Role of protein kinase Cµ isoform expression in dimethylhydrazine-induced vascular endothelial proliferation.

abstract：:Lactate is an important metabolite in cellular metabolism and fluctuates in certain disease conditions including cancer and immune diseases. It was hypothesized that a decrease in lactate would modulate the inflammatory response elicited by lipopolysaccharides (LPS) in macrophages. When RAW 264.7 macrophages were trea...

journal_title：Molecular medicine reports

authors： Song YJ,Kim A,Kim GT,Yu HY,Lee ES,Park MJ,Kim YJ,Shim SM,Park TS

更新日期：2019-01-01 00:00:00

abstract：:Wound healing impairment is increasingly recognized to be a consequence of hyperglycemia‑induced dysfunction of endothelial precursor cells (EPCs) in type 2 diabetes mellitus (T2DM). Metformin exhibits potential for the improvement of endothelial function and the wound healing process. However, the underlying mechanis...

journal_title：Molecular medicine reports

authors： Han X,Tao Y,Deng Y,Yu J,Sun Y,Jiang G

更新日期：2017-12-01 00:00:00

abstract：:Bacterial protection and epithelial repair are important against inflammatory bowel disease (IBD). The present study was designed to examine the effects of different bacterial components on the repair of normal and dextran sodium sulfate (DSS)‑treated colonic epithelial cells and the corresponding mechanisms. Human co...

journal_title：Molecular medicine reports

authors： Xu Z,Liao B,Zhang R,Sh R,Wang L

更新日期：2017-08-01 00:00:00

abstract：:Dysregulation of collagen type XII α1 chain (COL12A1) has been found in several cancer types and could be involved in tumor progression. However, its clinical significance in gastric cancer (GC) remains under exploration. Online databases (Gene Expression Omnibus and UALCAN), reverse transcription‑quantitative PCR and...

journal_title：Molecular medicine reports

authors： Jiang X,Wu M,Xu X,Zhang L,Huang Y,Xu Z,He K,Wang H,Wang H,Teng L

更新日期：2019-10-01 00:00:00

abstract：:A subset of cancer stem cells termed 'side population' (SP) cells has been identified in several types of solid tumor and is known to be responsible for the failure of chemotherapy and for cancer relapse. In the present study, the oral squamous cell carcinoma (OSCC) cell line SCC‑55 was used for analysis of the SP cel...

journal_title：Molecular medicine reports

authors： Liu Y,Cui P,Chen J,Li W

更新日期：2015-05-01 00:00:00

abstract：:Skeletal stem cells (SSCs) are a population of progenitor cells which give rise to postnatal skeletal tissues including bone, cartilage and bone marrow stroma, however not to adipose, haematopoietic or muscle tissue. Growth plate chondrocytes exhibit the ability of continuous proliferation and differentiation, which c...

journal_title：Molecular medicine reports

authors： Wu YX,Jing XZ,Sun Y,Ye YP,Guo JC,Huang JM,Xiang W,Zhang JM,Guo FJ

更新日期：2017-12-01 00:00:00

abstract：:Oxidative stress is known to play a key role in the progression of liver disease, including non-alcoholic steatohepatitis (NASH), which is often accompanied by hyperglycemia. This study examined the influence of high glucose on oxidative stress-induced hepatic cell death. Hc cells, a normal human hepatocyte-derived ce...

journal_title：Molecular medicine reports

authors： Shibata H,Ichikawa T,Nakao K,Miyaaki H,Takeshita S,Akiyama M,Fujimoto M,Miuma S,Kanda S,Yamasaki H,Eguchi K

更新日期：2008-05-01 00:00:00

abstract：:Human adipose tissue stem cells (ATSCs) can differentiate into various types of cell in response to lineage-specific induction factors. Reprogramming cells using nuclear and cytoplasmic extracts derived from another type of somatic cell is an effective method of producing specific types of differentiated cell. In the ...

journal_title：Molecular medicine reports

authors： Xie F,Tang X,Zhang Q,Deng C

更新日期：2015-01-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a life-threatening type of stroke. Previous studies have reported that bone marrow mesenchymal stem cells (BMSCs) may exert beneficial effects on the treatment of ICH. However, it remains unknown whether the neuroprotection exerted by BMSCs on ICH is due to the differentiation of BMSC...

journal_title：Molecular medicine reports

authors： Cui C,Cui Y,Gao J,Li R,Jiang X,Tian Y,Wang K,Cui J

更新日期：2017-04-01 00:00:00

abstract：:The present study investigated the effects of hypothyroidism on cyclooxygenase-2 (COX-2) and pro‑inflammatory cytokines in the dentate gyrus to elucidate the roles of COX‑2 in the hypothyroid hippocampus. Hypothyroidism was induced in rats by treating with 0.03% 2‑mercapto‑1‑methyl‑imidazole dissolved in drinking wate...

journal_title：Molecular medicine reports

authors： Nam SM,Kim JW,Yoo DY,Jung HY,Chung JY,Kim DW,Hwang IK,Yoon YS

更新日期：2018-04-01 00:00:00

abstract：:Hypertensive nephrosclerosis (HNS) is a major risk factor for end-stage renal disease. However, the underlying pathogenesis of HNS remains to be fully determined. The gene expression profile of GSE20602, which consists of 14 glomeruli samples from patients with HNS and 4 normal glomeruli control samples, was obtained ...

journal_title：Molecular medicine reports

authors： Liu T,Liu M,Shang P,Jin X,Liu W,Zhang Y,Li X,Ding Y,Li Y,Wen A

更新日期：2018-03-01 00:00:00

abstract：:Studies have shown that the cerebrospinal fluid‑contacting nucleus (CSF‑CN) may be associated with the transduction and regulation of pain signals. However, the role of the CSF‑CN remains to be elucidated. Emerging evidence has suggested that neurokinin 1 receptor (NK1R) is important in the development of visceral pai...

journal_title：Molecular medicine reports

authors： Zhang C,Li Y,Wang X,Fei Y,Zhang L

更新日期：2017-06-01 00:00:00

abstract：:Apoptosis serves a pivotal role in the pathogenesis of osteoarthritis (OA). Increasing evidence has demonstrated that paeoniflorin exerts key properties (including anticancer, anti-inflammation and neuroprotective) for clinical applications. However, the precise role of paeoniflorin in articular cartilage apoptosis re...

journal_title：Molecular medicine reports

authors： Hu PF,Chen WP,Bao JP,Wu LD

更新日期：2018-04-01 00:00:00

abstract：:The present study aimed to examine the status and clinical significance of cluster of differentiation (CD) 19+CD24highCD38high regulatory B cells (Bregs), serum interleukin (IL)‑10, serum transforming growth factor (TGF)‑β and IL‑10 receptor (IL‑10R) expression in peripheral blood from patients with systemic lupus ery...

journal_title：Molecular medicine reports

authors： Wang T,Li Z,Li X,Chen L,Zhao H,Jiang C,Song L

更新日期：2017-11-01 00:00:00

abstract：:In the present study, it was demonstrated that the protein level of the apoptosis inhibitor Aven is regulated by the Akt signaling pathway, evidenced by the observation that Aven levels were significantly increased in MCF7 constitutively active (CA)‑Akt cells and significantly inhibited following treatment with LY2940...

journal_title：Molecular medicine reports

authors： Han KY,Hwang JW,Bae GU,Kim SN,Kim YK

更新日期：2015-05-01 00:00:00

abstract：:Activation of renin-angiotensin system (RAS) is one of the pathological mechanisms associated with myocardial ischemia-reperfusion injury following resuscitation. The present study aimed to determine whether erythropoietin (EPO) improves post‑resuscitation myocardial dysfunction and how it affects the renin‑angiotensi...

journal_title：Molecular medicine reports

authors： Zhou H,Huang J,Zhu L,Cao Y

更新日期：2018-04-01 00:00:00

abstract：:Hepatitis B virus X protein (HBx) has been previously demonstrated to be associated with the regulation of cell proliferation; however, the exact mechanisms underlying this effect remain unclear. The present study aimed to investigate the regulatory mechanism of HBx on the cycle progression of primary renal tubular ep...

journal_title：Molecular medicine reports

authors： Han W,Luo M,He M,Zhu Y,Zhong Y,Ding H,Hu G,Liu L,Chen Q,Lu Y

更新日期：2018-08-01 00:00:00

abstract：:The present study aimed to investigate the role of S100B in the inflammation process during osteoarthritis (OA). OA cartilage samples were collected for S100B expression analysis. S100B expression levels were significantly increased in patients with OA compared with the Controls (1.28±0.66 vs. 0.42±0.31; P=0.01) and w...

journal_title：Molecular medicine reports

authors： Zhu L,Weng Z,Shen P,Zhou J,Zeng J,Weng F,Zhang X,Yang H

更新日期：2018-12-01 00:00:00

abstract：:Specific small interfering RNAs (siRNAs) targeting receptor for advanced glycation end products (RAGE) inhibit the expression of RAGE, α-smooth muscle actin and type I collagen in the T6 hepatic stellate cells (HSCs), indicating that RAGE is important for the activation of HSCs and the expression of collagen. The pres...

journal_title：Molecular medicine reports

authors： Xia JR,Chen TT,Li WD,Lu FL,Liu J,Cai XG,Lu Q,Yang CP

更新日期：2015-07-01 00:00:00

abstract：:Endometriosis is an enigmatic condition with an unknown etiology and a poorly understood pathogenesis. It is considered to appear from the interplay of many genetic and environmental factors, affecting up to 10% of women and represents a major cause of pain and infertility. The familial association of endometriosis, a...

journal_title：Molecular medicine reports

authors： Albertsen HM,Matalliotaki C,Matalliotakis M,Zervou MI,Matalliotakis I,Spandidos DA,Chettier R,Ward K,Goulielmos GN

更新日期：2019-03-01 00:00:00

abstract：:Dendritic cells (DCs) serve crucial roles in the activation of the immune response, and imbalance in the activation or inhibition of DCs has been associated with an increased susceptibility to develop immune‑induced diseases. However, the molecular mechanisms of regulating immune‑induced diseases of DCs are not well u...

journal_title：Molecular medicine reports

authors： Zheng Y,Zheng X,Li S,Zhang H,Liu M,Yang Q,Zhang M,Sun Y,Wu J,Yu B

更新日期：2018-06-01 00:00:00

abstract：:Osteosarcoma (OS) is the most frequent malignant primary bone tumor arising from primitive bone‑forming mesenchymal cells in children and adolescents. The dysregulation of microRNAs (miRNAs) has been reported in OS, and these aberrantly expressed miRNAs are involved in the initiation and progression of OS. The aim of ...

journal_title：Molecular medicine reports

authors： Yang X,Cui Y,Yang F,Sun C,Gao X

更新日期：2017-09-01 00:00:00

abstract：:Sepsis is a serious issue in the geriatric population due to its association with high mortality rates in the elderly. The increase in mortality in the elderly correlates with inflammation. We have previously demonstrated that the inflammatory response is exacerbated in a rodent endotoxemia model of sepsis in aged rat...

journal_title：Molecular medicine reports

authors： Lufrano M,Jacob A,Zhou M,Wang P

更新日期：2013-08-01 00:00:00

abstract：:The tumor suppressor protein LKB1 is a serine/threonine kinase that plays a critical role in cell proliferation, and its inactivation has been linked to tumorigenesis in various cancer types. Current understanding of the LKB1 function is largely restricted to results from experiments on LKB1‑deficient cancer cells, wh...

journal_title：Molecular medicine reports

authors： Liang X,Wang P,Gao Q,Tao X

更新日期：2014-03-01 00:00:00

abstract：:Minimally invasive aesthetic and cosmetic procedures have increased in popularity. Injectable dermal fillers provide soft tissue augmentation, improve facial rejuvenation and wrinkles, and correct tissue defects. To investigate the use of adipose‑derived stem cells integrated with a hyaluronic acid based gel as a derm...

journal_title：Molecular medicine reports

authors： Guo J,Guo S,Wang Y,Yu Y

更新日期：2017-10-01 00:00:00

abstract：:Although Frey syndrome is not life-threatening, it is identified as the most serious and widely recognized sequela of parotidectomy and has significant potential negative social and psychological implications. Several studies have investigated whether AlloDerm® implants prevent Frey syndrome effectively and safely, ho...

journal_title：Molecular medicine reports

authors： Zeng XT,Tang XJ,Wang XJ,Li MZ,Guo Y,Huang W,Niu YM,Leng WD

更新日期：2012-04-01 00:00:00

abstract：:It has previously been demonstrated that phosphatidylinositol-3-kinase (PI3K)/Akt and cleaved caspase-3 serve critical roles in the apoptosis of cardiac myocytes following ischemia/reperfusion injury. Epigallocatechin-3-gallate (EGCG), the predominant catechin component of green tea, has been reported to have potentia...

journal_title：Molecular medicine reports

authors： Zeng X,Tan X

更新日期：2015-08-01 00:00:00

abstract：:A limited number of studies have revealed that adding kidneys to liver perfusion may maintain an improved physiological balance; however, the underlying mechanism remains to be elucidated. The preset study confirmed the protective role of this new model and investigated the underlying mechanisms. Methods: A total of 1...

journal_title：Molecular medicine reports

authors： Li J,Jia J,He N,Jiang L,Yu H,Li H,Peng Y,Xie H,Zhou L,Zheng S

更新日期：2019-08-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is highly prevalent worldwide, and the outcome of HNSCC is still difficult to predict due to the lack of appropriate prognostic markers. In the present study, a prognostic model based on a miRNA panel was established to better predict the survival of HNSCC patients. miRNA ...

journal_title：Molecular medicine reports

authors： Lu L,Wu Y,Feng M,Xue X,Fan Y

更新日期：2019-11-01 00:00:00

abstract：:Caffeine is one of the most widely consumed substances found in beverages, and has demonstrated anticancer effects in several types of cancer. The present study aimed to examine the anticancer effects of caffeine on gastric cancer (GC) cells (MGC‑803 and SGC‑7901) in vitro, and to determine whether the apoptosis‑relat...

journal_title：Molecular medicine reports

authors： Liu H,Zhou Y,Tang L

更新日期：2017-09-01 00:00:00