Prostaglandin E1 attenuates post‑cardiac arrest myocardial dysfunction through inhibition of mitochondria‑mediated cardiomyocyte apoptosis.

abstract：:The aim of the present study was to explore the effects of co‑culturing bone marrow‑derived mesenchymal stem cells (BM-MSCs) cultured with hepatitis B virus (HBV)‑infected lymphocytes in vitro. BM‑MSCs and lymphocytes from Brown Norway rats were obtained from the bone marrow and spleen, respectively. Rats were divided...

journal_title：Molecular medicine reports

authors： Zheng WP,Zhang BY,Shen ZY,Yin ML,Cao Y,Song HL

更新日期：2017-05-01 00:00:00

abstract：:The present study was conducted to determine whether the activation of TRESK in the dorsal root ganglion (DRG) by the TRESK gene recombinant adenovirus vector inhibits the capsaicin-evoked substance P (SP) release using a radioimmunoassay. TRESK is an outwardly rectifying K+ current...

journal_title：Molecular medicine reports

authors： Zhou J,Yao SL,Yang CX,Zhong JY,Wang HB,Zhang Y

更新日期：2012-04-01 00:00:00

abstract：:The identification of tumor biomarkers to support early diagnosis and tumor progression monitoring may potentially reduce the mortality of gastric cancer (GC). The present study aimed to detect novel tumor‑associated antigens from the AGS GC cell line, and to identify their associated autoantibodies in sera from patie...

journal_title：Molecular medicine reports

authors： Liu XX,Ye H,Wang P,Zhang Y,Zhang JY

更新日期：2017-11-01 00:00:00

abstract：:In order to provide an abundant source of specimen and to reveal the correlation between the overexpression of urokinase plasminogen activator receptor isoform uPAR (D1D2) and hepatic cell malignant transformation, the optimal liver cell culture method was selected from three cell culture methods to culture and separa...

journal_title：Molecular medicine reports

authors： Zhou Y,Lǚ X,Li S,Zhan L

更新日期：2014-05-01 00:00:00

abstract：:Scarring is the inevitable consequence of wound repair, which may cause significant physical and mental pain to patients when excessive. Bone morphogenetic protein‑7 (BMP‑7) has been proved to inhibit TGF‑β‑induced fibrosis in various tissues including dermal papilla cells. However, the effect of BMP‑7 on hypertrophic...

journal_title：Molecular medicine reports

authors： Guo J,Lin Q,Shao Y,Rong L,Zhang D

更新日期：2017-08-01 00:00:00

abstract：:Aldosterone has an important role in the progression of renal fibrosis. In the present study, the concentration of aldosterone and klotho (KL) in the serum of patients with chronic kidney disease (CKD) were analyzed. A negative correlation was observed between aldosterone and KL, suggesting that KL may serve a protect...

journal_title：Molecular medicine reports

authors： Lai L,Cheng P,Yan M,Gu Y,Xue J

更新日期：2019-03-01 00:00:00

abstract：:Our previous study demonstrated that treatment with Tribulus terrestris (TT) extracts (120 mg/kg) promoted the muscle weight gain and performance of rats undergoing high intensity exercise. The present study was designed to explore the mechanisms underlying the effect of treatment with TT extracts and the involvement ...

journal_title：Molecular medicine reports

authors： Wu Y,Yang H,Wang X

更新日期：2017-09-01 00:00:00

abstract：:Circling mice is a mutant model of spontaneous deafness exhibiting degenerated spiral ganglion cells in the cochlea and loss of organ of Corti. The balance between glycinergic inhibition and glutamatergic excitation in the lateral superior olive (LSO) is essential for the detection of interaural level differences. Lon...

journal_title：Molecular medicine reports

authors： Yoo YB,Maskey D,Kim MJ

更新日期：2015-12-01 00:00:00

abstract：:Diabetic cardiomyopathy (DCM) is a major cause of mortality in patients with diabetes, particularly those with type 2 diabetes. Long non‑coding RNAs (lncRNAs), including terminal differentiation‑induced lncRNA (TINCR), myocardial infarction‑associated transcript (MIAT) and H19, serve a key role in the regulation of DC...

journal_title：Molecular medicine reports

authors： Chen K,Ma Y,Wu S,Zhuang Y,Liu X,Lv L,Zhang G

更新日期：2019-08-01 00:00:00

abstract：:The oral fluoropyrimidine S-1 has marked efficacy in treating metastatic colorectal cancer patients. In the present study, we explored the therapeutic potential of combined in vivo treatment in the human colon cancer cell lines COL-1, KM12C and KM20C with consecutive oral S-1 and leucovorin (LV) in 2-week therapeutic ...

journal_title：Molecular medicine reports

authors： Tsukioka S,Uchida J,Tsujimoto H,Nakagawa F,Sugimoto Y,Oka T,Kiniwa M

更新日期：2009-05-01 00:00:00

abstract：:Fibroblast growth factor receptors (FGFRs) have been implicated in the malignant transformation and chemoresistance of epithelial ovarian cancer; however, the underlying molecular mechanisms are poorly understood. Increased sialyltransferase activity that enhances protein sialylation is an important post‑translational...

journal_title：Molecular medicine reports

authors： Ou L,He X,Liu N,Song Y,Li J,Gao L,Huang X,Deng Z,Wang X,Lin S

更新日期：2020-03-01 00:00:00

abstract：:KIF2A is a member of the kinesin-13 family and is involved in cell mitosis and spindle assembly. The abnormal expression and dysfunction of KIF2A are associated with tumorigenesis and the progression of certain human cancer types; however, little is known about the expression and roles of KIF2A in glioma. In the prese...

journal_title：Molecular medicine reports

authors： Zhang X,Ma C,Wang Q,Liu J,Tian M,Yuan Y,Li X,Qu X

更新日期：2016-02-01 00:00:00

abstract：:Prostaglandin E2 has exhibited pleiotropic effects in the regulation of glomerulosclerosis progression through its four receptors. The current study aimed to evaluate the effect of prostaglandin receptor EP4 on mesangial cell proliferation. In vivo, 5/6 nephrectomy was introduced into EP4+/‑ and wild‑type (WT) mice. C...

journal_title：Molecular medicine reports

authors： Cao Y,Pan T,Chen X,Wu J,Guo N,Wang B

更新日期：2018-12-01 00:00:00

abstract：:Cerebral ischemic injury is a major cause of death and long‑term disability worldwide that leads to neurological and behavioral deficits, and for which successful treatments are still lacking. Ras homolog family member A (RhoA) and Rho‑associated coiled‑coil containing protein kinase (ROCK) are associated with the gro...

journal_title：Molecular medicine reports

authors： Li L,Liu B

更新日期：2019-10-01 00:00:00

abstract：:Microglia‑mediated neuroinflammation is key in the pathogenesis of Alzheimer's disease (AD). Several studies have suggested that NADPH oxidase contributes to microglia‑mediated neuroinflammation. Resveratrol, which is a natural polyphenolic compound, exerts neuroprotective effects in AD due to its anti‑inflammatory pr...

journal_title：Molecular medicine reports

authors： Yao Y,Li J,Niu Y,Yu JQ,Yan L,Miao ZH,Zhao XX,Li YJ,Yao WX,Zheng P,Li WQ

更新日期：2015-10-01 00:00:00

abstract：:The aim of the present study was to investigate the clinical characteristics and major causative gene in pediatric patients with Camurati‑Engelmann disease (CED). Biochemical and radiographic examinations, bone scintigraphy and genetic analyses were performed in two affected males and their parents. The two patients e...

journal_title：Molecular medicine reports

authors： Wang C,Zhang BH,Liu YJ,Hu YQ,He JW,Zhang ZL

更新日期：2013-05-01 00:00:00

abstract：:Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates T-cell activation and Th1/Th2 cytokine production and is involved in the immune response against Hepatitis B virus (HBV) infection. To detect the association of the CTLA-4 gene polymorphisms with susceptibility to HBV infection a hospital-based case-contro...

journal_title：Molecular medicine reports

authors： Chen M,Chang Y,Tang F,Xie QH,Li J,Yang H,He XX,Lin JS

更新日期：2014-02-01 00:00:00

abstract：:Prenatal clinical detection of thalassemia involves gap‑PCR and reverse dot blot (RDB) analysis of fetal DNA acquired through invasive methods. The present study aimed to develop a non‑invasive prenatal diagnostic method for thalassemia based on next‑generation sequencing (NGS). A total of eight families with proband ...

journal_title：Molecular medicine reports

authors： Yang X,Ye Y,Fan D,Lin S,Li M,Hou H,Zhang J,Yang X

更新日期：2020-08-01 00:00:00

abstract：:Colon cancer is a common malignancy worldwide and there is an urgent requirement to develop effective treatment strategies. In recent years, tumor immunotherapy has become a new method of effectively treating tumors. Chimeric antigen receptor (CAR) T cell technology combines the precise targeting specificity of monocl...

journal_title：Molecular medicine reports

authors： Zhou Y,Wen P,Li M,Li Y,Li XA

更新日期：2019-09-01 00:00:00

abstract：:Prostate cancer (PCa) poses a high risk to older men and it is the second most common type of male malignant tumor in western developed countries. Additionally, there is a lack of effective therapies for PCa at advanced stages. Novel treatment strategies such as adenovirus‑mediated gene therapy and virotherapy involve...

journal_title：Molecular medicine reports

authors： Cai Z,Lv H,Cao W,Zhou C,Liu Q,Li H,Zhou F

更新日期：2017-11-01 00:00:00

abstract：:Fatty acid synthase (FASN) is a key anabolic enzyme for de novo fatty acid synthesis, which is important in the development of colon carcinoma. The high expression of FASN is considered a promising molecular target for colon cancer therapy. Emodin, a naturally occurring anthraquinone, exhibits an anticancer effect in ...

journal_title：Molecular medicine reports

authors： Lee KH,Lee MS,Cha EY,Sul JY,Lee JS,Kim JS,Park JB,Kim JY

更新日期：2017-04-01 00:00:00

abstract：:The aim of the present study was to determine the role of interleukin-6 (IL-6) in the epithelial-mesenchymal transition (EMT) of human intrahepatic biliary epithelial cell (HIBEC) lines in vitro. HIBECs were stimulated with IL-6 at concentrations of 0, 10, 20, 50 and 100 µg/l for 24 h. A wound healing and Transwell as...

journal_title：Molecular medicine reports

authors： Jiang GX,Cao LP,Kang PC,Zhong XY,Lin TY,Cui YF

更新日期：2016-02-01 00:00:00

abstract：:Our previous study demonstrated that type II cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG II) inhibited epidermal growth factor (EGF)-induced phosphorylation/activation of epidermal growth factor receptor (EGFR). Since human epidermal growth factor receptor 2 (HER2) has a similar molecular struc...

journal_title：Molecular medicine reports

authors： Zhu M,Yao X,Wu M,Qian H,Wu Y,Chen Y

更新日期：2016-02-01 00:00:00

abstract：:Family with sequence similarity 172, member A (FAM172A), was cloned from human aortic tissues and confirmed in our previous study in 2009, however, its functions remain to be fully elucidated. In our previous studies, the protein expression of FAM172A in human aortic smooth muscle cells was found to be upregulated by ...

journal_title：Molecular medicine reports

authors： Li MF,Zhang R,Guo MG,Li LX,Lu HK,Lu JX,Jia WP

更新日期：2016-01-01 00:00:00

abstract：:Puerarin has attracted increasing attention because of its beneficial effects on anti‑osteoporosis, but the molecular mechanisms underlying its actions on osteoblasts are not fully understood. The current study aimed to investigate the effect of puerarin on the cell viability and differentiation of mouse MC3T3‑E1 oste...

journal_title：Molecular medicine reports

authors： Zhan XQ,Zeng XW,Zhang YY,Feng Q,Zhao FM,Jiang ZQ,Sun C

更新日期：2017-11-01 00:00:00

abstract：:Ephrin type‑A receptor 2 (EphA2) is a receptor tyrosine kinase that is associated with cancer cell metastasis. There has been little investigation into its impact on the regulation of sensitivity to paclitaxel in nasopharyngeal carcinoma (NPC). In the present study, upregulation of EphA2 expression enhanced the surviv...

journal_title：Molecular medicine reports

authors： Wang Y,Liu Y,Li G,Su Z,Ren S,Tan P,Zhang X,Qiu Y,Tian Y

更新日期：2015-02-01 00:00:00

abstract：:Smoking is an important factor that causes periodontitis, which manifests as alveolar bone injury and absorption, and has a high incidence and unfavorable treatment efficacy. Nicotine causes ischemia and inflammation of the periodontium and inhibits the mineralization of alveolar bones. Previous studies have revealed ...

journal_title：Molecular medicine reports

authors： Li Y,Jin X,Mao L

更新日期：2017-12-01 00:00:00

abstract：:Streptococcus mutans (S. mutans) bacterium is the most well recognized pathogen involved in pathogenesis of dental caries. Its virulence arises from its ability to produce a biofilm and acidogenicity, causing tooth decay. Discovery of natural products capable to inhibit biofilm formation is of high importance for deve...

journal_title：Molecular medicine reports

authors： Kacergius T,Abu-Lafi S,Kirkliauskiene A,Gabe V,Adawi A,Rayan M,Qutob M,Stukas R,Utkus A,Zeidan M,Rayan A

更新日期：2017-07-01 00:00:00

abstract：:Deafness and hearing loss may have functional, economic, social and emotional impacts on humans, including the ability of an individual to communicate with others, feelings of isolation and frustration, and health sector costs. The World Health Organization reported that there are 32 million children worldwide with he...

journal_title：Molecular medicine reports

authors： Zhang Z,Chen QD,Zhao LP,Ma J,Zhang TS,Pang JX,Li YF,Wang MF,Wang AP,Tang L,Li LJ,He WJ,Gu H

更新日期：2018-04-01 00:00:00

abstract：:Multipotent differentiation ability, low expression of co‑stimulatory molecules and immunosuppressive effects render mesenchymal stem cells (MSCs) the best candidate for use in cell‑based therapy. At present, MSCs are widely used in clinical trials, which have, however, failed to demonstrate any long‑term therapeutic ...

journal_title：Molecular medicine reports

authors： Li Q,Ma Y,Li L,Bao J,Zhang L

更新日期：2015-11-01 00:00:00