Upregulated microRNA-214 enhances cardiac injury by targeting ITCH during coxsackievirus infection.

abstract：:Doxorubicin (ADR) is successfully used to treat breast cancer, however, it is often associated with the acquired resistance of breast cancer cells which eliminates the therapeutic efficiency of ADR, leading to relapse and a poorer prognosis. It has been reported that microRNA-200c (miRNA-200c), a non-coding RNA, is im...

journal_title：Molecular medicine reports

authors： Chen Y,Sun Y,Chen L,Xu X,Zhang X,Wang B,Min L,Liu W

更新日期：2013-05-01 00:00:00

abstract：:4-Hydroxy-3-methoxybenzaldehyde (vanillin), contained in a number of species of plant, has been reported to display beneficial effects against brain injuries. In the present study, the impact of vanillin on scopolamine‑induced alterations in cognition and the expression of DNA binding protein inhibitor ID‑1 (ID1), one...

journal_title：Molecular medicine reports

authors： Lee JC,Kim IH,Cho JH,Lee TK,Park JH,Ahn JH,Shin BN,Yan BC,Kim JD,Jeon YH,Lee YJ,Won MH,Kang IJ

更新日期：2018-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumor. Studies have demonstrated that the toll‑like receptor 3 (TLR3)/interferon pathway is inhibitory in cancer cell proliferation, suggesting that the activation of this pathway may have therapeutic potential. In the present study, the inhib...

journal_title：Molecular medicine reports

authors： Xu YY,Chen L,Zhou JM,Wu YY,Zhu YY

更新日期：2013-10-01 00:00:00

abstract：:Mineralized bone matrix constituted with collagenous and non-collagenous proteins was synthesized by osteoblasts differentiated from mesenchymal stem cells. Secretory leukocyte protease inhibitor (SLPI), a serine protease inhibitor, promotes cell migration and proliferation, and suppresses the inflammatory response. R...

journal_title：Molecular medicine reports

authors： Choi BD,Lee SY,Jeong SJ,Lim DS,Cha HJ,Chung WG,Jeong MJ

更新日期：2016-08-01 00:00:00

abstract：:Although microRNA-296 (miR-296) has been studied in various types of human cancer, its expression, biological role and mechanism of action in pancreatic cancer remains to be elucidated. The aim of the current study was to investigate the expression level, possible roles and underlying molecular mechanisms of miR‑296 i...

journal_title：Molecular medicine reports

authors： Li H,Li J,Shi B,Chen F

更新日期：2017-07-01 00:00:00

abstract：:Osteosarcoma (OS) is the most frequent malignant primary bone tumor arising from primitive bone‑forming mesenchymal cells in children and adolescents. The dysregulation of microRNAs (miRNAs) has been reported in OS, and these aberrantly expressed miRNAs are involved in the initiation and progression of OS. The aim of ...

journal_title：Molecular medicine reports

authors： Yang X,Cui Y,Yang F,Sun C,Gao X

更新日期：2017-09-01 00:00:00

abstract：:The newly identified C1q/tumor necrosis factor (TNF)-related protein-6 (CTRP6) is a highly conserved paralog of adiponectin with modulatory effects on metabolism and inflammation. However, the role of CTRP6 in cerebral ischemia/reperfusion (I/R) injury remains unknown. The aim of the present study was to explore the p...

journal_title：Molecular medicine reports

authors： Li Y,Sun J,Gu L,Gao X

更新日期：2020-07-01 00:00:00

abstract：:Advances in the treatment of nasopharyngeal carcinoma (NPC) have significantly improved the local control rate; however, distant metastasis remains a principal cause of mortality. Previous studies have demonstrated that the expression levels of amyloid β precursor protein (APP) are increased in NPC. The present study ...

journal_title：Molecular medicine reports

authors： Xu J,Ying Y,Xiong G,Lai L,Wang Q,Yang Y

更新日期：2019-07-01 00:00:00

abstract：:Metastasis is the most lethal stage of cancer progression. The present study aimed to investigate the underlying molecular mechanisms of melanoma metastasis using bioinformatics. Using the microarray dataset GSE8401 from the Gene Expression Omnibus database, which included 52 biopsy specimens from patients with melano...

journal_title：Molecular medicine reports

authors： Chen J,Wu F,Shi Y,Yang D,Xu M,Lai Y,Liu Y

更新日期：2019-08-01 00:00:00

abstract：:The advanced glycosylation end product-specific receptor (RAGE) has been demonstrated to be an important mediator of asthma pathogenesis. The soluble isoform of RAGE (sRAGE) acts as a 'decoy' to sequester RAGE ligands, and thus prevents their binding to the receptor. A number of reports have linked deficiency of sRAGE...

journal_title：Molecular medicine reports

authors： Lyu Y,Zhao H,Ye Y,Liu L,Zhu S,Xia Y,Zou F,Cai S

更新日期：2018-03-01 00:00:00

abstract：:Brain‑type glycogen phosphorylase (PYGB) is an enzyme that metabolizes glycogen, whose function is to provide energy for an organism in an emergency state. The present study purposed to investigate the role and mechanism of PYGB silencing on the growth and apoptosis of prostate cancer cells. A cell counting kit‑8 assa...

journal_title：Molecular medicine reports

authors： Wang Z,Han G,Liu Q,Zhang W,Wang J

更新日期：2018-10-01 00:00:00

abstract：:In order to gain greater understanding of the mechanisms underlying the effect of epigallocatechin-3-gallate (EGCG) on DNA methylation and its chemopreventative action in oral squamous cell carcinoma (OSCC), a genome‑wide methylation and mRNA expression screen was performed in the CAL‑27 cell line with and without EGC...

journal_title：Molecular medicine reports

authors： Chen LL,Han WF,Geng Y,Su JS

更新日期：2015-10-01 00:00:00

abstract：:Allergen extracts are commonly utilized for diagnosis and immunotherapy; however, the stability of protease‑rich extracts is important for a precise diagnosis and treatment efficacy. The present study determines the optimal conditions for the storage of German cockroach allergen extract. Cockroach extracts were recons...

journal_title：Molecular medicine reports

authors： Jeong KY,Lee J,Yuk JE,Park KH,Lee JH,Kim JD,Park JW

更新日期：2020-02-01 00:00:00

abstract：:High density lipoproteins (HDL) are heterogeneous particles regarding their size and composition. They have vital functions in reverse cholesterol transport (RCT). RCT occurs when lipid-free apolipoprotein AI recruits cholesterol and phospholipid to form nascent HDL particles. Adenosine triphosphate‑binding cassette t...

journal_title：Molecular medicine reports

authors： Zhou L,Li C,Gao L,Wang A

更新日期：2015-09-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) affect atherosclerosis by regulating the physiological and pathological processes of endothelial cells; however, the role of lncRNA WEE2 antisense RNA 1 (WEE2‑AS1) in arteriosclerosis obliterans (ASO) is not completely understood. The present study aimed to explore the function of lncRNA...

journal_title：Molecular medicine reports

authors： Jiang B,Wang R,Lin Z,Ma J,Cui J,Wang M,Liu R,Wu W,Zhang C,Li W,Wang S

更新日期：2020-12-01 00:00:00

abstract：:Histone deacetylases (HDACs) are important in chromatin remodeling and epigenetic regulation of gene expression. Histone deacetylase inhibitors (HDACi) have highly effective anti-metastatic and anti-angiogenic activity in various types of cancer, while the molecular mechanisms involved in this process are not fully un...

journal_title：Molecular medicine reports

authors： Lu HG,Zhan W,Yan L,Qin RY,Yan YP,Yang ZJ,Liu GC,Li GQ,Wang HF,Li XL,Li Z,Gao L,Chen GQ

更新日期：2014-11-01 00:00:00

abstract：:Endothelial cell injury caused by reactive oxygen species (ROS) plays a critical role in the pathogenesis of atherosclerosis. Therefore, phytochemicals or antioxidants that inhibit the production of ROS have clinical value for the treatment of atherosclerosis. Rhein is one of the most important active components of rh...

journal_title：Molecular medicine reports

authors： Zhong XF,Huang GD,Luo T,Deng ZY,Hu JN

更新日期：2012-05-01 00:00:00

abstract：:β-crystallin B2 (CRYBB2) knockout mice exhibit morphological and functional abnormalities in the ovary. Long non‑coding RNAs (lncRNAs) regulate gene transcription and translation, and epigenetic modification of genomic DNA. The present study investigated the role of lncRNAs in mediating the effects of CRYBB2 in the re...

journal_title：Molecular medicine reports

authors： Gao Q,Ren H,Chen M,Niu Z,Tao H,Jia Y,Zhang J,Li W

更新日期：2016-11-01 00:00:00

abstract：:Stroke is a leading cause of impairment and disability worldwide, and motor imagery (MI) has been used in stroke rehabilitation. Electroencephalography (EEG) has been used to study MI. However, the characteristic features of EEG during MI in stroke patients have not been established. The purpose of this study was to i...

journal_title：Molecular medicine reports

authors： Gong W,Zhang T,Shan L

更新日期：2013-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by synovial inflammation. Fibroblast‑like synoviocytes (FLS) serve a vital role in the initiation and perpetuation of the immune response in patients with RA. The present study aimed to investigate the potential role of microRNA (miR)‑34a‑...

journal_title：Molecular medicine reports

authors： Hou C,Wang D,Zhang L

更新日期：2019-09-01 00:00:00

abstract：:Although monitoring and diagnosis of fetal diseases in utero remains a challenge, metabolomics may provide an additional tool to study the etiology and pathophysiology of fetal diseases at a functional level. In order to explore specific markers of fetal disease, metabolites were analyzed in two separate sets of exper...

journal_title：Molecular medicine reports

authors： Huang J,Mo J,Zhao G,Lin Q,Wei G,Deng W,Chen D,Yu B

更新日期：2017-11-01 00:00:00

abstract：:Pentatricopeptide repeat domain protein 3 (PTCD3) is a mitochondrial RNA‑binding protein that serves a role in mitochondrial translation. PTCD3 was originally reported as an oncogene that is involved in breast cancer and lymphoma. However, the expression and function of PTCD3 in prostate cancer (PCa) are unknown. Ther...

journal_title：Molecular medicine reports

authors： Huang Y,Jiang G,Liang X,Lan Z,Su Z,Wu H,Weng J,Jiang X

更新日期：2018-10-01 00:00:00

abstract：:The present study aimed to investigate functional networks underlying brain‑activity alterations in patients with acute unilateral open globe injury (OGI) and associations with their clinical features using the voxel‑wise degree centrality (DC) method. In total, 18 patients with acute OGI (16 males and 2 females), and...

journal_title：Molecular medicine reports

authors： Wang H,Chen T,Ye L,Yang QC,Wei R,Zhang Y,Jiang N,Shao Y

更新日期：2017-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common type of neurological disorder that results from brain cell death; however, not all brain regions are simultaneously affected to the same extent. Despite single biomarkers for AD having been determined on a genome‑wide scale, the differential co‑expression in gene pairs betwe...

journal_title：Molecular medicine reports

authors： Yu L,Qian S,Wei S

更新日期：2018-08-01 00:00:00

abstract：:Chronic periodontitis, a common oral disease, usually results in irreversible bone resorption. Bone regeneration is a complex process between bone‑forming activity of osteoblasts and bone‑resorbing activity of osteoclasts, and still remains a challenge for physicians clinically. A previous study demonstrated that the ...

journal_title：Molecular medicine reports

authors： Li X,Chang B,Wang B,Bu W,Zhao L,Liu J,Meng L,Wang L,Xin Y,Wang D,Tang Q,Zheng C,Sun H

更新日期：2017-12-01 00:00:00

abstract：:Small‑cell lung cancer (SCLC) is a type of lung cancer with early metastasis, and high recurrence and mortality rates. The molecular mechanism is still unclear and further research is required. The aim of the present study was to examine the pathogenesis and potential molecular markers of SCLC by comparing the differe...

journal_title：Molecular medicine reports

authors： Mao Y,Xue P,Li L,Xu P,Cai Y,Chu X,Jiang P,Zhu S

更新日期：2019-09-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL), the most frequently occurring type of lymphoid malignancy, has been demonstrated to be associated with mutations of Ten‑Eleven Translocation (TET). In order to explore the association between DLBCL and TET mutations, the present study analyzed the gene expression and methylation ...

journal_title：Molecular medicine reports

authors： Liu P,Jiang W,Zhao J,Zhang H

更新日期：2017-10-01 00:00:00

abstract：:Metabolic syndrome arises from a combination of disorders that increase the risk of cardiovascular disease and diabetes. In previous studies, it was observed that overexpression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) induced obesity and the insulin resistance that accompanies metabolic syndrome in roden...

journal_title：Molecular medicine reports

authors： Jung EM,An BS,Kim YK,Jeong YH,Hwang WS,Jeung EB

更新日期：2013-09-01 00:00:00

abstract：:The aim of the present study was to determine whether pyrroloquinoline quinine (PQQ) exerts a protective effect on ultraviolet A (UVA) irradiation‑induced senescence in human dermal fibroblasts (HDFs) and to elucidate its mechanism of action in vitro. A senescence model was constructed as follows: HDFs (1x10(4)‑1x10(6...

journal_title：Molecular medicine reports

authors： Zhang C,Wen C,Lin J,Shen G

更新日期：2015-09-01 00:00:00

abstract：:The medicinal fungus Paecilomyces tenuipes exhibits a variety of pharmacological effects, including antidepressive effects. The chronic unpredictable mild stress (CUMS)‑induced rat model has served an important role in studies involving antidepressants screening. The aim of the present study was to evaluate the antide...

journal_title：Molecular medicine reports

authors： Liu C,Wang J,Xu S,An S,Tang S,He J,Liu Y,Lee RJ,Wang D

更新日期：2017-08-01 00:00:00