Integrated analysis of DNA methylation and transcriptome profiling of polycystic ovary syndrome.

abstract：:Elevated plasma homocysteine (Hcy), known as hyperhomocysteinemia (HHcy), is an independent risk factor for neurodegenerative diseases. Hcy, even at a low concentration, can promote free radical formation and increase oxidative stress, leading to neuronal death, which may be an important mechanism underlying the patho...

journal_title：Molecular medicine reports

authors： Tian X,Gong L,Jin A,Wang Y,Zhou X,Tan Y

更新日期：2019-09-01 00:00:00

abstract：:MicroRNAs (miRs) can lead to mRNA degradation or inhibit protein translation through directly binding to the 3'‑untranslational region (UTR) of their target mRNAs. Deregulation of miR‑10b has been reported to be associated with chondrosarcoma. However, the role of miR‑10b in chondrosarcoma cell migration and invasion,...

journal_title：Molecular medicine reports

authors： Aili A,Chen Y,Zhang H

更新日期：2016-01-01 00:00:00

abstract：:Neuregulin-1 (NRG-1) is a type of epidermal growth factor‑like protein primarily distributed in the nervous and cardiovascular systems. When sepsis occurs, the incidence of cardiac dysfunction in myocardial injury is high and the mechanism is complicated. It directly causes myocardial cell damage, whilst also causing ...

journal_title：Molecular medicine reports

authors： Kang W,Cheng Y,Wang X,Zhou F,Zhou C,Wang L,Zhong L

更新日期：2020-06-01 00:00:00

abstract：:There is a distinct lack of knowledge on the prevalence of skin disorders in Tuvalu. The aim of the current study was to assess the prevalence of cutaneous diseases and to evaluate access dermatological care in Tuvalu. Cutaneous disorders in the people of Tuvalu between 2009 and 2012 were examined. The most common ski...

journal_title：Molecular medicine reports

authors： Lan LJ,Lien YS,Wang SC,Ituaso-Conway N,Tsai MC,Tseng PY,Yeh YL,Chen CT,Lue KH,Chung JG,Hsiao YP

更新日期：2015-09-01 00:00:00

abstract：:Ovarian hyperstimulation syndrome (OHSS) is a potentially life‑threatening, iatrogenic complication that occurs during assisted reproduction. Polycystic ovarian syndrome (PCOS) significantly increases the risk of OHSS during controlled ovarian stimulation. Therefore, a more effective early prediction technique is requ...

journal_title：Molecular medicine reports

authors： Wu L,Sun Y,Wan J,Luan T,Cheng Q,Tan Y

更新日期：2017-07-01 00:00:00

abstract：:MicroRNA (miR)-22 has previously been reported to be frequently downregulated in certain types of cancer. The present study examined the expression and effects of miR-22 in renal cell carcinoma (RCC). The results indicated that miR‑22 was downregulated in tumor tissue from patients with RCC. In addition, lower miR‑22 ...

journal_title：Molecular medicine reports

authors： Fan W,Huang J,Xiao H,Liang Z

更新日期：2016-06-01 00:00:00

abstract：:Tilianin, the main effective flavonoid monomer enriched from Dracocephalum moldavuca L., has been shown to have cardioprotective effects. However, the mechanism of tilianin cardioprotection remains largely unknown. The present study aimed to investigate the effects of tilianin preconditioning on myocardial ischemia/re...

journal_title：Molecular medicine reports

authors： Guo X,Cao W,Yao J,Yuan Y,Hong Y,Wang X,Xing J

更新日期：2015-03-01 00:00:00

abstract：:The present study aimed to investigate the role of S100B in the inflammation process during osteoarthritis (OA). OA cartilage samples were collected for S100B expression analysis. S100B expression levels were significantly increased in patients with OA compared with the Controls (1.28±0.66 vs. 0.42±0.31; P=0.01) and w...

journal_title：Molecular medicine reports

authors： Zhu L,Weng Z,Shen P,Zhou J,Zeng J,Weng F,Zhang X,Yang H

更新日期：2018-12-01 00:00:00

abstract：:The biochemical events involved in the upregulation of selected glucose‑responsive genes by 3‑O‑methyl‑D‑glucose (3‑MG) remain to be elucidated. The present study mainly aimed to re‑evaluate the possible role of 3‑MG phosphorylation in the upregulation of the thioredoxin interacting protein (TXNIP) and liver pyruvate ...

journal_title：Molecular medicine reports

authors： Svoboda M,Tastenoy M,Zhang Y,Gillet C,Rasschaert J,Malaisse WJ,Sener A

更新日期：2013-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been discovered to have pivotal roles in regulating the drug resistance of various types of human cancer, including cisplatin (DDP) resistance in non-small cell lung cancer (NSCLC). Fewer studies have explored the roles of miR-106a in NSCLC-cell resistance to DDP and its precise molecular mecha...

journal_title：Molecular medicine reports

authors： Ma Y,Li X,Cheng S,Wei W,Li Y

更新日期：2015-01-01 00:00:00

abstract：:Ovarian cancer (OC) is the gynecological malignancy with the highest rate of mortality, and lymphatic metastasis is a critical factor in disease recurrence and prognosis. In the current study, the SKOV-3/LN403 cell line, which has high potential for lymph node metastasis was established as a result of four rounds of s...

journal_title：Molecular medicine reports

authors： Kang Y,Pu T,Cai Q,Hong S,Zhang M,Li G,Zhu Z,Xu C

更新日期：2015-08-01 00:00:00

abstract：:β-crystallin B2 (CRYBB2) knockout mice exhibit morphological and functional abnormalities in the ovary. Long non‑coding RNAs (lncRNAs) regulate gene transcription and translation, and epigenetic modification of genomic DNA. The present study investigated the role of lncRNAs in mediating the effects of CRYBB2 in the re...

journal_title：Molecular medicine reports

authors： Gao Q,Ren H,Chen M,Niu Z,Tao H,Jia Y,Zhang J,Li W

更新日期：2016-11-01 00:00:00

abstract：:Aberrantly expressed microRNAs (miRs) are implicated in the regulation of osteosarcoma (OS) onset and development. Therefore, key miRs in OS must be identified to develop promising and effective therapeutic targets for patients with OS. In the present study, reverse transcription‑quantitative polymerase chain reaction...

journal_title：Molecular medicine reports

authors： Zhou G,Jiang H,Ma L

更新日期：2018-09-01 00:00:00

abstract：:Growth arrest‑specific 5 (GAS5) is a known tumor suppressor which negatively regulates cell survival and malignancy in several cancer cell types. The present study aimed to establish the correlation between GAS5 and unc‑51 like autophagy activating kinase (ULK)1/2, two key regulators of autophagy initiation in breast ...

journal_title：Molecular medicine reports

authors： Li G,Qian L,Tang X,Chen Y,Zhao Z,Zhang C

更新日期：2020-09-01 00:00:00

abstract：:The present study aimed to investigate the protective effects of ghrelin against oxidative stress, inducible nitric oxide synthase (iNOS) and inflammation in a mouse model of myocardial ischemia/reperfusion injury (MIRI). In addition, the study aimed to determine its underlying mechanisms. A mouse model of MIRI was us...

journal_title：Molecular medicine reports

authors： Sun N,Wang H,Wang L

更新日期：2016-09-01 00:00:00

abstract：:Intracranial aneurysm (IA) is a devastating disease, the pathogenesis of which remains to be elucidated. The present study aimed to determine the molecular mechanism of IA and to identify potential therapeutic targets using bioinformatics analysis. The GSE54083 dataset, which includes data from patients with ruptured ...

journal_title：Molecular medicine reports

authors： Wei L,Wang Q,Zhang Y,Yang C,Guan H,Chen Y,Sun Z

更新日期：2018-01-01 00:00:00

abstract：:One of the major reasons for failure after total joint arthroplasty is aseptic loosening of the implant. At articulating surfaces, defined as the interface between implant and surrounding bone cement, wear particles can be generated and released into the periprosthetic tissue, resulting in inflammation and osteolysis....

journal_title：Molecular medicine reports

authors： Jonitz-Heincke A,Lochner K,Schulze C,Pohle D,Pustlauk W,Hansmann D,Bader R

更新日期：2016-08-01 00:00:00

abstract：:Gastric cancer has become a serious disease in the past decade. It has the second highest mortality rate among the four most common cancer types, leading to ~700,000 mortalities annually. Previous studies have attempted to elucidate the underlying biological mechanisms of gastric cancer. The present study aimed to obt...

journal_title：Molecular medicine reports

authors： Qi W,Sun L,Liu N,Zhao S,Lv J,Qiu W

更新日期：2018-10-01 00:00:00

abstract：:Postmenopausal osteoporosis is a common systemic skeletal disease that is associated with estrogen‑deficiency. Bone loss associated with bisphosphonates therapy can increase the risk of developing oral osteonecrosis. Recent studies have indicated that enoxacin may inhibit osteoclast formation and bone resorption via a...

journal_title：Molecular medicine reports

authors： Zhang X,Xu X,Liu X,Mao C,Qin A,Lu E

更新日期：2018-02-01 00:00:00

abstract：:Glioma is the most common and aggressive of malignant brain tumours. MicroRNAs (miRNAs/miRs) are involved in tumour development of various human cancers, including glioma. Therefore, miRNAs may have potential tumour diagnostic, prognostic and therapeutic values in human glioma. miR‑103 is abnormally expressed in vario...

journal_title：Molecular medicine reports

authors： Wang L,Liu Y,Song J

更新日期：2018-03-01 00:00:00

abstract：:The present study aimed to investigate the expression and function of aquaporin (AQP)9 in the intestinal tract of acute liver injury rat models. A total of 20 Sprague Dawley rats were randomly divided into four groups: Normal control (NC) group and acute liver injury groups (24, 48 and 72 h). Acute liver injury rat mo...

journal_title：Molecular medicine reports

authors： Xiang T,Ge S,Wen J,Xie J,Yang L,Wu X,Cheng N

更新日期：2018-12-01 00:00:00

abstract：:The development of pharmaceutical agents possessing anti‑invasive and anti‑metastatic abilities, as well as apoptotic activity, is important in decreasing the incidence and recurrence of oral cancer. Cancer cells are known to acquire invasiveness not only through epigenetic changes, but also from inflammatory stimuli ...

journal_title：Molecular medicine reports

authors： Cho BH,Jung YH,Kim DJ,Woo BH,Jung JE,Lee JH,Choi YW,Park HR

更新日期：2018-02-01 00:00:00

abstract：:BP‑1‑102, a novel inhibitor of signal transducer and activator of transcription 3 (STAT3), exhibits significant antitumor effects in several malignancies in vitro and in vivo. However, its role in gastric cancer (GC) remains to be elucidated. In the present study, the effect and potential molecular mechanisms of BP‑10...

journal_title：Molecular medicine reports

authors： Jiang X,Tang J,Wu M,Chen S,Xu Z,Wang H,Wang H,Yu X,Li Z,Teng L

更新日期：2019-04-01 00:00:00

abstract：:Tumor progression can be affected by various cellular components of tumor cells and/or by tumor microenvironmental factors. The tumor microenvironment comprises a variety of nonmalignant stromal cells and inflammatory cytokines, which are pivotal in tumor promotion and progression. The transforming growth factor‑β (TG...

journal_title：Molecular medicine reports

authors： Liu S,Chen S,Zeng J

更新日期：2018-01-01 00:00:00

abstract：:Moutan cortex, the root bark of Paeonia suffruticosa Andrews (Paeoniaceae), is a traditional Chinese medicine widely used for the treatment of various diseases. In the present study, we examined the antiproliferative effect and apoptosis-inducing activity of paeonol and the crude total glycosides (CTG) extracted from ...

journal_title：Molecular medicine reports

authors： Xing G,Zhang Z,Liu J,Hu H,Sugiura N

更新日期：2010-01-01 00:00:00

abstract：:The present study aimed to identify the mutation causing an atypical syndrome. High-resolution single nucleotide polymorphism (SNP) arrays are considered to be a major detection method for submicroscopic chromosomal rearrangements smaller than 5 Mb in size. Genomic DNA samples of the patient and his parents were conve...

journal_title：Molecular medicine reports

authors： Hu S,Yang Y,Liu L,Tan Z,Zhao T

更新日期：2017-05-01 00:00:00

abstract：:Matrilin-2 (matn2) contains a unique domain, between the second von Willebrand factor A (vWFA) domain and the C-terminal coiled-coil domain, with no sequence homology with other family members. Complementary DNA (cDNA) sequence analysis of matn2 expression in both mice and humans re...

journal_title：Molecular medicine reports

authors： Li L,Zhang L,Shao Y,Wang G,Gong R,Wang Z,Peng J,Wang S,Genochio D,Zhao B,Luo J

更新日期：2012-11-01 00:00:00

abstract：:It was previously demonstrated that microRNA-210 (miR-210) exhibited neuroprotective effects in a murine model of hypoxic-ischemic encephalopathy via inhibition of apoptosis. The aim of the present study was to further elucidate the effect of miR-210 on apoptosis in PC12 cells following transfection with miR-210 inhib...

journal_title：Molecular medicine reports

authors： Qiu J,Zhou XY,Zhou XG,Li Y,Cheng R,Liu HY

更新日期：2015-01-01 00:00:00

abstract：:The present study aimed to investigate the clinical significance of histone methylation in sepsis. A total of 43 blood samples from trauma and esophageal cancer patients with or without sepsis were collected. Immunofluorescence staining of isolated peripheral white blood cells (WBCs) was conducted. Co‑stained 293T cel...

journal_title：Molecular medicine reports

authors： Jiang L,Wang Y,Zhu D,Xue Z,Mao H

更新日期：2016-12-01 00:00:00

abstract：:It has been previously reported that increased expression of coiled‑coil domain containing 34 (CCDC34), a member of the CCDCs family, may promote the proliferation and invasion of bladder cancer cells. However, its role in colorectal cancer (CRC) remains unclear. The present study investigated CCDC34 expression in CRC...

journal_title：Molecular medicine reports

authors： Geng W,Liang W,Fan Y,Ye Z,Zhang L

更新日期：2018-01-01 00:00:00