Adrenomedullin is involved in the progression of colonic adenocarcinoma.

abstract：:Mesenchymal stem cells (MSCs) possess three characteristics critical to tissue regeneration; multipotency, low immunogenicity and an undifferentiated status, providing plasticity. However, increasing evidence has indicated that induction of an immune response in vivo can injure and reject MSC‑based tissues. Toll‑like ...

journal_title：Molecular medicine reports

authors： Yang Y,Wang Y,Li L,Bao J,Chen F,Zhang L

更新日期：2015-12-01 00:00:00

abstract：:Reamed intramedullary nailing (RIN) is a surgical method of choice for treatment of diaphyseal fractures. This procedure affects the biological environment of bone tissue locally and systemically. This study investigated the influence of RIN on mesenchymal stem cells (MSCs) in patients with long bone fractures. The ax...

journal_title：Molecular medicine reports

authors： Sperelakis I,Tsitoura E,Koutoulaki C,Mastrodimou S,Tosounidis TH,Dimitriou H,Spandidos DA,Antoniou KM,Kontakis G

更新日期：2020-09-01 00:00:00

abstract：:The objective of the present study was to evaluate the influence of TAAAA repeat allele length on the levels of serum sex hormone binding globulin (SHBG) and cardiovascular risk factors in patients with polycystic ovary syndrome (PCOS). The study included 91 females with PCOS and 99 healthy controls. Phenotypic hypera...

journal_title：Molecular medicine reports

authors： Baldani DP,Skrgatic L,Cerne JZ,Oguic SK,Gersak BM,Gersak K

更新日期：2015-05-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are critical to vascular smooth muscle cell migration in vivo. The dysregulation of MMPs is involved in the pathogenesis of abnormal arterial remodeling, aneurysm formation and atherosclerotic plaque instability. It has been confirmed that lipopolysa...

journal_title：Molecular medicine reports

authors： Li H,Xu H,Sun B

更新日期：2012-10-01 00:00:00

abstract：:Connexin 43 (Cx43) is the main gap junction protein in astrocytes and exerts the same effects on growth inhibition in astrocytoma and glioma as microRNA-146a (miR-146a) in glioma. β2-adrenergic receptor (AR) signaling modulates Cx43 expression in myocytes via components downstream of protein kinase A (PKA) and exchang...

journal_title：Molecular medicine reports

authors： Khaksarian M,Mostafavi H,Soleimani M,Karimian SM,Ghahremani MH,Joghataee MT,Khorashadizadeh M,Aligholi H,Attari F,Hassanzadeh G

更新日期：2015-08-01 00:00:00

abstract：:The aim of this study was to explore the effect of bisphenol A (BPA) on the EGFR-STAT3 pathway in breast cancer. We applied 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay to the analysis of the responsiveness of MCF-7 cells to BPA. Gene expression was assayed at the transcription...

journal_title：Molecular medicine reports

authors： Zhang W,Fang Y,Shi X,Zhang M,Wang X,Tan Y

更新日期：2012-01-01 00:00:00

abstract：:Cochlear progenitor cells are considered as one of the best candidates for hair cell regeneration, thus, the regulation of cochlear progenitor cell proliferation has become a focus in this field. Several genes expressed in the inner ear during postnatal development have been demonstrated to be involved in maintaining ...

journal_title：Molecular medicine reports

authors： Song YL,Tian KY,Mi WJ,Ding ZJ,Qiu Y,Chen FQ,Zha DJ,Qiu JH

更新日期：2018-04-01 00:00:00

abstract：:Sepsis is a systemic inflammatory response resulting from the excessive production of pro-inflammatory cytokines, including tumor necrosis factor (TNF)‑α. Sirtuin 1 (SirT1) actively deacetylates histone proteins, and facilitates chromatin compaction and gene silencing. In the present study, a cell model of sepsis, com...

journal_title：Molecular medicine reports

authors： Chen GD,Yu WD,Chen XP

更新日期：2016-12-01 00:00:00

abstract：:Ovarian hyperstimulation syndrome (OHSS) is a potentially life‑threatening, iatrogenic complication that occurs during assisted reproduction. Polycystic ovarian syndrome (PCOS) significantly increases the risk of OHSS during controlled ovarian stimulation. Therefore, a more effective early prediction technique is requ...

journal_title：Molecular medicine reports

authors： Wu L,Sun Y,Wan J,Luan T,Cheng Q,Tan Y

更新日期：2017-07-01 00:00:00

abstract：:Theaflavin has been proven to own strong antioxidative capacity; however, the molecular mechanism underlying its protective effect against cerebral ischemia‑reperfusion (I/R) injury remains unclear. Therefore, the present study was designed to elucidate the neuroprotective effects of theaflavin on cerebral I/R injury ...

journal_title：Molecular medicine reports

authors： Li R,Li X,Wu H,Yang Z,Fei L,Zhu J

更新日期：2019-12-01 00:00:00

abstract：:Different sources of mesenchymal stem cells (MSCs) may differ in their biological characteristics, which are important for their clinical application. In the present study, MSCs were isolated from human exfoliated deciduous teeth (SHED), bone marrow, gingival tissue and umbilical cord tissue, and their biological char...

journal_title：Molecular medicine reports

authors： Li J,Xu SQ,Zhao YM,Yu S,Ge LH,Xu BH

更新日期：2018-12-01 00:00:00

abstract：:The present study investigated the immunopathological effect of Echinococcus multilocularis (Em) using cytokine detection. Expression of the T‑helper (Th) 17‑cytokine, interleukin 17 (IL‑17), was observed using immunohistochemical staining, and levels of cytokines, including IL‑17, transforming growth factor β1 (TGF‑β...

journal_title：Molecular medicine reports

authors： Ma X,Wang L,Zhao H,Pang N,Zhang F,Jiang T,Liu X,Mamuti W,Wen H,Ding J

更新日期：2014-07-01 00:00:00

abstract：:The present study aimed to investigate the dose-dependent modulating effect of estriol (E3), an estrogen predominantly produced during human pregnancy, on antigen‑induced production of specific antibodies in female BALB/c mice. The animals were immunized either with bovine serum albumin (BSA) or the pneumococcal polys...

journal_title：Molecular medicine reports

authors： Ding J,Zhu BT

更新日期：2016-01-01 00:00:00

abstract：:Transgelin 2 (TAGLN2) is a cytoskeletal protein of the calponin family. Abnormal expression of TAGLN2 was observed in various types of cancer. Our previous study reported that TAGLN2 expression was reduced in lymph node‑positive breast cancer patients; however, the role of TAGLN2 in breast cancer metastasis remains un...

journal_title：Molecular medicine reports

authors： Yang L,Hong Q,Xu SG,Kuang XY,Di GH,Liu GY,Wu J,Shao ZM,Yu SJ

更新日期：2019-11-01 00:00:00

abstract：:Decoy receptor 3 (DcR3) competitively binds to three ligands, Fas ligand, lymphotoxin‑related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells and tumor necrosis factor‑like ligand 1A (TL1A), to prevent their effects. Recent studies have suggested that DcR3 directly af...

journal_title：Molecular medicine reports

authors： Fukuda K,Miura Y,Maeda T,Hayashi S,Kurosaka M

更新日期：2016-04-01 00:00:00

abstract：:MicroRNA (miR)-22 has previously been reported to be frequently downregulated in certain types of cancer. The present study examined the expression and effects of miR-22 in renal cell carcinoma (RCC). The results indicated that miR‑22 was downregulated in tumor tissue from patients with RCC. In addition, lower miR‑22 ...

journal_title：Molecular medicine reports

authors： Fan W,Huang J,Xiao H,Liang Z

更新日期：2016-06-01 00:00:00

abstract：:Quantitative polymerase chain reaction (qPCR) analysis is a commonly used method for the study of mRNA expression throughout the field of mesenchymal stem cell (MSC) research. This technology is simple and sensitive; however the results may vary significantly due to the use of various reference genes (RGs) as normaliz...

journal_title：Molecular medicine reports

authors： Li X,Yang Q,Bai J,Yang Y,Zhong L,Wang Y

更新日期：2015-02-01 00:00:00

abstract：:Indoxyl sulfate (IS), a typical uremic toxin, is of great importance in the development of chronic kidney disease. In addition to its nephrotoxicity, previous studies have provided increasing evidence for its cardiovascular toxicity. The mechanism underlying IS‑induced cardiovascular toxicity has been elusive to date....

journal_title：Molecular medicine reports

authors： Tan X,Cao XS,Zhang P,Xiang FF,Teng J,Zou JZ,Ding XQ

更新日期：2018-12-01 00:00:00

abstract：:Recent epidemiological studies and animal experiments have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal carcinoma. Cyclooxygenase (COX), the first oxidase in the process of prostaglandin production from arachidonic acid, is the principal target of NSAIDs. Due to i...

journal_title：Molecular medicine reports

authors： Matsuyama M,Yoshimura R

更新日期：2009-07-01 00:00:00

abstract：:Alpinetin is a natural flavonoid widely distributed in Zingiberaceae. Previous studies have demonstrated that alpinetin markedly inhibits tumour growth. However, the molecular mechanisms underlying the antitumour effects of alpinetin are unclear. Bcl‑2‑associated X protein (Bax) tra...

journal_title：Molecular medicine reports

authors： Wang Z,Lu W,Li Y,Tang B

更新日期：2013-03-01 00:00:00

abstract：:The aim of the present study was to explore the effects of co‑culturing bone marrow‑derived mesenchymal stem cells (BM-MSCs) cultured with hepatitis B virus (HBV)‑infected lymphocytes in vitro. BM‑MSCs and lymphocytes from Brown Norway rats were obtained from the bone marrow and spleen, respectively. Rats were divided...

journal_title：Molecular medicine reports

authors： Zheng WP,Zhang BY,Shen ZY,Yin ML,Cao Y,Song HL

更新日期：2017-05-01 00:00:00

abstract：:Doxorubicin (Dox)-induced cardiotoxicity has been a well‑known phenomenon to clinicians and scientists for decades. It has been confirmed that Dox‑dependent cardiotoxicity is accompanied by cardiac cellular senescence. However, the molecular mechanisms underlying Dox cardiotoxicity remains to be fully elucidated. Long...

journal_title：Molecular medicine reports

authors： Xie Z,Xia W,Hou M

更新日期：2018-02-01 00:00:00

abstract：:Scutellarin (SC), mainly extracted from the Chinese herb Erigeron breviscapus (vant.), has been reported to possess various pharmacological activities; however, its effects on Alzheimer's disease (AD) have not been systemically reported. The protective effects of SC on AD were investigated using an L‑glutamic acid (L‑...

journal_title：Molecular medicine reports

authors： Hu X,Teng S,He J,Sun X,Du M,Kou L,Wang X

更新日期：2018-11-01 00:00:00

abstract：:Sepsis is a leading killer of children worldwide with numerous differentially expressed genes reported to be associated with sepsis. Identifying core pathways in an individual is important for understanding septic mechanisms and for the future application of custom therapeutic decisions. Samples used in the study were...

journal_title：Molecular medicine reports

authors： Li B,Zeng Q

更新日期：2017-10-01 00:00:00

abstract：:Gastric cancer (GC) is a leading cause of cancer‑associated mortality worldwide. Previous studies demonstrated that long noncoding RNAs (lncRNAs) may be dysregulated in GC and may serve important roles in cancer progression. The present study aimed to investigate the role of the novel lncRNA stomach cancer‑associated ...

journal_title：Molecular medicine reports

authors： Zhang JF,Jiang W,Zhang QF,Kuai XL,Mao ZB,Wang ZW

更新日期：2019-06-01 00:00:00

abstract：:BP‑1‑102, a novel inhibitor of signal transducer and activator of transcription 3 (STAT3), exhibits significant antitumor effects in several malignancies in vitro and in vivo. However, its role in gastric cancer (GC) remains to be elucidated. In the present study, the effect and potential molecular mechanisms of BP‑10...

journal_title：Molecular medicine reports

authors： Jiang X,Tang J,Wu M,Chen S,Xu Z,Wang H,Wang H,Yu X,Li Z,Teng L

更新日期：2019-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide, which is partially due to the lack of appropriate therapeutic options. The development of HCC is accompanied with unique and continuous genomic and epigenetic modifications. Therefore, the absence of a personalized and reprodu...

journal_title：Molecular medicine reports

authors： Wang Z,Bi B,Song H,Liu L,Zheng H,Wang S,Shen Z

更新日期：2019-06-01 00:00:00

abstract：:The sonic hedgehog (SHH) morphogen regulates cell differentiation and controls a number of genes during renal morphogenesis. To date, the effects of SHH on fibroblast growth factors (Fgfs) in embryonic kidney development remain unclear. In the present study, explants of BALB/c mouse embryonic kidney tissues were used ...

journal_title：Molecular medicine reports

authors： Chen X,Hou XM,Fan YF,Jin YT,Wang YL

更新日期：2016-10-01 00:00:00

abstract：:Osteopetrosis is a monogenic condition with various inheritance patterns, including autosomal dominant, autosomal recessive and X‑linked. Several disease‑causing genes have been identified and three distinguished types of osteopetrosis have been reported. In the present study, a family with osteopetrosis was investiga...

journal_title：Molecular medicine reports

authors： Yang Y,Ye W,Guo J,Zhao L,Tu M,Zheng Y,Li L

更新日期：2019-01-01 00:00:00

abstract：:Tanshinone IIA is the active compound isolated from Salvia miltiorrhiza bunge, which is a traditional Chinese medicine known as Danshen. The aim of the present study was to assess the effect of Tanshinone IIA on the regulation of lipid metabolism in the livers of hyperlipidemic rats and the underlying molecular events...

journal_title：Molecular medicine reports

authors： Jia L,Song N,Yang G,Ma Y,Li X,Lu R,Cao H,Zhang N,Zhu M,Wang J,Leng X,Cao Y,Du Y,Xu Y

更新日期：2016-06-01 00:00:00