Evaluation of a DNA vaccine encoding Brucella BvrR in BALB/c mice.

abstract：:Lower back pain (LBP) is one of the predominant factors contributing to dyskinesia and remains a serious social and economic burden worldwide. Intervertebral disc degeneration (IDD) is the leading cause of LBP; the existing IDD treatments cannot completely prevent IDD. Circular RNAs (circRNAs) are non‑coding RNAs resu...

journal_title：Molecular medicine reports

authors： Li Y,Zhou S,Peng P,Wang X,Du L,Huo Z,Xu B

更新日期：2020-10-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been reported to serve a crucial role in renal diseases; however, their role in immunoglobulin A nephropathy (IgAN) remains unclear. In the present study, peripheral blood mononuclear cells (PBMCs) were collected from both patients with IgAN and healthy controls. A microarray analys...

journal_title：Molecular medicine reports

authors： Zuo N,Li Y,Liu N,Wang L

更新日期：2017-11-01 00:00:00

abstract：:Our previous study demonstrated that treatment with Tribulus terrestris (TT) extracts (120 mg/kg) promoted the muscle weight gain and performance of rats undergoing high intensity exercise. The present study was designed to explore the mechanisms underlying the effect of treatment with TT extracts and the involvement ...

journal_title：Molecular medicine reports

authors： Wu Y,Yang H,Wang X

更新日期：2017-09-01 00:00:00

abstract：:The aim of the present study was to identify candidate microRNAs (miRNAs) involved in the progression of renal fibrosis. Dataset GSE42716 of miRNAs extracted from kidneys from mice with unilateral ureteral obstruction (UUO), and mice without UUO was downloaded from the Gene Expression Omnibus database. The Limma packa...

journal_title：Molecular medicine reports

authors： Xin G,Zhou G,Zhang X,Wang W

更新日期：2017-09-01 00:00:00

abstract：:Cervical cancer (CC) is a frequently occurring cancer in women with a high mortality rate. Despite improvements to therapeutic strategies, the survival outcome for patients with CC remains poor. Therefore, the present study aimed to investigate the molecular mechanism underlying CC inhibition involving microRNA (miR)‑...

journal_title：Molecular medicine reports

authors： Guo Y,Luo S

更新日期：2020-12-01 00:00:00

abstract：:Chlorotoxin (CTX) is an established blocker of small‑conductance Cl‑ channels and has previously been demonstrated to inhibit the invasion of glioma cells. Buthus martensii Karsch chlorotoxin‑like toxin (BmK CT) is the first chlorotoxin-like peptide. The present study aimed to determine the inhibitory effect of BmK CT...

journal_title：Molecular medicine reports

authors： Sun N,Zhao L,Qiao W,Xing Y,Zhao J

更新日期：2017-05-01 00:00:00

abstract：:Previous studies have shown that caspase-1 plays an important role in the acute inflammatory response of spinal cord injury (SCI). VX‑765, a novel and irreversible caspase‑1 inhibitor, has been reported to effectively intervene in inflammation. However, the effect of VX‑765 on genome‑wide transcription in acutely inju...

journal_title：Molecular medicine reports

authors： Chen J,Chen YQ,Wang SN,Duan FX,Shi YJ,Ding SQ,Hu JG,Lü HZ

更新日期：2020-07-01 00:00:00

abstract：:Postmenopausal osteoporosis is a common systemic skeletal disease that is associated with estrogen‑deficiency. Bone loss associated with bisphosphonates therapy can increase the risk of developing oral osteonecrosis. Recent studies have indicated that enoxacin may inhibit osteoclast formation and bone resorption via a...

journal_title：Molecular medicine reports

authors： Zhang X,Xu X,Liu X,Mao C,Qin A,Lu E

更新日期：2018-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most malignant types of tumor worldwide with a high rate of mortality. Diosmetin (DIOS) exhibits various activities, including anticancer activities. However, the role of DIOS in the metastasis of HCC, and its underlying molecular mechanism, remain to be fully elucidated. I...

journal_title：Molecular medicine reports

authors： Liu J,Wen X,Liu B,Zhang Q,Zhang J,Miao H,Zhu R

更新日期：2016-03-01 00:00:00

abstract：:Current studies have highlighted long non‑coding RNAs (lncRNAs) as critical regulators in various cancers, including colorectal cancer (CRC). By utilizing publicly available data from The Cancer Genome Atlas dataset, MLK7 antisense RNA 1 (MLK7‑AS1) was identified as a novel lncRNA that correlated with CRC progression....

journal_title：Molecular medicine reports

authors： Zhang R,Li J,Yan X,Jin K,Li W,Liu X,Zhao J,Shang W,Zhao X

更新日期：2019-02-01 00:00:00

abstract：:The present study was designed to determine the association between atrial fibrillation (AF) and inflammation in a goat sterile pericarditis model and to assess the effect of atorvastatin, a cholesterol‑reducing drug, on AF. A total of 15 adult male goats were randomly divided into control, untreated pericarditis and ...

journal_title：Molecular medicine reports

authors： Zhang Y,Wang YT,Shan ZL,Guo HY,Guan Y,Yuan HT

更新日期：2015-04-01 00:00:00

abstract：:The expression of the metastasis suppressor gene KISS-1 in osteosarcoma cells during apoptosis and autophagy was evaluated. MG-63 osteosarcoma cells were transfected with either KISS-1 overexpression or KISS-1 knockdown expression vector in vitro, and compared with cell lines transfected with empty vector. After 12, 2...

journal_title：Molecular medicine reports

authors： Yin Y,Tang L,Shi L

更新日期：2017-03-01 00:00:00

abstract：:Retinitis pigmentosa (RP) is a group of inherited diseases that primarily affect light‑sensitive rods and cones in the retina. Rhodopsin mutations, including the T17M mutation, are associated with the autosomal dominant form of retinitis pigmentosa (ADRP) and have been linked to abnormal protein folding. However, the ...

journal_title：Molecular medicine reports

authors： Jiang H,Xiong S,Xia X

更新日期：2014-05-01 00:00:00

abstract：:Roscovitine and purvalanol are purine derivative cyclin-dependent kinase (CDK) inhibitors that induce apoptosis in various types of cancer cells. However, their impact on the apoptotic cell death mechanism requires further elucidation. Natural polyamines putrescine, spermidine and spermine play essential roles in the ...

journal_title：Molecular medicine reports

authors： Çoker A,Arısan ED,Palavan-Ünsal N

更新日期：2012-04-01 00:00:00

abstract：:Molecular biologists have identified a number of genes and microRNAs (miRs) associated with chronic myelogenous leukemia (CML). However, their underlying mechanisms in CML remain unclear. In the present study, three regulatory networks of genes and miRs were constructed to elucidate the underlying mechanisms of CML. T...

journal_title：Molecular medicine reports

authors： Wang K,Xu Z,Wang N,Tian Y,Sun X,Ma Y

更新日期：2016-01-01 00:00:00

abstract：:The present study aimed to investigate the functional effects of microRNA‑195 on ovarian cancer cells and the underling mechanism involved. Reverse transcription‑quantitative polymerase chain reaction was used to measure the expression of microRNA‑195 in patients with ovarian cancer. Cell proliferation and apoptosis w...

journal_title：Molecular medicine reports

authors： Chen J

更新日期：2018-08-01 00:00:00

abstract：:The occurrence and development of hyperglycemia‑induced inflammation is associated with increased expression of receptor for advanced glycation end products (RAGE) and inflammatory factors, including IL‑1β, TNF‑α and IL‑6. Previous studies have reported that the nucleotide‑binding oligomerization domain‑like receptor ...

journal_title：Molecular medicine reports

authors： Jiang M,Wang X,Wang P,Peng W,Zhang B,Guo L

更新日期：2020-10-01 00:00:00

abstract：:Millions of infants and children are exposed to anesthesia every year during medical care. Sevoflurane is a volatile anesthetic that is frequently used for pediatric anesthesia. However, previous reports have suggested that the administration of sevoflurane promotes neurodegeneration, raising concerns regarding the sa...

journal_title：Molecular medicine reports

authors： Wang LY,Tang ZJ,Han YZ

更新日期：2016-10-01 00:00:00

abstract：:The aim of the present study was to investigate the possible metabolic alterations in the frontal cortex and parietal white matter in patients with diabetic hypertension (DHT) using proton magnetic resonance (MR) spectroscopic imaging. A total of 33 DHT patients and 30 healthy control subjects aged between 45 and 75 w...

journal_title：Molecular medicine reports

authors： Cao Z,Ye BD,Shen ZW,Cheng XF,Yang ZX,Liu YY,Wu RH,Geng K,Xiao YY

更新日期：2015-06-01 00:00:00

abstract：:Colorectal cancer has become a disease with one of the highest incidence rates worldwide, and liver metastasis threatens the prognosis of colorectal cancer. MicroRNA (miR)‑200 and miR‑141 have been confirmed to be aberrantly expressed in colorectal cancer, however, whether miR‑200 and miR‑141 are involved in the progr...

journal_title：Molecular medicine reports

authors： Ding M,Zhang T,Li S,Zhang Y,Qiu Y,Zhang B

更新日期：2017-11-01 00:00:00

abstract：:The hypoxic state of the brain tissue surrounding craniocerebral injury induces an increase in the secretion of HIF‑1α during the healing process. HIF‑1α can promote mesenchymal stem cell (MSC) migration to ischemic and hypoxic sites by regulating the expression levels of molecules such as stromal cell‑derived factor‑...

journal_title：Molecular medicine reports

authors： Xue Y,Li Z,Wang Y,Zhu X,Hu R,Xu W

更新日期：2020-10-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by synovial inflammation. Fibroblast‑like synoviocytes (FLS) serve a vital role in the initiation and perpetuation of the immune response in patients with RA. The present study aimed to investigate the potential role of microRNA (miR)‑34a‑...

journal_title：Molecular medicine reports

authors： Hou C,Wang D,Zhang L

更新日期：2019-09-01 00:00:00

abstract：:The aim of the study was to examine the expression of mammalian target of rapamycin (mTOR)/70S6K signaling pathway in pathological scar fibroblasts and the effects of resveratrol (Res) intervention. The mTOR and 70S6K in pathological scar and normal skin fibroblasts were detected by immunofluorescence following treatm...

journal_title：Molecular medicine reports

authors： Tang ZM,Zhai XX,Ding JC

更新日期：2017-05-01 00:00:00

abstract：:Numerous mechanisms and factors have been implicated in liver damage; however, the involvement of autophagy and endoplasmic reticulum (ER) stress during early‑stage liver injury remains to be fully elucidated. The present study was conducted to determine the expression of autophagy and ER‑stress‑associated proteins in...

journal_title：Molecular medicine reports

authors： Shi T,Song W,Xu R

更新日期：2017-11-01 00:00:00

abstract：:The dysregulation of renin-angiotensin system-signaling is a contributing factor to the development of atherosclerosis and cardiovascular disease. We studied the progression of angiotensin II (AngII)-induced arterial wall atherosclerosis after its induction. Atherosclerosis was accelerated in ApoE (-/-) C57B6 mice by ...

journal_title：Molecular medicine reports

authors： Cha J,Ivanov V,Ivanova S,Kalinovsky T,Rath M,Niedzwiecki A

更新日期：2010-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) accounts for the majority of liver cancers. A hypoxic microenvironment is a common feature of HCC, and is associated with malignant invasion, metastasis and epithelial-mesenchymal transition (EMT) changes. Curcumin is a botanical agent derived from the dried rhizome of Curcuma longa. Alt...

journal_title：Molecular medicine reports

authors： Duan W,Chang Y,Li R,Xu Q,Lei J,Yin C,Li T,Wu Y,Ma Q,Li X

更新日期：2014-11-01 00:00:00

abstract：:Tumor angiogenesis is important in the growth and metastasis of malignant tumors. In our previous study, we demonstrated that an arginine-arginine-leucine (RRL) peptide is a tumor endothelial cell-specific binding sequence that may be used as a molecular probe for the imaging of malignant tumors in vivo. The aim of th...

journal_title：Molecular medicine reports

authors： Zhao Q,Yan P,Yin L,Li L,Chen XQ,Ma C,Wang RF

更新日期：2013-04-01 00:00:00

abstract：:Apoptosis and necroptosis occur in renal tubular epithelial cell (RTEC) death in acute kidney injury (AKI), and may be regulated by several methods. The present study identified a protective effect of necrostatin‑1 (Nec‑1) on RTECs via a flow-control-like effect. The results established a hypoxic‑ischemic injury model...

journal_title：Molecular medicine reports

authors： Luo J,Tao Y,Liang X,Chen Y,Zhang L,Jiang F,Liu S,Ye Z,Li Z,Shi W

更新日期：2017-07-01 00:00:00

abstract：:The aim of the present study was to investigate the preconditioning effect and underlying mechanisms of cobalt-protoporphyrin (CoPP) in a mouse model of liver ischemia‑reperfusion (I/R) injury. Mice were divided into five groups: Sham‑operated (control), I/R, I/R + CoPP, I/R + CoPP and zinc‑protoporphyrin (ZnPP) and I...

journal_title：Molecular medicine reports

authors： Li J,Wu B,Teng D,Sun X,Li J,Li J,Zhang G,Cai J

更新日期：2018-03-01 00:00:00

abstract：:Pioglitazone (PIO) has been reported to be effective for nonalcoholic fatty liver disease (NAFLD) and alogliptin (ALO) may have efficacy against NAFLD progression in patients with type 2 diabetes mellitus (T2DM). The present study examined the effectiveness of ALO in a rodent model of NAFLD and diabetes mellitus. KK‑A...

journal_title：Molecular medicine reports

authors： Tobita H,Sato S,Yazaki T,Mishiro T,Ishimura N,Ishihara S,Kinoshita Y

更新日期：2018-05-01 00:00:00