Abstract:
:MicroRNAs (miRNAs) are small non-coding RNAs that inhibit the expression of target protein-coding genes, most often at the post-transcriptional level. miRNAs are often found to be misregulated in human cancer and they can act as potent oncogenes or tumor suppressor genes. In this study, we found that a germline mutation in the miR-125a coding region is associated with human gastric cancer. This mutation reduced the expression of mature miR-125a and alleviated its inhibitory effect on erythroblastic leukemia viral oncogene homolog 2 (ERBB2) gene expression and on gastric tumor cell proliferation. Thus, the data of this study suggested that this germline mutation in pri‑miR-125a likely contributes to the genetic predisposition to gastric cancer by reducing the production of miR-125a, thereby interfering with the expression of miR-125a target genes.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Shang H,Wang T,Shang F,Huang KM,Li YQdoi
10.3892/mmr.2014.2441subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1839-44issue
4eissn
1791-2997issn
1791-3004journal_volume
10pub_type
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