Secretory leukocyte protease inhibitor promotes differentiation and mineralization of MC3T3-E1 preosteoblasts on a titanium surface.

abstract：:The aim of the present study was to investigate the effect of the nuclear factor‑κB (NF‑κB) inhibitor, pyrrolidine dithiocarbamate (PDTC), on high‑mobility group protein B1 (HMGB1) expression in a rat model of chronic obstructive pulmonary disease (COPD). The COPD model was developed by administering lipopolysaccharid...

journal_title：Molecular medicine reports

authors： Wang CM,Jiang M,Wang HJ

更新日期：2013-02-01 00:00:00

abstract：:Krüppel-like factors (KLFs) regulate a wide variety of cellular functions and modulate pathological processes. In the present study, a post‑translational mechanism of microRNAs (miRs) was investigated in H2O2-induced human cardiomyocyte (HCM) injury. In H2O2‑cultured HCM cells, reactive oxygen species and apoptotic ce...

journal_title：Molecular medicine reports

authors： Zhang X,Liu F,Wang Q,Geng Y

更新日期：2017-10-01 00:00:00

abstract：:Recent advances in the treatment of non-small cell lung cancer (NSCLC) with new agents require accurate histological subtyping at diagnosis to avoid the higher risk of an adverse response and to obtain the maximum therapeutic response. However, interobserver variability, tumor heterogeneity and the degree of different...

journal_title：Molecular medicine reports

authors： Hamamoto J,Soejima K,Yoda S,Naoki K,Nakayama S,Satomi R,Terai H,Ikemura S,Sato T,Yasuda H,Hayashi Y,Sakamoto M,Takebayashi T,Betsuyaku T

更新日期：2013-08-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been demonstrated to be significant in numerous biological processes. Hypertension is a form of cardiovascular disease with at least one billion cases worldwide. The present study sought to compare the differential expression profiles of lncRNAs in the renal cortex of spontaneously ...

journal_title：Molecular medicine reports

authors： Hou L,Lin Z,Ni Y,Wu Y,Chen D,Song L,Huang X,Hu H,Yang D

更新日期：2016-01-01 00:00:00

abstract：:Low‑density lipoprotein receptors (LDLRs) may serve a role in the diabetogenic effect of statins; however, the effects of statins on LDLR expression and its regulation in the pancreas and islets have yet to be determined. To exclude the long‑term effects of treatment with atorvastatin, which allows mice to adapt, male...

journal_title：Molecular medicine reports

authors： Yu Q,Wang F,Meng X,Gong Y,Wang Y,Xu C,Wang S

更新日期：2018-09-01 00:00:00

abstract：:The cooperation and communication between different cell signaling transduction pathways are considered critical in the development of various types of cancer as well as drug resistance. There is evidence of crosstalk between the G protein-coupled receptor 30 (GPR30), the newly discovered estrogen receptor (ER), and t...

journal_title：Molecular medicine reports

authors： Ruan SQ,Wang SW,Wang ZH,Zhang SZ

更新日期：2012-07-01 00:00:00

abstract：:Indoleamine 2, 3-dioxygenase (IDO) catalyzes the initial and rate‑limiting step in the degradation pathway of the essential amino acid tryptophan and is expressed by professional antigen presenting cells (APCs), epithelial cells, vascular endothelium and tumor cells. IDO‑mediated catabolic products, which are addition...

journal_title：Molecular medicine reports

authors： Wu H,Gong J,Liu Y

更新日期：2018-04-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been reported to serve a key role in a variety of cardiovascular diseases, including in cardiac fibrosis. The present study aimed to investigate the biological role and underlying mechanisms of the induction of cardiac fibroblasts by the lncRNA, RNA component of mitochondrial RNA pr...

journal_title：Molecular medicine reports

authors： Zhang SY,Huang SH,Gao SX,Wang YB,Jin P,Lu FJ

更新日期：2019-10-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) was the first hematological malignancy to be associated with a specific genetic lesion. The Philadelphia translocation, producing a BCR‑ABL hybrid oncogene, is the most common mechanism of CML development. However, in the present study, b3a2, b2a2 and ela2 fusion junctions of the breakpo...

journal_title：Molecular medicine reports

authors： Zhou JB,Zhang T,Wang BF,Gao HZ,Xu X

更新日期：2013-02-01 00:00:00

abstract：:The aim of the present study was to identify miRNAs that were differentially expressed in hepatocellular carcinoma (HCC) by comparing normal and cancer tissue samples and to analyze the correlation of the target genes and HCC. The gene expression profile of GSE31383 was downloaded from the Gene Expression Omnibus data...

journal_title：Molecular medicine reports

authors： Han K,Li J,Zhao H,Liang P,Huang X,Zheng L,Li Y,Yang T,Wang L

更新日期：2014-07-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of a herbal medicine formula, Gan-fu-kang (GFK), on the treatment of liver fibrosis in rats and the mechanisms via which it exerts its effect. Liver fibrosis was induced in rats by subcutaneous injection of carbon tetrachloride (CCl4) at 0.5 mg/kg body weight,...

journal_title：Molecular medicine reports

authors： Zhang C,Wang Y,Chen H,Yang G,Wang S,Jiang M,Cong L,Yuan L,Li H,Jia Y

更新日期：2013-09-01 00:00:00

abstract：:Through searching for anti‑neuroinflammatory metabolites from Nardostachys jatamansi extracts, nardostachin was revealed to exert anti‑neuroinflammatory effects against lipopolysaccharide (LPS)‑induced overproduction of nitric oxide and prostaglandin E2 in BV2 and rat primary microglial cells. Furthermore, nardostachi...

journal_title：Molecular medicine reports

authors： Kim DC,Park JS,Yoon CS,Kim YC,Oh H

更新日期：2021-01-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a disease associated with high mortality and morbidity. MicroRNAs (miRNAs) have been reported to be associated with the pathogenesis of numerous cerebrovascular diseases, including ICH. miR‑222 has been revealed to play important roles in various physiological and pathological process...

journal_title：Molecular medicine reports

authors： Bai YY,Niu JZ

更新日期：2020-03-01 00:00:00

abstract：:Giant cell tumor (GCT) is an aggressive type of bone tumor consisting of multinucleated osteoclast-like giant cells. Imatinib is a selective inhibitor for certain type III tyrosine kinase receptor family members with a variety of beneficial effects. The purpose of the present study was to determine the therapeutic pot...

journal_title：Molecular medicine reports

authors： Liao Y,Lv G,Wang B,Kuang L,Wang X

更新日期：2016-02-01 00:00:00

abstract：:The aim of the present study was to identify potential key genes associated with the progression and prognosis of colorectal cancer (CRC). Differentially expressed genes (DEGs) between CRC and normal samples were screened by integrated analysis of gene expression profile datasets, including the Gene Expression Omnibus...

journal_title：Molecular medicine reports

authors： Yu C,Chen F,Jiang J,Zhang H,Zhou M

更新日期：2019-08-01 00:00:00

abstract：:Tongue squamous cell carcinoma (TSCC) is the most frequent type of oral cancer associated with high malignancy. Circular RNAs (circRNAs) are a form of non‑coding RNA with stable and conserved expression in mammalian cells. The aim of the present study was to investigate circRNAs expression profiles in TSCC, and examin...

journal_title：Molecular medicine reports

authors： Wei T,Ye P,Yu GY,Zhang ZY

更新日期：2020-04-01 00:00:00

abstract：:Breast cancer (BC) is the most common cancer among women worldwide. However, there is insufficient research that focuses on the expression and molecular mechanisms of microRNA (miR)‑204‑5p in BC. In the current study, data were downloaded from the Cancer Genome Atlas (TCGA), the Gene Expression Omnibus (GEO) and the U...

journal_title：Molecular medicine reports

authors： Cai KT,Liu AG,Wang ZF,Jiang HW,Zeng JJ,He RQ,Ma J,Chen G,Zhong JC

更新日期：2019-02-01 00:00:00

abstract：:Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a cancer suppressor gene and an important negative regulator in the phosphatidylinositide 3‑kinase (PI3K)/protein kinase B (Akt)/ mechanistic target of rapamycin (mTOR) signaling pathway. The PI3K/Akt/mTOR pathway can promote cancer cell survival, proli...

journal_title：Molecular medicine reports

authors： Liu S,Xu ZL,Sun L,Liu Y,Li CC,Li HM,Zhang W,Li CJ,Qin W

更新日期：2016-07-01 00:00:00

abstract：:MicroRNAs (miRs) can lead to mRNA degradation or inhibit protein translation through directly binding to the 3'‑untranslational region (UTR) of their target mRNAs. Deregulation of miR‑10b has been reported to be associated with chondrosarcoma. However, the role of miR‑10b in chondrosarcoma cell migration and invasion,...

journal_title：Molecular medicine reports

authors： Aili A,Chen Y,Zhang H

更新日期：2016-01-01 00:00:00

abstract：:Prospero homeobox protein 1 (PROX1) is highly expressed in high-grade malignant astrocytic gliomas. However, the role of PROX1 in the pathogenesis of glioblastoma multiforme (GBM) remains unclear. The present study overexpressed PROX1 in human GBM cell lines and examined its effects on cell growth, tumorigenesis, and ...

journal_title：Molecular medicine reports

authors： Xu X,Wan X,Wei X

更新日期：2017-02-01 00:00:00

abstract：:The transforming growth factor-β (TGF-β) signaling pathway exhibits an important role in cancer invasion and metastasis. Excessive expression of TGF-β activates Smad4, leading to the upregulation of downstream metastasis-associated genes. Thus, the inhibition of the TGF-β/Smad4 signaling pathway may be a novel strateg...

journal_title：Molecular medicine reports

authors： Chen F,Zhuang M,Peng J,Wang X,Huang T,Li S,Lin M,Lin H,Xu Y,Li J,Chen Z,Huang Y

更新日期：2014-10-01 00:00:00

abstract：:Astronauts are inevitably exposed to two major risks during space flight, microgravity and radiation. Exposure to microgravity has been discovered to lead to rapid and vigorous bone loss due to elevated osteoclastic activity. In addition, long‑term exposure to low‑dose‑rate space radiation was identified to promote DN...

journal_title：Molecular medicine reports

authors： Furusawa Y,Yamamoto T,Hattori A,Suzuki N,Hirayama J,Sekiguchi T,Tabuchi Y

更新日期：2020-10-01 00:00:00

abstract：:The study investigated the effects and underlying mechanisms of silent information regulation of transcription 1 (Sirt1) action on apoptosis in chondrocytes and degradation of the extracellular matrix. Cartilage tissue samples were derived from knee arthroplasty of patients with osteoarthritis (OA). The three groups w...

journal_title：Molecular medicine reports

authors： He DS,Hu XJ,Yan YQ,Liu H

更新日期：2017-07-01 00:00:00

abstract：:Curcumin is characterized by anti‑inflammatory, anti‑oxidative, antiviral, antifibrotic, anticoagulation and glucose regulatory functions. However, whether it is protective in diabetes mellitus‑associated cerebral infarction remains to be fully elucidated. In the present study, it was demonstrated for the first time, ...

journal_title：Molecular medicine reports

authors： Xia M,Ye Z,Shi Y,Zhou L,Hua Y

更新日期：2018-01-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic and irreversible interstitial lung disease with a poor prognosis and limited therapeutic options. Over the past decade, research efforts have focused on the pathogenetic mechanisms involved in this enigmatic lung disease. Rheumatoid arthritis (RA) is a chronic inflammat...

journal_title：Molecular medicine reports

authors： Vasarmidi E,Sarantoulaki S,Trachalaki A,Margaritopoulos G,Bibaki E,Spandidos DA,Tzanakis N,Antoniou K

更新日期：2018-10-01 00:00:00

abstract：:The present study aimed to investigate the anticancer effect of sorafenib combined with silencing of activating transcription factor 2 (ATF2) in hepatocellular carcinoma (HCC) cells and to assess the underlying molecular mechanisms. Huh‑7 HCC cell line was selected for the present study. Small interfering RNA (siRNA)‑...

journal_title：Molecular medicine reports

authors： Luo L,Cai L,Luo L,Tang Z,Meng X

更新日期：2018-06-01 00:00:00

abstract：:The present study aimed to evaluate the silencing effect of artificial microRNAs (amiRNAs) against the hepatitis C virus (HCV) 1b (HCV1b) genotype core (C) and non-structural protein 4B (NS4B) genes. pDsRed-monomer-Core and pDsRed-monomer-NS4B plasmids, containing the target genes were constructed. A total of eight ar...

journal_title：Molecular medicine reports

authors： Jiang XH,Xie YT,Jiang B,Tang MY,Ma T,Peng H

更新日期：2015-08-01 00:00:00

abstract：:The present study presented a protocol that can be used to obtain rapidly a high purity of proliferating rat Schwann cells from freshly dissociated rat peripheral nerves. The sciatic nerves of newborn rats (1‑3 day old) were dissociated, and the Schwann cells (SCs) were purified using fluorescence‑activated cell sorti...

journal_title：Molecular medicine reports

authors： Shen M,Tang W,Cao Z,Cao X,Ding F

更新日期：2017-08-01 00:00:00

abstract：:Millions of infants and children are exposed to anesthesia every year during medical care. Sevoflurane is a volatile anesthetic that is frequently used for pediatric anesthesia. However, previous reports have suggested that the administration of sevoflurane promotes neurodegeneration, raising concerns regarding the sa...

journal_title：Molecular medicine reports

authors： Wang LY,Tang ZJ,Han YZ

更新日期：2016-10-01 00:00:00

abstract：:The present study aimed to investigate functional networks underlying brain‑activity alterations in patients with acute unilateral open globe injury (OGI) and associations with their clinical features using the voxel‑wise degree centrality (DC) method. In total, 18 patients with acute OGI (16 males and 2 females), and...

journal_title：Molecular medicine reports

authors： Wang H,Chen T,Ye L,Yang QC,Wei R,Zhang Y,Jiang N,Shao Y

更新日期：2017-12-01 00:00:00