Epigallocatechin gallate improves airway inflammation through TGF‑β1 signaling pathway in asthmatic mice.

abstract：:MicroRNAs (miRNAs) are important regulators of a variety of biological processes and their dysregulation is closely related to cancer formation and progression. Therefore, examination of aberrantly expressed miRNAs in oral squamous cell carcinoma (OSCC) may provide important clues for the diagnosis and treatment of pa...

journal_title：Molecular medicine reports

authors： Wang Q,Lv L,Li Y,Ji H

更新日期：2018-09-01 00:00:00

abstract：:The non-steroidal anti-inflammatory drug-activated gene (NAG-1) is a newly identified member of the transforming growth factor (TGF)-β superfamily and plays significant roles in regulating proliferation and pro-apoptotic activities. In the present study, we studied the regulation of NAG-1 by troglitazone in the cultur...

journal_title：Molecular medicine reports

authors： Wang C,Wang J,Bai P

更新日期：2011-01-01 00:00:00

abstract：:Cip1-interacting zinc finger protein 1 (CIZ1) is a nuclear protein that was observed to bind to p21Cip1/Waf1. p21Cip1/Waf1 regulates the cell cycle and is associated with colorectal cancer (CRC) progression. However, the effect of CIZ1 on CRC cells remains unclear. In the present study, CIZ1 was observed to be highly ...

journal_title：Molecular medicine reports

authors： Yin J,Wang C,Tang X,Sun H,Shao Q,Yang X,Qu X

更新日期：2013-12-01 00:00:00

abstract：:The differentiation of pluripotent mesenchymal stem cells to mature osteoblasts is crucial for the maintenance of the adult skeleton. In rheumatic arthritis, osteoblast differentiation is impaired by the overproduction of cytokine tumor necrosis factor (TNF)‑α. It has been demonstrated that TNF-α is able to inhibit os...

journal_title：Molecular medicine reports

authors： Wang G,Zhang X,Yu B,Ren K

更新日期：2015-07-01 00:00:00

abstract：:Lysyl oxidase-like 2 (LOXL2) is key in the hepatocellular carcinoma (HCC) tumor microenvironment and metastatic niche formation. However, its effect on proliferation and clinical parameters in HCC require further elucidation. The present study aimed to investigate LOXL2 expression in HCC from in vitro and clinical asp...

journal_title：Molecular medicine reports

authors： Wu L,Zhang Y,Zhu Y,Cong Q,Xiang Y,Fu L

更新日期：2016-09-01 00:00:00

abstract：:Patients with respiratory overlap syndrome (OS), defined as concomitant chronic obstructive pulmonary disease and obstructive sleep apnea syndrome, may exhibit an increased blood concentration of ingested drugs. This poor elimination of drugs is primarily attributed to downregulated gene expression of the drug‑metabol...

journal_title：Molecular medicine reports

authors： Yu H,Shao H,Wu Q,Sun X,Li L,Li K,Li X,Li Y,Zhang Q,Wu J,Chen H

更新日期：2017-07-01 00:00:00

abstract：:The present study aimed to investigate the protective effects of ghrelin against oxidative stress, inducible nitric oxide synthase (iNOS) and inflammation in a mouse model of myocardial ischemia/reperfusion injury (MIRI). In addition, the study aimed to determine its underlying mechanisms. A mouse model of MIRI was us...

journal_title：Molecular medicine reports

authors： Sun N,Wang H,Wang L

更新日期：2016-09-01 00:00:00

abstract：:Cyclin-dependent kinase inhibitor 3 (CDKN3) belongs to the dual-specificity protein phosphatase family, which is hypothesized to regulate cell cycle progression in tumor cells. However, whether CDKN3 is a potential therapeutic target for breast cancer remains to be elucidated. The present in vitro study aimed to inves...

journal_title：Molecular medicine reports

authors： Deng M,Wang J,Chen Y,Zhang L,Xie G,Liu Q,Zhang T,Yuan P,Liu D

更新日期：2016-08-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a life-threatening type of stroke. Previous studies have reported that bone marrow mesenchymal stem cells (BMSCs) may exert beneficial effects on the treatment of ICH. However, it remains unknown whether the neuroprotection exerted by BMSCs on ICH is due to the differentiation of BMSC...

journal_title：Molecular medicine reports

authors： Cui C,Cui Y,Gao J,Li R,Jiang X,Tian Y,Wang K,Cui J

更新日期：2017-04-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been reported to serve a crucial role in renal diseases; however, their role in immunoglobulin A nephropathy (IgAN) remains unclear. In the present study, peripheral blood mononuclear cells (PBMCs) were collected from both patients with IgAN and healthy controls. A microarray analys...

journal_title：Molecular medicine reports

authors： Zuo N,Li Y,Liu N,Wang L

更新日期：2017-11-01 00:00:00

abstract：:Calcium dyshomeostasis is an important pathology of memory impairment. However, the mechanism of how calcium dyshomeostasis impairs neurons has remained elusive. The aim of the present study was to reveal the influence of calcium dyshomeostasis on the expression of calcium memory‑associated proteins and the ability of...

journal_title：Molecular medicine reports

authors： Zhou X,Yang Z,Han L,Li X,Feng M,Zhang T,Luo H,Zhu L,Zhang J,Zhang Q,Hu Q

更新日期：2015-10-01 00:00:00

abstract：:Apoptosis serves a pivotal role in the pathogenesis of osteoarthritis (OA). Increasing evidence has demonstrated that paeoniflorin exerts key properties (including anticancer, anti-inflammation and neuroprotective) for clinical applications. However, the precise role of paeoniflorin in articular cartilage apoptosis re...

journal_title：Molecular medicine reports

authors： Hu PF,Chen WP,Bao JP,Wu LD

更新日期：2018-04-01 00:00:00

abstract：:Dyslipidemia is an important risk factor for myocardial infarction (MI). We previously showed that gene polymorphisms associated with MI differed among individuals with different lipid profiles. We also showed that rs6929846 of BTN2A1 and rs2569512 of ILF3 were significantly associated with MI in Japanese individuals....

journal_title：Molecular medicine reports

authors： Yoshida T,Kato K,Oguri M,Horibe H,Kawamiya T,Yokoi K,Fujimaki T,Watanabe S,Satoh K,Aoyagi Y,Tanaka M,Yoshida H,Shinkai S,Nozawa Y,Yamada Y

更新日期：2011-05-01 00:00:00

abstract：:Glioblastoma multiforme is one of the most lethal types of brain cancer. With limited success from conventional therapies, the cancer stem cell theory was developed, and investigation into microRNAs (miRs) has facilitated understanding of this theory. The present study demonstrated that miR‑141 is suppressed in sorted...

journal_title：Molecular medicine reports

authors： Gao X,Zhu X,Sun Y,Liu J

更新日期：2017-07-01 00:00:00

abstract：:Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G protein-coupled receptor signaling pathways. RGS9‑2, a brain‑specific splice variant of the RGS9 gene, is highly expressed in the striatum but lowly expressed in the periaqueductal gray and spinal cord, which mediate various act...

journal_title：Molecular medicine reports

authors： Zhu Y,Zhang H

更新日期：2015-05-01 00:00:00

abstract：:Ovarian cancer (OC) is associated with a poor prognosis due to difficulties in early detection. The aims of the present study were to construct a recurrence risk prediction model and to reveal important OC genes or pathways. RNA sequencing data was obtained for 307 OC samples, and the corresponding clinical data were ...

journal_title：Molecular medicine reports

authors： Cheng L,Li L,Wang L,Li X,Xing H,Zhou J

更新日期：2018-09-01 00:00:00

abstract：:Toll-like receptors (TLRs) are critical in the induction of the immune response in tumor development. TLR7 has previously been demonstrated to be associated with the development of pancreatic cancer, and the release of cytokines and chemokines from other types of cancer cell; however, the specific expression induced b...

journal_title：Molecular medicine reports

authors： Wang F,Jin R,Zou BB,Li L,Cheng FW,Luo X,Geng X,Zhang SQ

更新日期：2016-02-01 00:00:00

abstract：:It has been reported that sevoflurane induces neurotoxicity in the developing brain. Dexmedetomidine is an α2 adrenoceptor agonist used for the prevention of sevoflurane‑induced agitation in children in clinical practice. The aim of the present study was to determine whether dexmedetomidine could prevent sevoflurane‑i...

journal_title：Molecular medicine reports

authors： Zhang Y,Li M,Cui E,Zhang H,Zhu X,Zhou J,Yan M,Sun J

更新日期：2021-01-01 00:00:00

abstract：:During orthodontic treatment, mechanical force is applied to the teeth, and following a series of complex metabolism changes, the position of the teeth in the alveolar bone change. This process is closely associated with primitive bone mesenchymal stem cells (BMSCs), which may differentiate into osteoblasts precursor ...

journal_title：Molecular medicine reports

authors： Yu H,Yu W,Liu Y,Yuan X,Yuan R,Guo Q

更新日期：2019-11-01 00:00:00

abstract：:Senescence is a result of cellular stress and is a potential mechanism for regulating cancer. As a member of the mitogen‑activated protein kinase family, ERK1/2 (extracellular signal‑regulated protein kinase) has an important role in delivering extracellular signals to the nucleus, and these signals regulate the cell ...

journal_title：Molecular medicine reports

authors： Zou J,Lei T,Guo P,Yu J,Xu Q,Luo Y,Ke R,Huang D

更新日期：2019-02-01 00:00:00

abstract：:The pathogenesis of Graves' ophthalmopathy (GO) remains to be entirely elucidated. The present study aimed to determine the association between phenotypic expression of the MTHFR gene and susceptibility to GO in patients with Graves' disease (GD). A prospective case‑controlled study was conducted with 122 patients wit...

journal_title：Molecular medicine reports

authors： Lee JY,Kim NK,Cho YW,Lew H

更新日期：2016-09-01 00:00:00

abstract：:Parkinson's disease (PD) is a type of movement disorder caused by loss of dopamine‑producing neurons in the midbrain. In order to identify the synergistic microRNA (miRNA) pattern in PD, miRNA and mRNA double expression profiles of PD were downloaded. Differentially expressed miRNA and mRNA were identified [P<0.01, fo...

journal_title：Molecular medicine reports

authors： Hao B,Chen X,Dai D,Zou C,Wu X,Chen J

更新日期：2015-02-01 00:00:00

abstract：:Hypoxia may induce apoptosis and autophagy to promote cardiomyocyte injury. The present study investigated the effect of berberine, a natural extract of Rhizoma Coptidis, on hypoxia‑induced autophagy and apoptosis in the H9c2 rat myocardial cell line. Expression levels of apoptosis and autophagy markers were upregulat...

journal_title：Molecular medicine reports

authors： Jia Z,Lin L,Huang S,Zhu Z,Huang W,Huang Z

更新日期：2017-08-01 00:00:00

abstract：:Hypertensive nephrosclerosis (HNS) is a major risk factor for end-stage renal disease. However, the underlying pathogenesis of HNS remains to be fully determined. The gene expression profile of GSE20602, which consists of 14 glomeruli samples from patients with HNS and 4 normal glomeruli control samples, was obtained ...

journal_title：Molecular medicine reports

authors： Liu T,Liu M,Shang P,Jin X,Liu W,Zhang Y,Li X,Ding Y,Li Y,Wen A

更新日期：2018-03-01 00:00:00

abstract：:Semaphorin 6B is a member of the semaphorin family of signaling proteins, which is implicated in a variety of biological processes, such as axon guidance and muscle regeneration. PPARα is known to be a regulator of semaphorin 6B in human cancer cell lines. In this study, we examined the effect of fenofibrate as a PPAR...

journal_title：Molecular medicine reports

authors： Murad H,Kasies F,Azroony R,Alya G,Madania A

更新日期：2011-05-01 00:00:00

abstract：:In order to observe the effects of cyclin E gene silencing by small interfering RNA (siRNA) on the growth, proliferation, invasion and apoptosis of esophageal cancer cell lines, including EC9706, Eca109 and KYSE30, siRNA vectors targeting cyclin E gene were constructed and then tran...

journal_title：Molecular medicine reports

authors： Wang N,Li M,Zang WQ,Ma YY,Wang YY,Zhao GQ

更新日期：2013-03-01 00:00:00

abstract：:Previous studies have reported that the Rho-associated coiled-coil containing protein kinase 2 (ROCKII) and glycogen synthase kinase‑3β (GSK)‑3β signaling pathways are involved in axonal regeneration. The present study investigated the effects of the combined application of Y27632 (a ROCKII inhibitor) and 4-benzyl-2‑m...

journal_title：Molecular medicine reports

authors： Zhang G,Lei F,Zhou Q,Feng D,Bai Y

更新日期：2016-12-01 00:00:00

abstract：:Metabolic syndrome based on insulin resistance (IR) and hypertension is a risk factor for advanced liver disease and cardiovascular disease in patients with nonalcoholic steatohepatitis (NASH). The present study investigated the effects of severe hypertension induced by a high‑salt (HS) diet and antihypertensive thera...

journal_title：Molecular medicine reports

authors： Kozono M,Uto H,Ibusuki R,Arima S,Oda K,Taguchi H,Sasaki F,Nasu Y,Hashimoto S,Setoyama H,Kanmura S,Numata M,Tsubouchi H,Ido A

更新日期：2016-12-01 00:00:00

abstract：:Tissue-engineered bone substitutes are frequently used to repair bone defects. Adipose-derived stem cells (ASCs) are a promising source of cells for repairing bone tissue, however, insufficient osteogenic potency remains the main obstacle for their application. The present study aimed to enhance the osteogenic potency...

journal_title：Molecular medicine reports

authors： Wang Z,Zhang D,Hu Z,Cheng J,Zhuo C,Fang X,Xing Y

更新日期：2015-09-01 00:00:00

abstract：:Our previous study demonstrated that type II cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG II) inhibited epidermal growth factor (EGF)-induced phosphorylation/activation of epidermal growth factor receptor (EGFR). Since human epidermal growth factor receptor 2 (HER2) has a similar molecular struc...

journal_title：Molecular medicine reports

authors： Zhu M,Yao X,Wu M,Qian H,Wu Y,Chen Y

更新日期：2016-02-01 00:00:00