Changes in the immunohistochemical localization of the glycine receptor in the superior olivary complex of adult circling mice.

abstract：:Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is a rare autosomal dominant disease, which has been divided into two types according to whether it involves premature ovarian failure (POF). Mutations in forkhead box L2 (FOXL2) have been identified in the majority of patients with BPES. The present study ai...

journal_title：Molecular medicine reports

authors： Yang L,Li T,Xing Y

更新日期：2017-10-01 00:00:00

abstract：:Osteopetrosis is a monogenic condition with various inheritance patterns, including autosomal dominant, autosomal recessive and X‑linked. Several disease‑causing genes have been identified and three distinguished types of osteopetrosis have been reported. In the present study, a family with osteopetrosis was investiga...

journal_title：Molecular medicine reports

authors： Yang Y,Ye W,Guo J,Zhao L,Tu M,Zheng Y,Li L

更新日期：2019-01-01 00:00:00

abstract：:Radix Salviae miltiorrhizae (SM) and Lignum Dalbergiae odoriferae (DO) are traditional Chinese medicinal herbs used to treat ischemic heart disease and other cardiovascular diseases; however, to the best of our knowledge, there are currently few studies regarding their effects. The present study aimed to investigate t...

journal_title：Molecular medicine reports

authors： Mu F,Duan J,Bian H,Yin Y,Zhu Y,Wei G,Guan Y,Wang Y,Guo C,Wen A,Yang Y,Xi M

更新日期：2017-08-01 00:00:00

abstract：:Metabolic syndrome is a combination of medical disorders including hypertension, dyslipidemia, hyperglycemia, insulin resistance and increased waist circumference, and is associated with a higher risk of cardiovascular disease. An increase in adipose tissue mass is associated with t...

journal_title：Molecular medicine reports

authors： Pérez PM,Moore-Carrasco R,González DR,Fuentes EQ,Palomo IG

更新日期：2012-05-01 00:00:00

abstract：:Hypertension affects one billion people worldwide and is an independent risk factor for death after acute coronary syndrome (ACS). The aim of this study was to examine the prevalence and medical treatment of hypertension among 1,301 ACS patients enrolled into the Chinese registry of acute coronary events (CRACE) trial...

journal_title：Molecular medicine reports

authors： Lin Y,Pan W,Ning S,Song X,Jin Z,Lv S

更新日期：2013-07-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a rare but devastating malignancy. Up to 90% of patients presenting with CCA have no identifiable risk factors. The base excision repair (BER) pathway has a principal role in the repair of mutations caused by oxidized or reduced bases. The MutY homolog (MUTYH, MYH) is one of the key protein...

journal_title：Molecular medicine reports

authors： You SH,Wang X,Huang S,Wang M,Ji GZ,Xia JR,Fan ZN

更新日期：2013-01-01 00:00:00

abstract：:Dehydrocostuslactone is a sesquiterpene lactone derived from Saussurea lappa, a plant used in traditional herbal medicines. The anti-proliferative activity of dehydrocostuslactone was investigated in human breast cancer (MDA-MB-231, MDA-MB-453 and SK-BR-3) and ovarian cancer (SK-OV-3 and OVCAR3) cell lines using the m...

journal_title：Molecular medicine reports

authors： Choi EJ,Kim GH

更新日期：2010-01-01 00:00:00

abstract：:Autophagy is a highly conserved pathway that permits recycling of nutrients within the cell and is rapidly upregulated during starvation or cell stress. Autophagy has been implicated in the pathophysiological process of warm ischemia‑reperfusion injury in the rat lung. Cold ischemia (CI) preservation for lung transpla...

journal_title：Molecular medicine reports

authors： Chen X,Wu JX,You XJ,Zhu HW,Wei JL,Xu MY

更新日期：2015-04-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common type of brain cancer; it usually recurs and patients have a short survival time. The present study aimed to construct a gene expression classifier and to screen key genes associated with GBM prognosis. GSE7696 microarray data set included samples from 10 recurrent GBM t...

journal_title：Molecular medicine reports

authors： Yang H,Jin L,Sun X

更新日期：2019-03-01 00:00:00

abstract：:Muscle atrophy is a disease that is usually caused by denervation. The aim of the present study was to determine whether electrical stimulation by semi-implantable electrodes is capable of decreasing the levels of specific proteins associated with sciatic nerve injury-induced muscle atrophy. Male Sprague Dawley (SD) r...

journal_title：Molecular medicine reports

authors： Liu J,Li K,Huang X,Xie J,Huang X

更新日期：2013-07-01 00:00:00

abstract：:Varicella‑zoster virus (VZV), a ubiquitous human α‑herpesvirus, is the causative agent of chickenpox and shingles. In the present study, we investigated the antiviral activity of a 70% ethanol extract of Lysimachia mauritiana (LME) against VZV. LME strongly interfered with the replication of both laboratory and clinic...

journal_title：Molecular medicine reports

authors： Bae S,Song YJ

更新日期：2017-06-01 00:00:00

abstract：:Cholangiocarcinoma is an intractable carcinoma originating from the bile duct epithelium. To gain an understanding of the cell biology of cholangiocarcinoma, in vitro cell culture is valuable. However, well‑characterized cell lines are limited. In the present study, the morphology of the TK cholangiocarcinoma cell lin...

journal_title：Molecular medicine reports

authors： Akiyoshi K,Kamada M,Akiyama N,Suzuki M,Watanabe M,Fujioka K,Ikeda K,Mizuno S,Manome Y

更新日期：2014-04-01 00:00:00

abstract：:Multidrug resistance (MDR) has become a significant challenge in chemotherapeutic treatment of cancer. Quercetin, a naturally occurring flavonoid, has been found to possess anti-proliferative, anti-inflammatory and immunoregulatory bioactivities. The present study was performed to examine the effect of quercetin on hu...

journal_title：Molecular medicine reports

authors： Chen FY,Cao LF,Wan HX,Zhang MY,Cai JY,Shen LJ,Zhong JH,Zhong H

更新日期：2015-01-01 00:00:00

abstract：:Smoking is an important factor that causes periodontitis, which manifests as alveolar bone injury and absorption, and has a high incidence and unfavorable treatment efficacy. Nicotine causes ischemia and inflammation of the periodontium and inhibits the mineralization of alveolar bones. Previous studies have revealed ...

journal_title：Molecular medicine reports

authors： Li Y,Jin X,Mao L

更新日期：2017-12-01 00:00:00

abstract：:Partial splenic embolization (PSE) or splenectomy is widely performed to increase platelet counts for interferon (IFN) therapy. The aim of the present study was to evaluate the long-term effects of splenectomy and subsequent IFN therapy in patients with hepatitis C virus (HCV)-related liver cirrhosis (LC). The present...

journal_title：Molecular medicine reports

authors： Inagaki Y,Sugimoto K,Shiraki K,Tameda M,Kusagawa S,Nojiri K,Ogura S,Yamamoto N,Takei Y,Ito M,Mizuno S,Usui M,Sakurai H,Isaji S

更新日期：2014-02-01 00:00:00

abstract：:The silent information regulator 2 related enzyme 2 (SIRT2) has been reported to have an important role in tumorigenesis. Although two distinct effects of SIRT2 have recently been revealed, which explain opposing expression patterns in different types of cancer, the specific function of SIRT2 in ovarian cancer remains...

journal_title：Molecular medicine reports

authors： Du Y,Wu J,Zhang H,Li S,Sun H

更新日期：2017-04-01 00:00:00

abstract：:Brucellosis is an important neglected zoonotic disease, and the pathogens responsible are Brucellae. In order to evaluate the immunogenicity and protective efficacy of a DNA vaccine encoding Brucella BvrR, the recombinant plasmid pCDNA‑BvrR was constructed by inserting the BvrR gene fragment into a pCDNA3.0 vector. Th...

journal_title：Molecular medicine reports

authors： Chen B,Liu B,Zhao Z,Wang G

更新日期：2019-02-01 00:00:00

abstract：:Glioma is one of the most common malignant tumors affecting the central nervous system. We screened active drugs from 12 classes to provide experimental data for the study of human glioma. Serum-free suspension clone formation was used to induce the formation of glioma stem‑like cel...

journal_title：Molecular medicine reports

authors： Feng X,Zhou Q,Liu C,Tao ML

更新日期：2012-11-01 00:00:00

abstract：:NIN1/RPN12 binding protein 1 homolog (Saccharomyces cerevisiae) (NOB1) encodes a chaperone protein that joins the 20S proteasome with the 19S regulatory particle in the nucleus and facilitates the biogenesis of the 26S proteasome, which plays a role in maintaining cellular homeostasis by controlling protein degradatio...

journal_title：Molecular medicine reports

authors： Chen B,Liu J,Wu D,Qin Y,Peng C,Li C,Wang J

更新日期：2014-06-01 00:00:00

abstract：:Magnesium, an important inorganic mineral component in bones, enhances osteoblast adhesion and osteogenic gene expression. Mg2+‑containing hydroxyapatite promotes mouse mesenchymal stem cell (MMSC) osteogenic differentiation. In the present study, MMSCs were cultured in media containing different concentrations of MgC...

journal_title：Molecular medicine reports

authors： Ni S,Xiong XB,Ni XY

更新日期：2020-11-01 00:00:00

abstract：:Family with sequence similarity 172, member A (FAM172A), was cloned from human aortic tissues and confirmed in our previous study in 2009, however, its functions remain to be fully elucidated. In our previous studies, the protein expression of FAM172A in human aortic smooth muscle cells was found to be upregulated by ...

journal_title：Molecular medicine reports

authors： Li MF,Zhang R,Guo MG,Li LX,Lu HK,Lu JX,Jia WP

更新日期：2016-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by synovial inflammation. Fibroblast‑like synoviocytes (FLS) serve a vital role in the initiation and perpetuation of the immune response in patients with RA. The present study aimed to investigate the potential role of microRNA (miR)‑34a‑...

journal_title：Molecular medicine reports

authors： Hou C,Wang D,Zhang L

更新日期：2019-09-01 00:00:00

abstract：:Ephrin type‑A receptor 2 (EphA2) is a receptor tyrosine kinase that is associated with cancer cell metastasis. There has been little investigation into its impact on the regulation of sensitivity to paclitaxel in nasopharyngeal carcinoma (NPC). In the present study, upregulation of EphA2 expression enhanced the surviv...

journal_title：Molecular medicine reports

authors： Wang Y,Liu Y,Li G,Su Z,Ren S,Tan P,Zhang X,Qiu Y,Tian Y

更新日期：2015-02-01 00:00:00

abstract：:Dbl-family guanine nucleotide exchange factors (GEFs) are important activators of Rho GTPases, which are significantly associated with tumorigenesis and metastasis. The catalytic ability of the Dbl-family GEFs to activate Rho GTPases depends on their Dbl-homology domain followed by a pleckstrin-homology domain. In the...

journal_title：Molecular medicine reports

authors： Wang H,Li Y,Wang Y,Han ZG,Cai B

更新日期：2012-05-01 00:00:00

abstract：:Studies have shown that the cerebrospinal fluid‑contacting nucleus (CSF‑CN) may be associated with the transduction and regulation of pain signals. However, the role of the CSF‑CN remains to be elucidated. Emerging evidence has suggested that neurokinin 1 receptor (NK1R) is important in the development of visceral pai...

journal_title：Molecular medicine reports

authors： Zhang C,Li Y,Wang X,Fei Y,Zhang L

更新日期：2017-06-01 00:00:00

abstract：:Moutan cortex, the root bark of Paeonia suffruticosa Andrews (Paeoniaceae), is a traditional Chinese medicine widely used for the treatment of various diseases. In the present study, we examined the antiproliferative effect and apoptosis-inducing activity of paeonol and the crude total glycosides (CTG) extracted from ...

journal_title：Molecular medicine reports

authors： Xing G,Zhang Z,Liu J,Hu H,Sugiura N

更新日期：2010-01-01 00:00:00

abstract：:Nerve growth factor (NGF) is expressed in the human corneal epithelium and stroma. It is an efficient therapy for human corneal ulcers caused by neurotropic disease. However, little is known about the molecular mechanism of NGF in healing human corneal epithelial diseases. Numerous microRNAs (miRNAs) are expressed in ...

journal_title：Molecular medicine reports

authors： Wu D,Qian T,Hong J,Li G,Shi W,Xu J

更新日期：2017-10-01 00:00:00

abstract：:Osteoclasts (OCs) are resorptive cells responsible for bone erosion in diseases, including osteoporosis, periodontitis and rheumatoid arthritis. Montelukast is a cysteinyl leukotriene receptor 1 (CysLTR1) antagonist clinically used for the treatment of asthma. In the present study, the role of CysLTR1 on OC formation ...

journal_title：Molecular medicine reports

authors： Kang JH,Lim H,Lee DS,Yim M

更新日期：2018-08-01 00:00:00

abstract：:Hypoxemia and hypercarbia resulting from a lack of surfactant is considered to be the primary mechanism underlying neonatal respiratory distress syndrome (NRDS). Surfactant replacement therapy may mitigate the symptoms of the disease by decreasing the surface tension of alveoli and facilitating inflation. However, sur...

journal_title：Molecular medicine reports

authors： Mei H,Zhang Y,Liu C,Zhang Y,Liu C,Song D,Xin C,Wang J,Josephs-Spaulding J,Zhu Y,Tang F

更新日期：2018-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are important regulators of a variety of biological processes and their dysregulation is closely related to cancer formation and progression. Therefore, examination of aberrantly expressed miRNAs in oral squamous cell carcinoma (OSCC) may provide important clues for the diagnosis and treatment of pa...

journal_title：Molecular medicine reports

authors： Wang Q,Lv L,Li Y,Ji H

更新日期：2018-09-01 00:00:00