Long non-coding RNA RP5-833A20.1 inhibits proliferation, metastasis and cell cycle progression by suppressing the expression of NFIA in U251 cells.

abstract：:The content stability of commonly used control genes is considered to vary significantly in different independent experimental systems, either in the expression of RNA expression or in the level of DNA content. The present study aimed to examine a panel of six common control genes, including β‑globin (HBB), telomerase...

journal_title：Molecular medicine reports

authors： Yang Q,Li X,Ali HA,Yu S,Zhang Y,Wu M,Gao S,Zhao G,Du Z,Zhang G

更新日期：2015-11-01 00:00:00

abstract：:Thymidylate synthase, as a rate-limiting step in DNA synthesis, catalyses the conversion of dUMP into dTMP using 5,10-methylenotetrahydrofolate as the methyl donor. Two polymorphisms have been described in this gene: a repeat polymorphism in the 5' promoter enhancer region (3R versus 2R) and a 6 bp deletion in the 3' ...

journal_title：Molecular medicine reports

authors： Carmona B,Guerreiro C,Cravo M,Nobre-Leitão C,Brito M

更新日期：2008-09-01 00:00:00

abstract：:Lung cancer is a leading cause of cancer-associated mortality worldwide. The cisplatin (DDP)‑based chemotherapy remains the foundation of treatment for the majority of patients affected by advanced non‑small cell lung cancer (NSCLC). However, DDP‑resistance limits the clinical utility of this drug in patients with adv...

journal_title：Molecular medicine reports

authors： Zuo Y,Yang D,Yu Y,Xiang M,Li H,Yang J,Li J,Jiang D,Zhou H,Xu Z,Yu Z

更新日期：2018-03-01 00:00:00

abstract：:Hypertension affects one billion people worldwide and is an independent risk factor for death after acute coronary syndrome (ACS). The aim of this study was to examine the prevalence and medical treatment of hypertension among 1,301 ACS patients enrolled into the Chinese registry of acute coronary events (CRACE) trial...

journal_title：Molecular medicine reports

authors： Lin Y,Pan W,Ning S,Song X,Jin Z,Lv S

更新日期：2013-07-01 00:00:00

abstract：:Glioma is the most common malignant and fatal primary tumor in the central nervous system in adults. Recent data has suggested a profound role for microRNAs (miRs) in cancer progression. The present study demonstrated, via quantitative polymerase chain reaction (qPCR) analysis, that miR-203 expression was markedly low...

journal_title：Molecular medicine reports

authors： Tang G,Wu J,Xiao G,Huo L

更新日期：2015-04-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a type of chronic inflammatory disturbance that affects a number of individuals worldwide; the precise mechanism is unclear and treatment is frequently insufficient to maintain patients in remission. Saccharomyces boulardii is a thermophilic, non‑pathogenic yeast that may be adminis...

journal_title：Molecular medicine reports

authors： Zhou H,Zhang HJ,Guan L,Zhang YN,Li Y,Sun MJ

更新日期：2018-12-01 00:00:00

abstract：:Isorhamnetin (ISH) is a flavonoid primarily obtained from the fruit of Hippophae rhamnoides L., which possesses anti‑inflammatory properties. However, the effect of ISH on the expression of inflammatory mediators in response to interleukin (IL)‑1β stimulation has not been elucidated. The present study investigated the...

journal_title：Molecular medicine reports

authors： Li J,Wu R,Qin X,Liu D,Lin F,Feng Q

更新日期：2017-10-01 00:00:00

abstract：:Muscle atrophy is a disease that is usually caused by denervation. The aim of the present study was to determine whether electrical stimulation by semi-implantable electrodes is capable of decreasing the levels of specific proteins associated with sciatic nerve injury-induced muscle atrophy. Male Sprague Dawley (SD) r...

journal_title：Molecular medicine reports

authors： Liu J,Li K,Huang X,Xie J,Huang X

更新日期：2013-07-01 00:00:00

abstract：:Diabetic muscle atrophy causes a reduction of skeletal muscle size and strength, which affects normal daily activities. However, pulsed electromagnetic fields (PEMFs) can retard the atrophy of type II fibers (ActRIIB) in denervated muscles. Therefore, the purpose of the present study was to determine whether PEMFs can...

journal_title：Molecular medicine reports

authors： Yang J,Sun L,Fan X,Yin B,Kang Y,An S,Tang L

更新日期：2018-07-01 00:00:00

abstract：:NIN1/RPN12 binding protein 1 homolog (Saccharomyces cerevisiae) (NOB1) encodes a chaperone protein that joins the 20S proteasome with the 19S regulatory particle in the nucleus and facilitates the biogenesis of the 26S proteasome, which plays a role in maintaining cellular homeostasis by controlling protein degradatio...

journal_title：Molecular medicine reports

authors： Chen B,Liu J,Wu D,Qin Y,Peng C,Li C,Wang J

更新日期：2014-06-01 00:00:00

abstract：:Alpinetin is a natural flavonoid widely distributed in Zingiberaceae. Previous studies have demonstrated that alpinetin markedly inhibits tumour growth. However, the molecular mechanisms underlying the antitumour effects of alpinetin are unclear. Bcl‑2‑associated X protein (Bax) tra...

journal_title：Molecular medicine reports

authors： Wang Z,Lu W,Li Y,Tang B

更新日期：2013-03-01 00:00:00

abstract：:Recent evidence has suggested that microRNAs (miRs), which are a class of non-coding RNAs, serve diverse roles in tumorigenesis. However, the role of miR‑635 in osteosarcoma (OS) remains unknown. The present study revealed that miR‑635 may be a tumor suppressive miR. The expression of miR‑635 was significantly decreas...

journal_title：Molecular medicine reports

authors： Tian L,Guo Z,Wang H,Liu X

更新日期：2017-10-01 00:00:00

abstract：:Pentatricopeptide repeat domain protein 3 (PTCD3) is a mitochondrial RNA‑binding protein that serves a role in mitochondrial translation. PTCD3 was originally reported as an oncogene that is involved in breast cancer and lymphoma. However, the expression and function of PTCD3 in prostate cancer (PCa) are unknown. Ther...

journal_title：Molecular medicine reports

authors： Huang Y,Jiang G,Liang X,Lan Z,Su Z,Wu H,Weng J,Jiang X

更新日期：2018-10-01 00:00:00

abstract：:De novo sequence variants, including truncating and splicing variants, in the additional sex‑combs like 3 gene (ASXL3) have been described as the cause of Bainbridge‑Ropers syndrome (BRS). This pathology is characterized by delayed psychomotor development, severe intellectual disability, growth delay, hypotonia and fa...

journal_title：Molecular medicine reports

authors： Wayhelova M,Oppelt J,Smetana J,Hladilkova E,Filkova H,Makaturova E,Nikolova P,Beharka R,Gaillyova R,Kuglik P

更新日期：2019-07-01 00:00:00

abstract：:Aberrant epigenetic modification is associated with the development and progression of cancer. Hypermethylation of tumor suppressor gene promoters and cooperative histone modification have been considered to be the primary mechanisms of epigenetic modification. Ovary granulosa cell tumors (GCTs) are relatively rare, a...

journal_title：Molecular medicine reports

authors： Xu Y,Li X,Wang H,Xie P,Yan X,Bai Y,Zhang T

更新日期：2016-09-01 00:00:00

abstract：:Keloids are benign fibrous overgrowths that occur as a result of abnormal wound healing following cutaneous injury. MicroRNAs (miRNAs/miRs) are short non‑coding RNAs that serve critical roles in numerous important biological processes, such as cell proliferation, differentiation and apoptosis. However, their role in k...

journal_title：Molecular medicine reports

authors： Jian X,Qu L,Wang Y,Zou Q,Zhao Q,Chen S,Gao X,Chen H,He C

更新日期：2019-06-01 00:00:00

abstract：:Multidrug resistance (MDR) in epithelial ovarian cancer (EOC) remains a public health issue for women worldwide, and its molecular mechanisms remain to be fully elucidated. The present study aimed to predict the potential genes involved in MDR, and examine the mechanisms underlying MDR in EOC using bioinformatics tech...

journal_title：Molecular medicine reports

authors： Chen C,Hu Y,Li L

更新日期：2016-01-01 00:00:00

abstract：:Icariside II (ICAII) is a bioflavonoid compound which has demonstrated anti‑oxidative, anti‑inflammatory and anti‑apoptotic biological activities. However, to the best of our knowledge, whether ICAII can alleviate myocardial ischemia and reperfusion injury (MIRI) remains unknown. The aim of the present study was to de...

journal_title：Molecular medicine reports

authors： Guan BF,Dai XF,Huang QB,Zhao D,Shi JL,Chen C,Zhu Y,Ai F

更新日期：2020-10-01 00:00:00

abstract：:Twenty‑three clinical Streptococcus pneumoniae (SP) strains were isolated from blood and sputum specimens from the Second Affiliated Hospital of Wenzhou Medical College in 2009. These strains and the ATCC 49619 standard strain were cultured and suspended in normal saline (at a turbidity of 1.0 McFarland). The producti...

journal_title：Molecular medicine reports

authors： Zhang J,Hu DK,Wang DG,Liu Y,Liu CB,Yu LH,Qu Y,Luo XH,Yang JH,Yu J,Liu SC,Li XY

更新日期：2013-11-01 00:00:00

abstract：:Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates T-cell activation and Th1/Th2 cytokine production and is involved in the immune response against Hepatitis B virus (HBV) infection. To detect the association of the CTLA-4 gene polymorphisms with susceptibility to HBV infection a hospital-based case-contro...

journal_title：Molecular medicine reports

authors： Chen M,Chang Y,Tang F,Xie QH,Li J,Yang H,He XX,Lin JS

更新日期：2014-02-01 00:00:00

abstract：:The poor prognosis of non‑small cell lung cancer (NSCLC) is related to epithelial‑mesenchymal transition (EMT). Recent studies demonstrated that non‑coding RNA activated by DNA damage (NORAD) displays a carcinogenic effect and targets microRNA (miR)‑422a, which may be involved in tumor cell migration and invasion. The...

journal_title：Molecular medicine reports

authors： Chen Z,Che Q,Xie C

更新日期：2021-02-01 00:00:00

abstract：:We wish to retract our article entitled 'Clinical, pathological and genetic characteristics of autosomal dominant inherited dynamin 2 centronuclear myopathy' published in Molecular Medicine Reports 13: 4273-4278, 2016. The article was submitted by the first author, Xinhong Liu, without the prior knowledge of the corre...

journal_title：Molecular medicine reports

authors： Liu X,Wu H,Gong J,Wang T,Yan C

更新日期：2016-07-01 00:00:00

abstract：:Through searching for anti‑neuroinflammatory metabolites from Nardostachys jatamansi extracts, nardostachin was revealed to exert anti‑neuroinflammatory effects against lipopolysaccharide (LPS)‑induced overproduction of nitric oxide and prostaglandin E2 in BV2 and rat primary microglial cells. Furthermore, nardostachi...

journal_title：Molecular medicine reports

authors： Kim DC,Park JS,Yoon CS,Kim YC,Oh H

更新日期：2021-01-01 00:00:00

abstract：:Previous studies have reported that the Rho-associated coiled-coil containing protein kinase 2 (ROCKII) and glycogen synthase kinase‑3β (GSK)‑3β signaling pathways are involved in axonal regeneration. The present study investigated the effects of the combined application of Y27632 (a ROCKII inhibitor) and 4-benzyl-2‑m...

journal_title：Molecular medicine reports

authors： Zhang G,Lei F,Zhou Q,Feng D,Bai Y

更新日期：2016-12-01 00:00:00

abstract：:Matrine is a widely used Chinese herbal medicine that has historically been used in the treatment of inflammation and cancer. However, the antimetastatic effects and associated molecular mechanisms of matrine on nasopharyngeal carcinoma (NPC) remain to be elucidated. Therefore, the aims of the present study were to as...

journal_title：Molecular medicine reports

authors： Sun B,Xu M

更新日期：2015-06-01 00:00:00

abstract：:Extracellular potassium homeostasis is dependent on the activity of potassium channels, which are expressed on the apical membrane of epithelial tubular cells. The renal outer medullary potassium channel (ROMK) is considered to be the major route for potassium transport into the tubule lumen. Hepatocyte growth factor ...

journal_title：Molecular medicine reports

authors： Kato T,Oka K,Nakamura T

更新日期：2018-01-01 00:00:00

abstract：:Genetically modified mesenchymal stem cells have been used in attempts to increase the expression of interleukin‑1 receptor antagonist (IL‑1Ra); however, the attempts thus far have been unsuccessful. The aim of the present study was to investigate whether the lentivirus transduced IL‑1Ra gene was able to be stably exp...

journal_title：Molecular medicine reports

authors： He T,Chi G,Tian B,Tang T,Dai K

更新日期：2015-09-01 00:00:00

abstract：:Indoleamine 2, 3-dioxygenase (IDO) catalyzes the initial and rate‑limiting step in the degradation pathway of the essential amino acid tryptophan and is expressed by professional antigen presenting cells (APCs), epithelial cells, vascular endothelium and tumor cells. IDO‑mediated catabolic products, which are addition...

journal_title：Molecular medicine reports

authors： Wu H,Gong J,Liu Y

更新日期：2018-04-01 00:00:00

abstract：:Senescence is a result of cellular stress and is a potential mechanism for regulating cancer. As a member of the mitogen‑activated protein kinase family, ERK1/2 (extracellular signal‑regulated protein kinase) has an important role in delivering extracellular signals to the nucleus, and these signals regulate the cell ...

journal_title：Molecular medicine reports

authors： Zou J,Lei T,Guo P,Yu J,Xu Q,Luo Y,Ke R,Huang D

更新日期：2019-02-01 00:00:00

abstract：:Abnormal migration of vascular smooth muscle cells (VSMCs) serves an important role in hypertension, atherosclerosis and restenosis following angioplasty, which is regulated numerous hormonal and humoral factors, including neuropeptide Y (NPY) and dopamine. Dopamine and NPY are both sympathetic neurotransmitters, and ...

journal_title：Molecular medicine reports

authors： Xia XW,Zhou YQ,Luo H,Zeng C

更新日期：2017-10-01 00:00:00