Microarray data analysis of neuroblastoma: Expression of SOX2 downregulates the expression of MYCN.

abstract：:NORAD (non‑coding RNA activated by DNA damage) is a long non‑coding RNA (lncRNA) that is upregulated and promotes cell progression in various human types of cancer; however, its function in non‑small cell lung cancer (NSCLC) remains unclear. The present study investigated the regulatory function and underlying mechani...

journal_title：Molecular medicine reports

authors： Gao W,Weng T,Wang L,Shi B,Meng W,Wang X,Wu Y,Jin L,Fei L

更新日期：2019-06-01 00:00:00

abstract：:The present study aimed to investigate the expression of the Hedgehog (Hh) signaling pathway between microsatellite-unstable (MSI) and microsatellite-unstable (MSS) colorectal cancers (CRCs). A total of 61 samples of CRC tissue and corresponding blood samples were obtained from the surgical department of our hospital....

journal_title：Molecular medicine reports

authors： Hu X,Lai D,Chen W,Zi S,Li J,Du P,Wang Z,Huang S,Long C

更新日期：2011-09-01 00:00:00

abstract：:MicroRN-143 (miR‑143) has been previously reported to be downregulated in specific types of cancer, including colorectal, bladder, oral squamous cell, pituitary, cervical, nasopharyngeal, lymphoma and prostate cancer. In the present study, the effects of miR-143 on prostate cancer cell migration and invasion were exam...

journal_title：Molecular medicine reports

authors： Wu D,Huang P,Wang L,Zhou Y,Pan H,Qu P

更新日期：2013-08-01 00:00:00

abstract：:Oxidized low-density lipoprotein (Ox-LDL), as a strong oxidant, results in renal injury through multiple mechanisms. The aim of the present study was to determine the injury effects of Ox‑LDL and the potential protective effects of the antioxidant reagent probucol on epithelial‑mesenchymal transition (EMT) in human re...

journal_title：Molecular medicine reports

authors： Zhu BB,Wang H,Chi YF,Wang YM,Yao XM,Liu S,Qiu H,Fang J,Yin PH,Zhang XM,Peng W

更新日期：2018-01-01 00:00:00

abstract：:We have recently described an immune system-released activating agent (ISRAA) as a nervous system-induced factor that stimulates immune responses in the mouse spleen. However, the human ISRAA has not yet been identified. In this study, we examined the effects of the mouse ISRAA protein on human peripheral blood mononu...

journal_title：Molecular medicine reports

authors： Taha S,Fathallah MD,Bakhiet M

更新日期：2014-07-01 00:00:00

abstract：:The hepatitis C virus (HCV) alternate reading frame protein (ARFP or F protein) of the HCV 1b genotype is a double-frameshift product of the HCV core protein (Core). The discovery of HCV F protein challenges various biological functions attributed to Core. However, the specific characteristics of the host cellular imm...

journal_title：Molecular medicine reports

authors： Xu X,Yu X,Deng X,Yue M,Zhang J,Zhu D,Zhou Z,Zhai X,Xu K,Zhang Y

更新日期：2014-02-01 00:00:00

abstract：:P-glycoprotein (P-gp) overexpression and tumor stem cells are thought to be important factors in the cross-resistance of cancer cells. There have been no studies on whether diallyl trisulfide (DATS) can reverse drug resistance in human osteosarcoma cells. In the present study, we demonstrated that DATS down-regulated ...

journal_title：Molecular medicine reports

authors： Li J,Liu W,Zhao K,Zhang Y,Li X,Yang Q,Li Z,Li J

更新日期：2009-03-01 00:00:00

abstract：:Increasing evidence has indicated that the generation of reactive oxygen species (ROS) contributes to H2O2‑induced nerve injury. This may result in oxidative stress that leads to cell damage or death. Dietary or pharmaceutical augmentation of the endogenous antioxidant defense capacity is a potential means by which to...

journal_title：Molecular medicine reports

authors： Lin P,Tian XH,Yi YS,Jiang WS,Zhou YJ,Cheng WJ

更新日期：2015-11-01 00:00:00

abstract：:Aquaporins (AQPs) are known to be important in cancer progression. The present study used a cDNA microarray to demonstrate that AQP3, a member of the AQP family, was overexpressed in prostate cancer cells. In order to determine the role of AQP3 in prostate cancer, AQP3 expression was silenced by transfection with smal...

journal_title：Molecular medicine reports

authors： Chen J,Wang Z,Xu D,Liu Y,Gao Y

更新日期：2015-04-01 00:00:00

abstract：:Stem cells from apical papilla (SCAP) possess clear osteo‑/odontogenic differentiation capabilities, and are regarded as the major cellular source for root dentin development. Bone morphogenetic protein 2 (BMP2) and vascular endothelial growth factor (VEGF) serve pivotal roles in the modulation of tooth development an...

journal_title：Molecular medicine reports

authors： Zhang W,Zhang X,Ling J,Wei X,Jian Y

更新日期：2016-05-01 00:00:00

abstract：:Cisplatin‑based chemotherapy may greatly enhance patient prognosis; however, chemotherapy resistance remains an obstacle to curing patients with non‑small cell lung cancer (NSCLC). The aim of the present study was to explore the microRNAs (miRs) that could regulate cisplatin sensitivity and provide a potential treatme...

journal_title：Molecular medicine reports

authors： Chen X,Zhu H,Ye W,Cui Y,Chen M

更新日期：2019-02-01 00:00:00

abstract：:Flavopiridol (FP) exerts antitumoral effects by triggering tumor cell cycle arrest and cytotoxicity in human breast cancer cell lines. The potent antitumor activity of FP is through its inhibition of cyclin‑dependent kinases; however, this may not be the only mechanism of action. The present study aimed to investigate...

journal_title：Molecular medicine reports

authors： Wang S,Wang K,Wang H,Han J,Sun H

更新日期：2017-12-01 00:00:00

abstract：:Eurycoma (E.) longifolia Jack (Tongkat Ali) is a widely applied medicine that has been reported to boost serum testosterone and increase muscle mass. However, its actual biological targets and effects on an in vitro level remain poorly understood. Therefore, the present study aimed to investigate the effects of a stan...

journal_title：Molecular medicine reports

authors： Khurshid Ahmed NA,Lim SK,Pandian GN,Sugiyama H,Lee CY,Khoo BY,Chan KL

更新日期：2020-11-01 00:00:00

abstract：:The aim of the present study was to investigate the possible metabolic alterations in the frontal cortex and parietal white matter in patients with diabetic hypertension (DHT) using proton magnetic resonance (MR) spectroscopic imaging. A total of 33 DHT patients and 30 healthy control subjects aged between 45 and 75 w...

journal_title：Molecular medicine reports

authors： Cao Z,Ye BD,Shen ZW,Cheng XF,Yang ZX,Liu YY,Wu RH,Geng K,Xiao YY

更新日期：2015-06-01 00:00:00

abstract：:Chronic periodontitis is the most common periodontal disease and is characterized by progressive degeneration of periodontal tissue. Periodontal‑specific pathogens can induce the expression of various inflammatory cytokines in periodontal ligament cells and their secretion into peripheral blood. These inflammatory cyt...

journal_title：Molecular medicine reports

authors： Wang F,Guan M,Wei L,Yan H

更新日期：2019-01-01 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is produced by various types of carcinomas, and is an important factor in the development of bone metastasis. The coexpression of PTHrP and parathyroid hormone/parathyroid hormone-related protein type 1 receptor (PTHR1) in cancer predicts poor patient survival. While genetic...

journal_title：Molecular medicine reports

authors： Miyashita H,Mori S,Fukumoto Y,Sato A,Fukumoto M,Kawamura H

更新日期：2008-11-01 00:00:00

abstract：:The primary cause of breast cancer‑associated mortality is the formation of distant metastasis. During the metastatic process, single tumor cells dissolve from the primary tumor site and undergo various changes in cell adhesion and motility properties. The tumor cells invade the blood stream and travel to different si...

journal_title：Molecular medicine reports

authors： Andergassen U,Schlenk K,Jeschke U,Sommer H,Kölbl A

更新日期：2018-08-01 00:00:00

abstract：:Extraocular dissemination is the main cause of death in patients with retinoblastoma (RB) in developing countries, and there are few molecular markers that are useful for the evaluation of minimal disseminated disease. The GD2 ganglioside is known to be expressed by RB cells that metastasize in bone marrow, and the ac...

journal_title：Molecular medicine reports

authors： Laurent VE,Otero LL,Vazquez V,Camarero S,Gabri MR,Labraga M,De Dávila MT,Chantada GL,Alonso DF

更新日期：2010-03-01 00:00:00

abstract：:Previous studies have demonstrated that metformin (Met) may reduce the risk of cancer development. In the present study, the anti-cancer effects of Met in A498 cells were investigated. It was found that Met inhibited A498 cell proliferation in a time- and dose-dependent manner, as well as induced the activation of AMP...

journal_title：Molecular medicine reports

authors： Fang Z,Xu X,Zhou Z,Xu Z,Liu Z

更新日期：2014-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancer types, and chemotherapy plays an important role in treatment of HCC. However, long‑term treatment with chemotherapeutic drugs such as 5‑fluorouracil (5‑FU) often results in chemoresistance, and the underlying mechanisms remain unclear. In this study, we s...

journal_title：Molecular medicine reports

authors： Wang C,Guo Y,Wang J,Min Z

更新日期：2015-03-01 00:00:00

abstract：:Gout is a type of serious arthritis that is caused by hyperuricemia. Celery is an umbelliferous plant that was shown to exhibit anti‑inflammatory activity in rodent. The present study aimed to investigate the effects and potential preliminary mechanisms of celery seed aqueous extract (CSAE) and celery seed oil extract...

journal_title：Molecular medicine reports

authors： Li S,Li L,Yan H,Jiang X,Hu W,Han N,Wang D

更新日期：2019-11-01 00:00:00

abstract：:Astragaloside is a saponin widely used in traditional Chinese medicine and has been reported to be a potent multidrug resistance (MDR) reversal agent. The present study investigated the role of astragaloside Ⅳ (ASIV) in the regulation of P-glycoprotein (P-gp, encoded by the mdr1 gene) and its effect on the reversal of...

journal_title：Molecular medicine reports

authors： Wang PP,Xu DJ,Huang C,Wang WP,Xu WK

更新日期：2014-06-01 00:00:00

abstract：:Previous studies have suggested that the B‑cell lymphoma 2 (Bcl‑2) inhibitor, TW37, may induce apoptosis of the non‑small cell lung cancer cell line, H1975/epidermal growth factor receptor‑tyrosine kinase inhibitor (EGFR‑TKI), which exhibits secondary resistance to EGFR‑TKI. However, the effects of TW37 on H1975/EGFR‑...

journal_title：Molecular medicine reports

authors： Liu J,Yao X,Wu D,Ye Y,Wu Q,Liu S,Wu H

更新日期：2018-02-01 00:00:00

abstract：:Aldose reductase (AR) is involved in the pathogenesis of nonalcoholic steatohepatitis. This study aimed to determine the mechanism by which AR affects the development of murine diet-induced nonalcoholic steatohepatitis. Steatohepatitis was induced in C57BL/6 mice by administration of a methionine-choline-deficient (MC...

journal_title：Molecular medicine reports

authors： Chen T,Shi D,Chen J,Yang Y,Qiu M,Wang W,Qiu L

更新日期：2015-01-01 00:00:00

abstract：:Ribavirin (RBV)-induced anemia is a serious side effect of pegylated interferon (PEG-IFN) plus RBV therapy which is the standard care most effective for hepatitis C virus (HCV) infection. In the present study, we investigated the association of inosine triphosphate pyrophosphatase (ITPA) genotypes with RBV-induced hem...

journal_title：Molecular medicine reports

authors： Nishimura T,Osaki R,Shioya M,Imaeda H,Aomatsu T,Takeuchi T,Okumura Y,Fujiyama Y,Andoh A

更新日期：2012-02-01 00:00:00

abstract：:Propofol is widely used for the induction and maintenance of pediatric anesthesia. Previous studies have indicated that propofol can induce apoptosis, and damage cognitive and memory functions. Dexmedetomidine is a potent α‑2 adrenoceptor agonist with high selectivity. Previous observations have shown that dexmedetomi...

journal_title：Molecular medicine reports

authors： Wei Y,Hu J,Liang Y,Zhong Y,He D,Qin Y,Li L,Chen J,Xiao Q,Xie Y

更新日期：2016-10-01 00:00:00

abstract：:The aim of the present study was to investigate the potential role and regulatory mechanism of long non‑coding RNA ferritin heavy polypeptide 1 pseudogene 3 (FTH1P3) in glioma development. The expression of FTH1P3 in low‑ and high‑grade glioma tissues was investigated using reverse transcription‑quantitative polymeras...

journal_title：Molecular medicine reports

authors： Zhang Y,Li Y,Wang J,Lei P

更新日期：2018-11-01 00:00:00

abstract：:Radix Dipsaci total saponins (RTS) are primary active components of Radix Dipsaci, which is administered orally for the treatment of osteoporosis according to Chinese Medicine. RTS have also been shown to reduce the risk of bone fractures in rats. However, the detailed molecular mechanisms underlying their action rema...

journal_title：Molecular medicine reports

authors： Niu YB,Kong XH,Li YH,Fan L,Pan YL,Li CR,Wu XL,Lu TL,Mei QB

更新日期：2015-06-01 00:00:00

abstract：:Colon cancer is a common malignancy worldwide and there is an urgent requirement to develop effective treatment strategies. In recent years, tumor immunotherapy has become a new method of effectively treating tumors. Chimeric antigen receptor (CAR) T cell technology combines the precise targeting specificity of monocl...

journal_title：Molecular medicine reports

authors： Zhou Y,Wen P,Li M,Li Y,Li XA

更新日期：2019-09-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common type of brain cancer; it usually recurs and patients have a short survival time. The present study aimed to construct a gene expression classifier and to screen key genes associated with GBM prognosis. GSE7696 microarray data set included samples from 10 recurrent GBM t...

journal_title：Molecular medicine reports

authors： Yang H,Jin L,Sun X

更新日期：2019-03-01 00:00:00