A novel variant in MITF in a child from Yunnan-Guizhou Plateau with autosomal dominant inheritance of nonsyndromic hearing loss: A case report.

abstract：:Full‑thickness and large area defects of articular cartilage are unable to completely repair themselves and require surgical intervention, including microfracture, autologous or allogeneic osteochondral grafts, and autologous chondrocyte implantation. A large proportion of regenerative cartilage exists as fibrocartila...

journal_title：Molecular medicine reports

authors： Li Z,Fei H,Wang Z,Zhu T

更新日期：2017-09-01 00:00:00

abstract：:Early reports suggest that nuclear factor IA (NFIA) is important in the pathogenesis of glioma. Our previous study demonstrated that the long non‑coding RNA (lncRNA), RP5‑833A20.1, suppressed the expression of NFIA in THP‑1 macrophage-derived foam cells. However, the effect and possible mechanism of RP5‑833A20.1 on gl...

journal_title：Molecular medicine reports

authors： Kang CM,Hu YW,Nie Y,Zhao JY,Li SF,Chu S,Li HX,Huang QS,Qiu YR

更新日期：2016-12-01 00:00:00

abstract：:Brucellosis is an important neglected zoonotic disease, and the pathogens responsible are Brucellae. In order to evaluate the immunogenicity and protective efficacy of a DNA vaccine encoding Brucella BvrR, the recombinant plasmid pCDNA‑BvrR was constructed by inserting the BvrR gene fragment into a pCDNA3.0 vector. Th...

journal_title：Molecular medicine reports

authors： Chen B,Liu B,Zhao Z,Wang G

更新日期：2019-02-01 00:00:00

abstract：:Neutrophilic asthma (NA) is characterized by neutrophil‑mediated inflammation and the presence of Th17 cells. However, the mechanisms underlying Th17 cell responses in NA remain unknown. The aim of the present study was to examine the effects of interleukin (IL)‑7 on Th17 cell responses in NA. A NA mouse model was sen...

journal_title：Molecular medicine reports

authors： Zhang X,Zhang M,Jiang M,Nong G

更新日期：2020-08-01 00:00:00

abstract：:Diabetic nephropathy (DN) is by far the most common cause of end‑stage renal disease (ESRD) in industrial countries, accounting for ~45% of all new ESRD cases in the United States. Grape seed proanthocyanidin extracts (GSPE) are powerful antioxidants, with an antioxidant ability 50‑fold greater than that of vitamin E ...

journal_title：Molecular medicine reports

authors： Gao Z,Liu G,Hu Z,Shi W,Chen B,Zou P,Li X

更新日期：2018-08-01 00:00:00

abstract：:The present study aimed to investigate whether the mammalian target of rapamycin (mTOR) signaling pathway is activated in invasive breast cancer. The expression levels of phosphorylated (p)‑mTOR at ser2448 were detected, as well as the expression levels of its downstream signaling molecules: Eukaryotic translation ini...

journal_title：Molecular medicine reports

authors： Ma BL,Shan MH,Sun G,Ren GH,Dong C,Yao X,Zhou M

更新日期：2015-10-01 00:00:00

abstract：:CXC195 exhibits strong protective effects against neuronal apoptosis by exerting antioxidant activity. However, the pharmacological function of CXC195 in cancer remains to be elucidated. The present study demonstrated that CXC195 exhibited significant cytotoxic effects, and induced cell cycle arrest and apoptosis in H...

journal_title：Molecular medicine reports

authors： Chen XL,Fu JP,Shi J,Wan P,Cao H,Tang ZM

更新日期：2015-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide, which is partially due to the lack of appropriate therapeutic options. The development of HCC is accompanied with unique and continuous genomic and epigenetic modifications. Therefore, the absence of a personalized and reprodu...

journal_title：Molecular medicine reports

authors： Wang Z,Bi B,Song H,Liu L,Zheng H,Wang S,Shen Z

更新日期：2019-06-01 00:00:00

abstract：:Colorectal cancer has become a disease with one of the highest incidence rates worldwide, and liver metastasis threatens the prognosis of colorectal cancer. MicroRNA (miR)‑200 and miR‑141 have been confirmed to be aberrantly expressed in colorectal cancer, however, whether miR‑200 and miR‑141 are involved in the progr...

journal_title：Molecular medicine reports

authors： Ding M,Zhang T,Li S,Zhang Y,Qiu Y,Zhang B

更新日期：2017-11-01 00:00:00

abstract：:The aim of the present study was to explore the effects of co‑culturing bone marrow‑derived mesenchymal stem cells (BM-MSCs) cultured with hepatitis B virus (HBV)‑infected lymphocytes in vitro. BM‑MSCs and lymphocytes from Brown Norway rats were obtained from the bone marrow and spleen, respectively. Rats were divided...

journal_title：Molecular medicine reports

authors： Zheng WP,Zhang BY,Shen ZY,Yin ML,Cao Y,Song HL

更新日期：2017-05-01 00:00:00

abstract：:Pregnancy complications are associated with abnormal cytotrophoblast differentiation and invasion. Hydrogen peroxide (H2O2) is an important mediator of oxidative ischemia/reperfusion stress in the placenta. Lycium barbarum polysaccharides (LBP) have been demonstrated to counteract oxidative free radicals. The effects ...

journal_title：Molecular medicine reports

authors： Li J,Ding Z,Yang Y,Mao B,Wang Y,Xu X

更新日期：2018-09-01 00:00:00

abstract：:The present study aimed to compare the expression levels of excitatory amino acid transporters (EAATs) and growth status of piglets weaned at 10‑20 days after birth with suckling piglets. A total of 40 hybrid piglets (Landrace x Large White x Duroc) born to 40 different sows, with similar body weight were selected for...

journal_title：Molecular medicine reports

authors： Wang QJ,Cui YZ,Zhang XY,Su J

更新日期：2017-11-01 00:00:00

abstract：:The dysregulation of renin-angiotensin system-signaling is a contributing factor to the development of atherosclerosis and cardiovascular disease. We studied the progression of angiotensin II (AngII)-induced arterial wall atherosclerosis after its induction. Atherosclerosis was accelerated in ApoE (-/-) C57B6 mice by ...

journal_title：Molecular medicine reports

authors： Cha J,Ivanov V,Ivanova S,Kalinovsky T,Rath M,Niedzwiecki A

更新日期：2010-07-01 00:00:00

abstract：:Intervertebral disc degeneration (IDD) and ligamentum flavum hypertrophy (LFH) are major causes of degenerative spinal disorders. Comparative and proteomic analysis was used to identify differentially expressed proteins (DEPs) in IDD and LFH discs compared with normal discs. Subsequent gene ontology term enrichment an...

journal_title：Molecular medicine reports

authors： Liu C,Yang M,Liu L,Zhang Y,Zhu Q,Huang C,Wang H,Zhang Y,Li H,Li C,Huang B,Feng C,Zhou Y

更新日期：2020-01-01 00:00:00

abstract：:Lung cancer is one of the primary causes of mortality worldwide and drug resistance is the key contributing factor which results in the failure of lung cancer chemotherapy. Previous studies have shown that microRNA (miR)‑10a was involved in the reversal of cisplatin (DDP) resistance in numerous types of tumors; howeve...

journal_title：Molecular medicine reports

authors： Sun W,Ma Y,Chen P,Wang D

更新日期：2015-05-01 00:00:00

abstract：:Brain‑type glycogen phosphorylase (PYGB) is an enzyme that metabolizes glycogen, whose function is to provide energy for an organism in an emergency state. The present study purposed to investigate the role and mechanism of PYGB silencing on the growth and apoptosis of prostate cancer cells. A cell counting kit‑8 assa...

journal_title：Molecular medicine reports

authors： Wang Z,Han G,Liu Q,Zhang W,Wang J

更新日期：2018-10-01 00:00:00

abstract：:The prostaglandin E2 (PGE2) E prostanoid (EP)1 receptor shown to be associated with lung cancer cell invasion. However, the mechanism of EP1 receptor-mediated cell migration remains to be elucidated. β1 integrin is an essential regulator of the tumorigenic properties of non-small-cell lung carcinoma (NSCLC) cells. To ...

journal_title：Molecular medicine reports

authors： Bai X,Yang Q,Shu W,Wang J,Zhang L,Ma J,Xia S,Zhang M,Cheng S,Wang Y,Leng J

更新日期：2014-05-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) comprises a range of liver diseases, between steatosis and non‑alcoholic steatohepatitis and liver cirrhosis, which are closely associated with diabetes mellitus. Previous studies have indicated that oxidative stress is a key factor in the development of NAFLD. Molecular hydro...

journal_title：Molecular medicine reports

authors： Zhai X,Chen X,Lu J,Zhang Y,Sun X,Huang Q,Wang Q

更新日期：2017-03-01 00:00:00

abstract：:The present study investigated the effect of certain 1,3,5‑triazine derivatives on epidermal growth factor receptor‑tyrosine kinase (EGFR‑TK). The results suggested that 1,3,5‑triazine derivatives exhibited optimal drug likeness via molinspiration and proved to be effective drug candidates as potential anticancer agen...

journal_title：Molecular medicine reports

authors： Yan W,Zhao Y,He J

更新日期：2018-11-01 00:00:00

abstract：:Aberrant DNA methylation is the most common type of epigenetic alteration and is associated with many types of cancer. Although previous studies have provided a few novel DNA methylation markers in hepatocellular carcinoma (HCC), specific DNA methylation patterns and comparisons of the aberrant alterations in methylat...

journal_title：Molecular medicine reports

authors： Sun N,Zhang J,Zhang C,Shi Y,Zhao B,Jiao A,Chen B

更新日期：2018-11-01 00:00:00

abstract：:Subsequently to the publication of the above article, the authors have realized that the bar charts shown for Fig. 3A and B, as they appeared in the paper, were the same as the bar charts shown for Fig. 4B and D. Fig. 3, as it should have appeared, is shown below. All the authors agree to this Corrigendum. Note that t...

journal_title：Molecular medicine reports

authors： Zhang L,Dai F,Chen G,Wang Y,Liu S,Zhang L,Xian S,Yuan M,Yang D,Zheng Y,Deng Z,Cheng Y,Yang X

更新日期：2021-01-01 00:00:00

abstract：:Doxorubicin (Dox)-induced cardiotoxicity has been a well‑known phenomenon to clinicians and scientists for decades. It has been confirmed that Dox‑dependent cardiotoxicity is accompanied by cardiac cellular senescence. However, the molecular mechanisms underlying Dox cardiotoxicity remains to be fully elucidated. Long...

journal_title：Molecular medicine reports

authors： Xie Z,Xia W,Hou M

更新日期：2018-02-01 00:00:00

abstract：:Even though standard treatment options are available for prostate cancer patients, prostate cancer is still a leading cause of death in many Western countries due to drug resistance and recurrence. Immune checkpoint blockade therapy has been proved to be very effective in some melanoma patients, which might dependent ...

journal_title：Molecular medicine reports

authors： Zhou J,Yang T,Liu L,Lu B

更新日期：2017-09-01 00:00:00

abstract：:The expression of Ferroportin (Fpn) was examined at different time points in rats following focal cerebral ischemia treated with or without the traditional Chinese medicine Naotaifang. Initially, rats were randomly divided into 2, 6, 12, 24 and 72 h groups following middle cerebral artery occlusion (MCAO) and the mRNA...

journal_title：Molecular medicine reports

authors： Liao J,Xia X,Wang GZ,Shi YM,Ge JW

更新日期：2015-06-01 00:00:00

abstract：:HS-1-associated protein X-1 (Hax-1) has been suggested to be expressed in various rodent and human tissues. Accumulating evidence has demonstrated that Hax‑1 exerts an anti‑apoptotic effect in neurological diseases. Furthermore, it has also been reported that Hax‑1 interacts with various apoptosis‑associated proteins,...

journal_title：Molecular medicine reports

authors： Cui L,He WJ,Xu F,Jiang L,Lv ML,Huang H,Xu JP,Wu Y,Zhong HB,Zhang SY,Chen LF,Shen CL,Yao G,Li L,Li M,Zeng SM

更新日期：2016-11-01 00:00:00

abstract：:Ras‑GTPase‑activating protein SH3 domain‑binding protein 1 (G3BP1) has been reported to be of importance in the occurrence and development of colon cancer. However, the underlying mechanisms remain largely unknown. Therefore, the aim of the present study was to investigate the role of Wnt/β‑catenin signaling in G3BP1‑...

journal_title：Molecular medicine reports

authors： Li Y,Wang J,Zhong S,Li J,Du W

更新日期：2020-11-01 00:00:00

abstract：:Antimycin A (AMA) is an inhibitor of the electron transport chain in mitochondria. In this study, we investigated the anti-apoptotic effects of pan-caspase inhibitor (Z-VAD), superoxide dismutase (SOD) or catalase on AMA-induced HeLa cell death in relation to the cell cycle. Treatment with Z-VAD, SOD or catalase rescu...

journal_title：Molecular medicine reports

authors： Han YH,Kim SH,Kim SZ,Park WH

更新日期：2009-03-01 00:00:00

abstract：:S100 calcium binding protein A16 (S100A16) is the most recent member of the S100 calcium-binding protein family. The function of S100A16 has been associated with various types of cancer; however, its role in colorectal cancer (CRC) remains unknown. Therefore, the aim of the present study was to investigate the role of...

journal_title：Molecular medicine reports

authors： Ou S,Liao Y,Shi J,Tang J,Ye Y,Wu F,Wang W,Fei J,Xie F,Bai L

更新日期：2021-02-01 00:00:00

abstract：:A polymorphism within the 3'-UTR 8473T↷C of the cyclooxygenase-2 (COX-2) gene, which plays a role in gastrointestinal cancer development, has been associated with susceptibility to malignant disease. Here, we report on the interaction between the COX-2 3'-UTR T↷C polymorphism and gastric cancer development. DNA from 1...

journal_title：Molecular medicine reports

authors： Shibata T,Arisawa T,Tahara T,Hirata I,Nakano H

更新日期：2008-07-01 00:00:00

abstract：:In the present study, we report the mutation of the 3β-hydroxysteroid dehydrogenase (3β-HSD) gene in a family suffering from adrenocortical insufficiency. The index patient was clinically diagnosed with adrenocortical insufficiency. Peripheral venous blood (5 ml) was collected from ...

journal_title：Molecular medicine reports

authors： Pan Y,Zhong S,Hu RM,Gong W

更新日期：2012-12-01 00:00:00