Altered gene expression of hepatic cytochrome P450 in a rat model of intermittent hypoxia with emphysema.

abstract：:Toll-like receptor (TLR) family members are pattern recognition receptors that are essential in the activation of innate and adaptive immune responses. Submandibular gland epithelial cells (SMGCs) may recognize microbial components through TLRs and be involved in the development of inflammatory reactions in the subman...

journal_title：Molecular medicine reports

authors： Ohta K,Ishida Y,Fukui A,Mizuta K,Nishi H,Takechi M,Kamata N

更新日期：2014-11-01 00:00:00

abstract：:Prostaglandin E2 has exhibited pleiotropic effects in the regulation of glomerulosclerosis progression through its four receptors. The current study aimed to evaluate the effect of prostaglandin receptor EP4 on mesangial cell proliferation. In vivo, 5/6 nephrectomy was introduced into EP4+/‑ and wild‑type (WT) mice. C...

journal_title：Molecular medicine reports

authors： Cao Y,Pan T,Chen X,Wu J,Guo N,Wang B

更新日期：2018-12-01 00:00:00

abstract：:The present study aimed to test whether 20-hydroxyeicosatetraenoic acid (20‑HETE) affected neddylation modification of E3‑ligase Nedd4‑2 (neural precursor cell expressed, developmentally down‑regulated 4‑like, E3 ubiquitin protein ligase). A cytochrome P450 family 4 subfamily F member 2 (CYP4F2) transgenic mouse model...

journal_title：Molecular medicine reports

authors： Zhao J,Zhang B,Lai G,Xu R,Chu G,Zhao Y

更新日期：2017-12-01 00:00:00

abstract：:Galectin-3 is an important mediator of cardiac fibrosis and heart failure. Cell viability of cardiomyocytes was measured using a CCK‑8 assay; flow cytometry was employed for the detection of the cell cycle and cardiomyocytes apoptosis. Reverse transcription‑quantitative polymerase chain reaction and western blotting w...

journal_title：Molecular medicine reports

authors： Li X,Tang X,Lu J,Yuan S

更新日期：2018-03-01 00:00:00

abstract：:Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a cancer suppressor gene and an important negative regulator in the phosphatidylinositide 3‑kinase (PI3K)/protein kinase B (Akt)/ mechanistic target of rapamycin (mTOR) signaling pathway. The PI3K/Akt/mTOR pathway can promote cancer cell survival, proli...

journal_title：Molecular medicine reports

authors： Liu S,Xu ZL,Sun L,Liu Y,Li CC,Li HM,Zhang W,Li CJ,Qin W

更新日期：2016-07-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved, multi-step lysosomal degradation process in which a cell degrades its own long-lived proteins and damaged organelles. Ataxia telangiectasia mutated (ATM) has recently been shown to upregulate the process of autophagy. Previous studies showed...

journal_title：Molecular medicine reports

authors： Qased AB,Yi H,Liang N,Ma S,Qiao S,Liu X

更新日期：2013-02-01 00:00:00

abstract：:Soy milk, which is produced from whole soybeans, contains a variety of biologically active components. Isoflavones are a class of soy-derived phytoestrogens with beneficial effects, among which genistein (GEN) has been previously indicated to reduce the risk of prostate cancer. The present study evaluated the effects ...

journal_title：Molecular medicine reports

authors： Kang NH,Shin HC,Oh S,Lee KH,Lee YB,Choi KC

更新日期：2016-08-01 00:00:00

abstract：:To evaluate the effect of melatonin supplementation in maturation medium for human 'rescue IVM' and investigate differences in transcriptomic profile of blastocysts developed from oocytes matured in vitro with/without melatonin treatment and in vivo, a total of 314 GV oocytes and 320 MI oocytes were collected from 200...

journal_title：Molecular medicine reports

authors： Hao Y,Zhang Z,Han D,Cao Y,Zhou P,Wei Z,Lv M,Chen D

更新日期：2017-08-01 00:00:00

abstract：:The primary effect of the endoplasmic reticulum (ER) stress response or unfolded protein response (UPR) is to reduce the load of unfolded protein and promote survival. However, prolonged and severe ER stress leads to tissue injury and serious diseases. Thus, it is important to identify drugs that can attenuate ER stre...

journal_title：Molecular medicine reports

authors： Qin HS,Yu PP,Sun Y,Wang DF,Deng XF,Bao YL,Song J,Sun LG,Song ZB,Li YX

更新日期：2016-06-01 00:00:00

abstract：:Primary human hepatocytes (PHHs) are the 'gold standard' for investigating hepatitis B virus (HBV) infection and antiviral drugs. However, poor availability, variation between batches and ethical issues regarding PHHs limit their applications. The discovery of human sodium taurocholate co‑transporting polypeptide (hNT...

journal_title：Molecular medicine reports

authors： Zhou M,Qin B,Deng XS,Zeng XL,Lu Y,Huang ZG,Wu CC,Mou LS

更新日期：2019-10-01 00:00:00

abstract：:Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl from lysine residues in histones and other proteins, which results in gene transcriptional repression and subsequent changes in signaling events. HDACs inhibitors (HDACIs) have been used to reverse the aberrant epigenetic changes associated w...

journal_title：Molecular medicine reports

authors： Han RF,Li K,Yang ZS,Chen ZG,Yang WC

更新日期：2014-12-01 00:00:00

abstract：:The occurrence and development of hyperglycemia‑induced inflammation is associated with increased expression of receptor for advanced glycation end products (RAGE) and inflammatory factors, including IL‑1β, TNF‑α and IL‑6. Previous studies have reported that the nucleotide‑binding oligomerization domain‑like receptor ...

journal_title：Molecular medicine reports

authors： Jiang M,Wang X,Wang P,Peng W,Zhang B,Guo L

更新日期：2020-10-01 00:00:00

abstract：:In the present study, the expression of microRNA (miR)‑671‑3p in non‑small‑cell lung cancer (NSCLC) was detected via reverse transcription‑quantitative polymerase chain reaction analysis, and its role in cell proliferation, apoptosis, migration and invasion was investigated via Cell Counting Kit‑8, colony formation, f...

journal_title：Molecular medicine reports

authors： Li ZY,Zhang ZZ,Bi H,Zhang QD,Zhang SJ,Zhou L,Zhu XQ,Zhou J

更新日期：2019-10-01 00:00:00

abstract：:The endogenously activated rheumatoid arthritis (RA) synovial fibroblasts (RSFs) are likely to be the key to curing the disease. RSFs express Toll‑like receptors (TLRs) rendering them prone to activation by exogenous and endogenous TLR ligands, resulting in the production of chemokines and cytokines Germline deletion ...

journal_title：Molecular medicine reports

authors： Shi C,Wang Y,Zhuang G,Qi Z,Li Y,Yin P

更新日期：2017-11-01 00:00:00

abstract：:Ilexonin A is a compound isolated from the root of a plant commonly used in traditional Chinese medicine. The aim of the present study was to investigate the possible protective mechanism of Ilexonin A in rats subjected to occlusion of the middle cerebral artery (MCAO). Transient focal cerebral ischemia was induced by...

journal_title：Molecular medicine reports

authors： Xu AL,Zheng GY,Wang ZJ,Chen XD,Jiang Q

更新日期：2016-04-01 00:00:00

abstract：:The tumorigenesis and maintenance of a cancer cells is dependent upon the collaboration of multiple signaling pathways. Signal transducer and activator of transcription 3 (STAT3) and β-catenin are at the center of multiple cancer-associated signaling pathways; therefore, simultaneously targeting STAT3 and β-catenin ma...

journal_title：Molecular medicine reports

authors： Wang XH,Liu MN,Huang P,Xu J,Liu AY,Chen J,Lv CQ,Xu RL

更新日期：2015-08-01 00:00:00

abstract：:Bone injury following radiotherapy has been confirmed by epidemiological and animal studies. However, the underlying mechanism remains to be elucidated and no preventive or curative solution has been identified for this bone loss. The present study aimed to investigate the irradiation‑altered osteogenesis and adipogen...

journal_title：Molecular medicine reports

authors： Wang Y,Zhu G,Wang J,Chen J

更新日期：2016-01-01 00:00:00

abstract：:The present study aimed to determine the potential molecular mechanisms underlying p21 (RAC1)‑activated kinase 7 (PAK7) expression in glioblastoma (GBM) and evaluate candidate prognosis biomarkers for GBM. Gene expression data from patients with GBM, including 144 tumor samples and 5 normal brain samples, were downloa...

journal_title：Molecular medicine reports

authors： Wang X,Liu S,Shao Z,Zhang P

更新日期：2020-08-01 00:00:00

abstract：:The present study aimed to evaluate the silencing effect of artificial microRNAs (amiRNAs) against the hepatitis C virus (HCV) 1b (HCV1b) genotype core (C) and non-structural protein 4B (NS4B) genes. pDsRed-monomer-Core and pDsRed-monomer-NS4B plasmids, containing the target genes were constructed. A total of eight ar...

journal_title：Molecular medicine reports

authors： Jiang XH,Xie YT,Jiang B,Tang MY,Ma T,Peng H

更新日期：2015-08-01 00:00:00

abstract：:The present study aimed to investigate the mechanism underlying the effects of minocycline on diabetic retinopathy‑associated cellular apoptosis. A total of 40 Sprague Dawley (SD) rats were used as a diabetic retinopathy model following injection with streptozotocin. Among the 34 rats in which the diabetes model was s...

journal_title：Molecular medicine reports

authors： Wu Y,Chen Y,Wu Q,Jia L,Du X

更新日期：2015-10-01 00:00:00

abstract：:Ovarian hyperstimulation syndrome (OHSS) is a potentially life‑threatening, iatrogenic complication that occurs during assisted reproduction. Polycystic ovarian syndrome (PCOS) significantly increases the risk of OHSS during controlled ovarian stimulation. Therefore, a more effective early prediction technique is requ...

journal_title：Molecular medicine reports

authors： Wu L,Sun Y,Wan J,Luan T,Cheng Q,Tan Y

更新日期：2017-07-01 00:00:00

abstract：:Uveal melanoma (UM) represents the most frequent primary tumor of the eye. Despite the development of new drugs and screening programs, the prognosis of patients with UM remains poor and no effective prognostic biomarkers are yet able to identify high‑risk patients. Therefore, in the present study, microRNA (miRNA or ...

journal_title：Molecular medicine reports

authors： Falzone L,Romano GL,Salemi R,Bucolo C,Tomasello B,Lupo G,Anfuso CD,Spandidos DA,Libra M,Candido S

更新日期：2019-04-01 00:00:00

abstract：:Cyclin-dependent kinase inhibitor 3 (CDKN3) belongs to the dual-specificity protein phosphatase family, which is hypothesized to regulate cell cycle progression in tumor cells. However, whether CDKN3 is a potential therapeutic target for breast cancer remains to be elucidated. The present in vitro study aimed to inves...

journal_title：Molecular medicine reports

authors： Deng M,Wang J,Chen Y,Zhang L,Xie G,Liu Q,Zhang T,Yuan P,Liu D

更新日期：2016-08-01 00:00:00

abstract：:Previous studies have suggested that the B‑cell lymphoma 2 (Bcl‑2) inhibitor, TW37, may induce apoptosis of the non‑small cell lung cancer cell line, H1975/epidermal growth factor receptor‑tyrosine kinase inhibitor (EGFR‑TKI), which exhibits secondary resistance to EGFR‑TKI. However, the effects of TW37 on H1975/EGFR‑...

journal_title：Molecular medicine reports

authors： Liu J,Yao X,Wu D,Ye Y,Wu Q,Liu S,Wu H

更新日期：2018-02-01 00:00:00

abstract：:Although microRNA-296 (miR-296) has been studied in various types of human cancer, its expression, biological role and mechanism of action in pancreatic cancer remains to be elucidated. The aim of the current study was to investigate the expression level, possible roles and underlying molecular mechanisms of miR‑296 i...

journal_title：Molecular medicine reports

authors： Li H,Li J,Shi B,Chen F

更新日期：2017-07-01 00:00:00

abstract：:Propofol is widely used for the induction and maintenance of pediatric anesthesia. Previous studies have indicated that propofol can induce apoptosis, and damage cognitive and memory functions. Dexmedetomidine is a potent α‑2 adrenoceptor agonist with high selectivity. Previous observations have shown that dexmedetomi...

journal_title：Molecular medicine reports

authors： Wei Y,Hu J,Liang Y,Zhong Y,He D,Qin Y,Li L,Chen J,Xiao Q,Xie Y

更新日期：2016-10-01 00:00:00

abstract：:The aim of the present study was to investigate the potential role and regulatory mechanism of long non‑coding RNA ferritin heavy polypeptide 1 pseudogene 3 (FTH1P3) in glioma development. The expression of FTH1P3 in low‑ and high‑grade glioma tissues was investigated using reverse transcription‑quantitative polymeras...

journal_title：Molecular medicine reports

authors： Zhang Y,Li Y,Wang J,Lei P

更新日期：2018-11-01 00:00:00

abstract：:The development of acute lung injury (ALI) during sepsis almost doubles the mortality rate of patients. The efficacy of current treatment strategies is low as treatment is usually initiated following the onset of symptoms. Inflammation is one of the main mechanisms of autoimmune disorders and is a common feature of se...

journal_title：Molecular medicine reports

authors： Li T,Zhang J,Feng J,Li Q,Wu L,Ye Q,Sun J,Lin Y,Zhang M,Huang R,Cheng J,Cao Y,Xiang G,Zhang J,Wu Q

更新日期：2013-06-01 00:00:00

abstract：:Activin receptor‑like kinases (ALKs), members of the type I activin receptor family, belong to the serine/threonine kinase receptors of the transforming growth factor‑β (TGF‑β) superfamily. ALKs mediate the roles of activin/TGF‑β in a wide variety of physiological and pathological processes, ranging from cell differen...

journal_title：Molecular medicine reports

authors： Cui X,Shang S,Lv X,Zhao J,Qi Y,Liu Z

更新日期：2019-06-01 00:00:00

abstract：:Gabapentin (GBP) and pregabalin (PGB) exert antinociceptive effects on chronic nociceptive responses with neuropathic or inflammatory conditions. Furthermore, it is considered that GBP and PGB exhibit anti‑inflammatory effects by modulating the substance P (SP)‑mediated neurokinin‑1 receptor (NK1R; a SP receptor) resp...

journal_title：Molecular medicine reports

authors： Yamaguchi K,Kumakura S,Someya A,Iseki M,Inada E,Nagaoka I

更新日期：2017-11-01 00:00:00