The effect of LOXL2 in hepatocellular carcinoma.

abstract：:Neural stem cells (NSCs) have the potential to give rise to offspring cells and hypoxic injury can impair the function of NSCs. The present study investigated the effects of mesenchymal stem cell (MSC)‑derived extracellular vesicles (EVs) on NSC injury, as well as the underlying mechanisms. MSC‑EVs were isolated and i...

journal_title：Molecular medicine reports

authors： Li F,Zhang J,Liao R,Duan Y,Tao L,Xu Y,Chen A

更新日期：2020-11-01 00:00:00

abstract：:The aim of the current study was to implement whole transcriptome massively parallel sequencing (RNASeq) and copy number analysis to investigate the molecular biology of pancreatic ductal adenocarcinoma (PDAC). Samples from 16 patients with PDAC were collected by ultrasound‑guided biopsy or from surgical specimens for...

journal_title：Molecular medicine reports

authors： Di Marco M,Astolfi A,Grassi E,Vecchiarelli S,Macchini M,Indio V,Casadei R,Ricci C,D'Ambra M,Taffurelli G,Serra C,Ercolani G,Santini D,D'Errico A,Pinna AD,Minni F,Durante S,Martella LR,Biasco G

更新日期：2015-11-01 00:00:00

abstract：:Cervical cancer is the third highest cause of death in developing countries and most commonly results from high‑risk human papillomavirus (HR‑HPV) infection. Among HR‑HPV genotypes, HPV16 and HPV18 are the most prevalent in cervical cancers. Therefore, the present study aimed to develop a detection assay for HPV16 and...

journal_title：Molecular medicine reports

authors： Kumvongpin R,Jearanaikoon P,Wilailuckana C,Sae-Ung N,Prasongdee P,Daduang S,Wongsena M,Boonsiri P,Kiatpathomchai W,Swangvaree SS,Sandee A,Daduang J

更新日期：2017-05-01 00:00:00

abstract：:MicroRNA‑133a (miR‑133a) is downregulated in various types of human malignancy, including hepatocellular carcinoma (HCC), renal cell carcinoma, esophageal squamous cell carcinoma, bladder cancer, ileal carcinoid and rhabdomyosarcoma. The aim of the present study was to examine the effects of miR‑133a on HCC cell proli...

journal_title：Molecular medicine reports

authors： Chen X,Bo L,Zhao X,Chen Q

更新日期：2015-05-01 00:00:00

abstract：:Isoniazid (INH) and rifampicin (RIF) continue to be first line anti‑tuberculosis (TB) drugs. However, the use of these drugs is associated with hepatotoxicity. Nuclear factor‑κB (NF‑κB) plays a crucial role in regulating immunity and inflammation. It has been reported that pyrrolidine dithiocarbamate (PDTC), an inhibi...

journal_title：Molecular medicine reports

authors： He X,Song Y,Wang L,Xu J

更新日期：2020-01-01 00:00:00

abstract：:Despite increasing evidence to suggest that microRNA (miR)-146a and miR-181b are involved in the regulation of immune responses and tumor progression, their roles in silicosis remain to be fully elucidated. Therefore, the present study examined the roles of miR‑146a and miR‑181b in inflammatory responses, and their ef...

journal_title：Molecular medicine reports

authors： Zhang Y,Wang F,Lan Y,Zhou D,Ren X,Zhao L,Zhang Q

更新日期：2015-10-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) affect atherosclerosis by regulating the physiological and pathological processes of endothelial cells; however, the role of lncRNA WEE2 antisense RNA 1 (WEE2‑AS1) in arteriosclerosis obliterans (ASO) is not completely understood. The present study aimed to explore the function of lncRNA...

journal_title：Molecular medicine reports

authors： Jiang B,Wang R,Lin Z,Ma J,Cui J,Wang M,Liu R,Wu W,Zhang C,Li W,Wang S

更新日期：2020-12-01 00:00:00

abstract：:Ginsenosides exhibit various neuroprotective effects against oxidative stress. However, which ginsenoside provides optimal effects for the treatment of neurological disorders as a potent antioxidant remains to be elucidated. Therefore, the present study investigated and compared the neuroprotective effects of the Rb1,...

journal_title：Molecular medicine reports

authors： Ye J,Yao JP,Wang X,Zheng M,Li P,He C,Wan JB,Yao X,Su H

更新日期：2016-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common type of neurological disorder that results from brain cell death; however, not all brain regions are simultaneously affected to the same extent. Despite single biomarkers for AD having been determined on a genome‑wide scale, the differential co‑expression in gene pairs betwe...

journal_title：Molecular medicine reports

authors： Yu L,Qian S,Wei S

更新日期：2018-08-01 00:00:00

abstract：:Socheongryeong‑tang (SCRT) is a herbal formula previously used to treat pulmonary diseases primarily caused by the common cold virus, including airway inflammation, asthma and allergy. The aim of the present study was to investigate the inhibitory effect of SCRT water extract and its 13 constituent components on chemo...

journal_title：Molecular medicine reports

authors： Kim JH,Jeon WY,Lee MY,Seo CS,Lim HS,Shin HK

更新日期：2014-12-01 00:00:00

abstract：:In the present study, optically active cis and trans α-hydroxy-β-lactams were prepared by Baker's yeast reduction of a racemic α-keto-β-lactam and by the hydrolysis of a racemic α-acetoxy β-lactam with the resting cells of Bacillus Subtilis. ...

journal_title：Molecular medicine reports

authors： Banik BK,Negi M,Manhas MS,Bose AK

更新日期：2010-03-01 00:00:00

abstract：:Adoptive transfer of bone marrow‑derived mesenchymal stem cells (BMSCs) significantly alleviates smoking‑induced chronic obstructive pulmonary disease (COPD) in rats. Considering the critical roles of T cells during COPD development, the present study aimed to further identify the molecular mechanisms underlying the a...

journal_title：Molecular medicine reports

authors： Li X,Xu J,Li P

更新日期：2020-05-01 00:00:00

abstract：:LIM homeobox domain 6 (LHX6), a member of the LHX family of proteins, has been implicated in cancer development. However, the involvement of LHX6 in the development of breast cancer remains unclear. In the present study, the epigenetic regulation, biological function and associated molecular mechanisms of LHX6 in brea...

journal_title：Molecular medicine reports

authors： Hu Z,Xie L

更新日期：2015-09-01 00:00:00

abstract：:Breast cancer is the most common type of cancer among females and the adenosine triphosphate (ATP) binding cassette E1 (ABCE1) gene is a member of the ATP‑binding cassette (ABC) family. Studies in lung cancer have shown that overexpression of ABCE1 in tumor cells promotes growth and inhibits apoptosis. However, little...

journal_title：Molecular medicine reports

authors： Huang B,Zhou H,Lang X,Liu Z

更新日期：2014-10-01 00:00:00

abstract：:Peritoneal dialysis (PD)-associated peritoneal fibrosis is a serious complication in patients with chronic renal failure on dialysis maintenance. Studies have shown that patients on long‑term PD have chronic inflammation. The epithelial-to-mesenchymal transition (EMT) induced by inflammation is a major cause of perito...

journal_title：Molecular medicine reports

authors： Shi S,Zhang Y,Wen W,Zhao Y,Sun L

更新日期：2016-11-01 00:00:00

abstract：:Paraquat is a highly toxic pesticide, which often causes pulmonary interstitial fibrosis after poisoning, and there is no specific antidote. At present, limited studies have reported that tacrolimus, as an immunosuppressant, can inhibit pulmonary fibrosis, but the specific mechanism remains unknown. The aim of the pre...

journal_title：Molecular medicine reports

authors： Ren Y,Jian X,Zhang Z,Ning Q,Kan B,Kong L

更新日期：2020-11-01 00:00:00

abstract：:In the last 30 years, the 5-year-survival rate of patients with osteosarcoma has not improved as a result of the low prevalence and large tumor heterogeneity. Therefore, the development of novel drugs for the treatment of osteosarcoma is urgently required. The present study aimed to identify potential novel drugs for ...

journal_title：Molecular medicine reports

authors： Zou Y,Yang J,Jiang D

更新日期：2015-11-01 00:00:00

abstract：:The aim of the present study was to identify potential biomarkers associated with colorectal cancer (CRC). The GSE32323 and GSE53592 mRNA and microRNA (miRNA) expression profiles were selected from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs...

journal_title：Molecular medicine reports

authors： Hu J,Yue X,Liu J,Kong D

更新日期：2018-12-01 00:00:00

abstract：:The aim of the present study was to examine the protective effects and mechanism of sika deer (Cervus nippon Temminck) velvet antler polypeptides (VAPs) against MPP+ exposure in the SH‑SY5Y human neuroblastoma cell line. MPP+ cytotoxicity and the protective effects of VAPs on the SH‑SY5Y cells were determined using an...

journal_title：Molecular medicine reports

authors： Xin JL,Zhang Y,Li Y,Zhang LZ,Lin Y,Zheng LW

更新日期：2017-10-01 00:00:00

abstract：:Kashin-Beck disease (KBD) is a degenerative osteoarticular disease of unknown etiology. The management of KBD would benefit from the identification of the biomarkers related to this disease. In this study, mass spectrometry (MS)-based proteomic profiling was used to identify potential biomarkers of the disease. One hu...

journal_title：Molecular medicine reports

authors： Du J,Wu X,Zhang H,Wang S,Tan W,Guo X

更新日期：2010-09-01 00:00:00

abstract：:Tumor necrosis factor α-induced protein 8 (TNFAIP8) has been associated with the tumorigenicity of various types of cancer, however, the expression of TNFAIP8 and its function in gastric cancer remain to be fully elucidated. Therefore, the present study examined the expression and biological function of TNFAIP8 in gas...

journal_title：Molecular medicine reports

authors： Li Y,Jing C,Chen Y,Wang J,Zhou M,Liu X,Sun D,Mu L,Li L,Guo X

更新日期：2015-08-01 00:00:00

abstract：:The present study investigated the role of microRNA (miR)‑146a in a diabetic nephropathy (DN) model, and its molecular mechanism. DN mice were given intraperitoneal injections of streptozotocin (55 mg/kg/day) for 5 consecutive days as an in vivo DN model. The HK‑2 human kidney cell line were exposed to 45% D‑glucose a...

journal_title：Molecular medicine reports

authors： Wan RJ,Li YH

更新日期：2018-03-01 00:00:00

abstract：:The aim of the present study was to identify miRNAs that were differentially expressed in hepatocellular carcinoma (HCC) by comparing normal and cancer tissue samples and to analyze the correlation of the target genes and HCC. The gene expression profile of GSE31383 was downloaded from the Gene Expression Omnibus data...

journal_title：Molecular medicine reports

authors： Han K,Li J,Zhao H,Liang P,Huang X,Zheng L,Li Y,Yang T,Wang L

更新日期：2014-07-01 00:00:00

abstract：:Low molecular weight heparin (LMWH) has a structure similar to heparan sulfate, which exerts anti‑inflammatory effects via inhibiting elastase (Ela) activity. Release of Ela along the glomerular capillary wall may induce glomerular injury and proteinuria. The present study aimed to investigate the influence of LMWH on...

journal_title：Molecular medicine reports

authors： Zhai S,Hu L,Zhong L,Tao Y,Wang Z

更新日期：2017-12-01 00:00:00

abstract：:A subset of cancer stem cells termed 'side population' (SP) cells has been identified in several types of solid tumor and is known to be responsible for the failure of chemotherapy and for cancer relapse. In the present study, the oral squamous cell carcinoma (OSCC) cell line SCC‑55 was used for analysis of the SP cel...

journal_title：Molecular medicine reports

authors： Liu Y,Cui P,Chen J,Li W

更新日期：2015-05-01 00:00:00

abstract：:Osteoblasts produce various types of cytokines under pathological conditions and control osteoclast differentiation. Tumor necrosis factor-α (TNF-α) has been demonstrated to exert complex effects in osteoblasts under local inflammatory conditions, including in periodontal and periapical diseases. Interleukin-34 (IL-34...

journal_title：Molecular medicine reports

authors： Yu Y,Yang D,Qiu L,Okamura H,Guo J,Haneji T

更新日期：2014-09-01 00:00:00

abstract：:Methyl‑CpG‑binding protein 2 (MeCP2) is a transcriptional repressor that has been implicated in tumor onset and progression. Compared with normal and other tumorous tissue, MeCP2 is highly expressed in well‑differentiated adenocarcinoma and mucinous adenocarcinoma tissues, particularly at the invasion site of colorect...

journal_title：Molecular medicine reports

authors： Song N,Li K,Wang Y,Chen Z,Shi L

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of hepatitis B virus X protein (HBx) on the expression of DNA methyltransferase (DNMT)3A/3B and suppressors of cytokine signaling‑1 (SOCS‑1), as well as promoter CpG island methylation of the SOCS‑1 gene. Stable hepatocyte cell lines expressing the HBx gene (p...

journal_title：Molecular medicine reports

authors： Fu X,Song X,Li Y,Tan D,Liu G

更新日期：2016-01-01 00:00:00

abstract：:Histone deacetylase inhibitor (HDACi) has been a major target of anticancer agents. Quisinostat (JNJ‑26481585), a novel second‑generation HDACi, has previously demonstrated antiproliferative activity against non‑small cell lung cancer; however, the function of quisinostat in hepatocellular carcinoma (HCC) remains to b...

journal_title：Molecular medicine reports

authors： Li F,Wang T,Wang Z,Chen X,Liu R

更新日期：2017-11-01 00:00:00

abstract：:We investigated the effects of mechanical strain on the progressive ankylosis (ANK) gene and extracellular nucleotide phosphatase/phosphodiesterase (ENPP)1 mRNA expression and TGF-β1 protein expression in rat endplate chondrocytes in vitro. Endplate chondrocytes were isolated and cultured in vitro. Following identific...

journal_title：Molecular medicine reports

authors： Xu HG,Hu CJ,Wang H,Liu P,Yang XM,Zhang Y,Wang LT

更新日期：2011-09-01 00:00:00