High-density lipoprotein synthesis and metabolism (Review).

abstract：:Radiotherapy is commonly used to treat thoracic malignancies, but often causes severe lung injury. Currently there are no effective protective strategies against radiation-induced lung injury (RILI). This study aimed to evaluate the ability of an angiogenesis antagonist, Endostar, against RILI, and the underlying mech...

journal_title：Molecular medicine reports

authors： Zhang K,Yang S,Zhu Y,Mo A,Zhang D,Liu L

更新日期：2012-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that inhibit the expression of target protein-coding genes, most often at the post-transcriptional level. miRNAs are often found to be misregulated in human cancer and they can act as potent oncogenes or tumor suppressor genes. In this study, we found that a germline mutati...

journal_title：Molecular medicine reports

authors： Shang H,Wang T,Shang F,Huang KM,Li YQ

更新日期：2014-10-01 00:00:00

abstract：:Despite increasing evidence to suggest that microRNA (miR)-146a and miR-181b are involved in the regulation of immune responses and tumor progression, their roles in silicosis remain to be fully elucidated. Therefore, the present study examined the roles of miR‑146a and miR‑181b in inflammatory responses, and their ef...

journal_title：Molecular medicine reports

authors： Zhang Y,Wang F,Lan Y,Zhou D,Ren X,Zhao L,Zhang Q

更新日期：2015-10-01 00:00:00

abstract：:Multidrug resistance (MDR) has become a significant challenge in chemotherapeutic treatment of cancer. Quercetin, a naturally occurring flavonoid, has been found to possess anti-proliferative, anti-inflammatory and immunoregulatory bioactivities. The present study was performed to examine the effect of quercetin on hu...

journal_title：Molecular medicine reports

authors： Chen FY,Cao LF,Wan HX,Zhang MY,Cai JY,Shen LJ,Zhong JH,Zhong H

更新日期：2015-01-01 00:00:00

abstract：:B cells are critically important for the pathogenesis of IgA nephropathy (IgAN). The present study aimed to investigate the abundance of B cell activating factor (BAFF), which belongs to the tumor necrosis factor superfamily, in the peripheral blood of patients with IgAN. The different forms of BAFF in peripheral bloo...

journal_title：Molecular medicine reports

authors： Zheng N,Fan J,Wang B,Wang D,Feng P,Yang Q,Yu X

更新日期：2017-04-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) is considered to have a critical role in the occurrence and development of atherosclerosis in atherosclerosis-prone mice; however, it remains uncertain whether treatment with a TLR4 inhibitor may attenuate atherosclerosis. The present study aimed to determine the vascular protective effects...

journal_title：Molecular medicine reports

authors： Wang XQ,Wan HQ,Wei XJ,Zhang Y,Qu P

更新日期：2016-07-01 00:00:00

abstract：:In order to provide an abundant source of specimen and to reveal the correlation between the overexpression of urokinase plasminogen activator receptor isoform uPAR (D1D2) and hepatic cell malignant transformation, the optimal liver cell culture method was selected from three cell culture methods to culture and separa...

journal_title：Molecular medicine reports

authors： Zhou Y,Lǚ X,Li S,Zhan L

更新日期：2014-05-01 00:00:00

abstract：:Glioma is the most common malignant and fatal primary tumor in the central nervous system in adults. Recent data has suggested a profound role for microRNAs (miRs) in cancer progression. The present study demonstrated, via quantitative polymerase chain reaction (qPCR) analysis, that miR-203 expression was markedly low...

journal_title：Molecular medicine reports

authors： Tang G,Wu J,Xiao G,Huo L

更新日期：2015-04-01 00:00:00

abstract：:Gemcitabine is a first‑line chemotherapeutic agent used in the treatment of pancreatic cancer; however resistance of the disease to the drug often develops over time. Agents that can either enhance the effects of gemcitabine, or help to overcome the chemoresistance to the drug are needed for the successful treatment o...

journal_title：Molecular medicine reports

authors： Liu DL,Bu HQ,Jin HM,Zhao JF,Li Y,Huang H

更新日期：2014-12-01 00:00:00

abstract：:In the past decade, a group of cases with persisting haemocytopenia were separated from those with idiopathic cytopenia of undetermined significance due to the optimal response of these patients to immunosuppression therapy and due to the detection of autoantibodies in the bone marrow of haemopoietic cells. This condi...

journal_title：Molecular medicine reports

authors： Chen J,Liu H,Li L,Wang H,Li Y,Wang Y,Ding K,Hao S,Shao Y,Li L,Song J,Wang G,Shao Z,Fu R

更新日期：2019-11-01 00:00:00

abstract：:The present study aimed to explore the role and underlying molecular mechanism of microRNA‑663b (miR‑663b) in the tumorigenesis of bladder cancer. The miR‑663b expression in human bladder cancer tissues and cell lines was measured determined reverse transcription‑quantitative polymerase chain reaction. TargetScan was ...

journal_title：Molecular medicine reports

authors： Chen J,Song B,Kong G

更新日期：2019-05-01 00:00:00

abstract：:Clear-cell renal cell carcinoma (CCRCC) is the most frequent primary malignancy in the adult kidney. Most patients with advanced CCRCC have poor prognosis as CCRCC remains resistant to chemotherapy. The present study explored the possible mechanism underlying CCRCC resistance to chemotherapy and found that loss of PTE...

journal_title：Molecular medicine reports

authors： Chen J,Zhu H,Zhang Y,Cui MH,Han LY,Jia ZH,Wang L,Teng H,Miao LN

更新日期：2015-08-01 00:00:00

abstract：:Sepsis is a leading killer of children worldwide with numerous differentially expressed genes reported to be associated with sepsis. Identifying core pathways in an individual is important for understanding septic mechanisms and for the future application of custom therapeutic decisions. Samples used in the study were...

journal_title：Molecular medicine reports

authors： Li B,Zeng Q

更新日期：2017-10-01 00:00:00

abstract：:Identification of novel risk factors that are critical to the initiation of lung cancer will be key for its prevention. Recently, it has been reported that glycine dehydrogenase (GLDC) can drive the formation of lung cancer initiating cells. However, there have been no perspective studies on the association between ci...

journal_title：Molecular medicine reports

authors： Wei HY,Feng R,Shao H,Feng B,Liu HQ,Men JL,Zou W

更新日期：2018-08-01 00:00:00

abstract：:We have recently described an immune system-released activating agent (ISRAA) as a nervous system-induced factor that stimulates immune responses in the mouse spleen. However, the human ISRAA has not yet been identified. In this study, we examined the effects of the mouse ISRAA protein on human peripheral blood mononu...

journal_title：Molecular medicine reports

authors： Taha S,Fathallah MD,Bakhiet M

更新日期：2014-07-01 00:00:00

abstract：:Different sources of mesenchymal stem cells (MSCs) may differ in their biological characteristics, which are important for their clinical application. In the present study, MSCs were isolated from human exfoliated deciduous teeth (SHED), bone marrow, gingival tissue and umbilical cord tissue, and their biological char...

journal_title：Molecular medicine reports

authors： Li J,Xu SQ,Zhao YM,Yu S,Ge LH,Xu BH

更新日期：2018-12-01 00:00:00

abstract：:Pirarubicin is frequently used in chemotherapy against tumors. However, clinical use is severely limited by the development of progressive dose-dependent cardiomyopathy and acquired drug resistance. LY294002 is a commonly used pharmacologic inhibitor, which selectively inhibits the phosphoinositide 3-kinase-AKT nexus....

journal_title：Molecular medicine reports

authors： Long XH,Zhong ZH,Peng AF,Zhu LB,Wang H,Zhang GM,Liu ZL

更新日期：2014-12-01 00:00:00

abstract：:Circular RNAs (circRNAs) are non-coding RNAs forming closed-loop structures, and their aberrant expression may lead to disease. However, the potential network of circRNA‑associated competing endogenous RNA (ceRNA) involved in nonvalvular persistent atrial fibrillation (NPAF) has not been previously reported. In the pr...

journal_title：Molecular medicine reports

authors： Zhang Y,Ke X,Liu J,Ma X,Liu Y,Liang D,Wang L,Guo C,Luo Y

更新日期：2019-01-01 00:00:00

abstract：:The development of acute lung injury (ALI) during sepsis almost doubles the mortality rate of patients. The efficacy of current treatment strategies is low as treatment is usually initiated following the onset of symptoms. Inflammation is one of the main mechanisms of autoimmune disorders and is a common feature of se...

journal_title：Molecular medicine reports

authors： Li T,Zhang J,Feng J,Li Q,Wu L,Ye Q,Sun J,Lin Y,Zhang M,Huang R,Cheng J,Cao Y,Xiang G,Zhang J,Wu Q

更新日期：2013-06-01 00:00:00

abstract：:Differentiation of glioblastoma stem cells (GSCs) may lead to inhibition of their self‑renewing ability and tumorigenic potential, as well as increasing their sensitivity to treatment. The critical role of long non‑coding RNAs (lncRNAs) in numerous biological processes has been revealed. However, the involvement of ln...

journal_title：Molecular medicine reports

authors： Li H,Li H,Hao Y,Jiao Y,Li Z,Yue H,Xu Z,Wang S,Cao Y,Zhao J

更新日期：2016-09-01 00:00:00

abstract：:Currently, the role of tumor endothelial marker 8 (TEM8) in the occurrence, development, invasion and metastasis of lung cancer and its mechanism are poorly understood. The present study aimed to investigate the effects of TEM8 on proliferation, apoptosis, migration and invasion of XWLC‑05 lung cancer cells. The expre...

journal_title：Molecular medicine reports

authors： Gong Q,Liu C,Wang C,Zhuang L,Zhang L,Wang X

更新日期：2018-01-01 00:00:00

abstract：:The aim of the present study was to identify potential biomarkers associated with colorectal cancer (CRC). The GSE32323 and GSE53592 mRNA and microRNA (miRNA) expression profiles were selected from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs...

journal_title：Molecular medicine reports

authors： Hu J,Yue X,Liu J,Kong D

更新日期：2018-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumor. Studies have demonstrated that the toll‑like receptor 3 (TLR3)/interferon pathway is inhibitory in cancer cell proliferation, suggesting that the activation of this pathway may have therapeutic potential. In the present study, the inhib...

journal_title：Molecular medicine reports

authors： Xu YY,Chen L,Zhou JM,Wu YY,Zhu YY

更新日期：2013-10-01 00:00:00

abstract：:The synergistic mechanism underlying the effects of multi‑component combined drug use for complex diseases remains to be fully elucidated. Microglial activation following ischemia can either affect neural survival or cause neuronal injury. The aim of the present study was to determine the synergistic effect of genipos...

journal_title：Molecular medicine reports

authors： Wang J,Hou J,Lei H,Fu J,Pan Y,Liu J

更新日期：2015-10-01 00:00:00

abstract：:Oxidized low-density lipoprotein (Ox-LDL), as a strong oxidant, results in renal injury through multiple mechanisms. The aim of the present study was to determine the injury effects of Ox‑LDL and the potential protective effects of the antioxidant reagent probucol on epithelial‑mesenchymal transition (EMT) in human re...

journal_title：Molecular medicine reports

authors： Zhu BB,Wang H,Chi YF,Wang YM,Yao XM,Liu S,Qiu H,Fang J,Yin PH,Zhang XM,Peng W

更新日期：2018-01-01 00:00:00

abstract：:Gastric cancer (GC) is the fifth most common malignancy and the third leading cause of cancer‑associated mortality in the world. However, its mechanisms of occurrence and development have not been clearly elucidated. Furthermore, there is no effective tumor marker for GC. Using DNA microarray analysis, the present stu...

journal_title：Molecular medicine reports

authors： Duan S,Gong B,Wang P,Huang H,Luo L,Liu F

更新日期：2018-10-01 00:00:00

abstract：:The aim of this study was to investigate the expression pattern of regenerating gene I (Reg I) in the lung and intestinal tissues of rats with acute necrotizing pancreatitis (ANP), as well as the correlation of Reg I expression with lung and intestinal injury. Sprague-Dawley rats were randomly allocated to control (n=...

journal_title：Molecular medicine reports

authors： Hu HL,Zhang Q,Kong B,Shi X

更新日期：2013-02-01 00:00:00

abstract：:In the present study, it was demonstrated that the protein level of the apoptosis inhibitor Aven is regulated by the Akt signaling pathway, evidenced by the observation that Aven levels were significantly increased in MCF7 constitutively active (CA)‑Akt cells and significantly inhibited following treatment with LY2940...

journal_title：Molecular medicine reports

authors： Han KY,Hwang JW,Bae GU,Kim SN,Kim YK

更新日期：2015-05-01 00:00:00

abstract：:The objective of the current study was to investigate the impact of Brachyury on epithelial-mesenchymal transitions and chemosensitivity in non-small cell lung cancer (NSCLC). In 115 archived NSCLC tissue samples, the expression of Brachyury was observed to be significantly higher than that in adjacent normal lung tis...

journal_title：Molecular medicine reports

authors： Xu K,Liu B,Liu Y

更新日期：2015-07-01 00:00:00

abstract：:In order to gain greater understanding of the mechanisms underlying the effect of epigallocatechin-3-gallate (EGCG) on DNA methylation and its chemopreventative action in oral squamous cell carcinoma (OSCC), a genome‑wide methylation and mRNA expression screen was performed in the CAL‑27 cell line with and without EGC...

journal_title：Molecular medicine reports

authors： Chen LL,Han WF,Geng Y,Su JS

更新日期：2015-10-01 00:00:00