Intermedin improves cardiac function and sympathetic neural remodeling in a rat model of post myocardial infarction heart failure.

abstract：:Aberrant epigenetic modification is associated with the development and progression of cancer. Hypermethylation of tumor suppressor gene promoters and cooperative histone modification have been considered to be the primary mechanisms of epigenetic modification. Ovary granulosa cell tumors (GCTs) are relatively rare, a...

journal_title：Molecular medicine reports

authors： Xu Y,Li X,Wang H,Xie P,Yan X,Bai Y,Zhang T

更新日期：2016-09-01 00:00:00

abstract：:Platelet‑rich plasma (PRP) is a promising strategy for intervertebral disc degeneration (IDD). However, the short half‑life of growth factors released from PRP cannot continuously stimulate the degenerated discs. Thus, the present study hypothesized that the combined use of PRP and bone marrow‑derived mesenchymal stem...

journal_title：Molecular medicine reports

authors： Wang SZ,Jin JY,Guo YD,Ma LY,Chang Q,Peng XG,Guo FF,Zhang HX,Hu XF,Wang C

更新日期：2016-04-01 00:00:00

abstract：:Findings of previous studies have revealed that intestinal mucosal mast cells (IMMCs) are involved in small intestinal ischemia‑reperfusion injury (IIRI). However, time-course changes of mast cell counts and mast cell function in this process remain unclear. The present study aimed to observe the number of IMMCs and t...

journal_title：Molecular medicine reports

authors： Ge M,Gan X,Liu D,Zhang W,Gao W,Huang P,Hei Z

更新日期：2013-08-01 00:00:00

abstract：:Recent advances in the treatment of non-small cell lung cancer (NSCLC) with new agents require accurate histological subtyping at diagnosis to avoid the higher risk of an adverse response and to obtain the maximum therapeutic response. However, interobserver variability, tumor heterogeneity and the degree of different...

journal_title：Molecular medicine reports

authors： Hamamoto J,Soejima K,Yoda S,Naoki K,Nakayama S,Satomi R,Terai H,Ikemura S,Sato T,Yasuda H,Hayashi Y,Sakamoto M,Takebayashi T,Betsuyaku T

更新日期：2013-08-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) affect atherosclerosis by regulating the physiological and pathological processes of endothelial cells; however, the role of lncRNA WEE2 antisense RNA 1 (WEE2‑AS1) in arteriosclerosis obliterans (ASO) is not completely understood. The present study aimed to explore the function of lncRNA...

journal_title：Molecular medicine reports

authors： Jiang B,Wang R,Lin Z,Ma J,Cui J,Wang M,Liu R,Wu W,Zhang C,Li W,Wang S

更新日期：2020-12-01 00:00:00

abstract：:The primary cause of breast cancer‑associated mortality is the formation of distant metastasis. During the metastatic process, single tumor cells dissolve from the primary tumor site and undergo various changes in cell adhesion and motility properties. The tumor cells invade the blood stream and travel to different si...

journal_title：Molecular medicine reports

authors： Andergassen U,Schlenk K,Jeschke U,Sommer H,Kölbl A

更新日期：2018-08-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are a potential cell source for the development of therapeutic products. Recent studies have shown that the transplantation of MSCs to damaged organs, including the heart, liver and kidneys, results in the restoration of the damaged tissues. However, the mechanisms underlying this rege...

journal_title：Molecular medicine reports

authors： Cho KA,Ju SY,Ryu KH,Woo SY

更新日期：2009-01-01 00:00:00

abstract：:The hepatitis C virus (HCV) alternate reading frame protein (ARFP or F protein) of the HCV 1b genotype is a double-frameshift product of the HCV core protein (Core). The discovery of HCV F protein challenges various biological functions attributed to Core. However, the specific characteristics of the host cellular imm...

journal_title：Molecular medicine reports

authors： Xu X,Yu X,Deng X,Yue M,Zhang J,Zhu D,Zhou Z,Zhai X,Xu K,Zhang Y

更新日期：2014-02-01 00:00:00

abstract：:The aim of the present study was to report on a complete synthetic approach, namely benzylation-hydrolysis-acylation‑hydrogenation, to the synthesis of regioselectively acylated quercetin analogues using low‑cost rutin as a starting material. Three quercetin analogues, quercetin‑3‑O‑propionate (Q‑pr), quercetin‑3‑O‑bu...

journal_title：Molecular medicine reports

authors： Duan Y,Sun N,Xue M,Wang X,Yang H

更新日期：2017-12-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a common multifactorial disorder characterized by hyperandrogenism, insulin resistance and chronic oligoanovulation. In addition, a number of females with PCOS have ovaries with multiple cysts, an irregular or no menstrual cycle and an imbalance of female hormones compared with norm...

journal_title：Molecular medicine reports

authors： Park JH,Li L,Baek KH

更新日期：2015-09-01 00:00:00

abstract：:Intermittent fasting has been shown to have neuroprotective effects against transient focal cerebral ischemic insults. However, the effects of intermittent fasting on transient global ischemic insult has not been studied much yet. The present study examined effects of intermittent fasting on endogenous antioxidant enz...

journal_title：Molecular medicine reports

authors： Ahn JH,Noh Y,Shin BN,Kim SS,Park JH,Lee TK,Song M,Kim H,Lee JC,Yong JH,Kang IJ,Lee YL,Won MH,Kim JD

更新日期：2018-12-01 00:00:00

abstract：:The tumorigenesis and maintenance of a cancer cells is dependent upon the collaboration of multiple signaling pathways. Signal transducer and activator of transcription 3 (STAT3) and β-catenin are at the center of multiple cancer-associated signaling pathways; therefore, simultaneously targeting STAT3 and β-catenin ma...

journal_title：Molecular medicine reports

authors： Wang XH,Liu MN,Huang P,Xu J,Liu AY,Chen J,Lv CQ,Xu RL

更新日期：2015-08-01 00:00:00

abstract：:Abnormal expression of matrix metalloproteinase 9 (MMP9) is correlated with podocyte epithelial-to---mesenchymal transition (EMT) in diabetic nephropathy (DN). However, the mechanisms underlying this process are not well defined. Site‑specific demethylation may sustain high expression levels of target genes. In the pr...

journal_title：Molecular medicine reports

authors： Ling L,Chen L,Zhang C,Gui S,Zhao H,Li Z

更新日期：2018-04-01 00:00:00

abstract：:Endothelial cell injury caused by reactive oxygen species (ROS) plays a critical role in the pathogenesis of atherosclerosis. Therefore, phytochemicals or antioxidants that inhibit the production of ROS have clinical value for the treatment of atherosclerosis. Rhein is one of the most important active components of rh...

journal_title：Molecular medicine reports

authors： Zhong XF,Huang GD,Luo T,Deng ZY,Hu JN

更新日期：2012-05-01 00:00:00

abstract：:Even though standard treatment options are available for prostate cancer patients, prostate cancer is still a leading cause of death in many Western countries due to drug resistance and recurrence. Immune checkpoint blockade therapy has been proved to be very effective in some melanoma patients, which might dependent ...

journal_title：Molecular medicine reports

authors： Zhou J,Yang T,Liu L,Lu B

更新日期：2017-09-01 00:00:00

abstract：:Theaflavin has been proven to own strong antioxidative capacity; however, the molecular mechanism underlying its protective effect against cerebral ischemia‑reperfusion (I/R) injury remains unclear. Therefore, the present study was designed to elucidate the neuroprotective effects of theaflavin on cerebral I/R injury ...

journal_title：Molecular medicine reports

authors： Li R,Li X,Wu H,Yang Z,Fei L,Zhu J

更新日期：2019-12-01 00:00:00

abstract：:The aim of the present study was to examine the protective effects and mechanism of sika deer (Cervus nippon Temminck) velvet antler polypeptides (VAPs) against MPP+ exposure in the SH‑SY5Y human neuroblastoma cell line. MPP+ cytotoxicity and the protective effects of VAPs on the SH‑SY5Y cells were determined using an...

journal_title：Molecular medicine reports

authors： Xin JL,Zhang Y,Li Y,Zhang LZ,Lin Y,Zheng LW

更新日期：2017-10-01 00:00:00

abstract：:Keloids are benign fibrous overgrowths that occur as a result of abnormal wound healing following cutaneous injury. MicroRNAs (miRNAs/miRs) are short non‑coding RNAs that serve critical roles in numerous important biological processes, such as cell proliferation, differentiation and apoptosis. However, their role in k...

journal_title：Molecular medicine reports

authors： Jian X,Qu L,Wang Y,Zou Q,Zhao Q,Chen S,Gao X,Chen H,He C

更新日期：2019-06-01 00:00:00

abstract：:Our previous study demonstrated that human umbilical cord mesenchymal stem cells (HUMSCs) were capable of differentiation into germ cells in vitro. To assess this potential in vivo, HUMSCs were microinjected into the lumen of seminiferous tubules of immunocompetent mice, which were treated with busulfan to destroy end...

journal_title：Molecular medicine reports

authors： Chen H,Tang QL,Wu XY,Xie LC,Lin LM,Ho GY,Ma L

更新日期：2015-07-01 00:00:00

abstract：:Several studies have noted benign thecoma‑fibroma tumors with positive F‑18 fluorodeoxyglucose (FDG) accumulation mimicking malignant ovarian tumors following F‑18 FDG positron emission tomography (PET). The present study analyzed four cases with false‑positive F‑18 FDG PET/computed tomography (CT) diagnoses of thecom...

journal_title：Molecular medicine reports

authors： Seino H,Ono S,Miura H,Morohashi S,Wu Y,Tsushima F,Takai Y,Kijima H

更新日期：2016-05-01 00:00:00

abstract：:Ampelopsin (AMP), a plant flavonoid, has been reported to inhibit cell growth and/or induce apoptosis in various types of tumor. The aim of the present study was to assess the apoptosis-inducing activity of AMP in A549 human lung adenocarcinoma epithelial cells and the associated underlying mechanism. A549 cells were ...

journal_title：Molecular medicine reports

authors： Chen XM,Xie XB,Zhao Q,Wang F,Bai Y,Yin JQ,Jiang H,Xie XL,Jia Q,Huang G

更新日期：2015-01-01 00:00:00

abstract：:Atorvastatin (Lipitor™) is a lipid‑lowering agent that is widely used in the treatment of cardiovascular diseases. Previous research has largely focused on its cholesterol‑lowering effects; however, a limited number of studies have investigated the actions of atorvastatin on vascular endothelial cells. In the present ...

journal_title：Molecular medicine reports

authors： Zhao WB,Fu H,Chang F,Liu J,Wang J,Li F,Zhao J

更新日期：2019-03-01 00:00:00

abstract：:Resistin, an adipocytokine secreted by fat tissues, has been shown to be associated with increased local and systemic complications in acute pancreatitis (AP). However, the mechanism underlying the effect of resistin in the aggravation of AP remains to be elucidated. The aim of the present study was to investigate the...

journal_title：Molecular medicine reports

authors： Jiang CY,Wang W

更新日期：2017-01-01 00:00:00

abstract：:Excessive bone resorption mediated by osteoclasts may lead to the risk of various lytic bone diseases. In the present study, the effects of I‑BET151, a bromodomain and extra terminal domain protein inhibitor, on osteoclastogenesis in RAW264.7 cells and the underlying mechanism of this process was investigated. Cells w...

journal_title：Molecular medicine reports

authors： Cheng J,Zheng J,Guo N,Zi F

更新日期：2017-12-01 00:00:00

abstract：:Trienones are curcuminoid analogues and are minor constituents in the rhizomes of numerous Curcuma plant species. Studies investigating the biological activities of trienones, particularly their anti‑inflammatory activities, are limited. In the present study, the trienone 1,7‑bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑hepta...

journal_title：Molecular medicine reports

authors： Jansakun C,Chulrik W,Chaichompoo W,Yotmanee P,Lehboon K,Chunglok W,Sattayakhom A,Hiransai P,Kamdee K,Utaipan T,Suksamrarn A,Chunglok W

更新日期：2021-03-01 00:00:00

abstract：:Neuregulin-1 (NRG-1) is a type of epidermal growth factor‑like protein primarily distributed in the nervous and cardiovascular systems. When sepsis occurs, the incidence of cardiac dysfunction in myocardial injury is high and the mechanism is complicated. It directly causes myocardial cell damage, whilst also causing ...

journal_title：Molecular medicine reports

authors： Kang W,Cheng Y,Wang X,Zhou F,Zhou C,Wang L,Zhong L

更新日期：2020-06-01 00:00:00

abstract：:Lower back pain (LBP) is one of the predominant factors contributing to dyskinesia and remains a serious social and economic burden worldwide. Intervertebral disc degeneration (IDD) is the leading cause of LBP; the existing IDD treatments cannot completely prevent IDD. Circular RNAs (circRNAs) are non‑coding RNAs resu...

journal_title：Molecular medicine reports

authors： Li Y,Zhou S,Peng P,Wang X,Du L,Huo Z,Xu B

更新日期：2020-10-01 00:00:00

abstract：:Small non‑coding RNAs from the microRNA family (miRs) are important elements in the posttranscriptional control of gene expression. miRs are known to regulate numerous cellular processes and are of crucial importance during development and in pathological conditions, including tumor initiation and progression. In the ...

journal_title：Molecular medicine reports

authors： Wang F,Sun JY,Zhu YH,Liu NT,Wu YF,Yu F

更新日期：2014-10-01 00:00:00

abstract：:The synergistic mechanism underlying the effects of multi‑component combined drug use for complex diseases remains to be fully elucidated. Microglial activation following ischemia can either affect neural survival or cause neuronal injury. The aim of the present study was to determine the synergistic effect of genipos...

journal_title：Molecular medicine reports

authors： Wang J,Hou J,Lei H,Fu J,Pan Y,Liu J

更新日期：2015-10-01 00:00:00

abstract：:The present study aimed to identify potentially important biomarkers associated with polycystic ovary syndrome (PCOS) by integrating DNA methylation with transcriptome profiling. The transcription (E‑MTAB‑3768) and methylation (E‑MTAB‑3777) datasets were retrieved from ArrayExpress. Paired transcription and methylatio...

journal_title：Molecular medicine reports

authors： Liu L,He D,Wang Y,Sheng M

更新日期：2020-05-01 00:00:00