...

journal_title：Molecular medicine reports

authors： Liu C,Cai Z,Hu T,Yao Q,Zhang L

更新日期：2020-12-01 00:00:00

abstract：:Colon cancer is characterized by invasion and migration. DNA methylation of CpG islands in tumor suppressor genes is considered to be an epigenetic mechanism underlying cancer development. Epigenetic silencing of a gene may be reversed by drugs, including genistein. The present study aimed to determine the effect of g...

journal_title：Molecular medicine reports

authors： Zhu J,Ren J,Tang L

更新日期：2018-05-01 00:00:00

abstract：:The multipotent and easily accessible characteristics of dental pulp stem cells (DPSCs) make them a promising target for bone tissue engineering. Long non‑coding RNAs (lncRNAs) have an important role in the osteogenic differentiation of mesenchymal stem cells. Nevertheless, whether lncRNAs are involved in the osteogen...

journal_title：Molecular medicine reports

authors： Tao R,Li YX,Liu YK,Liu F,Zhou ZY

更新日期：2019-04-01 00:00:00

abstract：:The present study investigated the role of the c‑Jun N‑terminal kinase (JNK)/transforming growth factor‑β (TGF‑β)/Smad3 pathway in endoplasmic reticulum stress (ERS)‑mediated renal interstitial fibrosis, which would be beneficial for chronic kidney disease (CKD) therapy. In human renal biopsy tissue, the expression le...

journal_title：Molecular medicine reports

authors： Liu Y,Shen P,Zhou Y,Tang L,Chai H

更新日期：2019-07-01 00:00:00

abstract：:Soy sauce is a traditional fermented seasoning of Japan and is available throughout the world. The two main raw ingredients of soy sauce are soybean and wheat, both of which are established food allergens. The present study examined the degradation and removal of soybean allergens in soy sauce by immunoblotting with a...

journal_title：Molecular medicine reports

authors： Magishi N,Yuikawa N,Kobayashi M,Taniuchi S

更新日期：2017-08-01 00:00:00

abstract：:Autophagy is a highly conserved pathway that permits recycling of nutrients within the cell and is rapidly upregulated during starvation or cell stress. Autophagy has been implicated in the pathophysiological process of warm ischemia‑reperfusion injury in the rat lung. Cold ischemia (CI) preservation for lung transpla...

journal_title：Molecular medicine reports

authors： Chen X,Wu JX,You XJ,Zhu HW,Wei JL,Xu MY

更新日期：2015-04-01 00:00:00

abstract：:It has previously been demonstrated that phosphatidylinositol-3-kinase (PI3K)/Akt and cleaved caspase-3 serve critical roles in the apoptosis of cardiac myocytes following ischemia/reperfusion injury. Epigallocatechin-3-gallate (EGCG), the predominant catechin component of green tea, has been reported to have potentia...

journal_title：Molecular medicine reports

authors： Zeng X,Tan X

更新日期：2015-08-01 00:00:00

abstract：:Macrophages can be polarized into the inflammatory M1 lineage or the immunomodulatory M2 lineage, depending on the differential tissue microenvironment signaling, specific pathogens or cytokine stimulation. Tumor necrosis factor α‑induced protein 8‑like protein 2 (TIPE2) has been demonstrated to negatively regulate in...

journal_title：Molecular medicine reports

authors： Jiang Y,Li Q,Zhang Y,Gao Y,Jiang L,Chen Z

更新日期：2018-01-01 00:00:00

abstract：:Sepsis is a systemic inflammatory response resulting from the excessive production of pro-inflammatory cytokines, including tumor necrosis factor (TNF)‑α. Sirtuin 1 (SirT1) actively deacetylates histone proteins, and facilitates chromatin compaction and gene silencing. In the present study, a cell model of sepsis, com...

journal_title：Molecular medicine reports

authors： Chen GD,Yu WD,Chen XP

更新日期：2016-12-01 00:00:00

abstract：:The present study aimed to investigate the effects of the long non‑coding RNA (lncRNA) growth arrest‑specific transcript 5 (GAS5) on proliferation, apoptosis and the inflammatory response of osteoarthritic chondrocytes (OACs) and its associated mechanism of action. Primary chondrocytes were isolated from cartilage tis...

journal_title：Molecular medicine reports

authors： Ji Q,Qiao X,Liu Y,Wang D,Yan J

更新日期：2020-03-01 00:00:00

abstract：:Human glioma is a pernicious tumor from the central nervous system; it has been reported that microRNAs (miRs) may have carcinogenic or tumor suppressor effects on human glioma. The aim of the present study was to assess miR‑141 expression and functional role in human primary glioma, as well as in tumor‑derived cell l...

journal_title：Molecular medicine reports

authors： Li G,Huang M,Cai Y,Ke Y,Yang Y,Sun X

更新日期：2018-08-01 00:00:00

abstract：:Cobalt nanoparticles (CoNPs) released from metal‑on‑metal implants have caused considerable concern. Oxidative stress is associated with the mechanism underlying cobalt‑induced cytotoxicity and genotoxicity. The indolamine melatonin exhibits protective effects against damage induced by metals. The present study invest...

journal_title：Molecular medicine reports

authors： Liu Y,Yang X,Wang W,Wu X,Zhu H,Liu F

更新日期：2017-10-01 00:00:00

abstract：:Radix Polygalae is a traditional Chinese medicine that has been used as a sedative and to improve memory for a number of years. The impact of Radix Polygalae in patients with Alzheimer's disease has been investigated. However the mechanisms underlying its effects remain unclear. In the current study, the toxicity of v...

journal_title：Molecular medicine reports

authors： Zhao H,Wang ZC,Wang KF,Chen XY

更新日期：2015-08-01 00:00:00

abstract：:The differentiation of pluripotent mesenchymal stem cells to mature osteoblasts is crucial for the maintenance of the adult skeleton. In rheumatic arthritis, osteoblast differentiation is impaired by the overproduction of cytokine tumor necrosis factor (TNF)‑α. It has been demonstrated that TNF-α is able to inhibit os...

journal_title：Molecular medicine reports

authors： Wang G,Zhang X,Yu B,Ren K

更新日期：2015-07-01 00:00:00