Distinct roles of two alternative splice variants of matrilin-2 in protein oligomerization and proteolysis.

abstract：:Acute lung injury (ALI) is a common complication following intestinal ischemia/reperfusion (I/R) and is a major contributing factor to its high mortality rate. Sirtuin 1 (SIRT1), a NAD+-dependent deacetylase, has been reported to have an important role in apoptosis inhibition, oxidative stress resistance and cell life...

journal_title：Molecular medicine reports

authors： Zhang F,Li ZL,Xu XM,Hu Y,Yao JH,Xu W,Jing HR,Wang S,Ning SL,Tian XF

更新日期：2015-01-01 00:00:00

abstract：:The clinical significance of microRNA (miR)‑136‑5p in hepatocellular carcinoma (HCC) has not been verified. Therefore, in the current study, the authors aimed to explore miR‑136‑5p expression and its clinical significance in HCC, as well as to investigate its potential target genes function. The authors detected the l...

journal_title：Molecular medicine reports

authors： Ding H,Ye ZH,Wen DY,Huang XL,Zeng CM,Mo J,Jiang YQ,Li JJ,Cai XY,Yang H,Chen G

更新日期：2017-10-01 00:00:00

abstract：:A total of 60 breast cancer (BC) tissues and adjacent healthy tissues from patients who underwent surgery in Renmin Hospital of Wuhan University were collected for analysis in the present study. Results from reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) demonstrated that, compared with the adj...

journal_title：Molecular medicine reports

authors： Xu W,Wang W

更新日期：2018-06-01 00:00:00

abstract：:Non‑alcoholic fatty liver disease (NAFLD) is the most common fatty liver disease in developed countries, in which fat accumulation in the liver is induced by non‑alcoholic factors. The present study was conducted to identify NAFLD‑associated long non‑coding RNAs (lncRNAs), mRNAs and microRNAs (miRNAs). The microarray ...

journal_title：Molecular medicine reports

authors： Wu H,Song X,Ling Y,Zhou J,Tao Z,Shen Y

更新日期：2019-04-01 00:00:00

abstract：:Promoter hypermethylation is a marginal approach to inactivating tumor suppressor genes in cancer. DNA hypermethylation is a well-recognized epigenetic malfunction observed in several malignancies, most predominantly in prostate cancer. Aberrant DNA methylation patterns are considered to be the earliest somatic genome...

journal_title：Molecular medicine reports

authors： Syeed N,Syed Sameer A,Hamid A,Shah ZA,Afroze D,Rasool R,Siddiqi MA

更新日期：2010-09-01 00:00:00

abstract：:Caffeine is one of the most widely consumed substances found in beverages, and has demonstrated anticancer effects in several types of cancer. The present study aimed to examine the anticancer effects of caffeine on gastric cancer (GC) cells (MGC‑803 and SGC‑7901) in vitro, and to determine whether the apoptosis‑relat...

journal_title：Molecular medicine reports

authors： Liu H,Zhou Y,Tang L

更新日期：2017-09-01 00:00:00

abstract：:The present study investigated the effect of microRNA (miR)‑15a‑3p on the proliferation, migration and apoptosis of lens epithelial cells and its potential mechanism, in order to further elucidate the pathogenesis of age‑related cataracts (ARCs). The HLE‑B3 human lens epithelial cell line was transfected with miR‑15a‑...

journal_title：Molecular medicine reports

authors： Liu SJ,Wang WT,Zhang FL,Yu YH,Yu HJ,Liang Y,Li N,Li YB

更新日期：2019-02-01 00:00:00

abstract：:Ischemic stroke is one of the leading causes of mortality and disability worldwide. However, there is a current lack of effective therapies available. As the resident macrophages of the brain, microglia can monitor the microenvironment and initiate immune responses. In response to various brain injuries, such as ische...

journal_title：Molecular medicine reports

authors： Jiang CT,Wu WF,Deng YH,Ge JW

更新日期：2020-05-01 00:00:00

abstract：:Chronic bacterial prostatitis (CBP) is a persistent infection of the prostate characterized by poor quality of life mainly due to frequent relapse episodes caused by incomplete eradication of causative pathogens. Aggressive antibacterial therapy is required to attenuate the severe symptoms of CBP and to achieve a perm...

journal_title：Molecular medicine reports

authors： Perletti G,Skerk V,Magri V,Markotic A,Mazzoli S,Parnham MJ,Wagenlehner FM,Naber KG

更新日期：2011-11-01 00:00:00

abstract：:Embryonic stem cells (ESCs) are pluripotent stem cells derived from early stage embryos. It remains unclear whether inhibiting the Wnt/β‑catenin signaling pathway using dickkopf Wnt signaling pathway inhibitor 1 (DKK1) impacts on the differentiation potential of mouse ESCs in vitro and in vivo. In the present study, i...

journal_title：Molecular medicine reports

authors： Ou L,Fang L,Tang H,Qiao H,Zhang X,Wang Z

更新日期：2016-01-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress plays a key role in the development of neurodegenerative diseases, including Parkinson's disease (PD). Sulforaphane (SF) is a natural drug derived from isothiocyanate found in cruciferous vegetables. Although there are reports indicating that SF is ...

journal_title：Molecular medicine reports

authors： Deng C,Tao R,Yu SZ,Jin H

更新日期：2012-07-01 00:00:00

abstract：:The present study hypothesized that caffeic acid (3,4‑dihydroxycinnamic acid; CaA) may exert antidepressant‑like effects in rats with chronic unpredictable mild stress via epigenetic mechanisms, such as DNA methylation and hydroxymethylation. The chronic unpredictable mild stress (CUMS) model was used to analyze the e...

journal_title：Molecular medicine reports

authors： Hu J,Cao S,Zhang Z,Wang L,Wang D,Wu Q,Li L

更新日期：2020-12-01 00:00:00

abstract：:Galectin-3 is an important mediator of cardiac fibrosis and heart failure. Cell viability of cardiomyocytes was measured using a CCK‑8 assay; flow cytometry was employed for the detection of the cell cycle and cardiomyocytes apoptosis. Reverse transcription‑quantitative polymerase chain reaction and western blotting w...

journal_title：Molecular medicine reports

authors： Li X,Tang X,Lu J,Yuan S

更新日期：2018-03-01 00:00:00

abstract：:Previous studies have suggested that the B‑cell lymphoma 2 (Bcl‑2) inhibitor, TW37, may induce apoptosis of the non‑small cell lung cancer cell line, H1975/epidermal growth factor receptor‑tyrosine kinase inhibitor (EGFR‑TKI), which exhibits secondary resistance to EGFR‑TKI. However, the effects of TW37 on H1975/EGFR‑...

journal_title：Molecular medicine reports

authors： Liu J,Yao X,Wu D,Ye Y,Wu Q,Liu S,Wu H

更新日期：2018-02-01 00:00:00

abstract：:N-acetyl cysteine (NAC) has been extensively reported to exert neuroprotective effects on the central nervous system. Oxidative stress may contribute to the underlying mechanisms causing Alzheimer's disease (AD). The effect of NAC against oxidative stress injury was investigated in a cellular model of AD in the presen...

journal_title：Molecular medicine reports

authors： Wu W,Liu BH,Xie CL,Xia XD,Zhang YM

更新日期：2018-05-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is commonly considered to occur as a result of disturbance of the immune system. T-box expressed in T cells (T-bet) is an essential transcription factor for T helper (Th) cell differentiation and function. The aim of this study was to investigate the effect of T-bet overexpres...

journal_title：Molecular medicine reports

authors： Liu X,Tang Z,Zhang Y,Hu J,Li D,Zang G,Yu Y

更新日期：2012-08-01 00:00:00

abstract：:Pirarubicin is frequently used in chemotherapy against tumors. However, clinical use is severely limited by the development of progressive dose-dependent cardiomyopathy and acquired drug resistance. LY294002 is a commonly used pharmacologic inhibitor, which selectively inhibits the phosphoinositide 3-kinase-AKT nexus....

journal_title：Molecular medicine reports

authors： Long XH,Zhong ZH,Peng AF,Zhu LB,Wang H,Zhang GM,Liu ZL

更新日期：2014-12-01 00:00:00

abstract：:Giant cell tumor (GCT) is an aggressive type of bone tumor consisting of multinucleated osteoclast-like giant cells. Imatinib is a selective inhibitor for certain type III tyrosine kinase receptor family members with a variety of beneficial effects. The purpose of the present study was to determine the therapeutic pot...

journal_title：Molecular medicine reports

authors： Liao Y,Lv G,Wang B,Kuang L,Wang X

更新日期：2016-02-01 00:00:00

abstract：:Physical exercise is beneficial for the functional recovery of neurons after stroke. It has been suggested that exercise regulates proliferation and differentiation of endogenous neural stem cells (NSCs); however, the underlying molecular mechanisms are still largely unknown. In the present study, the aim was to inves...

journal_title：Molecular medicine reports

authors： Liu W,Wu W,Lin G,Cheng J,Zeng Y,Shi Y

更新日期：2018-08-01 00:00:00

abstract：:A few patients have been shown to develop severe abdominal pain and gastrointestinal dysmotility during treatment with gonadotropin‑releasing hormone (GnRH) analogs. A rat model of enteric neuropathy has been developed by administration of the GnRH analog buserelin to rats. Loss of enteric neurons and ganglioneuritis ...

journal_title：Molecular medicine reports

authors： Jönsson A,Sand E,Ekblad E,Ohlsson B

更新日期：2016-04-01 00:00:00

abstract：:Emerging evidence has suggested that intermedin (IMD), a novel member of the calcitonin gene‑related peptide (CGRP) family, has a wide range of cardioprotective effects. The present study investigated the effects of long‑term administration of IMD on cardiac function and sympathetic neural remodeling in heart failure ...

journal_title：Molecular medicine reports

authors： Xu B,Xu H,Cao H,Liu X,Qin C,Zhao Y,Han X,Li H

更新日期：2017-08-01 00:00:00

abstract：:The high risk of developing colorectal carcinoma (CRC), from ulcerative colitis (UC), is well known. Macrophages are widely distributed immune cells that have an indispensable role in UC, as well as in CRC. However, little is currently known about the dynamic changes that occur in macrophage and M1/M2 macrophage subpo...

journal_title：Molecular medicine reports

authors： Wang W,Li X,Zheng D,Zhang D,Peng X,Zhang X,Ai F,Wang X,Ma J,Xiong W,Li G,Zhou Y,Shen S

更新日期：2015-04-01 00:00:00

abstract：:Plants or herb extracts have emerged as a novel approach to controling various diseases, including cancers. Among them, Pulsatilla koreana extract (PKE) has been widely used as an anti-inflammatory agent and for treating dysentery in traditional Korean and Chinese medicine. However, the effect of PKE as a cancer drug ...

journal_title：Molecular medicine reports

authors： Park BH,Jung KH,Son MK,Seo JH,Lee HS,Lee JH,Hong SS

更新日期：2013-01-01 00:00:00

abstract：:Sepsis is a systemic inflammatory response resulting from the excessive production of pro-inflammatory cytokines, including tumor necrosis factor (TNF)‑α. Sirtuin 1 (SirT1) actively deacetylates histone proteins, and facilitates chromatin compaction and gene silencing. In the present study, a cell model of sepsis, com...

journal_title：Molecular medicine reports

authors： Chen GD,Yu WD,Chen XP

更新日期：2016-12-01 00:00:00

abstract：:The sonic hedgehog (SHH) morphogen regulates cell differentiation and controls a number of genes during renal morphogenesis. To date, the effects of SHH on fibroblast growth factors (Fgfs) in embryonic kidney development remain unclear. In the present study, explants of BALB/c mouse embryonic kidney tissues were used ...

journal_title：Molecular medicine reports

authors： Chen X,Hou XM,Fan YF,Jin YT,Wang YL

更新日期：2016-10-01 00:00:00

abstract：:S100 calcium binding protein A16 (S100A16) is the most recent member of the S100 calcium-binding protein family. The function of S100A16 has been associated with various types of cancer; however, its role in colorectal cancer (CRC) remains unknown. Therefore, the aim of the present study was to investigate the role of...

journal_title：Molecular medicine reports

authors： Ou S,Liao Y,Shi J,Tang J,Ye Y,Wu F,Wang W,Fei J,Xie F,Bai L

更新日期：2021-02-01 00:00:00

abstract：:Dyslipidemia is an important risk factor for myocardial infarction (MI). We previously showed that gene polymorphisms associated with MI differed among individuals with different lipid profiles. We also showed that rs6929846 of BTN2A1 and rs2569512 of ILF3 were significantly associated with MI in Japanese individuals....

journal_title：Molecular medicine reports

authors： Yoshida T,Kato K,Oguri M,Horibe H,Kawamiya T,Yokoi K,Fujimaki T,Watanabe S,Satoh K,Aoyagi Y,Tanaka M,Yoshida H,Shinkai S,Nozawa Y,Yamada Y

更新日期：2011-05-01 00:00:00

abstract：:Colorectal cancer has become a disease with one of the highest incidence rates worldwide, and liver metastasis threatens the prognosis of colorectal cancer. MicroRNA (miR)‑200 and miR‑141 have been confirmed to be aberrantly expressed in colorectal cancer, however, whether miR‑200 and miR‑141 are involved in the progr...

journal_title：Molecular medicine reports

authors： Ding M,Zhang T,Li S,Zhang Y,Qiu Y,Zhang B

更新日期：2017-11-01 00:00:00

abstract：:Cryoinjury, or injury caused by extremely low temperatures, can occur in corneal endothelial cells (CECs) and lead to visual impairment. However, the mechanism of cryoinjury in CECs is not clear. The Stk11‑p53 signaling pathway regulates the proliferation and division of cells. Activity of the Stk11‑p53 signaling path...

journal_title：Molecular medicine reports

authors： Zhao S,Fei X,Liu T,Liu Y

更新日期：2015-11-01 00:00:00

abstract：:Nuclear factor-κB (NF-κB) is involved in the regulation of inflammation‑associated genes. NF-κB forms dimers which bind with sequences referred to as NF-κB sites (9-11 bp). A disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 (ADAMTS9) is a type of proteoglycanase, which proteolytically cleaves ...

journal_title：Molecular medicine reports

authors： Altuntas A,Halacli SO,Cakmak O,Erden G,Akyol S,Ugurcu V,Hirohata S,Demircan K

更新日期：2015-07-01 00:00:00