Abstract:
:Bone morphogenetic proteins (BMPs) are involved in diverse biological processes, including cell proliferation, differentiation and apoptosis. Results from the MTT assay revealed that BMP-2 significantly inhibited the proliferation of MDA-MB‑231 and MCF-7 breast cancer cells. The flow cytometric analysis demonstrated that BMP-2 caused G1 arrest and promoted apoptosis. An increase in p21 and cleaved caspase-3 in the two cell lines was detected by western blot analysis, which may be responsible for the suppression of cancer cell proliferation caused by BMP-2. BMP-2 protected MDA-MB-231 and MCF-7 cells from generating xenograft tumors in nude mice. Thus, BMP-2 may be considered as an inhibitor of breast cancer at the early stages of disease.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Chen A,Wang D,Liu X,He S,Yu Z,Wang Jdoi
10.3892/mmr.2012.962subject
Has Abstractpub_date
2012-09-01 00:00:00pages
615-20issue
3eissn
1791-2997issn
1791-3004journal_volume
6pub_type
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