Expression of mTOR/70S6K signaling pathway in pathological scar fibroblasts and the effects of resveratrol intervention.

abstract：:Autogenous microfat grafting is widely used to augment depressed deformities or for other cosmetic purposes. Since the microfat survival rate is unpredictable due to absorption and calcification, previously cryopreserved fat is widely used for secondary procedures. Sphingosylphosphorylcholine (SPC) is a lysophospholip...

journal_title：Molecular medicine reports

authors： Bae YC,Choi CW,Nam KW,Song JS,Lee JW

更新日期：2016-10-01 00:00:00

abstract：:Platelet‑rich plasma (PRP) is a promising strategy for intervertebral disc degeneration (IDD). However, the short half‑life of growth factors released from PRP cannot continuously stimulate the degenerated discs. Thus, the present study hypothesized that the combined use of PRP and bone marrow‑derived mesenchymal stem...

journal_title：Molecular medicine reports

authors： Wang SZ,Jin JY,Guo YD,Ma LY,Chang Q,Peng XG,Guo FF,Zhang HX,Hu XF,Wang C

更新日期：2016-04-01 00:00:00

abstract：:As one of main active ingredients of salvia miltiorrhizae, which is a traditional Chinese medicine, tanshinone IIA is the basis of its pharmacological activities. In the present study, the effect of tanshinone IIA on weakening spastic cerebral palsy (SCP) in neonatal rats was investigated. Radial arm water maze and ho...

journal_title：Molecular medicine reports

authors： Zhang WL,Cao YA,Xia J,Tian L,Yang L,Peng CS

更新日期：2018-01-01 00:00:00

abstract：:Tumor angiogenesis is important in the growth and metastasis of malignant tumors. In our previous study, we demonstrated that an arginine-arginine-leucine (RRL) peptide is a tumor endothelial cell-specific binding sequence that may be used as a molecular probe for the imaging of malignant tumors in vivo. The aim of th...

journal_title：Molecular medicine reports

authors： Zhao Q,Yan P,Yin L,Li L,Chen XQ,Ma C,Wang RF

更新日期：2013-04-01 00:00:00

abstract：:Cell division cycle 42 (CDC42), which is a member of the Rho GTPase family, has been reported to regulate the metastasis of various human cancer cells; however, the role of CDC42 in gastric cancer (GC) remains unclear. The present study aimed to investigate the effects of CDC42 on the proliferation, migration and inva...

journal_title：Molecular medicine reports

authors： Du DS,Yang XZ,Wang Q,Dai WJ,Kuai WX,Liu YL,Chu D,Tang XJ

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present study was to evaluate differences in the expression of complement system genes, and serum levels of CH50, C3 and C4 in peripheral blood mononuclear cells from patients with myocardial infarction (AMI), stable angina pectoris (SA) and controls. A total of 100 patients with AMI, 100 with SA and 10...

journal_title：Molecular medicine reports

authors： Yan W,Che L,Jiang J,Yang F,Duan Q,Song H,Liu X,Shen Y,Wang L

更新日期：2016-12-01 00:00:00

abstract：:Senescence is a result of cellular stress and is a potential mechanism for regulating cancer. As a member of the mitogen‑activated protein kinase family, ERK1/2 (extracellular signal‑regulated protein kinase) has an important role in delivering extracellular signals to the nucleus, and these signals regulate the cell ...

journal_title：Molecular medicine reports

authors： Zou J,Lei T,Guo P,Yu J,Xu Q,Luo Y,Ke R,Huang D

更新日期：2019-02-01 00:00:00

abstract：:Socheongryeong‑tang (SCRT) is a herbal formula previously used to treat pulmonary diseases primarily caused by the common cold virus, including airway inflammation, asthma and allergy. The aim of the present study was to investigate the inhibitory effect of SCRT water extract and its 13 constituent components on chemo...

journal_title：Molecular medicine reports

authors： Kim JH,Jeon WY,Lee MY,Seo CS,Lim HS,Shin HK

更新日期：2014-12-01 00:00:00

abstract：:β-elemene, a plant-derived drug extracted from Curcuma wenyujin, has demonstrated marked antiproliferative effects on glioblastoma, while toxicity remains low. However, the underlying molecular mechanisms of the antitumor activity of β-elemene remain to be elucidated. Previously, it was identified that the glia matura...

journal_title：Molecular medicine reports

authors： Zhu TZ,Li XM,Luo LH,Xu YH,Cao P,Liu Y,Liang GB

更新日期：2014-08-01 00:00:00

abstract：:It is well known that the occupational exposure to contaminants and carcinogens leads to the development of cancer in exposed workers. In the 18th century, Percivall Pott was the first to hypothesize that chronic exposure to dust in the London chimney sweeps was associated with an increased risk of developing cancer. ...

journal_title：Molecular medicine reports

authors： Falzone L,Marconi A,Loreto C,Franco S,Spandidos DA,Libra M

更新日期：2016-11-01 00:00:00

abstract：:Glucocorticoids (GCs) are important stress hormones, which are used as a concomitant medication during malignant tumor chemotherapy. Clinical and preclinical studies have linked GCs to melanoma growth and progression. However, the effects and mechanism of action of GCs on the adhesion and survival of melanoma cells ar...

journal_title：Molecular medicine reports

authors： Huang GX,Qi MF,Li XL,Tang F,Zhu L

更新日期：2018-02-01 00:00:00

abstract：:Histone deacetylase inhibitor (HDACi) has been a major target of anticancer agents. Quisinostat (JNJ‑26481585), a novel second‑generation HDACi, has previously demonstrated antiproliferative activity against non‑small cell lung cancer; however, the function of quisinostat in hepatocellular carcinoma (HCC) remains to b...

journal_title：Molecular medicine reports

authors： Li F,Wang T,Wang Z,Chen X,Liu R

更新日期：2017-11-01 00:00:00

abstract：:Despite increasing evidence to suggest that microRNA (miR)-146a and miR-181b are involved in the regulation of immune responses and tumor progression, their roles in silicosis remain to be fully elucidated. Therefore, the present study examined the roles of miR‑146a and miR‑181b in inflammatory responses, and their ef...

journal_title：Molecular medicine reports

authors： Zhang Y,Wang F,Lan Y,Zhou D,Ren X,Zhao L,Zhang Q

更新日期：2015-10-01 00:00:00

abstract：:The replication of hepatitis B virus (HBV) may be modulated by a variety of cell signaling pathways, including the phosphatidylinositol 3‑kinase (PI3K)‑RAC‑α serine/threonine‑protein kinase (AKT)‑serine/threonine‑protein kinase mTOR (mTOR) pathway. The aim of the present study was to determine the regulatory effects o...

journal_title：Molecular medicine reports

authors： Xiang K,Wang B

更新日期：2018-03-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic and irreversible interstitial lung disease with a poor prognosis and limited therapeutic options. Over the past decade, research efforts have focused on the pathogenetic mechanisms involved in this enigmatic lung disease. Rheumatoid arthritis (RA) is a chronic inflammat...

journal_title：Molecular medicine reports

authors： Vasarmidi E,Sarantoulaki S,Trachalaki A,Margaritopoulos G,Bibaki E,Spandidos DA,Tzanakis N,Antoniou K

更新日期：2018-10-01 00:00:00

abstract：:Embryonic stem cells (ESCs) have unlimited expansion potential and the ability to differentiate into all somatic cell types for regenerative medicine and disease model studies. Octamer‑binding transcription factor 4 (OCT4), encoded by the POU domain, class 5, transcription factor 1 gene, is a transcription factor vita...

journal_title：Molecular medicine reports

authors： She S,Wei Q,Kang B,Wang YJ

更新日期：2017-11-01 00:00:00

abstract：:The present study aimed to investigate the effects of sufentanil on sepsis-induced acute lung injury (ALI), and identify the potential molecular mechanisms underlying its effect. In order to achieve this, a rat sepsis model was established. Following treatment with sufentanil, the lung wet/dry (W/D) weight ratio was c...

journal_title：Molecular medicine reports

authors： Hu Q,Wang Q,Han C,Yang Y

更新日期：2020-11-01 00:00:00

abstract：:The aim of the present study was to explore the survival of pig-rhesus corneal xenografts following donor bone marrow transplantation (BMT). Wuzhishan pigs were used as donors and rhesus monkeys as recipients for corneal xenotransplantation. Twelve rhesus monkeys were divided into t...

journal_title：Molecular medicine reports

authors： Jie Y,Liu L,Pan Z,Wang L

更新日期：2013-03-01 00:00:00

abstract：:Formononetin (Form), a phytoestrogen extracted from the roots of Astragalus membranaceus, is one of the fundamental herbs used in traditional Chinese medicine because of its protective effects against certain malignant tumors. However, its role in colon carcinoma cells and the underlying molecular mechanisms have not ...

journal_title：Molecular medicine reports

authors： Wang AL,Li Y,Zhao Q,Fan LQ

更新日期：2018-06-01 00:00:00

abstract：:MicroRNA (miR)-22 has previously been reported to be frequently downregulated in certain types of cancer. The present study examined the expression and effects of miR-22 in renal cell carcinoma (RCC). The results indicated that miR‑22 was downregulated in tumor tissue from patients with RCC. In addition, lower miR‑22 ...

journal_title：Molecular medicine reports

authors： Fan W,Huang J,Xiao H,Liang Z

更新日期：2016-06-01 00:00:00

abstract：:The aim of the present study was to investigate the efficacy and safety of ultrasound-targeted microbubble destruction (UTMD)-mediated polyethylenimine (PEI) transfection in cultured human retinal pigment epithelial (RPE) cells in vitro and rat retinas in vivo. An enhanced green fluorescent protein plasmid (pEGFP) was...

journal_title：Molecular medicine reports

authors： Wan C,Qian J,Li F,Li H

更新日期：2015-08-01 00:00:00

abstract：:Patients with skull base chordomas have a poor prognosis, and the role of the protein expression of brachyury in chordomas remains to be fully elucidated. The present study used immunohistochemistry to analyze 57 cases of skull base chordoma, and analyzed the clinical data of the patients. The results demonstrated tha...

journal_title：Molecular medicine reports

authors： Wang K,Tian K,Wang L,Wu Z,Ren C,Hao S,Feng J,Li J,Wan H,Jia G,Zhang L,Zhang J

更新日期：2015-09-01 00:00:00

abstract：:Cervical cancer is a prevalent disease that may lead to mortality in women. In spite of the development of common therapeutic agents to treat cancer, there are several limitations of their use owing to side effects and drug resistance, which may induce cancer recurrence. The anticancer effects of the new herbal mixtur...

journal_title：Molecular medicine reports

authors： Lee KM,Lee K,Choi YK,Choi YJ,Seo HS,Ko SG

更新日期：2017-12-01 00:00:00

abstract：:Even though standard treatment options are available for prostate cancer patients, prostate cancer is still a leading cause of death in many Western countries due to drug resistance and recurrence. Immune checkpoint blockade therapy has been proved to be very effective in some melanoma patients, which might dependent ...

journal_title：Molecular medicine reports

authors： Zhou J,Yang T,Liu L,Lu B

更新日期：2017-09-01 00:00:00

abstract：:Kallikrein-related peptidase 14 (KLK14) is a member of the tissue kallikrein family of proteases, which are associated with the pathogenesis of malignant tumors and are over-expressed in ovarian carcinoma. However, the mechanism through which KLK14 is implicated in ovarian cancer remains unclear. The aim of the presen...

journal_title：Molecular medicine reports

authors： Zhang R,Shi H,Chen Z,Feng W,Zhang H,Wu K

更新日期：2012-01-01 00:00:00

abstract：:The current study was performed with aim to investigate the fibroblast growth factor receptor 2 (FGFR2) gene in two Chinese families with two different forms of syndromic craniosynostosis, and to characterize their associated clinical features. Two families underwent complete ophthalmic examinations, and two patients ...

journal_title：Molecular medicine reports

authors： Lin Y,Gao H,Ai S,Eswarakumar JVP,Chen C,Zhu Y,Li T,Liu B,Liu X,Luo L,Jiang H,Li Y,Liang X,Jin C,Huang X,Lu L

更新日期：2017-10-01 00:00:00

abstract：:Esculin is a derivative of coumarin, which is also an active ingredient of ash bark, and has antibacterial, anti-inflammatory, anti‑allergy and skin protective effects. The underlying mechanism and protective effects of esculin on cognitive impairment in experimental diabetic nephropathy (DN) was investigated in the p...

journal_title：Molecular medicine reports

authors： Song Y,Wang X,Qin S,Zhou S,Li J,Gao Y

更新日期：2018-05-01 00:00:00

abstract：:Methyl‑CpG‑binding protein 2 (MeCP2) is a transcriptional repressor that has been implicated in tumor onset and progression. Compared with normal and other tumorous tissue, MeCP2 is highly expressed in well‑differentiated adenocarcinoma and mucinous adenocarcinoma tissues, particularly at the invasion site of colorect...

journal_title：Molecular medicine reports

authors： Song N,Li K,Wang Y,Chen Z,Shi L

更新日期：2016-01-01 00:00:00

abstract：:We investigated the effects of mechanical strain on the progressive ankylosis (ANK) gene and extracellular nucleotide phosphatase/phosphodiesterase (ENPP)1 mRNA expression and TGF-β1 protein expression in rat endplate chondrocytes in vitro. Endplate chondrocytes were isolated and cultured in vitro. Following identific...

journal_title：Molecular medicine reports

authors： Xu HG,Hu CJ,Wang H,Liu P,Yang XM,Zhang Y,Wang LT

更新日期：2011-09-01 00:00:00

abstract：:Hair follicle stem cells (HFSCs) possess powerful expansion and multi‑differentiation potential, properties that place them at the forefront of the field of tissue engineering and stem cell‑based therapy. The aim of the present study was to investigate the differentiation of human HFSCs (hHFSCs) into cells of an endot...

journal_title：Molecular medicine reports

authors： Xu ZC,Zhang Q,Li H

更新日期：2014-01-01 00:00:00