Inhibitory capacity of Rhus coriaria L. extract and its major component methyl gallate on Streptococcus mutans biofilm formation by optical profilometry: Potential applications for oral health.

Abstract:

:Streptococcus mutans (S. mutans) bacterium is the most well recognized pathogen involved in pathogenesis of dental caries. Its virulence arises from its ability to produce a biofilm and acidogenicity, causing tooth decay. Discovery of natural products capable to inhibit biofilm formation is of high importance for developing health care products. To the best of our knowledge, in all previous scientific reports, a colorimetric assay was applied to test the effect of sumac and methyl gallate (MG) on S. mutans adherence. Quantitative assessment of the developed biofilm should be further performed by applying an optical profilometry assay, and by testing the effect on both surface roughness and thickness parameters of the biofilm. To the best of our knowledge, this is the first study to report the effect of sumac extract and its constituent MG on biofilm formation using an optical profilometry assay. Testing antibacterial activity of the sumac extract and its fractions revealed that MG is the most bioactive component against S. mutans bacteria. It reduced S. mutans biofilm biomass on the polystyrene surface by 68‑93%, whereas 1 mg/ml MG was able to decrease the biofilm roughness and thickness on the glass surface by 99%. MG also prevented a decrease in pH level by 97%. These bioactivities of MG occurred in a dose‑dependent manner and were significant vs. untreated bacteria. The findings are important for the development of novel pharmaceuticals and formulations of natural products and extracts that possess anti‑biofilm activities with primary applications for oral health, and in a broader context, for the treatment of various bacterial infections.

journal_name

Mol Med Rep

authors

Kacergius T,Abu-Lafi S,Kirkliauskiene A,Gabe V,Adawi A,Rayan M,Qutob M,Stukas R,Utkus A,Zeidan M,Rayan A

doi

10.3892/mmr.2017.6674

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

949-956

issue

1

eissn

1791-2997

issn

1791-3004

journal_volume

16

pub_type

杂志文章
  • INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program.

    abstract::Single nucleotide polymorphisms associated with lipid metabolism and energy balance are implicated in the weight loss response caused by nutritional interventions. Diet‑induced weight loss is also associated with differential global DNA methylation. DNA methylation has been proposed as a predictive biomarker for weigh...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2017.8039

    authors: Pirini F,Rodriguez-Torres S,Ayandibu BG,Orera-Clemente M,Gonzalez-de la Vega A,Lawson F,Thorpe RJ Jr,Sidransky D,Guerrero-Preston R

    更新日期:2018-01-01 00:00:00

  • Resistin aggravates the expression of proinflammatory cytokines in cerulein‑stimulated AR42J pancreatic acinar cells.

    abstract::Resistin, an adipocytokine secreted by fat tissues, has been shown to be associated with increased local and systemic complications in acute pancreatitis (AP). However, the mechanism underlying the effect of resistin in the aggravation of AP remains to be elucidated. The aim of the present study was to investigate the...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2016.6027

    authors: Jiang CY,Wang W

    更新日期:2017-01-01 00:00:00

  • Niclosamide enhances the cytotoxic effect of cisplatin in cisplatin-resistant human lung cancer cells via suppression of lung resistance-related protein and c-myc.

    abstract::Lung cancer is a leading cause of cancer-associated mortality worldwide. The cisplatin (DDP)‑based chemotherapy remains the foundation of treatment for the majority of patients affected by advanced non‑small cell lung cancer (NSCLC). However, DDP‑resistance limits the clinical utility of this drug in patients with adv...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2017.8301

    authors: Zuo Y,Yang D,Yu Y,Xiang M,Li H,Yang J,Li J,Jiang D,Zhou H,Xu Z,Yu Z

    更新日期:2018-03-01 00:00:00

  • Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression.

    abstract::The present study aimed to investigate the effects of sufentanil on sepsis-induced acute lung injury (ALI), and identify the potential molecular mechanisms underlying its effect. In order to achieve this, a rat sepsis model was established. Following treatment with sufentanil, the lung wet/dry (W/D) weight ratio was c...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2020.11526

    authors: Hu Q,Wang Q,Han C,Yang Y

    更新日期:2020-11-01 00:00:00

  • Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells.

    abstract::Dermal papilla (DP) cells function as important regulators of the hair growth cycle. The loss of these cells is a primary cause of diseases characterized by hair loss, including alopecia, and evidence has revealed significantly increased levels of reactive oxygen species (ROS) in hair tissue and DP cells in the baldin...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2015.3717

    authors: Lim KM,An S,Lee OK,Lee MJ,Lee JP,Lee KS,Lee GT,Lee KK,Bae S

    更新日期:2015-08-01 00:00:00

  • Liraglutide reduces hepatic glucolipotoxicity‑induced liver cell apoptosis through NRF2 signaling in Zucker diabetic fatty rats.

    abstract::The primary aim of the present study was to evaluate the effects of liraglutide on glucolipotoxicity‑induced liver cell apoptosis and the underlying mechanisms in Zucker diabetic fatty (ZDF) rats. The results revealed that liraglutide significantly decreased the body weight, hyperglycemia and hyperlipidemia of ZDF rat...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.8919

    authors: Guo J,Li C,Yang C,Li B,Wei J,Lin Y,Ye P,Hu G,Li J

    更新日期:2018-06-01 00:00:00

  • Rapid and sensitive detection of Plesiomonas shigelloides by cross‑priming amplification of the hugA gene.

    abstract::Plesiomonas shigelloides (P. shigelloides) is implicated as an aetiological agent of human gastroenteritis in humans, for which reliable laboratory detection of P. shigelloides is clinically and epidemiologically desirable. A simple molecular method for rapid detection of P. shigelloides using cross‑priming amplificat...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2016.5937

    authors: Meng S,Wang Y,Wang Y,Ye C

    更新日期:2016-12-01 00:00:00

  • Personalized identification of differentially expressed pathways in pediatric sepsis.

    abstract::Sepsis is a leading killer of children worldwide with numerous differentially expressed genes reported to be associated with sepsis. Identifying core pathways in an individual is important for understanding septic mechanisms and for the future application of custom therapeutic decisions. Samples used in the study were...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章,meta分析

    doi:10.3892/mmr.2017.7217

    authors: Li B,Zeng Q

    更新日期:2017-10-01 00:00:00

  • Vanillin improves scopolamine‑induced memory impairment through restoration of ID1 expression in the mouse hippocampus.

    abstract::4-Hydroxy-3-methoxybenzaldehyde (vanillin), contained in a number of species of plant, has been reported to display beneficial effects against brain injuries. In the present study, the impact of vanillin on scopolamine‑induced alterations in cognition and the expression of DNA binding protein inhibitor ID‑1 (ID1), one...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.8401

    authors: Lee JC,Kim IH,Cho JH,Lee TK,Park JH,Ahn JH,Shin BN,Yan BC,Kim JD,Jeon YH,Lee YJ,Won MH,Kang IJ

    更新日期:2018-03-01 00:00:00

  • Prevention and modulation of aminoglycoside ototoxicity (Review).

    abstract::More than 60 years after their isolation and characterization, aminoglycoside (AG) antibiotics remain powerful agents in the treatment of severe gram-negative, enterococcal or mycobacterial infections. However, the clinical use of AGs is hampered by nephrotoxicity and ototoxicity, which often develop as a consequence ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:

    authors: Perletti G,Vral A,Patrosso MC,Marras E,Ceriani I,Willems P,Fasano M,Magri V

    更新日期:2008-01-01 00:00:00

  • Identification of differentially expressed genes between lung adenocarcinoma and lung squamous cell carcinoma by gene expression profiling.

    abstract::The present study aimed to identify the differentially expressed genes (DEGs) between lung adenocarcinoma and normal lung tissues, and between lung squamous cell carcinoma and normal lung tissues, with the purpose of identifying potential biomarkers for the treatment of lung cancer. The gene expression profile (GSE604...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2016.5420

    authors: Lu C,Chen H,Shan Z,Yang L

    更新日期:2016-08-01 00:00:00

  • Kinesin family member 20B regulates tongue cancer progression by promoting cell proliferation.

    abstract::Oral cancer refers to the malignant tumors that occur in the oral cavity, of which 80% are squamous cell carcinomas. The incidence of oral cancer accounts for ~5% of the incidence of systemic malignancies, with rapid progression, extensive infiltration and poor prognosis. In the present study, Kinesin family member (K...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2019.9851

    authors: Li ZY,Wang ZX,Li CC

    更新日期:2019-03-01 00:00:00

  • Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression.

    abstract::The silent information regulator 2 related enzyme 2 (SIRT2) has been reported to have an important role in tumorigenesis. Although two distinct effects of SIRT2 have recently been revealed, which explain opposing expression patterns in different types of cancer, the specific function of SIRT2 in ovarian cancer remains...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2017.6183

    authors: Du Y,Wu J,Zhang H,Li S,Sun H

    更新日期:2017-04-01 00:00:00

  • Putative role of the mTOR/4E-BP1 signaling pathway in the carcinogenesis and progression of gastric cardiac adenocarcinoma.

    abstract::The mammalian target of rapamycin/eukaryotic translation inititiation factor 4E binding protein 1 (mTOR/4E-BP1) transduction pathway is activated in a range of malignant cancers, but its role in human gastric cardiac adenocarcinoma (GCA) has not been well defined. The present study used western blotting and reverse tr...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2012.1208

    authors: Yang HY,Xue LY,Xing LX,Wang J,Wang JL,Yan X,Zhang XH

    更新日期:2013-02-01 00:00:00

  • Expression and function of microRNA-497 in human osteosarcoma.

    abstract::The expression and function of microRNA-497 (miR-497) has previously been reported in various types of human cancer; however, miR-497 has not previously been investigated in human osteosarcoma (OS). In the present study, the expression levels of miR‑497 were analyzed by reverse transcription‑quantitative polymerase ch...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2016.5256

    authors: Liu Q,Wang H,Singh A,Shou F

    更新日期:2016-07-01 00:00:00

  • Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression.

    abstract::Colon cancer is characterized by invasion and migration. DNA methylation of CpG islands in tumor suppressor genes is considered to be an epigenetic mechanism underlying cancer development. Epigenetic silencing of a gene may be reversed by drugs, including genistein. The present study aimed to determine the effect of g...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.8760

    authors: Zhu J,Ren J,Tang L

    更新日期:2018-05-01 00:00:00

  • Complement factor H‑related 3 overexpression affects hepatocellular carcinoma proliferation and apoptosis.

    abstract::Complement factor H‑related 3 (CFHR3) belongs to the human factor H protein family and is associated with various human diseases, including nephropathy, age‑related macular degeneration and atypical hemolytic uremic syndrome. However, to the best of our knowledge, the role of CFHR3 in hepatocellular carcinoma (HCC) re...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2019.10514

    authors: Liu H,Zhang L,Wang P

    更新日期:2019-09-01 00:00:00

  • MicroRNA‑185 regulates transforming growth factor‑β1 and collagen‑1 in hypertrophic scar fibroblasts.

    abstract::Transforming growth factor-β1 (TGF-β1) and collagen type I (Col-1) serve a critical role in the development and progression of hypertrophic scarring (HS). The present study hypothesized that a post‑translational mechanism of microRNAs (miR) regulated the expression of TGF‑β1 and Col‑1 in HS fibroblasts (HSFBs). A coll...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2017.6179

    authors: Xiao K,Luo X,Wang X,Gao Z

    更新日期:2017-04-01 00:00:00

  • miRNAs and their role in the correlation between schizophrenia and cancer (Review).

    abstract::Schizophrenia (SZ) and cancer (Ca) have a broad spectrum of clinical phenotypes and a complex biological background, implicating a large number of genetic and epigenetic factors. SZ is a chronic neurodevelopmental disorder signified by an increase in the expression of apoptotic molecular signals, whereas Ca is convers...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章,评审

    doi:10.3892/mmr.2016.5853

    authors: Rizos E,Siafakas N,Skourti E,Papageorgiou C,Tsoporis J,Parker TH,Christodoulou DI,Spandidos DA,Katsantoni E,Zoumpourlis V

    更新日期:2016-12-01 00:00:00

  • Isorhamnetin inhibits IL‑1β‑induced expression of inflammatory mediators in human chondrocytes.

    abstract::Isorhamnetin (ISH) is a flavonoid primarily obtained from the fruit of Hippophae rhamnoides L., which possesses anti‑inflammatory properties. However, the effect of ISH on the expression of inflammatory mediators in response to interleukin (IL)‑1β stimulation has not been elucidated. The present study investigated the...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2017.7041

    authors: Li J,Wu R,Qin X,Liu D,Lin F,Feng Q

    更新日期:2017-10-01 00:00:00

  • High and fluctuating glucose levels increase the expression and secretion of interleukin‑18 in mouse peritoneal macrophages.

    abstract::Macrophages are involved in the progression of atherosclerosis by releasing pro-inflammatory cytokines. High levels of interleukin (IL)-18 are associated with an increased risk of developing diabetes and atherosclerosis. The present study aimed to investigate the association between IL-18, and high and fluctuating glu...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2015.3753

    authors: Zhang C,Bi Y,Jin G,Gan H,Yu L

    更新日期:2015-08-01 00:00:00

  • Long non‑coding RNA growth arrest‑specific 5 (GAS5) acts as a tumor suppressor by promoting autophagy in breast cancer.

    abstract::Growth arrest‑specific 5 (GAS5) is a known tumor suppressor which negatively regulates cell survival and malignancy in several cancer cell types. The present study aimed to establish the correlation between GAS5 and unc‑51 like autophagy activating kinase (ULK)1/2, two key regulators of autophagy initiation in breast ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2020.11334

    authors: Li G,Qian L,Tang X,Chen Y,Zhao Z,Zhang C

    更新日期:2020-09-01 00:00:00

  • Autophagy is essential for flavopiridol‑induced cytotoxicity against MCF‑7 breast cancer cells.

    abstract::Flavopiridol (FP) exerts antitumoral effects by triggering tumor cell cycle arrest and cytotoxicity in human breast cancer cell lines. The potent antitumor activity of FP is through its inhibition of cyclin‑dependent kinases; however, this may not be the only mechanism of action. The present study aimed to investigate...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2017.7815

    authors: Wang S,Wang K,Wang H,Han J,Sun H

    更新日期:2017-12-01 00:00:00

  • Moscatilin induces apoptosis of pancreatic cancer cells via reactive oxygen species and the JNK/SAPK pathway.

    abstract::Moscatilin is a bibenzyl derivative extracted from the Dendrobium aurantiacum var. denneanum, which has traditionally been used as an immunomodulatory treatment in China. The present study was designed to determine whether moscatilin is a pro‑apoptotic agent in pancreatic cancer, and to elucidate the underlying mechan...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2017.6144

    authors: Zhang L,Fang Y,Xu XF,Jin DY

    更新日期:2017-03-01 00:00:00

  • Toll-like receptor (TLR) expression and TLR‑mediated interleukin-8 production by human submandibular gland epithelial cells.

    abstract::Toll-like receptor (TLR) family members are pattern recognition receptors that are essential in the activation of innate and adaptive immune responses. Submandibular gland epithelial cells (SMGCs) may recognize microbial components through TLRs and be involved in the development of inflammatory reactions in the subman...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2014.2507

    authors: Ohta K,Ishida Y,Fukui A,Mizuta K,Nishi H,Takechi M,Kamata N

    更新日期:2014-11-01 00:00:00

  • Role of p53β in the inhibition of proliferation of gastric cancer cells expressing wild-type or mutated p53.

    abstract::p53 is a tumor suppressor gene whose mutation is highly associated with tumorigenesis. The present study investigated the role of p53β in the inhibition of proliferation of gastric cancer cell lines expressing wild-type or mutated p53. Wild-type p53 is expressed in MKN45 cells, but deleted in KATOIII cells, whereas mu...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2015.3370

    authors: Ji W,Ma J,Zhang H,Zhong H,Li L,Ding N,Jiao J,Gao Z

    更新日期:2015-07-01 00:00:00

  • miRNA‑1284 inhibits cell growth and induces apoptosis of lung cancer cells.

    abstract::Lung cancer is the most common cancer worldwide, and morbidity and mortality associated with lung cancer has been increasing annually in recent decades. MicroRNAs (miRNAs), which are short non‑coding RNA sequences that are involved in the regulation of gene expression, have been previously demonstrated to be key regul...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2017.6949

    authors: Li J,Jin H,Yu H,Wang B,Tang J

    更新日期:2017-09-01 00:00:00

  • A sensitive and specific indirect competitive enzyme‑linked immunosorbent assay for the detection of icariin.

    abstract::In the present study, a novel monoclonal antibody (MAb) specific for icariin (ICA) was prepared and characterized. A hybridoma‑secreting MAb against icariin was produced by fusing splenocytes immunized with an ICA‑bovine serum albumin conjugate with a hypoxanthine‑aminopterin‑thymidine‑sensitive mouse myeloma SP2/0 ce...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2016.5975

    authors: Cheng J,Zhang Y,Liu S,Qu B,Zhang M,Liu X,Zhao Y,Qu H

    更新日期:2017-01-01 00:00:00

  • Silencing of PYGB suppresses growth and promotes the apoptosis of prostate cancer cells via the NF‑κB/Nrf2 signaling pathway.

    abstract::Brain‑type glycogen phosphorylase (PYGB) is an enzyme that metabolizes glycogen, whose function is to provide energy for an organism in an emergency state. The present study purposed to investigate the role and mechanism of PYGB silencing on the growth and apoptosis of prostate cancer cells. A cell counting kit‑8 assa...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.9388

    authors: Wang Z,Han G,Liu Q,Zhang W,Wang J

    更新日期:2018-10-01 00:00:00

  • MicroRNA‑655 suppresses cell proliferation and invasion in oral squamous cell carcinoma by directly targeting metadherin and regulating the PTEN/AKT pathway.

    abstract::MicroRNAs (miRNAs) are important regulators of a variety of biological processes and their dysregulation is closely related to cancer formation and progression. Therefore, examination of aberrantly expressed miRNAs in oral squamous cell carcinoma (OSCC) may provide important clues for the diagnosis and treatment of pa...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章

    doi:10.3892/mmr.2018.9292

    authors: Wang Q,Lv L,Li Y,Ji H

    更新日期:2018-09-01 00:00:00