MicroRNA‑296 targets AKT2 in pancreatic cancer and functions as a potential tumor suppressor.

abstract：:Genistein is an important chemopreventive agent against atherosclerosis and cancer. However, whether genistein is effective in the treatment of lung cancer, and its underlying mechanism, remains to be determined. The present study demonstrated that genistein treatment of A549 lung cancer cells decreased viability in a...

journal_title：Molecular medicine reports

authors： Zhang J,Su H,Li Q,Li J,Zhao Q

更新日期：2017-04-01 00:00:00

abstract：:The prostaglandin E2 (PGE2) E prostanoid (EP)1 receptor shown to be associated with lung cancer cell invasion. However, the mechanism of EP1 receptor-mediated cell migration remains to be elucidated. β1 integrin is an essential regulator of the tumorigenic properties of non-small-cell lung carcinoma (NSCLC) cells. To ...

journal_title：Molecular medicine reports

authors： Bai X,Yang Q,Shu W,Wang J,Zhang L,Ma J,Xia S,Zhang M,Cheng S,Wang Y,Leng J

更新日期：2014-05-01 00:00:00

abstract：:Matrilin-2 (matn2) contains a unique domain, between the second von Willebrand factor A (vWFA) domain and the C-terminal coiled-coil domain, with no sequence homology with other family members. Complementary DNA (cDNA) sequence analysis of matn2 expression in both mice and humans re...

journal_title：Molecular medicine reports

authors： Li L,Zhang L,Shao Y,Wang G,Gong R,Wang Z,Peng J,Wang S,Genochio D,Zhao B,Luo J

更新日期：2012-11-01 00:00:00

abstract：:The aim of the present study was to establish an integrated network of DNA methylation and RNA expression in an ovalbumin (OVA)‑induced asthma model, and to investigate the epigenetically‑regulated genes involved in asthma development. Genome‑wide CpG‑DNA methylation profiling was conducted through the use of a methyl...

journal_title：Molecular medicine reports

authors： Kim JS,Shin IS,Shin NR,Nam JY,Kim C

更新日期：2020-09-01 00:00:00

abstract：:microRNAs (miRNAs) are small, non‑coding RNAs involved in multiple biological pathways by regulating post-transcriptional gene expression. Previously, autophagy has been reported to suppress the progression of non-small cell lung cancer (NSCLC). However, how miRNAs regulate autophagy in NSCLC remains to be elucidated....

journal_title：Molecular medicine reports

authors： Wei J,Ma Z,Li Y,Zhao B,Wang D,Jin Y,Jin Y

更新日期：2015-01-01 00:00:00

abstract：:Our previous study demonstrated that type II cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG II) inhibited epidermal growth factor (EGF)-induced phosphorylation/activation of epidermal growth factor receptor (EGFR). Since human epidermal growth factor receptor 2 (HER2) has a similar molecular struc...

journal_title：Molecular medicine reports

authors： Zhu M,Yao X,Wu M,Qian H,Wu Y,Chen Y

更新日期：2016-02-01 00:00:00

abstract：:Cordyceps militaris (CM), an entomopathogenic fungus belonging to the class ascomycetes, possesses various pharmacological activities, including cytotoxic effects, on various types of human tumor cells. The present study investigated the anti‑hepatocellular carcinoma (HCC) and anti‑breast cancer effects of CM in in vi...

journal_title：Molecular medicine reports

authors： Song J,Wang Y,Teng M,Zhang S,Yin M,Lu J,Liu Y,Lee RJ,Wang D,Teng L

更新日期：2016-06-01 00:00:00

abstract：:Although Frey syndrome is not life-threatening, it is identified as the most serious and widely recognized sequela of parotidectomy and has significant potential negative social and psychological implications. Several studies have investigated whether AlloDerm® implants prevent Frey syndrome effectively and safely, ho...

journal_title：Molecular medicine reports

authors： Zeng XT,Tang XJ,Wang XJ,Li MZ,Guo Y,Huang W,Niu YM,Leng WD

更新日期：2012-04-01 00:00:00

abstract：:Abnormal migration of vascular smooth muscle cells (VSMCs) serves an important role in hypertension, atherosclerosis and restenosis following angioplasty, which is regulated numerous hormonal and humoral factors, including neuropeptide Y (NPY) and dopamine. Dopamine and NPY are both sympathetic neurotransmitters, and ...

journal_title：Molecular medicine reports

authors： Xia XW,Zhou YQ,Luo H,Zeng C

更新日期：2017-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate biogenesis and disease development by targeting numerous mRNAs. miRNA (miR)‑124 and its direct target, inhibitor of apoptosis‑stimulating protein of p53 (iASPP), may be involved in tumor development and progression. The aim of the present study was to explore the role of miR‑124‑targeted iA...

journal_title：Molecular medicine reports

authors： Liu X,Kang J,Sun S,Luo Y,Ji X,Zeng X,Zhao S

更新日期：2018-01-01 00:00:00

abstract：:Lung cancer is a leading cause of cancer-associated mortality worldwide. The cisplatin (DDP)‑based chemotherapy remains the foundation of treatment for the majority of patients affected by advanced non‑small cell lung cancer (NSCLC). However, DDP‑resistance limits the clinical utility of this drug in patients with adv...

journal_title：Molecular medicine reports

authors： Zuo Y,Yang D,Yu Y,Xiang M,Li H,Yang J,Li J,Jiang D,Zhou H,Xu Z,Yu Z

更新日期：2018-03-01 00:00:00

abstract：:Matrine is a widely used Chinese herbal medicine that has historically been used in the treatment of inflammation and cancer. However, the antimetastatic effects and associated molecular mechanisms of matrine on nasopharyngeal carcinoma (NPC) remain to be elucidated. Therefore, the aims of the present study were to as...

journal_title：Molecular medicine reports

authors： Sun B,Xu M

更新日期：2015-06-01 00:00:00

abstract：:As well-known regulators of gene expression, microRNAs (miRNAs) are important not only in cell proliferation and differentiation, but also in tumorigenesis and organ development. It has been estimated that miRNAs may be responsible for regulating the expression of almost one third of the human genome. Simultaneously, ...

journal_title：Molecular medicine reports

authors： Kan Q,Ding S,Yang Y,Zhou X

更新日期：2015-08-01 00:00:00

abstract：:The aim of this study was to investigate the correlation between brain-derived neurotrophic factor (BDNF) expression and cognitive impairment in post‑stroke depression (PSD) rats and to explore the mechanism(s) involved in the process of cognitive impairment. A rat model of focal ce...

journal_title：Molecular medicine reports

authors： Zhang ZH,Wu LN,Song JG,Li WQ

更新日期：2012-10-01 00:00:00

abstract：:Pneumonia accounts for ~1.3 million mortalities in children per year worldwide. MicroRNAs are implicated in several diseases, including cancer and pneumonia; however, the role of let7f‑5p in pneumonia is not completely understood. In the present study, lipopolysaccharide (LPS) was used to establish an in vitro pneumon...

journal_title：Molecular medicine reports

authors： Xu L,Song Q,Ouyang Z,Zhang X,Zhang C

更新日期：2021-02-01 00:00:00

abstract：:The transmembrane 7 superfamily member 2 (Tm7sf2) gene been reported to be involved in the reduced cholesterol levels of patients with large burn areas. To investigate the importance of Tm7sf2 in the burn wound healing process, a total of 10 Sprague‑Dawley rats underwent electrical burns. Blood serum was collected for...

journal_title：Molecular medicine reports

authors： Lei N,Wang P,Meng Q

更新日期：2016-07-01 00:00:00

abstract：:The existence of cancer stem cells (CSCs) is considered to be the main reason for chemoresistance, metastasis and the ultimate failure of treatment in hepatocellular carcinoma (HCC). However, there are a few chemical agents that may inhibit CSCs. The present study identified that 4,4'‑bond secalonic acid D (4,4'‑SAD),...

journal_title：Molecular medicine reports

authors： Chen L,Cheng MM,Li YP,Lin SF,Zheng QH,Liu QY

更新日期：2020-06-01 00:00:00

abstract：:Hypothermia is an effective neuroprotective treatment for brain injury caused by intracerebral hemorrhage (ICH). It is reported to reduce brain edema and neuronal cell death. Thrombin, a coagulation protease released from blood clots, is critical in brain edema formation following ICH. Protease activated receptor‑1 (P...

journal_title：Molecular medicine reports

authors： Gao D,Ding F,Lei G,Luan G,Zhang S,Li K,Wang D,Zhang L,Dai D

更新日期：2015-04-01 00:00:00

abstract：:The present study aimed to identify the differentially expressed genes (DEGs) between lung adenocarcinoma and normal lung tissues, and between lung squamous cell carcinoma and normal lung tissues, with the purpose of identifying potential biomarkers for the treatment of lung cancer. The gene expression profile (GSE604...

journal_title：Molecular medicine reports

authors： Lu C,Chen H,Shan Z,Yang L

更新日期：2016-08-01 00:00:00

abstract：:Paraquat is a highly toxic pesticide, which often causes pulmonary interstitial fibrosis after poisoning, and there is no specific antidote. At present, limited studies have reported that tacrolimus, as an immunosuppressant, can inhibit pulmonary fibrosis, but the specific mechanism remains unknown. The aim of the pre...

journal_title：Molecular medicine reports

authors： Ren Y,Jian X,Zhang Z,Ning Q,Kan B,Kong L

更新日期：2020-11-01 00:00:00

abstract：:Growing evidence indicates that cyclin dependent kinases regulatory subunit 2 (CKS2) serves an essential role in the regulation of multiple cellular processes in diverse human cancer types. The present study investigated the contribution of CKS2 to breast cancer (BC) progression. In the present study, CKS2 expression ...

journal_title：Molecular medicine reports

authors： Huang N,Wu Z,Hong H,Wang X,Yang F,Li H

更新日期：2019-06-01 00:00:00

abstract：:Hepatoblastoma (HB) is the most common type of pediatric liver malignancy, which predominantly occurs in young children (aged <5 years), and continues to be a therapeutic challenge in terms of metastasis and drug resistance. As a new pattern of tumor blood supply, vasculogenic mimicry (VM) is a channel structure lined...

journal_title：Molecular medicine reports

authors： Zhang F,Zhang CM,Li S,Wang KK,Guo BB,Fu Y,Liu LY,Zhang Y,Jiang HY,Wu CJ

更新日期：2018-01-01 00:00:00

abstract：:The baseline concentration of C-reactive protein (CRP) has been associated with a wide array of human diseases. In epidemiological studies and in the clinic, CRP is typically measured as a pentamer, composed of 5 identical CRP subunits. The present study aimed to determine whether other isoforms were present in the bl...

journal_title：Molecular medicine reports

authors： Li Q,Xu W,Xue X,Wang Q,Han L,Li W,Lv S,Liu D,Richards J,Shen Z,Ma L,Song Q

更新日期：2016-12-01 00:00:00

abstract：:While most cancer types are resistant to mammalian target of rapamycin complex 1 (mTORC1) inhibitor rapamycin, recent studies have identified mTORC2 as an important prospective therapeutic target for cancer. The present study assessed the effects of mTORC2 inhibitor PP242 on the proliferation and migration of bladder ...

journal_title：Molecular medicine reports

authors： Zhang Z,Zhang G,Kong C,Gong D

更新日期：2016-01-01 00:00:00

abstract：:Trefoil factor 3 (TFF3) serves an important role in intestinal mucosal damage and healing, and contributes to the pathogenesis and treatment of inflammatory bowel disease (IBD). The aim of the present study was to determine the association between TFF3 and microRNA‑7‑5p (miR‑7‑5p) in IBD. Tissue immunohistochemistry w...

journal_title：Molecular medicine reports

authors： Guo J,Sun M,Teng X,Xu L

更新日期：2017-08-01 00:00:00

abstract：:Chronic microglial activation endangers neuronal survival through the release of various pro-inflammatory and neurotoxic factors. As such, negative regulators of microglial activation have been considered as potential therapeutic candidates to reduce the risk of neurodegeneration associated with inflammation. Uncaria ...

journal_title：Molecular medicine reports

authors： Jung HY,Nam KN,Woo BC,Kim KP,Kim SO,Lee EH

更新日期：2013-01-01 00:00:00

abstract：:Glucocorticoids (GCs) are important stress hormones, which are used as a concomitant medication during malignant tumor chemotherapy. Clinical and preclinical studies have linked GCs to melanoma growth and progression. However, the effects and mechanism of action of GCs on the adhesion and survival of melanoma cells ar...

journal_title：Molecular medicine reports

authors： Huang GX,Qi MF,Li XL,Tang F,Zhu L

更新日期：2018-02-01 00:00:00

abstract：:In order to observe the effects of cyclin E gene silencing by small interfering RNA (siRNA) on the growth, proliferation, invasion and apoptosis of esophageal cancer cell lines, including EC9706, Eca109 and KYSE30, siRNA vectors targeting cyclin E gene were constructed and then tran...

journal_title：Molecular medicine reports

authors： Wang N,Li M,Zang WQ,Ma YY,Wang YY,Zhao GQ

更新日期：2013-03-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been demonstrated to be significant in numerous biological processes. Hypertension is a form of cardiovascular disease with at least one billion cases worldwide. The present study sought to compare the differential expression profiles of lncRNAs in the renal cortex of spontaneously ...

journal_title：Molecular medicine reports

authors： Hou L,Lin Z,Ni Y,Wu Y,Chen D,Song L,Huang X,Hu H,Yang D

更新日期：2016-01-01 00:00:00

abstract：:Previous genome-wide association studies have demonstrated that single nucleotide polymorphisms in T‑box (TBX)5 are associated with increased susceptibility to atrial fibrillation (AF), and a recent study has causally linked a TBX5 mutation to atypical Holt-Oram syndrome and paroxysmal AF. However, the prevalence and ...

journal_title：Molecular medicine reports

authors： Guo DF,Li RG,Yuan F,Shi HY,Hou XM,Qu XK,Xu YJ,Zhang M,Liu X,Jiang JQ,Yang YQ,Qiu XB

更新日期：2016-05-01 00:00:00