Bioinformatics analysis of genetic variants of endoplasmic reticulum aminopeptidase 1 in ankylosing spondylitis.

abstract：:Nestin, a type-VI intermediate filament protein, serves as a marker for neural stem cells, and is also known to be expressed in follicle stem cells. Hair follicles go through repeated cycles of anagen (growth), catagen (regression) and telogen (quiescence) throughout the life of mammals following morphogenesis. In the...

journal_title：Molecular medicine reports

authors： Chen R,Miao Y,Hu Z

更新日期：2019-01-01 00:00:00

abstract：:The aim of the study was to examine the expression of mammalian target of rapamycin (mTOR)/70S6K signaling pathway in pathological scar fibroblasts and the effects of resveratrol (Res) intervention. The mTOR and 70S6K in pathological scar and normal skin fibroblasts were detected by immunofluorescence following treatm...

journal_title：Molecular medicine reports

authors： Tang ZM,Zhai XX,Ding JC

更新日期：2017-05-01 00:00:00

abstract：:The present study aimed to investigate the antifibrogenic effects of genistein (GEN) on the kidney in streptozotocin (STZ)‑induced diabetic rats and to determine the associated mechanisms. Rats were randomized into four groups: Normal control (N), STZ (S), L (STZ + low‑dose GEN) and H (STZ + high‑dose GEN). After 8 we...

journal_title：Molecular medicine reports

authors： Jia Q,Yang R,Liu XF,Ma SF,Wang L

更新日期：2019-01-01 00:00:00

abstract：:Roux-en-Y gastric bypass (RYGB) has become an effective treatment for type 2 diabetes mellitus (T2DM). However, the blood glucose mechanism involved remains unclear. In this study, 60 male Goto-Kakizaki (GK) rats were randomly divided into 6 groups (each with 10 rats): the GB1/2 gro...

journal_title：Molecular medicine reports

authors： Li J,Wang Y,Zhou Y,Liu J

更新日期：2012-11-01 00:00:00

abstract：:Obesity is a confirmed risk factor for hyperlipidemia, type‑II diabetes, hypertension, and cardiovascular disease. MicroRNAs (miRs) have emerged as an important field of study within energy metabolism and obesity. A previous study demonstrated miR‑1275 to be markedly down‑regulated during maturation of human preadipoc...

journal_title：Molecular medicine reports

authors： Zhou YF,Fu ZY,Chen XH,Cui Y,Ji CB,Guo XR

更新日期：2017-11-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by synovial inflammation. Fibroblast‑like synoviocytes (FLS) serve a vital role in the initiation and perpetuation of the immune response in patients with RA. The present study aimed to investigate the potential role of microRNA (miR)‑34a‑...

journal_title：Molecular medicine reports

authors： Hou C,Wang D,Zhang L

更新日期：2019-09-01 00:00:00

abstract：:The present study aimed to identify potentially important biomarkers associated with polycystic ovary syndrome (PCOS) by integrating DNA methylation with transcriptome profiling. The transcription (E‑MTAB‑3768) and methylation (E‑MTAB‑3777) datasets were retrieved from ArrayExpress. Paired transcription and methylatio...

journal_title：Molecular medicine reports

authors： Liu L,He D,Wang Y,Sheng M

更新日期：2020-05-01 00:00:00

abstract：:Fluid shear stress has been revealed to differentially regulate endothelial nitric oxide synthase (eNOS) distribution in vessels. eNOS, a key enzyme in controlling nitric oxide (NO) release, has a crucial role in mediating oxidative stress, and resveratrol (RSV)‑mediated eNOS also attenuates oxidative damage and suppr...

journal_title：Molecular medicine reports

authors： Wang Z,Zhang J,Li B,Gao X,Liu Y,Mao W,Chen SL

更新日期：2014-10-01 00:00:00

abstract：:Cip1-interacting zinc finger protein 1 (CIZ1) is a nuclear protein that was observed to bind to p21Cip1/Waf1. p21Cip1/Waf1 regulates the cell cycle and is associated with colorectal cancer (CRC) progression. However, the effect of CIZ1 on CRC cells remains unclear. In the present study, CIZ1 was observed to be highly ...

journal_title：Molecular medicine reports

authors： Yin J,Wang C,Tang X,Sun H,Shao Q,Yang X,Qu X

更新日期：2013-12-01 00:00:00

abstract：:The echinoderm microtubule associated protein like 4‑anaplastic lymphoma kinase (EML4‑ALK) fusion is almost mutually exclusive to epidermal growth factor receptor (EGFR) or K‑RAS mutation in non‑small cell lung cancer (NSCLC), and it is extremely rare for patients to exhibit both mutations. The present study reported ...

journal_title：Molecular medicine reports

authors： Xu CW,Cai XY,Shao Y,Li Y,Shi MW,Zhang LY,Wang L,Zhang YP,Wang LP,Tian YW

更新日期：2015-09-01 00:00:00

abstract：:Osteosarcoma is the most common type of primary malignant tumor of the bone. However, mechanisms underlying osteosarcoma cell proliferation are poorly understood. The present study shows that RBEL1, a newly identified Rab-like GTPase, may be a key regulator of osteosarcoma cell proliferation. Knockdown of RBEL1 in ost...

journal_title：Molecular medicine reports

authors： Tang H,Ji F,Sun J,Xie Y,Xu Y,Yue H

更新日期：2016-02-01 00:00:00

abstract：:LEOPARD syndrome (LS) is an autosomal dominant inherited disorder primarily caused by mutations in the PTPN11, RAF1 and BRAF genes. Characteristic features include lentigines, craniofacial dysmorphism, myocardium or valve abnormalities, eletrocardiographic conduction defects and deafness. LS, neurofibromatosis type 1,...

journal_title：Molecular medicine reports

authors： Zhang J,Shen J,Cheng R,Ni C,Liang J,Li M,Yao Z

更新日期：2016-09-01 00:00:00

abstract：:Lipids extracted from Halocynthia roretzi contain n-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid, as well as carotenoids. The aim of the present study was to evaluate the effect of H. roretzi lipids on white adipose tissue (WAT) weight and high blood glucose levels in diabetic/o...

journal_title：Molecular medicine reports

authors： Mikami N,Hosokawa M,Miyashita K

更新日期：2010-05-01 00:00:00

abstract：:Previous studies have demonstrated that microRNAs (miRNAs), a class of single‑stranded RNA molecules that are 18‑27 nucleotides in length, serve a critical function in tumorigenesis, including in the development of colon cancer. In the current study, miR‑100 levels were demonstrated to be reduced in colon cancer tissu...

journal_title：Molecular medicine reports

authors： Zhou MK,Liu XJ,Zhao ZG,Cheng YM

更新日期：2015-04-01 00:00:00

abstract：:Colorectal carcinoma (CRC) is one of the most common types of malignancy worldwide. Recently, neoadjuvant chemotherapy has become an important treatment strategy for CRC. However, treatment frequently fails due to the development of chemoresistance, which is a major obstacle for positive prognosis. However, the underl...

journal_title：Molecular medicine reports

authors： Ju T,Jin H,Ying R,Xie Q,Zhou C,Gao D

更新日期：2017-09-01 00:00:00

abstract：:The aim of the present study was to assess the association between chondrocytes and the extracellular matrix (ECM), and determine whether this contributes to osteoarthritis (OA). Chondrocyte hypertrophy was measured in articular cartilage samples from early-stage OA patients. In addition, rat chondrocytes were culture...

journal_title：Molecular medicine reports

authors： Zhang S,Zhong Y,Li R,Wang W,Zeng L,Wang Z,Jia P,Wu R

更新日期：2014-09-01 00:00:00

abstract：:A type of aplastic anemia (AA), non-severe aplastic anemia (NSAA) is defined as AA that does not meet the diagnostic criteria of severe aplastic anemia (SAA). Complement component 1q (C1q) has an important role in the pathogenesis of various autoimmune diseases; however, the role of C1q in the immune pathogenesis of N...

journal_title：Molecular medicine reports

authors： Ding S,Liu C,Li Y,Liu H,Liu Z,Chen T,Zhang T,Shao Z,Fu R

更新日期：2019-02-01 00:00:00

abstract：:Progressive cardiac conduction defect (PCCD) is an inherited autosomal dominant cardiac disorder characterized by an age‑dependent cardiac electrical conduction block. Several genes have been associated with the genetic pathogenesis of PCCD. The present study aimed to identify the causal mutation of PCCD and to invest...

journal_title：Molecular medicine reports

authors： Fan P,Zhang D,Yang KQ,Tian T,Luo F,Liu YX,Wang LP,Zhou XL

更新日期：2020-06-01 00:00:00

abstract：:Trienones are curcuminoid analogues and are minor constituents in the rhizomes of numerous Curcuma plant species. Studies investigating the biological activities of trienones, particularly their anti‑inflammatory activities, are limited. In the present study, the trienone 1,7‑bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑hepta...

journal_title：Molecular medicine reports

authors： Jansakun C,Chulrik W,Chaichompoo W,Yotmanee P,Lehboon K,Chunglok W,Sattayakhom A,Hiransai P,Kamdee K,Utaipan T,Suksamrarn A,Chunglok W

更新日期：2021-03-01 00:00:00

abstract：:The purpose of this study was to assess the efficacy and predictive biomarkers of combination docetaxel-trastuzumab in a neoadjuvant setting by means of a phase II trial. Women with histologically-confirmed advanced invasive breast cancer whose tumours overexpressed HER-2 received 4 cycles of docetaxel (70 mg/m2 every...

journal_title：Molecular medicine reports

authors： Kurosumi M,Tabei T,Sano M,Honma K,Yanagita Y,Yamamoto N,Inoue K,Sato N,Kimura M

更新日期：2008-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancer types worldwide. The signal transducer and activator of transcription 3 (STAT3) protein is a member of the STAT transcription factor family. Oncogenesis, invasion, and metastasis of HCC are associated with activation of STAT3. However, whether aberrant ex...

journal_title：Molecular medicine reports

authors： Wang X,Xin W,Zhang H,Zhang F,Gao M,Yuan L,Xu X,Hu X,Zhao M

更新日期：2014-11-01 00:00:00

abstract：:There is much interest in the potential application of vector-induced gene therapeutic approaches to several forms of hearing disorders due to the poor efficacy of existing treatments. The cochlea is an ideal site for local gene transfection due to its anatomical encapsulation and fluid flow within its ducts. However,...

journal_title：Molecular medicine reports

authors： Xia L,Yin S

更新日期：2013-07-01 00:00:00

abstract：:Senescence is a result of cellular stress and is a potential mechanism for regulating cancer. As a member of the mitogen‑activated protein kinase family, ERK1/2 (extracellular signal‑regulated protein kinase) has an important role in delivering extracellular signals to the nucleus, and these signals regulate the cell ...

journal_title：Molecular medicine reports

authors： Zou J,Lei T,Guo P,Yu J,Xu Q,Luo Y,Ke R,Huang D

更新日期：2019-02-01 00:00:00

abstract：:Lung adenocarcinoma (AC) is one of the most deadly malignancies. The disease has a low five-year survival rate; therefore, the identification of novel therapeutic agents is required. This study aimed to investigate the effect of small interfering RNA (siRNA) targeting hypoxia‑inducible factor 1α (HIF‑1α) on the growth...

journal_title：Molecular medicine reports

authors： Liao HY,Wang GP,Huang SH,Li Y,Cai SW,Zhang J,Chen HG,Wu WB

更新日期：2014-03-01 00:00:00

abstract：:Resistin, an adipocytokine secreted by fat tissues, has been shown to be associated with increased local and systemic complications in acute pancreatitis (AP). However, the mechanism underlying the effect of resistin in the aggravation of AP remains to be elucidated. The aim of the present study was to investigate the...

journal_title：Molecular medicine reports

authors： Jiang CY,Wang W

更新日期：2017-01-01 00:00:00

abstract：:Deoxyribonuclease I (DNase I) is an endonuclease responsible for the destruction of chromatin during apoptosis. However, its role in diabetes remains unclear. The aim of the current study was to investigate the role of DNase I combined with high glucose levels in β‑cell apoptosis. Human samples were collected and the ...

journal_title：Molecular medicine reports

authors： Zhu B,Zhang L,Zhang YY,Wang L,Li XG,Liu T,Fu YK,Zheng YF,Li P,Zhao ZG

更新日期：2016-06-01 00:00:00

abstract：:G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-bound estrogen receptor that is involved in the mediation of non-genomic estradiol signalling. In this study, we demonstrated that male, but not female, GPR30-deficient mice suffer from impaired left‑ventricular cardiac function. Left ventric...

journal_title：Molecular medicine reports

authors： Delbeck M,Golz S,Vonk R,Janssen W,Hucho T,Isensee J,Schäfer S,Otto C

更新日期：2011-01-01 00:00:00

abstract：:Dendritic cells (DCs) serve crucial roles in the activation of the immune response, and imbalance in the activation or inhibition of DCs has been associated with an increased susceptibility to develop immune‑induced diseases. However, the molecular mechanisms of regulating immune‑induced diseases of DCs are not well u...

journal_title：Molecular medicine reports

authors： Zheng Y,Zheng X,Li S,Zhang H,Liu M,Yang Q,Zhang M,Sun Y,Wu J,Yu B

更新日期：2018-06-01 00:00:00

abstract：:Atrial fibrillation (AF) is one of the most common types of arrhythmia worldwide; although a number of theories have been proposed to explain the mechanisms of AF, the treatment of AF is far from satisfactory. Energy metabolism is associated with the development of AF. Mitochondrial transcription factor A (TFAM) serve...

journal_title：Molecular medicine reports

authors： Liu Y,Zhao Y,Tang R,Jiang X,Wang Y,Gu T

更新日期：2020-12-01 00:00:00

abstract：:Pancreatic carcinoma is one of the leading causes of cancer mortality worldwide, although the molecular mechanisms of this disease are poorly understood. The aim of this study was to examine the expression of cyclin-dependent kinase inhibitors (CDKIs) and the epigenetic modification...

journal_title：Molecular medicine reports

authors： Li G,Ji Y,Liu C,Li J,Zhou Y

更新日期：2012-04-01 00:00:00