Long non‑coding RNA NORAD promotes cell proliferation and glycolysis in non‑small cell lung cancer by acting as a sponge for miR‑136‑5p.

abstract：:Astragaloside is a saponin widely used in traditional Chinese medicine and has been reported to be a potent multidrug resistance (MDR) reversal agent. The present study investigated the role of astragaloside Ⅳ (ASIV) in the regulation of P-glycoprotein (P-gp, encoded by the mdr1 gene) and its effect on the reversal of...

journal_title：Molecular medicine reports

authors： Wang PP,Xu DJ,Huang C,Wang WP,Xu WK

更新日期：2014-06-01 00:00:00

abstract：:Acupuncture has been demonstrated to be an effective treatment for various diseases. However, little attention has been paid to its physiological influences, especially on the changes in protein and mRNA levels following acupuncture treatment under normal conditions. In this study, we investigated the gene expression ...

journal_title：Molecular medicine reports

authors： Yin LM,Wang Y,Wang Y,Xu YD,Liu YY,Jin WR,Zhang QH,Yang YQ

更新日期：2012-08-01 00:00:00

abstract：:Dysregulation of collagen type XII α1 chain (COL12A1) has been found in several cancer types and could be involved in tumor progression. However, its clinical significance in gastric cancer (GC) remains under exploration. Online databases (Gene Expression Omnibus and UALCAN), reverse transcription‑quantitative PCR and...

journal_title：Molecular medicine reports

authors： Jiang X,Wu M,Xu X,Zhang L,Huang Y,Xu Z,He K,Wang H,Wang H,Teng L

更新日期：2019-10-01 00:00:00

abstract：:Transgelin 2 (TAGLN2) is a cytoskeletal protein of the calponin family. Abnormal expression of TAGLN2 was observed in various types of cancer. Our previous study reported that TAGLN2 expression was reduced in lymph node‑positive breast cancer patients; however, the role of TAGLN2 in breast cancer metastasis remains un...

journal_title：Molecular medicine reports

authors： Yang L,Hong Q,Xu SG,Kuang XY,Di GH,Liu GY,Wu J,Shao ZM,Yu SJ

更新日期：2019-11-01 00:00:00

abstract：:Chemokines are known to have anti-tumor effects due to their chemoattractant properties, which stimulate the accumulation of infiltrating immune cells in tumors. CCL22 (macrophage-derived chemokine, MDC) attracts killer T?cells, helper T cells and antigen-presenting cells expressing the CCL22 receptor, CCR4. Thus, CCL...

journal_title：Molecular medicine reports

authors： Cho S,Koizumi K,Takeno N,Kato S,Yamada M,Hashimoto I,Sakurai H,Tsukada K,Saiki I

更新日期：2009-09-01 00:00:00

abstract：:During orthodontic treatment, mechanical force is applied to the teeth, and following a series of complex metabolism changes, the position of the teeth in the alveolar bone change. This process is closely associated with primitive bone mesenchymal stem cells (BMSCs), which may differentiate into osteoblasts precursor ...

journal_title：Molecular medicine reports

authors： Yu H,Yu W,Liu Y,Yuan X,Yuan R,Guo Q

更新日期：2019-11-01 00:00:00

abstract：:The present study aimed to investigate the clinical significance of histone methylation in sepsis. A total of 43 blood samples from trauma and esophageal cancer patients with or without sepsis were collected. Immunofluorescence staining of isolated peripheral white blood cells (WBCs) was conducted. Co‑stained 293T cel...

journal_title：Molecular medicine reports

authors： Jiang L,Wang Y,Zhu D,Xue Z,Mao H

更新日期：2016-12-01 00:00:00

abstract：:The present study investigated the function of oncostatin M (OSM), which may be associated with monocyte chemotactic protein‑1 (MCP‑1), on mouse MC3T3‑E1 osteoblast development and bone remodeling. Levels of MCP‑1, macrophage inflammatory protein 1α (MIP1α) and regulated upon activation normal T cell expressed and sec...

journal_title：Molecular medicine reports

authors： Zheng W,Guan J

更新日期：2018-09-01 00:00:00

abstract：:In order to gain greater understanding of the mechanisms underlying the effect of epigallocatechin-3-gallate (EGCG) on DNA methylation and its chemopreventative action in oral squamous cell carcinoma (OSCC), a genome‑wide methylation and mRNA expression screen was performed in the CAL‑27 cell line with and without EGC...

journal_title：Molecular medicine reports

authors： Chen LL,Han WF,Geng Y,Su JS

更新日期：2015-10-01 00:00:00

abstract：:Disruption of the intestinal mucosal barrier integrity is a pathogenic process in inflammatory bowel disease (IBD) development, and is therefore considered a drug discovery target for IBD. The well‑known traditional Chinese formulation Qing Hua Chang Yin (QHCY) has been suggested as a potential therapeutic agent for t...

journal_title：Molecular medicine reports

authors： Fang W,Zhao P,Shen A,Liu L,Chen H,Chen Y,Peng J,Sferra TJ,Sankararaman S,Luo Y,Ke X

更新日期：2021-03-01 00:00:00

abstract：:The objective of the present study was to evaluate the influence of TAAAA repeat allele length on the levels of serum sex hormone binding globulin (SHBG) and cardiovascular risk factors in patients with polycystic ovary syndrome (PCOS). The study included 91 females with PCOS and 99 healthy controls. Phenotypic hypera...

journal_title：Molecular medicine reports

authors： Baldani DP,Skrgatic L,Cerne JZ,Oguic SK,Gersak BM,Gersak K

更新日期：2015-05-01 00:00:00

abstract：:Honokiol is the main active constituent of Magnolia officinalis. With effective and long‑term pharmacological functions of being antibacterial, anti‑oxidative, anti‑inflammatory, antitumor, anti‑spasmic, anti‑anxiety and anti‑viral, Honokiol is clinically used in the treatment of acute enteritis and chronic gastritis....

journal_title：Molecular medicine reports

authors： Li Z,Dong H,Li M,Wu Y,Liu Y,Zhao Y,Chen X,Ma M

更新日期：2018-02-01 00:00:00

abstract：:The present study aimed to reveal the underlying mechanism of angiotensin II (AngII)‑induced cardiac remodeling and to identify potential therapeutic targets for prevention. Rat cardiac fibroblasts (CFs) were cultured with 10 nM AngII for 12 h, and CFs without AngII were used as the control. Following RNA isolation fr...

journal_title：Molecular medicine reports

authors： Shu J,Liu Z,Jin L,Wang H

更新日期：2018-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a common liver disease that currently has no standard treatment. The present study aimed to evaluate the effects of Lycium ruthenicum extract (LRE) on high‑fat diet (HFD)-induced NAFLD, and elucidate the underlying molecular mechanisms. To determine the hepatoprotective effe...

journal_title：Molecular medicine reports

authors： Lin J,Zhang Y,Wang X,Wang W

更新日期：2015-09-01 00:00:00

abstract：:Cullin7 (CUL7) is a member of Cullin protein family and exhibits a tumor‑promoting role in several types of tumors, including breast, liver and ovarian. However, its roles in esophageal carcinoma (EC) have not yet been reported. In the present study, CUL7 expression in EC tissue was revealed to be significantly higher...

journal_title：Molecular medicine reports

authors： Tian P,Liu D,Sun L,Sun H

更新日期：2018-04-01 00:00:00

abstract：:According to the results of the first genome-wide association study of ankylosing spondylitis (AS), endoplasmic reticulum aminopeptidase 1 (ERAP1) may serve an important role. However, a number of case-control studies have not been able to replicate this result using the same genetic markers. In the present study, the...

journal_title：Molecular medicine reports

authors： Wang X,Ma J,Ma J,Wen Y,Meng L,Yang H,Zhang R,Hao D

更新日期：2017-11-01 00:00:00

abstract：:Pulmonary hypertension (PH) in newborns and adults is a disease that can lead to right heart failure and result in a shorter lifespan. PH was induced by maintaining pregnant rats in a hypoxic chamber for 4 h twice a day, from days 7‑21 of pregnancy. Hypoxia was confirmed by a decrease in the partial pressure of oxygen...

journal_title：Molecular medicine reports

authors： Ding H,Luo Y,Hu K,Huang H,Liu P,Xiong M,Zhu L,Yi J,Xu Y

更新日期：2020-11-01 00:00:00

abstract：:CXC195 exhibits strong protective effects against neuronal apoptosis by exerting antioxidant activity. However, the pharmacological function of CXC195 in cancer remains to be elucidated. The present study demonstrated that CXC195 exhibited significant cytotoxic effects, and induced cell cycle arrest and apoptosis in H...

journal_title：Molecular medicine reports

authors： Chen XL,Fu JP,Shi J,Wan P,Cao H,Tang ZM

更新日期：2015-12-01 00:00:00

abstract：:Deafness and hearing loss may have functional, economic, social and emotional impacts on humans, including the ability of an individual to communicate with others, feelings of isolation and frustration, and health sector costs. The World Health Organization reported that there are 32 million children worldwide with he...

journal_title：Molecular medicine reports

authors： Zhang Z,Chen QD,Zhao LP,Ma J,Zhang TS,Pang JX,Li YF,Wang MF,Wang AP,Tang L,Li LJ,He WJ,Gu H

更新日期：2018-04-01 00:00:00

abstract：:The association of the peripheral lymphocyte‑to‑monocyte ratio (LMR) with α‑fetoprotein (AFP) status in patients with AFP‑positive and AFP‑negative hepatocellular carcinoma (HCC) has not been investigated in detail. The aim of the present study was to examine the association between the LMR and AFP status in these pat...

journal_title：Molecular medicine reports

authors： Wang H,Xiang Y,Li X,Liu S,Liu L

更新日期：2020-10-01 00:00:00

abstract：:The primary aim of the current study was to investigate the antitumor effects of ferruginol in OVCAR‑3 human ovary cancer cells. The effects of ferruginol on cell apoptosis, cell migration and cell cycle phase distribution were also evaluated. Cell cytotoxicity induced by ferruginol was determined by an MTT assay, whi...

journal_title：Molecular medicine reports

authors： Xiong WD,Gong J,Xing C

更新日期：2017-11-01 00:00:00

abstract：:Pingyangmycin (PYM), a glycopeptide antibiotic, has been recommended as a stand treatment for hemangioma. However, the underlying mechanisms of its anti‑tumor effects have remained elusive. The purpose of the present study was to explore the effects of PYM on the biological behavior of the EOMA mouse hemangioendotheli...

journal_title：Molecular medicine reports

authors： Peng LX,Zhao P,Zhao HS,Pan E,Yang BB,Li Q

更新日期：2015-12-01 00:00:00

abstract：:Diabetes mellitus poses a major threat towards global heath due to a lack of effective treatment. Fluoxetine hydrochloride, a selective 5‑hydroxytryptamine reuptake inhibitor, is the most commonly used antidepressant in clinical therapy; however, the potential molecular mechanisms of fluoxetine in diabetes remain unkn...

journal_title：Molecular medicine reports

authors： Yang H,Cao Q,Xiong X,Zhao P,Shen D,Zhang Y,Zhang N

更新日期：2020-10-01 00:00:00

abstract：:Cellular prion protein (PrPC) can replace other pivotal molecules due to its interaction with several partners in performing a variety of important biological functions that may differ between embryonic and mature stem cells. Recent studies have revealed major advances in elucidating the putative role of PrPC in the r...

journal_title：Molecular medicine reports

authors： Yun SP,Han YS,Lee JH,Yoon YM,Yun CW,Rhee P,Lee SH

更新日期：2017-11-01 00:00:00

abstract：:The co-delivery of a drug and a target gene has become a primary strategy in cancer therapy. Based on our previous study, a synthesized star‑shaped co‑polymer consisting of β‑cyclodextrin (CD) and a poly(L‑lysine) dendron (PLLD) was used to co-deliver docetaxel (DOC) and matrix metalloproteinase 9 (MMP‑9) small interf...

journal_title：Molecular medicine reports

authors： Liu T,Wu X,Wang Y,Hou X,Jiang G,Wu T,Xie H,Xie M

更新日期：2017-08-01 00:00:00

abstract：:Accumulated evidence has demonstrated that the microenvironment of a given tumor is important in determining its drug resistance, tumorigenesis, progression and metastasis. These microenvironments, like tumor cells, are vital targets for cancer therapy. The cross-talk between tumor cells and cancer-associated fibrobla...

journal_title：Molecular medicine reports

authors： Zi F,He J,He D,Li Y,Yang L,Cai Z

更新日期：2015-05-01 00:00:00

abstract：:The present study aimed to evaluate the effects of Krüppel‑like factor 2 (KLF2) on the differentiation of endothelial progenitor cells (EPCs) to endothelial cells (ECs) induced by shear stress, and to investigate the corresponding mechanisms. Cultured rat late EPCs were exposed to shear stress (12 dyn/cm2) for differe...

journal_title：Molecular medicine reports

authors： Chu HR,Sun YC,Gao Y,Guan XM,Yan H,Cui XD,Zhang XY,Li X,Li H,Cheng M

更新日期：2019-03-01 00:00:00

abstract：:Lung adenocarcinoma (AC) is one of the most deadly malignancies. The disease has a low five-year survival rate; therefore, the identification of novel therapeutic agents is required. This study aimed to investigate the effect of small interfering RNA (siRNA) targeting hypoxia‑inducible factor 1α (HIF‑1α) on the growth...

journal_title：Molecular medicine reports

authors： Liao HY,Wang GP,Huang SH,Li Y,Cai SW,Zhang J,Chen HG,Wu WB

更新日期：2014-03-01 00:00:00

abstract：:Ehlers-Danlos syndrome type IV is an autosomal dominant connective tissue disease. Mutations in COL3A1 have been identified to underlie this disease; however, to the best of our knowledge, no COL3A1 mutations have been reported in Ehlers-Danlos syndrome type IV patients with an ascending aortic aneurysm. In order to d...

journal_title：Molecular medicine reports

authors： Deng Y,Wei S,Hu S,Chen J,Tan Z,Yang Y

更新日期：2015-07-01 00:00:00

abstract：:MicroRNAs (miRs) have been demonstrated to be important in the establishment and progression of colon cancer. However the underlying molecular mechanisms remain to be fully elucidated. Polypeptide N‑acetylgalactosaminyltransferase4 (GALNT4) participates in numerous cellular processes, including tumorigenesis. The pres...

journal_title：Molecular medicine reports

authors： Qu JJ,Qu XY,Zhou DZ

更新日期：2017-10-01 00:00:00