BMP‑7 suppresses excessive scar formation by activating the BMP‑7/Smad1/5/8 signaling pathway.

abstract：:Asparaginase like 1 (ASRGL1) protein belongs to the N‑terminal nucleophile group, cleaving the isoaspartyl‑dipeptides and L‑asparagine by adding water. It tends to be overexpressed in cancerous tumors including ovarian cancer and breast tumors. The present study assessed the potential ability of ASRGL1 as a molecular ...

journal_title：Molecular medicine reports

authors： Lv XF,Hong HQ,Liu L,Cui SH,Ren CC,Li HY,Zhang XA,Zhang LD,Wei TX,Liu JJ,Xing WY,Fu H,Yan SJ

更新日期：2018-07-01 00:00:00

abstract：:Abnormal migration of vascular smooth muscle cells (VSMCs) serves an important role in hypertension, atherosclerosis and restenosis following angioplasty, which is regulated numerous hormonal and humoral factors, including neuropeptide Y (NPY) and dopamine. Dopamine and NPY are both sympathetic neurotransmitters, and ...

journal_title：Molecular medicine reports

authors： Xia XW,Zhou YQ,Luo H,Zeng C

更新日期：2017-10-01 00:00:00

abstract：:It has been suggested that survivin, a member of the inhibitor of apoptosis protein (IAP) family, is an attractive novel target for anticancer therapy. The present study investigated the expression of survivin during the early stages of hepatocellular carcinoma (HCC) and associated hepatitis, and attempted to elucidat...

journal_title：Molecular medicine reports

authors： Mamori S,Matsushima M,Matsuura T,Tajiri H

更新日期：2009-11-01 00:00:00

abstract：:Cinobufacini is widely used in the treatment of advanced cancers. It has been previously reported that microRNA (miR)‑494 was upregulated in cinobufacini‑treated gastric cancer cells; however, the detailed role of miR‑494 in the anti‑tumor activity of cinobufacini is unclear. The present study aimed to clarify the fun...

journal_title：Molecular medicine reports

authors： Shen Z,Li Y,Zhao C,Wang F,Zhou R,Chen G

更新日期：2018-05-01 00:00:00

abstract：:Myocyte apoptosis and oxidative stress key critical roles in the process of doxorubicin (DOX)‑induced cardiotoxicity. However, how apoptosis and oxidative stress arise in DOX‑induced heart injury remains largely unknown. Cathepsin B (CTSB) is a typical lysosomal cysteine protease that is associated with apoptosis, inf...

journal_title：Molecular medicine reports

authors： Liu C,Cai Z,Hu T,Yao Q,Zhang L

更新日期：2020-12-01 00:00:00

abstract：:Neural stem cells (NSCs) have the potential to give rise to offspring cells and hypoxic injury can impair the function of NSCs. The present study investigated the effects of mesenchymal stem cell (MSC)‑derived extracellular vesicles (EVs) on NSC injury, as well as the underlying mechanisms. MSC‑EVs were isolated and i...

journal_title：Molecular medicine reports

authors： Li F,Zhang J,Liao R,Duan Y,Tao L,Xu Y,Chen A

更新日期：2020-11-01 00:00:00

abstract：:Hepatic stellate cells (HSCs) have an important role in liver fibrosis. Epithelial‑to‑mesenchymal transition (EMT), which is promoted by the Hedgehog (Hh) signaling pathway, is involved in the activation of HSCs. MicroRNAs (miRNAs/miRs) have been reported to be involved in the progression of liver fibrosis. A previous...

journal_title：Molecular medicine reports

authors： Yu F,Zheng Y,Hong W,Chen B,Dong P,Zheng J

更新日期：2015-12-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common neurodegenerative diseases. For decades, the unilateral 6‑hydroxydopamine (6‑OHDA) rat model has been employed to investigate the pathogenesis and therapy of PD. However, the behavior and associated pathological features of the model long term have not previously been...

journal_title：Molecular medicine reports

authors： Su RJ,Zhen JL,Wang W,Zhang JL,Zheng Y,Wang XM

更新日期：2018-02-01 00:00:00

abstract：:To evaluate the effect of melatonin supplementation in maturation medium for human 'rescue IVM' and investigate differences in transcriptomic profile of blastocysts developed from oocytes matured in vitro with/without melatonin treatment and in vivo, a total of 314 GV oocytes and 320 MI oocytes were collected from 200...

journal_title：Molecular medicine reports

authors： Hao Y,Zhang Z,Han D,Cao Y,Zhou P,Wei Z,Lv M,Chen D

更新日期：2017-08-01 00:00:00

abstract：:Patients with skull base chordomas have a poor prognosis, and the role of the protein expression of brachyury in chordomas remains to be fully elucidated. The present study used immunohistochemistry to analyze 57 cases of skull base chordoma, and analyzed the clinical data of the patients. The results demonstrated tha...

journal_title：Molecular medicine reports

authors： Wang K,Tian K,Wang L,Wu Z,Ren C,Hao S,Feng J,Li J,Wan H,Jia G,Zhang L,Zhang J

更新日期：2015-09-01 00:00:00

abstract：:IQ motif containing GTPase activating protein 1 (IQGAP1) is a scaffold protein, which is aberrantly expressed in several tumor types and is closely associated with the development, metastasis and prognosis of cancer. Several studies have demonstrated that IQGAP1 has broad prospects in the basic and clinical research o...

journal_title：Molecular medicine reports

authors： Diao B,Liu Y,Zhang Y,Yu J,Xie J,Xu GZ

更新日期：2017-04-01 00:00:00

abstract：:Previous studies have demonstrated the overexpression of paired basic amino acid cleaving enzyme 4 (PACE4) mRNA in prostate cancer tissues. This overexpression is correlated with higher circulating protein levels in certain patients, however, the role of PACE4 in apoptosis and the potential molecular mechanisms of pan...

journal_title：Molecular medicine reports

authors： Tian XF,Huang GM,Zang HL,Cao H

更新日期：2016-12-01 00:00:00

abstract：:The efficacy of traditional chemoradiotherapies for pancreatic cancer remains limited, and no effective targeted therapies or screening tests are currently available. Therefore more individualized drug screening is warranted for the clinical treatment of pancreatic cancer. A patient‑derived xenograft (PDX) model of pa...

journal_title：Molecular medicine reports

authors： Guan Z,Lan H,Chen X,Jiang X,Wang X,Jin K

更新日期：2017-10-01 00:00:00

abstract：:Abnormal paired box 9 (PAX9) expression is associated with tumorigenesis, cancer development, invasion and metastasis. The present study investigated the prognostic significance of PAX9 in esophageal squamous cell carcinoma (ESCC) and its role in predicting radiation sensitivity. A total of 52.8% (121/229) ESCC tissue...

journal_title：Molecular medicine reports

authors： Tan B,Wang J,Song Q,Wang N,Jia Y,Wang C,Yao B,Liu Z,Zhang X,Cheng Y

更新日期：2017-07-01 00:00:00

abstract：:Numerous studies have demonstrated that microRNAs (miRNAs) are upregulated or downregulated in retinoblastoma (RB), and that this phenomenon is associated with the modulation of various malignant behaviours during RB occurrence and development. Therefore, the mechanisms that associate deregulated miRNAs with RB initia...

journal_title：Molecular medicine reports

authors： Sun Z,Zhang A,Zhang L

更新日期：2019-03-01 00:00:00

abstract：:microRNAs (miRNAs) are small, non‑coding RNAs involved in multiple biological pathways by regulating post-transcriptional gene expression. Previously, autophagy has been reported to suppress the progression of non-small cell lung cancer (NSCLC). However, how miRNAs regulate autophagy in NSCLC remains to be elucidated....

journal_title：Molecular medicine reports

authors： Wei J,Ma Z,Li Y,Zhao B,Wang D,Jin Y,Jin Y

更新日期：2015-01-01 00:00:00

abstract：:The present study aimed to explore the factors that affect polymerase chain reaction using sequence-specific primers (PCR-SSP) and to establish an optimized PCR-SSP method for detecting multiple gene polymorphisms simultaneously. The amplification system parameters, including the concentrations of Mg2+, dNTPs, pfu Taq...

journal_title：Molecular medicine reports

authors： Yang R,Zhang JH,Yuan GY

更新日期：2013-01-01 00:00:00

abstract：:Obesity has a negative effect on ovarian functions, which is reported to increase the risk of infertility. The mechanism underlying obesity‑induced infertility is not yet clear. The present study established a high‑fat diet (HFD)‑induced obesity mouse model to elucidate the mechanisms underlying the effect of HFD‑indu...

journal_title：Molecular medicine reports

authors： Wu Y,Zhang Z,Liao X,Qi L,Liu Y,Wang Z

更新日期：2016-10-01 00:00:00

abstract：:It is well known that the local renin-angiotensin system (RAS) is activated in the diabetic state, which results in an increase in the level of oxidative stress injury to pancreatic β cells. The angiotensin‑converting enzyme 2 (ACE2)/angiotensin (1‑7) [Ang (1‑7)]/Mas axis is a negative regulator of the classical renin...

journal_title：Molecular medicine reports

authors： Zhang F,Liu C,Wang L,Cao X,Wang YY,Yang JK

更新日期：2016-09-01 00:00:00

abstract：:Ectomesenchymal stem cells (EMSCs) represent a type of adult stem cells derived from the cranial neural crest. These cells are capable of self‑renewal and have the potential for multidirectional differentiation. Tissue transglutaminase type 2 (TG2) is a ubiquitously expressed member of the transglutaminase family of C...

journal_title：Molecular medicine reports

authors： Shi W,Que Y,Lv D,Bi S,Xu Z,Wang D,Zhang Z

更新日期：2019-09-01 00:00:00

abstract：:The pro-apoptotic and anti-proliferative effects of 3,3'-diindolylmethane (DIM) in various tumor cell types have been widely investigated. The underlying mechanisms were suggested to include cell cycle arrest, cell signaling inhibition and downregulation of the androgen receptor. The present study demonstrated that DI...

journal_title：Molecular medicine reports

authors： Li F,Xu Y,Chen C,Chen SM,Xiao BK,Tao ZZ

更新日期：2015-09-01 00:00:00

abstract：:In the present study, the expression of microRNA (miR)‑671‑3p in non‑small‑cell lung cancer (NSCLC) was detected via reverse transcription‑quantitative polymerase chain reaction analysis, and its role in cell proliferation, apoptosis, migration and invasion was investigated via Cell Counting Kit‑8, colony formation, f...

journal_title：Molecular medicine reports

authors： Li ZY,Zhang ZZ,Bi H,Zhang QD,Zhang SJ,Zhou L,Zhu XQ,Zhou J

更新日期：2019-10-01 00:00:00

abstract：:Pirarubicin is frequently used in chemotherapy against tumors. However, clinical use is severely limited by the development of progressive dose-dependent cardiomyopathy and acquired drug resistance. LY294002 is a commonly used pharmacologic inhibitor, which selectively inhibits the phosphoinositide 3-kinase-AKT nexus....

journal_title：Molecular medicine reports

authors： Long XH,Zhong ZH,Peng AF,Zhu LB,Wang H,Zhang GM,Liu ZL

更新日期：2014-12-01 00:00:00

abstract：:The generation of β‑amyloid protein (Aβ) is considered a key step in the pathogenesis of Alzheimer's disease (AD) and the regulation of its production is an important therapeutic strategy. It was hypothesized in the present study that Nogo‑A may be involved in AD and may regulate the generation of Aβ. Nogo‑A is known ...

journal_title：Molecular medicine reports

authors： Xie QQ,Feng X,Huang YΥ,Fang N,Yi H,Wang ZJ,Cao QΥ,Lou GF,Pan JP,Hu Y,Li FC,Zheng Q,Xiao F

更新日期：2021-03-01 00:00:00

abstract：:Recent advances in the treatment of non-small cell lung cancer (NSCLC) with new agents require accurate histological subtyping at diagnosis to avoid the higher risk of an adverse response and to obtain the maximum therapeutic response. However, interobserver variability, tumor heterogeneity and the degree of different...

journal_title：Molecular medicine reports

authors： Hamamoto J,Soejima K,Yoda S,Naoki K,Nakayama S,Satomi R,Terai H,Ikemura S,Sato T,Yasuda H,Hayashi Y,Sakamoto M,Takebayashi T,Betsuyaku T

更新日期：2013-08-01 00:00:00

abstract：:Chronic iron overload may result in hepatic fibrosis and even neoplastic transformation due to a burst of reactive oxygen species (ROS). Mitochondria have been proposed to be important in the production of ROS. The purpose of this study was to investigate the role of the mitochondrial permeability transition pore (mPT...

journal_title：Molecular medicine reports

authors： Liu D,He H,Yin D,Que A,Tang L,Liao Z,Huang Q,He M

更新日期：2013-04-01 00:00:00

abstract：:Human glioma is a pernicious tumor from the central nervous system; it has been reported that microRNAs (miRs) may have carcinogenic or tumor suppressor effects on human glioma. The aim of the present study was to assess miR‑141 expression and functional role in human primary glioma, as well as in tumor‑derived cell l...

journal_title：Molecular medicine reports

authors： Li G,Huang M,Cai Y,Ke Y,Yang Y,Sun X

更新日期：2018-08-01 00:00:00

abstract：:The aim of the present study was to identify potential biomarkers associated with colorectal cancer (CRC). The GSE32323 and GSE53592 mRNA and microRNA (miRNA) expression profiles were selected from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs...

journal_title：Molecular medicine reports

authors： Hu J,Yue X,Liu J,Kong D

更新日期：2018-12-01 00:00:00

abstract：:This study investigated the role of microRNA-21 (miR-21) and microRNA-24 (miR-24) in the pathological processes that follow cerebral ischemic injury and examined the potential use of miR-21 and -24 in stroke diagnostics as sensitive plasma biomarkers. An oxygen-glucose deprivation (OGD) model was constructed using mou...

journal_title：Molecular medicine reports

authors： Zhou J,Zhang J

更新日期：2014-08-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are involved in diverse biological processes, including cell proliferation, differentiation and apoptosis. Results from the MTT assay revealed that BMP-2 significantly inhibited the proliferation of MDA-MB‑231 and MCF-7 breast cancer cells. The flo...

journal_title：Molecular medicine reports

authors： Chen A,Wang D,Liu X,He S,Yu Z,Wang J

更新日期：2012-09-01 00:00:00