Abstract:
:In the present study, it was demonstrated that the protein level of the apoptosis inhibitor Aven is regulated by the Akt signaling pathway, evidenced by the observation that Aven levels were significantly increased in MCF7 constitutively active (CA)‑Akt cells and significantly inhibited following treatment with LY294002. This increase in Aven appears not to be mediated by transcriptional regulation and protein stabilization. However, the level of Aven was inversely correlated with the level of cathepsin D, which is a protease responsible for generating the C‑terminal of Aven, ΔN‑Aven, indicating that the level of Aven appears to be regulated by cathepsin D activity. It has previously been reported that ΔN‑Aven is the active form of Aven, which functions as an anti‑apoptotic molecule. Notably, low levels of ΔN‑Aven were detected in MCF7 CA‑Akt cells, which were more sensitive to anticancer drugs. Taken together, the current results suggest that the expression of Aven is regulated by the Akt signaling pathway through cathepsin D activity, which contributes to the sensitivity of cancer cells to chemotherapeutic agents.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Han KY,Hwang JW,Bae GU,Kim SN,Kim YKdoi
10.3892/mmr.2015.3158subject
Has Abstractpub_date
2015-05-01 00:00:00pages
3866-71issue
5eissn
1791-2997issn
1791-3004journal_volume
11pub_type
杂志文章abstract::Idiopathic pulmonary fibrosis is a chronic pulmonary disease that is characterized by formation of scar tissue in lungs. Transforming growth factor-β (TGF-β) is considered an important cytokine in the pathogenesis of this disease. Hence, the antifibrotic effect of an inhibitor of the TGF-β type I receptor, namely, SB ...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2015.3193
更新日期:2015-05-01 00:00:00
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journal_title:Molecular medicine reports
pub_type: 杂志文章,评审
doi:10.3892/mmr.2013.1770
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journal_title:Molecular medicine reports
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journal_title:Molecular medicine reports
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular medicine reports
pub_type: 杂志文章,评审
doi:10.3892/mmr.2015.4001
更新日期:2015-09-01 00:00:00
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journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2016.5401
更新日期:2016-08-01 00:00:00
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journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2015.4064
更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章
doi:10.3892/mmr.2018.9484
更新日期:2018-11-01 00:00:00
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Molecular medicine reports
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2016.5824
更新日期:2016-11-01 00:00:00
abstract::The overexpression and hypersecretion of mucus is a hallmark of several chronic pulmonary inflammatory diseases, including chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis. Mucin 5ac (MUC5AC) is a major component of airway mucus. Annexin II (ANXII) has been reported to be expressed in various c...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2013.1795
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journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2016.5069
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journal_title:Molecular medicine reports
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journal_title:Molecular medicine reports
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doi:10.3892/mmr.2018.8708
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journal_title:Molecular medicine reports
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doi:10.3892/mmr_00000081
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journal_title:Molecular medicine reports
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abstract::Glioblastoma multiforme (GBM) is the most common and malignant brain tumor of the adult central nervous system and is associated with poor prognosis. The present study aimed to identify the hub genes in GBM in order to improve the current understanding of the underlying mechanism of GBM. The RNA‑seq data were download...
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pub_type: 杂志文章
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pub_type: 杂志文章
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