Theaflavin attenuates cerebral ischemia/reperfusion injury by abolishing miRNA‑128‑3p‑mediated Nrf2 inhibition and reducing oxidative stress.

abstract：:GLI family zinc finger 3 (Gli3), as the upstream transcriptional activator of hedgehog signaling, has previously been demonstrated to participate in the process of liver fibrosis. The present study aimed to investigate the potential functions of microRNA (miR)‑200a and Gli3 in the progression of liver fibrosis. The ex...

journal_title：Molecular medicine reports

authors： Li L,Ran J,Li L,Chen G,Zhang S,Wang Y

更新日期：2020-04-01 00:00:00

abstract：:Core2 β-1,6-N-acetylglucosaminyltransferase (C2GnT) forms an N-acetylglucosamine branch in the O-glycans (core2 O-glycans) of cell surface glycoproteins. We previously revealed that the expression of C2GnT is positively correlated with poor prognosis in prostate cancer patients. However, the detailed mechanisms underl...

journal_title：Molecular medicine reports

authors： Okamoto T,Yoneyama MS,Hatakeyama S,Mori K,Yamamoto H,Koie T,Saitoh H,Yamaya K,Funyu T,Fukuda M,Ohyama C,Tsuboi S

更新日期：2013-02-01 00:00:00

abstract：:The present study aimed to identify the genes directly or indirectly correlated with the amplification of MYCN in neuroblastoma (NB). Microarray data (GSE53371) were downloaded from Gene Expression Omnibus, and included 10 NB cell lines with MYCN amplification and 10 NB cell lines with normal MYCN copy numbers. Differ...

journal_title：Molecular medicine reports

authors： Bao J,Qin L,Cui L,Wang X,Meng Q,Zhu L,Zhang S

更新日期：2015-11-01 00:00:00

abstract：:The aim of the present study was to investigate the preconditioning effect and underlying mechanisms of cobalt-protoporphyrin (CoPP) in a mouse model of liver ischemia‑reperfusion (I/R) injury. Mice were divided into five groups: Sham‑operated (control), I/R, I/R + CoPP, I/R + CoPP and zinc‑protoporphyrin (ZnPP) and I...

journal_title：Molecular medicine reports

authors： Li J,Wu B,Teng D,Sun X,Li J,Li J,Zhang G,Cai J

更新日期：2018-03-01 00:00:00

abstract：:In order to evaluate SCN2A as a candidate gene for epileptic susceptibility and the use of a Cu-Zn superoxide dismutase (SOD) supplement as a potential therapy for epilepsy, SCN2A expression in the cortex and the correlation between SCN2A and Cu-Zn SOD in SH-SY5Y cells were examined. SCN2A expression and the concentra...

journal_title：Molecular medicine reports

authors： Xiang J,Jiang Y

更新日期：2014-01-01 00:00:00

abstract：:Human keratinocytes are located in the outermost skin layer and thus particularly vulnerable to ultraviolet B (UVB) radiation exposure. Previous studies have focused on the cellular and molecular perspectives of UVB-induced keratinocyte damage. In the present study, it was demonstrated that pretreatment with the phyto...

journal_title：Molecular medicine reports

authors： Cha HJ,Lee GT,Lee KS,Lee KK,Hong JT,Lee NK,Kim SY,Lee BM,An IS,Hahn HJ,Ahn KJ,Lee SJ,An S,Bae S

更新日期：2014-09-01 00:00:00

abstract：:Fluid shear stress has been revealed to differentially regulate endothelial nitric oxide synthase (eNOS) distribution in vessels. eNOS, a key enzyme in controlling nitric oxide (NO) release, has a crucial role in mediating oxidative stress, and resveratrol (RSV)‑mediated eNOS also attenuates oxidative damage and suppr...

journal_title：Molecular medicine reports

authors： Wang Z,Zhang J,Li B,Gao X,Liu Y,Mao W,Chen SL

更新日期：2014-10-01 00:00:00

abstract：:B7-H4 is a co‑inhibitory molecule of the B7 family, which is expressed on antigen‑presenting cells (APCs) and is able to limit the T‑cell immune response. Macrophages act as professional APCs and are important for immunoregulation of the tumor microenvironment in breast cancer. In order to identify the association bet...

journal_title：Molecular medicine reports

authors： Liu L,Li D,Chen S,Zhao R,Pang D,Li D,Fu Z

更新日期：2016-09-01 00:00:00

abstract：:Giant cell tumor (GCT) is an aggressive type of bone tumor consisting of multinucleated osteoclast-like giant cells. Imatinib is a selective inhibitor for certain type III tyrosine kinase receptor family members with a variety of beneficial effects. The purpose of the present study was to determine the therapeutic pot...

journal_title：Molecular medicine reports

authors： Liao Y,Lv G,Wang B,Kuang L,Wang X

更新日期：2016-02-01 00:00:00

abstract：:microRNAs (miRNAs) are small, highly conserved, non-coding RNAs that regulate gene expression at the post‑transcriptional level. The expression of these small RNA genes is tightly regulated during development, differentiation and apoptosis of normal cells, however, they are often deregulated in various types of cancer...

journal_title：Molecular medicine reports

authors： Liang G,Li G,Wang Y,Lei W,Xiao Z

更新日期：2014-03-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe disease characterized by immune hyperactivation and cytokine storm. Given the high mortality rate of HLH, there is a need for more effective diagnostic tools and treatments. The present study developed a dendrimer‑based protein biochip for rapid, sensitive ...

journal_title：Molecular medicine reports

authors： Du YX,Ye L,Song ZJ,Lv H,Liu Q,Li SG,Liu SS,Hong J,Gao Y,Schneider ME,Du WD

更新日期：2020-12-01 00:00:00

abstract：:Diabetic muscle atrophy causes a reduction of skeletal muscle size and strength, which affects normal daily activities. However, pulsed electromagnetic fields (PEMFs) can retard the atrophy of type II fibers (ActRIIB) in denervated muscles. Therefore, the purpose of the present study was to determine whether PEMFs can...

journal_title：Molecular medicine reports

authors： Yang J,Sun L,Fan X,Yin B,Kang Y,An S,Tang L

更新日期：2018-07-01 00:00:00

abstract：:Aberrant DNA methylation is the most common type of epigenetic alteration and is associated with many types of cancer. Although previous studies have provided a few novel DNA methylation markers in hepatocellular carcinoma (HCC), specific DNA methylation patterns and comparisons of the aberrant alterations in methylat...

journal_title：Molecular medicine reports

authors： Sun N,Zhang J,Zhang C,Shi Y,Zhao B,Jiao A,Chen B

更新日期：2018-11-01 00:00:00

abstract：:Sulforaphane (SFN) is a naturally occurring chemopreventive agent, which effectively inhibits proliferation of HepG2 human hepatocellular carcinoma cells via mitochondria‑mediated apoptosis. Endoplasmic reticulum stress is considered the most important cause of cell apoptosis; therefore, the present study aimed to det...

journal_title：Molecular medicine reports

authors： Zou X,Qu Z,Fang Y,Shi X,Ji Y

更新日期：2017-01-01 00:00:00

abstract：:Ilexonin A is a compound isolated from the root of a plant commonly used in traditional Chinese medicine. The aim of the present study was to investigate the possible protective mechanism of Ilexonin A in rats subjected to occlusion of the middle cerebral artery (MCAO). Transient focal cerebral ischemia was induced by...

journal_title：Molecular medicine reports

authors： Xu AL,Zheng GY,Wang ZJ,Chen XD,Jiang Q

更新日期：2016-04-01 00:00:00

abstract：:Dengue virus (DENV) causes self‑limiting dengue fever (DF), severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). It is generally considered that cytokine storm leads to the increased plasma leakage characteristic of DHF/DSS. In the present study, peripheral blood m...

journal_title：Molecular medicine reports

authors： Qi Y,Li Y,Zhang L,Huang J

更新日期：2013-03-01 00:00:00

abstract：:Prostate carcinoma (PCa) is one of the most common cancers in men. Prostate-specific antigen (PSA) has been widely used to predict the outcome of PCa and screening with PSA has resulted in a decline in mortality. However, PSA is not an optimal prognostic tool as its sensitivity may be too low to reduce morbidity and m...

journal_title：Molecular medicine reports

authors： Hernandez-Cueto A,Hernandez-Cueto D,Antonio-Andres G,Mendoza-Marin M,Jimenez-Gutierrez C,Sandoval-Mejia AL,Mora-Campos R,Gonzalez-Bonilla C,Vega MI,Bonavida B,Huerta-Yepez S

更新日期：2014-11-01 00:00:00

abstract：:MicroRNA (miR)-185, which has been reported to be abnormally expressed in some types of cancer, exerts significant effects on the proliferation, apoptosis, drug resistance and metastasis of cancer cells. The present study aimed to explore the effects and underlying molecular mechanisms of miR‑185 upregulation on the a...

journal_title：Molecular medicine reports

authors： Fan L,Tan B,Li Y,Zhao Q,Yuan H,Liu Y,Wang D,Zhang Z

更新日期：2018-02-01 00:00:00

abstract：:1,2-Dimethylthdrazine (DMH) has been known to induce vascular neoplasms, such as malignant endothelioma, in animal experiments through the induction of abnormal proliferation of human umbilical vein endothelial cells (HUVECs). We studied the effect of protein kinase C (PKC) isoforms...

journal_title：Molecular medicine reports

authors： Nam S,Choi S,Lee J,Kim J,Song J,Bae Y

更新日期：2012-08-01 00:00:00

abstract：:Pregnancy complications are associated with abnormal cytotrophoblast differentiation and invasion. Hydrogen peroxide (H2O2) is an important mediator of oxidative ischemia/reperfusion stress in the placenta. Lycium barbarum polysaccharides (LBP) have been demonstrated to counteract oxidative free radicals. The effects ...

journal_title：Molecular medicine reports

authors： Li J,Ding Z,Yang Y,Mao B,Wang Y,Xu X

更新日期：2018-09-01 00:00:00

abstract：:Tuberculosis (TB) infections, caused by multidrug‑resistant Mycobacterium tuberculosis (MDR MTB), remain a significant public health concern worldwide. The regulatory mechanisms underlying the emergence of MDR MTB strains remain to be fully elucidated, and further investigation is required in order to develop better s...

journal_title：Molecular medicine reports

authors： Ren N,Gao G,Sun Y,Zhang L,Wang H,Hua W,Wan K,Li X

更新日期：2015-11-01 00:00:00

abstract：:Genistein is an important chemopreventive agent against atherosclerosis and cancer. However, whether genistein is effective in the treatment of lung cancer, and its underlying mechanism, remains to be determined. The present study demonstrated that genistein treatment of A549 lung cancer cells decreased viability in a...

journal_title：Molecular medicine reports

authors： Zhang J,Su H,Li Q,Li J,Zhao Q

更新日期：2017-04-01 00:00:00

abstract：:Prenatal clinical detection of thalassemia involves gap‑PCR and reverse dot blot (RDB) analysis of fetal DNA acquired through invasive methods. The present study aimed to develop a non‑invasive prenatal diagnostic method for thalassemia based on next‑generation sequencing (NGS). A total of eight families with proband ...

journal_title：Molecular medicine reports

authors： Yang X,Ye Y,Fan D,Lin S,Li M,Hou H,Zhang J,Yang X

更新日期：2020-08-01 00:00:00

abstract：:In contrast with mature brain‑derived neurotrophic factor (mBDNF), proBDNF induces cell apoptosis. However, the function of proBDNF in oligodendrocytes remains unclear. In the present study, the OLN‑93 oligodendroglia cell line was utilized as an in vitro model to analyse the functions of proBDNF in oligodendroglia. p...

journal_title：Molecular medicine reports

authors： Liu S,Guo W,Zhou H,Tang L,Feng S,Zhong JH,Zhou XF

更新日期：2018-10-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis is a chronic pulmonary disease that is characterized by formation of scar tissue in lungs. Transforming growth factor-β (TGF-β) is considered an important cytokine in the pathogenesis of this disease. Hence, the antifibrotic effect of an inhibitor of the TGF-β type I receptor, namely, SB ...

journal_title：Molecular medicine reports

authors： Koh RY,Lim CL,Uhal BD,Abdullah M,Vidyadaran S,Ho CC,Seow HF

更新日期：2015-05-01 00:00:00

abstract：:Hypoxia may induce apoptosis and autophagy to promote cardiomyocyte injury. The present study investigated the effect of berberine, a natural extract of Rhizoma Coptidis, on hypoxia‑induced autophagy and apoptosis in the H9c2 rat myocardial cell line. Expression levels of apoptosis and autophagy markers were upregulat...

journal_title：Molecular medicine reports

authors： Jia Z,Lin L,Huang S,Zhu Z,Huang W,Huang Z

更新日期：2017-08-01 00:00:00

abstract：:An increasing amount of evidence indicates that the inhibition of β adrenergic signaling can result in the inhibition of tumor growth. However, the role of propranolol in liver cancer and the underlying mechanism remain to be elucidated. The present study aimed to investigate the role of propranolol in liver cancer ce...

journal_title：Molecular medicine reports

authors： Wang F,Liu H,Wang F,Xu R,Wang P,Tang F,Zhang X,Zhu Z,Lv H,Han T

更新日期：2018-04-01 00:00:00

abstract：:The occurrence and development of hyperglycemia‑induced inflammation is associated with increased expression of receptor for advanced glycation end products (RAGE) and inflammatory factors, including IL‑1β, TNF‑α and IL‑6. Previous studies have reported that the nucleotide‑binding oligomerization domain‑like receptor ...

journal_title：Molecular medicine reports

authors： Jiang M,Wang X,Wang P,Peng W,Zhang B,Guo L

更新日期：2020-10-01 00:00:00

abstract：:Protein 4.1N (4.1N) is a member of the protein 4.1 family and is essential for the regulation of cell adhesion, motility and signaling. Previous studies have suggested that 4.1N may serve a tumor suppressor role. However, the molecular mechanisms remain unclear. In the current study, the role of 4.1N in the downregula...

journal_title：Molecular medicine reports

authors： Zhang L,Hu A,Li M,Zhang H,Ren C,An X,Liu C

更新日期：2016-01-01 00:00:00

abstract：:Gestational diabetes mellitus (GDM) is a type of diabetes mellitus (DM) that occurs during pregnancy. The present study aimed to investigate the roles of microRNA (miR)‑195‑5p and enhancer of zeste homolog 2 (EZH2) in GDM, and their potential association. Human umbilical vein endothelial cells (HUVECs) were collected ...

journal_title：Molecular medicine reports

authors： Liao X,Zhou Z,Zhang X

更新日期：2020-08-01 00:00:00