Cell cycle and pluripotency: Convergence on octamer‑binding transcription factor 4 (Review).

abstract：:The two‑edged effect of matrix metalloproteinase‑9 (MMP9) makes it difficult to understand its role in liver fibrogenesis and fibrosis resolution. The present study aimed to investigate the dynamic features of liver fibrogenesis and fibrosis resolution in the absence of MMP9. MMP9‑/‑ mice were used to induce liver fib...

journal_title：Molecular medicine reports

authors： Wang Q,Liu X,Zhang J,Lu L,Feng M,Wang J

更新日期：2019-12-01 00:00:00

abstract：:Endothelial microparticles (EMPs) and endothelial cells (ECs) are involved in the pathophysiological mechanisms of sepsis and septic shock. EMPs are small vesicles released by ECs and are considered biomarkers for endothelial cell function and mediators for intercellular information exchange. However, the effect of EM...

journal_title：Molecular medicine reports

authors： Liu Y,Zhang R,Qu H,Wu J,Li L,Tang Y

更新日期：2017-03-01 00:00:00

abstract：:As the resident macrophages of the brain's innate immune system, microglial cells are key modulators in the neurodegenerative disease Alzheimer's disease (AD). In particular, the activation and accumulation of microglial cells around amyloid plaques is considered to result in chronic neuroinflammation. Although the pa...

journal_title：Molecular medicine reports

authors： Chen PL,Wang WJ,Rao YQ,Li J,Cheng MJ

更新日期：2018-04-01 00:00:00

abstract：:MicroRNAs (miRs) have been demonstrated to be important in the establishment and progression of colon cancer. However the underlying molecular mechanisms remain to be fully elucidated. Polypeptide N‑acetylgalactosaminyltransferase4 (GALNT4) participates in numerous cellular processes, including tumorigenesis. The pres...

journal_title：Molecular medicine reports

authors： Qu JJ,Qu XY,Zhou DZ

更新日期：2017-10-01 00:00:00

abstract：:Macrophages are involved in the progression of atherosclerosis by releasing pro-inflammatory cytokines. High levels of interleukin (IL)-18 are associated with an increased risk of developing diabetes and atherosclerosis. The present study aimed to investigate the association between IL-18, and high and fluctuating glu...

journal_title：Molecular medicine reports

authors： Zhang C,Bi Y,Jin G,Gan H,Yu L

更新日期：2015-08-01 00:00:00

abstract：:The use of human bone marrow mesenchymal stem cells (hBMSCs) as a tissue engineering application for individuals affected by osteoporosis and other types of bone loss diseases has been well studied in recent years. The osteogenic differentiation of hBMSCs can be regulated by a number of cues. MicroRNAs (miRNAs/miRs) s...

journal_title：Molecular medicine reports

authors： Zhang Y,Zhou L,Zhang Z,Ren F,Chen L,Lan Z

更新日期：2020-07-01 00:00:00

abstract：:Tissue-engineered bone substitutes are frequently used to repair bone defects. Adipose-derived stem cells (ASCs) are a promising source of cells for repairing bone tissue, however, insufficient osteogenic potency remains the main obstacle for their application. The present study aimed to enhance the osteogenic potency...

journal_title：Molecular medicine reports

authors： Wang Z,Zhang D,Hu Z,Cheng J,Zhuo C,Fang X,Xing Y

更新日期：2015-09-01 00:00:00

abstract：:Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the main causes of death and nervous system damage in neonates. The aim of the present study was to investigate the effect of the Toll‑like receptor 4 (TLR4) antagonist TAK‑242 on HIE. The Rice‑Vannucci method was used for ligation of the left common carotid art...

journal_title：Molecular medicine reports

authors： Jiang L,Xu Z,Li H,Wu M,Wang F,Liu S,Tao J,Feng X

更新日期：2020-08-01 00:00:00

abstract：:During orthodontic treatment, mechanical force is applied to the teeth, and following a series of complex metabolism changes, the position of the teeth in the alveolar bone change. This process is closely associated with primitive bone mesenchymal stem cells (BMSCs), which may differentiate into osteoblasts precursor ...

journal_title：Molecular medicine reports

authors： Yu H,Yu W,Liu Y,Yuan X,Yuan R,Guo Q

更新日期：2019-11-01 00:00:00

abstract：:Tumor necrosis factor‑related apoptosis-inducing ligand (TRAIL) is well known as a transmembrane cytokine and has been proposed as one of the most effective anti‑cancer therapeutic agents, owing to its efficiency to selectively induce cell death in a variety of tumor cells. Suppression of autophagy flux has been incre...

journal_title：Molecular medicine reports

authors： Nazim UM,Yin H,Park SY

更新日期：2019-02-01 00:00:00

abstract：:Hepatitis B virus X protein (HBx) has been previously demonstrated to be associated with the regulation of cell proliferation; however, the exact mechanisms underlying this effect remain unclear. The present study aimed to investigate the regulatory mechanism of HBx on the cycle progression of primary renal tubular ep...

journal_title：Molecular medicine reports

authors： Han W,Luo M,He M,Zhu Y,Zhong Y,Ding H,Hu G,Liu L,Chen Q,Lu Y

更新日期：2018-08-01 00:00:00

abstract：:As demonstrated in previous studies, the phosphorylated form of 4E‑binding protein 1 (p‑4E‑BP1) may be a suitable tumor biomarker. The aim of the current study was to examine the expression status of p‑4E‑BP1 in colorectal cancer (CRC), in order to determine its clinical significance. The present study enrolled 89 pat...

journal_title：Molecular medicine reports

authors： Miao Y,Chen L,Shi C,Fan R,Chen P,Liu H,Xia A,Qian H

更新日期：2017-05-01 00:00:00

abstract：:Brain‑type glycogen phosphorylase (PYGB) is an enzyme that metabolizes glycogen, whose function is to provide energy for an organism in an emergency state. The present study purposed to investigate the role and mechanism of PYGB silencing on the growth and apoptosis of prostate cancer cells. A cell counting kit‑8 assa...

journal_title：Molecular medicine reports

authors： Wang Z,Han G,Liu Q,Zhang W,Wang J

更新日期：2018-10-01 00:00:00

abstract：:Inflammation has been implicated in the pathogenesis of type 2 diabetes (T2D), which is a progressive disease characterized by pancreatic β‑cell dysfunction and apoptosis with consequential insufficient insulin secretion. Autophagy is necessary to maintain the structure, mass and function of pancreatic β‑cells. The pr...

journal_title：Molecular medicine reports

authors： Zhu LB,Cao MM,Wang J,Su Y,Jiang W,Liu GD,Li YB

更新日期：2019-06-01 00:00:00

abstract：:The expression of microRNA‑206 (miR‑206) is aberrantly induced in steroid‑induced avascular necrosis of femoral head (SANFH). Therefore, investigating the function of miR‑206 in SANFH and uncovering the functional mechanism associated with the condition will promote the understanding and treatment of the disease. The ...

journal_title：Molecular medicine reports

authors： Zhang Z,Jin A,Yan D

更新日期：2018-01-01 00:00:00

abstract：:Triptolide is known to exert anti-inflammatory and immunomodulatory activities; however, its impact on intestinal fibrosis has not been previously examined. Based on our previous studies of the suppressive activity of triptolide on human colonic subepithelial myofibroblasts and the therapeutic efficacy of triptolide i...

journal_title：Molecular medicine reports

authors： Tao Q,Wang B,Zheng Y,Li G,Ren J

更新日期：2015-08-01 00:00:00

abstract：:Blood stasis syndrome (BSS), additionally called Eohyul, is a basic pathological concept in Traditional Korean Medicine. Do In Seung Gi‑Tang (DISGT) is herbal medicine used for the treatment of BSS. It primarily treats metabolic diseases (MDs) including obesity, hypertension, diabetes mellitus and gynecological diseas...

journal_title：Molecular medicine reports

authors： Shim EH,Lee MS,Lee JA,Lee H

更新日期：2017-06-01 00:00:00

abstract：:Viral myocarditis (VM), a severe clinical condition characterized by cardiac inflammation, is most frequently induced as a result of coxsackievirus infection. Evidence suggests that microRNAs may have significant roles in the progression of cardiac injury during coxsackievirus infection. Concurrently, microRNA (miR)-2...

journal_title：Molecular medicine reports

authors： Chen ZG,Liu H,Zhang JB,Zhang SL,Zhao LH,Liang WQ

更新日期：2015-07-01 00:00:00

abstract：:Lung fibrosis is associated with inflammation, apoptosis and oxidative damage. The transcription factor nuclear factor erythroid 2‑related factor‑2 (Nrf2) prevents damage to cells from oxidative stress by regulating the expression of antioxidant proteins. Sulforaphane (SFN), an Nrf2 activator, additionally regulates e...

journal_title：Molecular medicine reports

authors： Yan B,Ma Z,Shi S,Hu Y,Ma T,Rong G,Yang J

更新日期：2017-06-01 00:00:00

abstract：:The overexpression and hypersecretion of mucus is a hallmark of chronic pulmonary inflammatory disease. Mucin5AC (MUC5AC) is a major component of airway gel‑forming mucin. Members of the Unc13 (Munc13) protein family act as important activators of granule exocytosis from various types of mammalian cells. The present s...

journal_title：Molecular medicine reports

authors： Xu R,Zhou J,Zhou XD,Li Q,Perelman JM,Kolosov VP

更新日期：2018-07-01 00:00:00

abstract：:Although the etiology of intervertebral disc degeneration is poorly understood, one approach to prevent this process may be to inhibit apoptosis. In the current study, the anti‑apoptotic effects of carboxymethylated chitosan (CMCS) in nucleus pulposus (NP) cells were investigated with the aim to enhance disc cell surv...

journal_title：Molecular medicine reports

authors： He B,Tao H,Liu S,Wei A

更新日期：2015-03-01 00:00:00

abstract：:A disintegrin and metalloproteinases (ADAMs), a family of transmembrane glycoproteins, are expressed in numerous tissues and organs, and have been implicated in a variety of physiological and pathological processes. ADAM15 is unique among the ADAMs in having an Arg-Gly-Asp motif in its disintegrin domain. In the prese...

journal_title：Molecular medicine reports

authors： Hou Y,Chu M,Cai Y,Lei J,Chen Y,Zhu R,Gong X,Ma X,Jin J

更新日期：2015-08-01 00:00:00

abstract：:Obesity is marked by deposition of collagen I in adipose tissue. Toll like receptor (TLR)2 is involved in lipid metabolism, however the association between TLR2 and collagen I remains unclear. The present study was designed to investigate the effect of TLR2 knockout on collagen I in adipose tissue in obese mice. TLR2 ...

journal_title：Molecular medicine reports

authors： Song B,Zhang H,Zhang S

更新日期：2018-04-01 00:00:00

abstract：:To investigate the genotype-phenotype correlation in Chinese familial and sporadic hypertrophic cardiomyopathy, specific exons of the myosin binding protein-c gene (MYBPC3) were screened in six families with hypertrophic cardiomyopathy (HCM; FHCM) and in 20 patients with sporadic HCM (SHCM) from the Anhui Province reg...

journal_title：Molecular medicine reports

authors： Wang AL,Kong DH,Chen DX,Wan J,Yu YX

更新日期：2010-09-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is important for the proliferation and differentiation of gastric mucosal cells. Betacellulin (BTC) is a novel ligand for EGFR Since their role is unclear in the ulcer healing process, we investigated their expression. Gastric ulcers in 30 Sprague-Dawley rats were induced by ace...

journal_title：Molecular medicine reports

authors： Choi GH,Park HS,Kim KR,Choi HN,Jang KY,Chung MJ,Kang MJ,Lee DG,Moon WS

更新日期：2008-07-01 00:00:00

abstract：:Tumor angiogenesis is important in the growth and metastasis of malignant tumors. In our previous study, we demonstrated that an arginine-arginine-leucine (RRL) peptide is a tumor endothelial cell-specific binding sequence that may be used as a molecular probe for the imaging of malignant tumors in vivo. The aim of th...

journal_title：Molecular medicine reports

authors： Zhao Q,Yan P,Yin L,Li L,Chen XQ,Ma C,Wang RF

更新日期：2013-04-01 00:00:00

abstract：:p53 is a tumor suppressor gene whose mutation is highly associated with tumorigenesis. The present study investigated the role of p53β in the inhibition of proliferation of gastric cancer cell lines expressing wild-type or mutated p53. Wild-type p53 is expressed in MKN45 cells, but deleted in KATOIII cells, whereas mu...

journal_title：Molecular medicine reports

authors： Ji W,Ma J,Zhang H,Zhong H,Li L,Ding N,Jiao J,Gao Z

更新日期：2015-07-01 00:00:00

abstract：:Hyperbaric oxygen (HBO) therapy is an effective therapy for ischemia/reperfusion (I/R) injury of the brain, small intestine, testes and liver. However, the detailed molecular mechanisms underlying the effect of HBO therapy remain undetermined. In the current study, the hypothesis that preconditioning rats with HBO pro...

journal_title：Molecular medicine reports

authors： Kang N,Hai Y,Liang F,Gao CJ,Liu XH

更新日期：2014-06-01 00:00:00

abstract：:Many studies have reported that lutein may exert its biological activities, including anti‑inflammation, anti‑oxidase and anti‑apoptosis, through effects on reactive oxygen species (ROS). Thus, lutein may prevent the damaging activities of ROS in cells. The current study investigated the effect of lutein against sever...

journal_title：Molecular medicine reports

authors： Tan D,Yu X,Chen M,Chen J,Xu J

更新日期：2017-10-01 00:00:00

abstract：:Full‑thickness and large area defects of articular cartilage are unable to completely repair themselves and require surgical intervention, including microfracture, autologous or allogeneic osteochondral grafts, and autologous chondrocyte implantation. A large proportion of regenerative cartilage exists as fibrocartila...

journal_title：Molecular medicine reports

authors： Li Z,Fei H,Wang Z,Zhu T

更新日期：2017-09-01 00:00:00