Imatinib promotes apoptosis of giant cell tumor cells by targeting microRNA-30a-mediated runt-related transcription factor 2.

abstract：:Curcumin is a well‑known phenolic substance and has many pharmacological effects associated with metabolism. However, the exact molecular mechanisms underlying this process have yet to be determined. The Notch pathway is a signal transduction pathway involved in energy metabolism. The present study aimed to investigat...

journal_title：Molecular medicine reports

authors： Zhao NJ,Liao MJ,Wu JJ,Chu KX

更新日期：2018-01-01 00:00:00

abstract：:Previous studies have suggested that the B‑cell lymphoma 2 (Bcl‑2) inhibitor, TW37, may induce apoptosis of the non‑small cell lung cancer cell line, H1975/epidermal growth factor receptor‑tyrosine kinase inhibitor (EGFR‑TKI), which exhibits secondary resistance to EGFR‑TKI. However, the effects of TW37 on H1975/EGFR‑...

journal_title：Molecular medicine reports

authors： Liu J,Yao X,Wu D,Ye Y,Wu Q,Liu S,Wu H

更新日期：2018-02-01 00:00:00

abstract：:The present study aimed to investigate the role of S100B in the inflammation process during osteoarthritis (OA). OA cartilage samples were collected for S100B expression analysis. S100B expression levels were significantly increased in patients with OA compared with the Controls (1.28±0.66 vs. 0.42±0.31; P=0.01) and w...

journal_title：Molecular medicine reports

authors： Zhu L,Weng Z,Shen P,Zhou J,Zeng J,Weng F,Zhang X,Yang H

更新日期：2018-12-01 00:00:00

abstract：:Nestin, a type-VI intermediate filament protein, serves as a marker for neural stem cells, and is also known to be expressed in follicle stem cells. Hair follicles go through repeated cycles of anagen (growth), catagen (regression) and telogen (quiescence) throughout the life of mammals following morphogenesis. In the...

journal_title：Molecular medicine reports

authors： Chen R,Miao Y,Hu Z

更新日期：2019-01-01 00:00:00

abstract：:As the resident macrophages of the brain's innate immune system, microglial cells are key modulators in the neurodegenerative disease Alzheimer's disease (AD). In particular, the activation and accumulation of microglial cells around amyloid plaques is considered to result in chronic neuroinflammation. Although the pa...

journal_title：Molecular medicine reports

authors： Chen PL,Wang WJ,Rao YQ,Li J,Cheng MJ

更新日期：2018-04-01 00:00:00

abstract：:The aim of the present study was to determine whether pyrroloquinoline quinine (PQQ) exerts a protective effect on ultraviolet A (UVA) irradiation‑induced senescence in human dermal fibroblasts (HDFs) and to elucidate its mechanism of action in vitro. A senescence model was constructed as follows: HDFs (1x10(4)‑1x10(6...

journal_title：Molecular medicine reports

authors： Zhang C,Wen C,Lin J,Shen G

更新日期：2015-09-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD), common in elderly patients, refers to a decline in cognitive function following surgery, which may persist or even evolve into Alzheimer's disease (AD). Despite great efforts, the mechanism of POCD remains unclear. In the present study, we tested the hypothesis that Toll-lik...

journal_title：Molecular medicine reports

authors： Wang Y,He H,Li D,Zhu W,Duan K,Le Y,Liao Y,Ou Y

更新日期：2013-04-01 00:00:00

abstract：:Oxidative stress serves important roles in cardiac injury during the process of ischemia/reperfusion (I/R). Y‑box protein 1 (YB1), a member of the highly conserved Y‑box protein family, is closely associated with inflammation and stress responses by regulating gene transcription, RNA splicing and mRNA translation. How...

journal_title：Molecular medicine reports

authors： Wang S,He F,Li Z,Hu Y,Huangfu N,Chen X

更新日期：2019-06-01 00:00:00

abstract：:The poor prognosis of non‑small cell lung cancer (NSCLC) is related to epithelial‑mesenchymal transition (EMT). Recent studies demonstrated that non‑coding RNA activated by DNA damage (NORAD) displays a carcinogenic effect and targets microRNA (miR)‑422a, which may be involved in tumor cell migration and invasion. The...

journal_title：Molecular medicine reports

authors： Chen Z,Che Q,Xie C

更新日期：2021-02-01 00:00:00

abstract：:Antimycin A (AMA) is an inhibitor of the electron transport chain in mitochondria. In this study, we investigated the anti-apoptotic effects of pan-caspase inhibitor (Z-VAD), superoxide dismutase (SOD) or catalase on AMA-induced HeLa cell death in relation to the cell cycle. Treatment with Z-VAD, SOD or catalase rescu...

journal_title：Molecular medicine reports

authors： Han YH,Kim SH,Kim SZ,Park WH

更新日期：2009-03-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) exert regulatory functions on various biological processes in cancer cells, including proliferation, apoptosis and mobility. Prostate cancer-associated transcript 1 (PCAT-1) is a novel lncRNA that promotes cell proliferation in prostate cancer, however, the effect of PCAT‑1 in hepatocell...

journal_title：Molecular medicine reports

authors： Wen J,Xu J,Sun Q,Xing C,Yin W

更新日期：2016-05-01 00:00:00

abstract：:Keloids are a skin fibrotic disease that cause a number of problems for reconstructive surgeons. MicroRNAs (miRs) are crucial for the development of keloids. The present study aimed to investigate the function of the miR‑194‑5p/nuclear receptor subfamily 2 group F member 2 (NR2F2) interactome in human keloid fibroblas...

journal_title：Molecular medicine reports

authors： Xu Q,Jiang S

更新日期：2021-01-01 00:00:00

abstract：:DNA methylation and hydroxymethylation are the most common epigenetic modifications associated with the cell cycle and the inflammatory response. The present study aimed to investigate the role of 5‑hydroxymethyl‑cytosine (5‑hmC) and ten‑eleven translocation‑2 (TET2) in keratinocytes. Following TET2 knockdown, dot blo...

journal_title：Molecular medicine reports

authors： Liu X,Wang X,Liu N,Zhu K,Zhang S,Duan X,Huang Y,Jin Z,Jaypaul H,Wu Y,Chen H

更新日期：2020-04-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by the presence of the BCR‑ABL1 fusion gene, a constitutively active, oncogenic tyrosine kinase that is responsible for the clinical features of CML. Tyrosine kinase inhibitors, such as imatinib, have markedly altered the treatment of CML. Ho...

journal_title：Molecular medicine reports

authors： Mehlig LM,Garve C,Tauer JT,Suttorp M,Bauer A

更新日期：2015-04-01 00:00:00

abstract：:Human parvovirus B19 (B19V) infection has symptoms similar to those of anti‑phospholipid syndrome (APS). Antibodies against B19V‑VP1 unique region (VP1u) exhibit activity similar to that of anti‑phospholipid antibodies (aPLs) by inducing vascular endothelial cell adhesion factors and APS‑like syndrome. Previous studie...

journal_title：Molecular medicine reports

authors： Su CC,Hsu TC,Hsiao CH,Chiu CC,Tzang BS

更新日期：2020-03-01 00:00:00

abstract：:Hepatitis C virus (HCV)‑encoded protein p7 is a viroporin that acts as an ion channel and is indispensable for HCV particle production. Although the main target of HCV p7 is the endoplasmic reticulum, it also targets mitochondria. HCV‑infected cells show mitochondrial depolarization and ATP depletion; however, the fun...

journal_title：Molecular medicine reports

authors： You DG,Lee HR,Kim WK,Kim HJ,Lee GY,Yoo YD

更新日期：2017-12-01 00:00:00

abstract：:The present study aimed to investigate genes and transcription factors (TFs) that may contribute to neuroblastoma (NB) development. The GSE78061 dataset that included 25 human NB cell lines and four retinal pigment epithelial cell lines was used to analyze differentially expressed genes (DEGs) between groups. Function...

journal_title：Molecular medicine reports

authors： Liu J,Li Y

更新日期：2019-10-01 00:00:00

abstract：:Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) is toxic against transformed tumor cells. Cornification is the terminal differentiation of keratinocytes and a specific form of programmed cell death caused by TRAIL that occurs in keratinocytes. Apoptosis can also be triggered when TRAIL induces expressi...

journal_title：Molecular medicine reports

authors： Kim SW,Park SY

更新日期：2016-01-01 00:00:00

abstract：:The aims of the current study were to systematically analyze the regulation of the expression of NALP3 by the P2X7 receptor in P388D1 murine macrophage‑like cells, and to investigate the association between the P2X7 receptor and the NALP3 at the molecular level. Cell culture, RNA transfection, adenosine triphosphate (...

journal_title：Molecular medicine reports

authors： Chen Z,Jin H,Hou Y,Wang B,Chen C,Yang Z,Ding D,Zuo Y,Ren S

更新日期：2015-02-01 00:00:00

abstract：:The aim of the present study was to predict and identify B‑cell epitopes for mouse tumor necrosis factor‑α (mTNF‑α). DNAStar and BcePred software were used to predict B‑cell epitopes for mTNF‑α. A predicted eight‑branch multiple antigenic polypeptide (MAP) was synthesized and used to immunize BALB/c mice, combined wit...

journal_title：Molecular medicine reports

authors： Zhang J,Cui Y,Wu Y,Wang H,Ke J

更新日期：2017-09-01 00:00:00

abstract：:Ilexonin A is a compound isolated from the root of a plant commonly used in traditional Chinese medicine. The aim of the present study was to investigate the possible protective mechanism of Ilexonin A in rats subjected to occlusion of the middle cerebral artery (MCAO). Transient focal cerebral ischemia was induced by...

journal_title：Molecular medicine reports

authors： Xu AL,Zheng GY,Wang ZJ,Chen XD,Jiang Q

更新日期：2016-04-01 00:00:00

abstract：:The production of reactive oxygen species (ROS) is a common phenomenon in podocyte impairment, which leads to the irreversible progression of chronic kidney diseases, such as diabetic kidney disease (DKD). Previous research has indicated that peroxisome proliferator‑activated receptor γ (PPARγ) coactivator‑1α (PGC‑1α)...

journal_title：Molecular medicine reports

authors： Zhang L,Liu J,Zhou F,Wang W,Chen N

更新日期：2018-03-01 00:00:00

abstract：:MicroRN-143 (miR‑143) has been previously reported to be downregulated in specific types of cancer, including colorectal, bladder, oral squamous cell, pituitary, cervical, nasopharyngeal, lymphoma and prostate cancer. In the present study, the effects of miR-143 on prostate cancer cell migration and invasion were exam...

journal_title：Molecular medicine reports

authors： Wu D,Huang P,Wang L,Zhou Y,Pan H,Qu P

更新日期：2013-08-01 00:00:00

abstract：:Brain‑type glycogen phosphorylase (PYGB) is an enzyme that metabolizes glycogen, whose function is to provide energy for an organism in an emergency state. The present study purposed to investigate the role and mechanism of PYGB silencing on the growth and apoptosis of prostate cancer cells. A cell counting kit‑8 assa...

journal_title：Molecular medicine reports

authors： Wang Z,Han G,Liu Q,Zhang W,Wang J

更新日期：2018-10-01 00:00:00

abstract：:Adrenomedullin (ADM), initially identified in human pheochromocytoma, participates in a wide range of physiological and pathological processes, including vasorelaxation, angiogenesis and apoptosis. Recent studies have reported that ADM protected tumor cells against apoptotic cell de...

journal_title：Molecular medicine reports

authors： Kim JY,Park WD,Lee S,Park JH

更新日期：2012-11-01 00:00:00

abstract：:Chlorotoxin (CTX) is an established blocker of small‑conductance Cl‑ channels and has previously been demonstrated to inhibit the invasion of glioma cells. Buthus martensii Karsch chlorotoxin‑like toxin (BmK CT) is the first chlorotoxin-like peptide. The present study aimed to determine the inhibitory effect of BmK CT...

journal_title：Molecular medicine reports

authors： Sun N,Zhao L,Qiao W,Xing Y,Zhao J

更新日期：2017-05-01 00:00:00

abstract：:Osteosarcoma is the most common malignant bone tumour and the second leading cause of cancer‑related death in children and adolescents. Microwave ablation has an excellent therapeutic effect on bone tumours by instantaneously increasing the temperature in the tumour; however, there is a risk of damaging the surroundin...

journal_title：Molecular medicine reports

authors： Chen L,Wang M,Lin Z,Yao M,Wang W,Cheng S,Li B,Zhang Y,Yin Q

更新日期：2020-08-01 00:00:00

abstract：:Dysregulation of collagen type XII α1 chain (COL12A1) has been found in several cancer types and could be involved in tumor progression. However, its clinical significance in gastric cancer (GC) remains under exploration. Online databases (Gene Expression Omnibus and UALCAN), reverse transcription‑quantitative PCR and...

journal_title：Molecular medicine reports

authors： Jiang X,Wu M,Xu X,Zhang L,Huang Y,Xu Z,He K,Wang H,Wang H,Teng L

更新日期：2019-10-01 00:00:00

abstract：:Circling mice is a mutant model of spontaneous deafness exhibiting degenerated spiral ganglion cells in the cochlea and loss of organ of Corti. The balance between glycinergic inhibition and glutamatergic excitation in the lateral superior olive (LSO) is essential for the detection of interaural level differences. Lon...

journal_title：Molecular medicine reports

authors： Yoo YB,Maskey D,Kim MJ

更新日期：2015-12-01 00:00:00

abstract：:To explore the restraining effect of baicalein and the mitogen-activation protein kinase kinase inhibitor, U0126, on human cervical cell line HeLa proliferation, apoptosis and migration. HeLa cells were treated by different concentrations of baicalein or U0126. A Cell Counting Kit (CCK)‑8 assay was applied to examine ...

journal_title：Molecular medicine reports

authors： Ye H,Zhang Y,Wang Y,Xia J,Mao X,Yu X

更新日期：2017-07-01 00:00:00