SirT1 activator represses the transcription of TNF‑α in THP‑1 cells of a sepsis model via deacetylation of H4K16.

abstract：:Interleukin (IL)-1β-induced chondrocyte apoptosis is associated with the pathogenesis of arthritis. Platelet‑rich plasma (PRP), which is derived from the patient's own blood and contains numerous growth factors, has the potential for arthritis treatment. Therefore, the present study aimed to determine the effects of P...

journal_title：Molecular medicine reports

authors： Yang J,Lu Y,Guo A

更新日期：2016-11-01 00:00:00

abstract：:SC1, an immunoglobulin superfamily cell adhesion molecule, is expressed in embryonic tissues and plays an important role in development through its cell adhesive activity. SC1 is also found in a variety of tumors and its expression is associated with a poor prognosis. The expressional patterns of SC1 were examined in ...

journal_title：Molecular medicine reports

authors： Adachi K,Hagimori K,Kato H,Fukuda K,Kikuta M,Tsukamoto Y

更新日期：2008-03-01 00:00:00

abstract：:Glaucoma is one of the leading causes of blindness. Previous studies have indicated that the oxidative stress‑induced apoptosis of trabecular meshwork cells (TMCs) may serve a key role in the pathogenesis of glaucoma, and that micro RNA(miR)‑17‑5p may be involved in this process. However, the specific mechanisms requi...

journal_title：Molecular medicine reports

authors： Wang X,Li Z,Bai J,Song W,Zhang F

更新日期：2019-04-01 00:00:00

abstract：:Sonodynamic therapy (SDT) with 5-aminolevulinic acid (5-ALA) can effectively inhibit various types of tumor in vitro and in vivo. However, the association between the efficacy of SDT and the phase of the cell cycle remains to be elucidated. 5-ALA may generate different quantities of sonosensitizer, protoporphyrin IX (...

journal_title：Molecular medicine reports

authors： Li N,Sun M,Wang Y,Lv Y,Hu Z,Cao W,Zheng J,Jiao X

更新日期：2015-08-01 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) is associated with the occurrence and development of clear cell renal cell carcinoma (ccRCC) through their participation in a number of critical biological processes. Therefore, an in‑depth investigation into miRNAs and their biological roles within ccRCC may provide useful insights...

journal_title：Molecular medicine reports

authors： Zhao H,Zhao H,Xia X,Liu X

更新日期：2018-05-01 00:00:00

abstract：:Nuclear respiratory factor 1 (NRF-1) has important roles in the regulation of several key metabolic genes required for cellular growth and respiration. A previous study by our group indicated that NRF‑1 is involved in mitochondrial dysfunction induced by the environmental pollutant benzo[a]pyrene in the 16HBE human br...

journal_title：Molecular medicine reports

authors： Wu J,Wang Y,Wo D,Zhang L,Li J

更新日期：2016-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate biogenesis and disease development by targeting numerous mRNAs. miRNA (miR)‑124 and its direct target, inhibitor of apoptosis‑stimulating protein of p53 (iASPP), may be involved in tumor development and progression. The aim of the present study was to explore the role of miR‑124‑targeted iA...

journal_title：Molecular medicine reports

authors： Liu X,Kang J,Sun S,Luo Y,Ji X,Zeng X,Zhao S

更新日期：2018-01-01 00:00:00

abstract：:p53 is a tumor suppressor gene whose mutation is highly associated with tumorigenesis. The present study investigated the role of p53β in the inhibition of proliferation of gastric cancer cell lines expressing wild-type or mutated p53. Wild-type p53 is expressed in MKN45 cells, but deleted in KATOIII cells, whereas mu...

journal_title：Molecular medicine reports

authors： Ji W,Ma J,Zhang H,Zhong H,Li L,Ding N,Jiao J,Gao Z

更新日期：2015-07-01 00:00:00

abstract：:The expression of microRNA‑206 (miR‑206) is aberrantly induced in steroid‑induced avascular necrosis of femoral head (SANFH). Therefore, investigating the function of miR‑206 in SANFH and uncovering the functional mechanism associated with the condition will promote the understanding and treatment of the disease. The ...

journal_title：Molecular medicine reports

authors： Zhang Z,Jin A,Yan D

更新日期：2018-01-01 00:00:00

abstract：:The primary effect of the endoplasmic reticulum (ER) stress response or unfolded protein response (UPR) is to reduce the load of unfolded protein and promote survival. However, prolonged and severe ER stress leads to tissue injury and serious diseases. Thus, it is important to identify drugs that can attenuate ER stre...

journal_title：Molecular medicine reports

authors： Qin HS,Yu PP,Sun Y,Wang DF,Deng XF,Bao YL,Song J,Sun LG,Song ZB,Li YX

更新日期：2016-06-01 00:00:00

abstract：:Lactate is an important metabolite in cellular metabolism and fluctuates in certain disease conditions including cancer and immune diseases. It was hypothesized that a decrease in lactate would modulate the inflammatory response elicited by lipopolysaccharides (LPS) in macrophages. When RAW 264.7 macrophages were trea...

journal_title：Molecular medicine reports

authors： Song YJ,Kim A,Kim GT,Yu HY,Lee ES,Park MJ,Kim YJ,Shim SM,Park TS

更新日期：2019-01-01 00:00:00

abstract：:According to the results of the first genome-wide association study of ankylosing spondylitis (AS), endoplasmic reticulum aminopeptidase 1 (ERAP1) may serve an important role. However, a number of case-control studies have not been able to replicate this result using the same genetic markers. In the present study, the...

journal_title：Molecular medicine reports

authors： Wang X,Ma J,Ma J,Wen Y,Meng L,Yang H,Zhang R,Hao D

更新日期：2017-11-01 00:00:00

abstract：:E-cadherin, β-catenin and N‑cadherin serve key roles in the epithelial‑to‑mesenchymal transition (EMT) that leads to human lens epithelial cell (LEC) transdifferentiation and subsequent cataract formation. The present study aimed to investigate the role of E‑cadherin in LEC transdifferentiation. SRA01/04 human LECs we...

journal_title：Molecular medicine reports

authors： Huang L,Jiang J,Guo Q,Yang H

更新日期：2017-10-01 00:00:00

abstract：:Severe invasive aspergillosis infection occurs when human immune function is impaired. The interaction between Aspergillus fumigatus (A. fumigatus) conidia and type II lung epithelial cells serves an important role in disease progression. The present study compared the proteomes of A549 human lung epithelial cells wit...

journal_title：Molecular medicine reports

authors： Zhang X,He D,Gao S,Wei Y,Wang L

更新日期：2020-12-01 00:00:00

abstract：:The high risk of developing colorectal carcinoma (CRC), from ulcerative colitis (UC), is well known. Macrophages are widely distributed immune cells that have an indispensable role in UC, as well as in CRC. However, little is currently known about the dynamic changes that occur in macrophage and M1/M2 macrophage subpo...

journal_title：Molecular medicine reports

authors： Wang W,Li X,Zheng D,Zhang D,Peng X,Zhang X,Ai F,Wang X,Ma J,Xiong W,Li G,Zhou Y,Shen S

更新日期：2015-04-01 00:00:00

abstract：:Circular RNAs (circRNAs) are class of endogenous RNAs that have a role in the regulation of gene expression. The present study aimed to investigate the diagnostic value and role of circRNA in the pathogenesis of leukoaraiosis (LA). The present study performed Arraystar Human circRNA Array analysis of 6 samples from LA...

journal_title：Molecular medicine reports

authors： Mi T,Luo C,Hu Y,Qu C,Wang X,Guo S,Du Y

更新日期：2017-09-01 00:00:00

abstract：:The presence of excess glutamate in the brain interstitial fluid characterizes several acute pathological conditions of the brain, including traumatic brain injury and stroke. It has been demonstrated that it is possible to eliminate excess glutamate in the brain by decreasing blood glutamate levels and, accordingly, ...

journal_title：Molecular medicine reports

authors： Li Y,Hou X,Qi Q,Wang L,Luo L,Yang S,Zhang Y,Miao Z,Zhang Y,Wang F,Wang H,Huang W,Wang Z,Shen Y,Wang Y

更新日期：2014-01-01 00:00:00

abstract：:Several single nucleotide polymorphisms (SNPs) influencing DNA repair capacity and apoptotic status may confer genetic predisposition to Philadelphia‑chromosome negative myeloproliferative neoplasms (PN‑MPNs), and influence therapeutic response and the clinical course. In the present study, whether SNPs in genes invol...

journal_title：Molecular medicine reports

authors： Azevedo AP,Silva SN,Reichert A,Lima F,Júnior E,Rueff J

更新日期：2018-12-01 00:00:00

abstract：:In Parkinson's disease (PD), microglial activation-mediated neuroinflammation is associated with dopaminergic neurons degeneration in the substantia nigra pars compacta. Previous studies that have investigated this neurodegenerative disease have reported that the Sonic hedgehog (SHH) signaling pathway, through inhibit...

journal_title：Molecular medicine reports

authors： Shao S,Wang GL,Raymond C,Deng XH,Zhu XL,Wang D,Hong LP

更新日期：2017-08-01 00:00:00

abstract：:Sulforaphane (SFN) is a naturally occurring chemopreventive agent, which effectively inhibits proliferation of HepG2 human hepatocellular carcinoma cells via mitochondria‑mediated apoptosis. Endoplasmic reticulum stress is considered the most important cause of cell apoptosis; therefore, the present study aimed to det...

journal_title：Molecular medicine reports

authors： Zou X,Qu Z,Fang Y,Shi X,Ji Y

更新日期：2017-01-01 00:00:00

abstract：:In Crohn's disease (CD), clinical symptoms correspond poorly to inflammatory disease activity. Biomarkers, which reflect the level of intestinal inflammation are considered to enable effective monitoring of disease activity. The present study evaluated the role of serum pentraxin 3 (PTX3) as a marker of disease activi...

journal_title：Molecular medicine reports

authors： Chen J,Xu X,Xia L,Xi X,Liu B,Yang M

更新日期：2015-07-01 00:00:00

abstract：:Wound healing impairment is increasingly recognized to be a consequence of hyperglycemia‑induced dysfunction of endothelial precursor cells (EPCs) in type 2 diabetes mellitus (T2DM). Metformin exhibits potential for the improvement of endothelial function and the wound healing process. However, the underlying mechanis...

journal_title：Molecular medicine reports

authors： Han X,Tao Y,Deng Y,Yu J,Sun Y,Jiang G

更新日期：2017-12-01 00:00:00

abstract：:Previous studies have confirmed that exposure to particulate matter with a diameter of ≤2.5 µm (PM2.5) is associated with inflammation. PM2.5 decreases cardiac cell viability and increases apoptosis through overproduction of reactive oxygen species (ROS). In the present study, the role of PM2.5 in ECs was investigated...

journal_title：Molecular medicine reports

authors： Chen S,Wu X,Hu J,Dai G,Rong A,Guo G

更新日期：2017-09-01 00:00:00

abstract：:High density lipoproteins (HDL) are heterogeneous particles regarding their size and composition. They have vital functions in reverse cholesterol transport (RCT). RCT occurs when lipid-free apolipoprotein AI recruits cholesterol and phospholipid to form nascent HDL particles. Adenosine triphosphate‑binding cassette t...

journal_title：Molecular medicine reports

authors： Zhou L,Li C,Gao L,Wang A

更新日期：2015-09-01 00:00:00

abstract：:The present study was designed to determine the association between atrial fibrillation (AF) and inflammation in a goat sterile pericarditis model and to assess the effect of atorvastatin, a cholesterol‑reducing drug, on AF. A total of 15 adult male goats were randomly divided into control, untreated pericarditis and ...

journal_title：Molecular medicine reports

authors： Zhang Y,Wang YT,Shan ZL,Guo HY,Guan Y,Yuan HT

更新日期：2015-04-01 00:00:00

abstract：:Cisplatin-induced heart damage is associated with enzymes and protein alterations. The purpose of this study was to investigate cisplatin-induced alterations in cardiac endothelin (ET)-1 and type III collagen following administration of cisplatin. Male Wistar rats were randomly divided into two groups: a control and a...

journal_title：Molecular medicine reports

authors： Huang QY,Li XF,Liu SP

更新日期：2012-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are non‑coding RNAs of ~22 nucleotides in length, which serve an important role in numerous diseases. Asthma is a chronic airway inflammatory disease, which is the most common chronic disease among children. The role of miRNA (miR)‑16 in asthma is unclear. The objective of the present study was to e...

journal_title：Molecular medicine reports

authors： Yu B,Yao L,Liu C,Tang L,Xing T

更新日期：2019-05-01 00:00:00

abstract：:The present study aimed to investigate the clinical significance of histone methylation in sepsis. A total of 43 blood samples from trauma and esophageal cancer patients with or without sepsis were collected. Immunofluorescence staining of isolated peripheral white blood cells (WBCs) was conducted. Co‑stained 293T cel...

journal_title：Molecular medicine reports

authors： Jiang L,Wang Y,Zhu D,Xue Z,Mao H

更新日期：2016-12-01 00:00:00

abstract：:Puerarin has attracted increasing attention because of its beneficial effects on anti‑osteoporosis, but the molecular mechanisms underlying its actions on osteoblasts are not fully understood. The current study aimed to investigate the effect of puerarin on the cell viability and differentiation of mouse MC3T3‑E1 oste...

journal_title：Molecular medicine reports

authors： Zhan XQ,Zeng XW,Zhang YY,Feng Q,Zhao FM,Jiang ZQ,Sun C

更新日期：2017-11-01 00:00:00

abstract：:Myocyte apoptosis and oxidative stress key critical roles in the process of doxorubicin (DOX)‑induced cardiotoxicity. However, how apoptosis and oxidative stress arise in DOX‑induced heart injury remains largely unknown. Cathepsin B (CTSB) is a typical lysosomal cysteine protease that is associated with apoptosis, inf...

journal_title：Molecular medicine reports

authors： Liu C,Cai Z,Hu T,Yao Q,Zhang L

更新日期：2020-12-01 00:00:00