Nardostachin from Nardostachys jatamansi exerts anti‑neuroinflammatory effects through TLR4/MyD88‑related suppression of the NF‑κB and JNK MAPK signaling pathways in lipopolysaccharide‑induced BV2 and primary microglial cells.

abstract：:Runt-related transcription factor 2 (RUNX2) is a vital regulatory factor that controls osteoblast-specific gene expression; however, RUNX2‑regulated genes in human mesenchymal stem cells (hMSCs) remain to be fully elucidated. In the present study, chromatin immunoprecipitation (ChIP)-on-chip analysis of RUNX2 in hMSCs...

journal_title：Molecular medicine reports

authors： Xiong J,Hu Z,Wang T,Xu X,Liu J,Wu P,Che X,Li W

更新日期：2016-08-01 00:00:00

abstract：:Kallikrein-related peptidase 14 (KLK14) is a member of the tissue kallikrein family of proteases, which are associated with the pathogenesis of malignant tumors and are over-expressed in ovarian carcinoma. However, the mechanism through which KLK14 is implicated in ovarian cancer remains unclear. The aim of the presen...

journal_title：Molecular medicine reports

authors： Zhang R,Shi H,Chen Z,Feng W,Zhang H,Wu K

更新日期：2012-01-01 00:00:00

abstract：:Saikosaponin‑d (SSd) the primary active component of triterpene saponin derived from Bupleurum falcatum L., possesses anti‑inflammatory and antioxidant properties. The present study aimed to examine the potential therapeutic effects of SSd on carbon tetrachloride (CCl4)‑induced acute hepatocellular injury in the HL‑77...

journal_title：Molecular medicine reports

authors： Lin L,Que R,Shen Y,Chen Y,Yan N,Li Y

更新日期：2018-06-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) comprise a sizeable class of non‑coding RNAs with a length of over 200 base pairs. Little is known about their biological function, although over 20,000 lncRNAs have been annotated in the human genome. Through a diverse range of mechanisms, their primary function is in the regulation of ...

journal_title：Molecular medicine reports

authors： Kołat D,Hammouz R,Bednarek AK,Płuciennik E

更新日期：2019-08-01 00:00:00

abstract：:Rhus javanica Linn, a traditional medicinal herb from the family Anacardiaceae, has been used in the treatment of liver diseases, cancer, parasitic infections, malaria and respiratory diseases in China, Korea and other Asian countries for centuries. In the present study, the protective effects of R. javanica ethanolic...

journal_title：Molecular medicine reports

authors： Yoon C,Koppula S,Yoo S,Yum M,Kim J,Lee J,Song M

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are a potential cell source for the development of therapeutic products. Recent studies have shown that the transplantation of MSCs to damaged organs, including the heart, liver and kidneys, results in the restoration of the damaged tissues. However, the mechanisms underlying this rege...

journal_title：Molecular medicine reports

authors： Cho KA,Ju SY,Ryu KH,Woo SY

更新日期：2009-01-01 00:00:00

abstract：:In Crohn's disease (CD), clinical symptoms correspond poorly to inflammatory disease activity. Biomarkers, which reflect the level of intestinal inflammation are considered to enable effective monitoring of disease activity. The present study evaluated the role of serum pentraxin 3 (PTX3) as a marker of disease activi...

journal_title：Molecular medicine reports

authors： Chen J,Xu X,Xia L,Xi X,Liu B,Yang M

更新日期：2015-07-01 00:00:00

abstract：:Although Frey syndrome is not life-threatening, it is identified as the most serious and widely recognized sequela of parotidectomy and has significant potential negative social and psychological implications. Several studies have investigated whether AlloDerm® implants prevent Frey syndrome effectively and safely, ho...

journal_title：Molecular medicine reports

authors： Zeng XT,Tang XJ,Wang XJ,Li MZ,Guo Y,Huang W,Niu YM,Leng WD

更新日期：2012-04-01 00:00:00

abstract：:The present study investigated the synergic effects and potential mechanisms of action of Astragalus polysaccharides (APS) combined with Crataegus flavonoids (CF) in the treatment of type 1 diabetes. Diabetes was induced by intraperitoneal injection of 100 mg/kg streptozotocin in mice. Normal and untreated diabetic co...

journal_title：Molecular medicine reports

authors： Cui K,Zhang S,Jiang X,Xie W

更新日期：2016-06-01 00:00:00

abstract：:Heme oxygenase‑1 (HO‑1), as an inducible and cytoprotective enzyme, has a protective effect against cellular oxidative stress. In the present study, cholesterol was used to induce lipid overload and increase reactive oxygen species (ROS), leading to oxidative stress in EA.hy926 cells. In the present study, western blo...

journal_title：Molecular medicine reports

authors： Jin X,Xu Z,Fan R,Wang C,Ji W,Ma Y,Cai W,Zhang Y,Yang N,Zou S,Zhou X,Li Y

更新日期：2017-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Although numerous studies have suggested the potentially oncogenic roles of wild‑type or mutant hepatitis B virus X (HBx) protein in hepatocarcinogenesis, their exact mechanism remains unclear. Increasing evidence suggests that microRNAs ...

journal_title：Molecular medicine reports

authors： Fu X,Tan D,Hou Z,Hu Z,Liu G,Ouyang Y,Liu F

更新日期：2013-02-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) have therapeutic potential for repairing tissue damage and are involved in immune regulation. MSCs are predominantly isolated from bone marrow (BM), adipose tissue or placental tissue. Further to these well‑known sources, the isolation of MSCs from human tonsils was previously reported...

journal_title：Molecular medicine reports

authors： Ryu JH,Park M,Kim BK,Kim YH,Woo SY,Ryu KH

更新日期：2016-10-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL), the most frequently occurring type of lymphoid malignancy, has been demonstrated to be associated with mutations of Ten‑Eleven Translocation (TET). In order to explore the association between DLBCL and TET mutations, the present study analyzed the gene expression and methylation ...

journal_title：Molecular medicine reports

authors： Liu P,Jiang W,Zhao J,Zhang H

更新日期：2017-10-01 00:00:00

abstract：:The aim of the present study was to investigate the preconditioning effect and underlying mechanisms of cobalt-protoporphyrin (CoPP) in a mouse model of liver ischemia‑reperfusion (I/R) injury. Mice were divided into five groups: Sham‑operated (control), I/R, I/R + CoPP, I/R + CoPP and zinc‑protoporphyrin (ZnPP) and I...

journal_title：Molecular medicine reports

authors： Li J,Wu B,Teng D,Sun X,Li J,Li J,Zhang G,Cai J

更新日期：2018-03-01 00:00:00

abstract：:Cochlear progenitor cells are considered as one of the best candidates for hair cell regeneration, thus, the regulation of cochlear progenitor cell proliferation has become a focus in this field. Several genes expressed in the inner ear during postnatal development have been demonstrated to be involved in maintaining ...

journal_title：Molecular medicine reports

authors： Song YL,Tian KY,Mi WJ,Ding ZJ,Qiu Y,Chen FQ,Zha DJ,Qiu JH

更新日期：2018-04-01 00:00:00

abstract：:Irinotecan (CTP-11) is a topoisomerase I inhibitor used in the treatment of colorectal cancer and non-small cell lung cancer (NSCLC). Despite an initial response to therapy, resistance to irinotecan reduces its efficacy. We isolated irinotecan-resistant human NSCLC A549 cells, termed A549/CTP-11R cells. A549/CTP-11R c...

journal_title：Molecular medicine reports

authors： Ikeda R,Vermeulen LC,Lau E,Jiang Z,Pomplun M,Kolesar JM

更新日期：2010-11-01 00:00:00

abstract：:Early reports suggest that nuclear factor IA (NFIA) is important in the pathogenesis of glioma. Our previous study demonstrated that the long non‑coding RNA (lncRNA), RP5‑833A20.1, suppressed the expression of NFIA in THP‑1 macrophage-derived foam cells. However, the effect and possible mechanism of RP5‑833A20.1 on gl...

journal_title：Molecular medicine reports

authors： Kang CM,Hu YW,Nie Y,Zhao JY,Li SF,Chu S,Li HX,Huang QS,Qiu YR

更新日期：2016-12-01 00:00:00

abstract：:Receptor interacting protein kinase 4 (RIPK4) is a serine/threonine kinase that plays an important role in the regulation of cell proliferation, invasion and metastasis in several malignancies; however, its clinical significance and biological function in osteosarcoma (OS) remains unknown. In the present study, the RI...

journal_title：Molecular medicine reports

authors： Yi Z,Pu Y,Gou R,Chen Y,Ren X,Liu W,Dong P

更新日期：2020-03-01 00:00:00

abstract：:Cell division cycle 42 (CDC42), which is a member of the Rho GTPase family, has been reported to regulate the metastasis of various human cancer cells; however, the role of CDC42 in gastric cancer (GC) remains unclear. The present study aimed to investigate the effects of CDC42 on the proliferation, migration and inva...

journal_title：Molecular medicine reports

authors： Du DS,Yang XZ,Wang Q,Dai WJ,Kuai WX,Liu YL,Chu D,Tang XJ

更新日期：2016-01-01 00:00:00

abstract：:The present study aimed to investigate the effect of SOX2 on odontoblast differentiation of dental pulp stem cells (DPSCs), and to examine the potential application of DPSCs on dental restoration. SRY‑box 2 (SOX2) overexpression in human DPSCs (DPSCs‑SOX2) was established by retroviral infection. The empty vector‑infe...

journal_title：Molecular medicine reports

authors： Yang Y,Zhao Y,Liu X,Chen Y,Liu P,Zhao L

更新日期：2017-12-01 00:00:00

abstract：:Purple sweet potato color (PSPC) is a natural anthocyanin pigment that is derived from purple sweet potato storage roots. PSPC possesses a variety of biological activities, including antioxidant, anti‑inflammatory and neuroprotective effects; however, the detailed effects of PSPC on high‑fat diet (HFD)‑induced neuroin...

journal_title：Molecular medicine reports

authors： Li J,Shi Z,Mi Y

更新日期：2018-03-01 00:00:00

abstract：:Pseudomonas aeruginosa continues to be a predominant cause of infections with high intrinsic resistance to antibiotics, resulting in treatment failure. P. aeruginosa is the leading cause of respiratory infections among cystic fibrosis (CF) patients. Resistance to carbapenem antibiotics among P. aeruginosa has been rep...

journal_title：Molecular medicine reports

authors： Li Y,Zhang X,Wang C,Hu Y,Niu X,Pei D,He Z,Bi Y

更新日期：2015-01-01 00:00:00

abstract：:The aim of the present study was to identify key genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis (JSA). The gene expression profile dataset GSE58667, including data from 15 human whole blood samples collected from 11 patients with JSA and four healthy controls, was analyzed ...

journal_title：Molecular medicine reports

authors： Wang Z,Han Y,Zhang Z,Jia C,Zhao Q,Song W,Chen T,Zhang Y,Wang X

更新日期：2018-08-01 00:00:00

abstract：:Although the etiology of intervertebral disc degeneration is poorly understood, one approach to prevent this process may be to inhibit apoptosis. In the current study, the anti‑apoptotic effects of carboxymethylated chitosan (CMCS) in nucleus pulposus (NP) cells were investigated with the aim to enhance disc cell surv...

journal_title：Molecular medicine reports

authors： He B,Tao H,Liu S,Wei A

更新日期：2015-03-01 00:00:00

abstract：:The aim of the present study was to investigate Fas expression in tumor samples from patients with gastric cancer, in order to determine the involvement of the Fas signaling pathway. The protein expression levels of Fas, caspase-8, caspase‑3 and poly (adenosine diphosphate‑ribose) polymerase 1 (PARP1) were examined in...

journal_title：Molecular medicine reports

authors： Wang X,Fu Z,Chen Y,Liu L

更新日期：2017-02-01 00:00:00

abstract：:Post‑cardiac arrest myocardial dysfunction (PAMD) is a leading cause of death in patients undergoing resuscitation patients following cardiac arrest (CA). Although prostaglandin E1 (PGE1) is a clinical drug used to mitigate ischemia injury, its effect on PAMD remains unknown. In the present study, the protective effec...

journal_title：Molecular medicine reports

authors： Su C,Fan X,Xu F,Wang J,Chen Y

更新日期：2021-02-01 00:00:00

abstract：:Intracranial aneurysm (IA) is a devastating disease, the pathogenesis of which remains to be elucidated. The present study aimed to determine the molecular mechanism of IA and to identify potential therapeutic targets using bioinformatics analysis. The GSE54083 dataset, which includes data from patients with ruptured ...

journal_title：Molecular medicine reports

authors： Wei L,Wang Q,Zhang Y,Yang C,Guan H,Chen Y,Sun Z

更新日期：2018-01-01 00:00:00

abstract：:BP‑1‑102, a novel inhibitor of signal transducer and activator of transcription 3 (STAT3), exhibits significant antitumor effects in several malignancies in vitro and in vivo. However, its role in gastric cancer (GC) remains to be elucidated. In the present study, the effect and potential molecular mechanisms of BP‑10...

journal_title：Molecular medicine reports

authors： Jiang X,Tang J,Wu M,Chen S,Xu Z,Wang H,Wang H,Yu X,Li Z,Teng L

更新日期：2019-04-01 00:00:00

abstract：:Mycoplasma are the smallest prokaryotic microbes present in nature. These wall‑less, malleable organisms can pass through cell filters, and grow and propagate under cell‑free conditions in vitro. Of the pathogenic Mycoplasma Mycoplasma pneumoniae has been examined the most. In addition to primary atypical pneumonia an...

journal_title：Molecular medicine reports

authors： He J,Liu M,Ye Z,Tan T,Liu X,You X,Zeng Y,Wu Y

更新日期：2016-11-01 00:00:00

abstract：:Endothelial dysfunction and impaired endothelial regenerative capacity are key contributors to the high incidence of cardiovascular disease in patients with chronic kidney disease (CKD). Uremic toxins are associated with this pathogenesis. Previous studies have revealed that a uremic toxin, para‑cresol (p‑cresol), exe...

journal_title：Molecular medicine reports

authors： Pan L,Ye X,Ding J,Zhou Y

更新日期：2017-04-01 00:00:00