Abstract:
:The present study was conducted to determine whether the activation of TRESK in the dorsal root ganglion (DRG) by the TRESK gene recombinant adenovirus vector inhibits the capsaicin-evoked substance P (SP) release using a radioimmunoassay. TRESK is an outwardly rectifying K+ current channel that contributes to the resting potential and is the most important background potassium channel in DRG. Previous studies have shown that neuropathic pain (NP) is closely related to the regulation of certain potassium channels in DRG neurons, while DRG-released SP is important in the peripheral mechanism of NP. In the present study, the TRESK gene adenovirus vector significantly enhanced the TRESK mRNA and protein of the cultured rat DRG neurons. Radioimmunoassay analysis revealed that the capsaicin‑mediated SP release was significantly inhibited by the TRESK gene recombinant adenovirus vector in rat DRG neurons. These findings suggest that TRESK plays a role in adjusting the release of SP in DRG, which is related to NP.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Zhou J,Yao SL,Yang CX,Zhong JY,Wang HB,Zhang Ydoi
10.3892/mmr.2012.778subject
Has Abstractpub_date
2012-04-01 00:00:00pages
1049-52issue
4eissn
1791-2997issn
1791-3004journal_volume
5pub_type
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