Insights into the pathogenesis of Mycoplasma pneumoniae (Review).

abstract：:Aquaporins (AQPs) are known to be important in cancer progression. The present study used a cDNA microarray to demonstrate that AQP3, a member of the AQP family, was overexpressed in prostate cancer cells. In order to determine the role of AQP3 in prostate cancer, AQP3 expression was silenced by transfection with smal...

journal_title：Molecular medicine reports

authors： Chen J,Wang Z,Xu D,Liu Y,Gao Y

更新日期：2015-04-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of the serum of patients with secondary hyperparathyroidism (SHPT) on endothelial cells and to examine the protective effect and the possible mechanism of Klotho. A total of three types of mixed serum from 15 patients with SHPT scheduled for parathyroidectomy,...

journal_title：Molecular medicine reports

authors： Chen C,Mao H,Yu X,Sun B,Zeng M,Zhao X,Qian J,Liu J,Xing C

更新日期：2015-08-01 00:00:00

abstract：:High glucose (HG) in peritoneal dialysates has been demonstrated to induce extracellular matrix (ECM) synthesis by peritoneal mesothelial cells (PMCs) and to contribute to peritoneal fibrosis during continuous ambulatory peritoneal dialysis (CAPD). In the present study, we investigated the effects of pioglitazone, a p...

journal_title：Molecular medicine reports

authors： Zhou G,Su X,Ma J,Wang L,Li D

更新日期：2013-04-01 00:00:00

abstract：:The costs of spinal cord injury and its complications are high in personal, social and financial terms. Complications include bladder cancer, for which the risk is 16-28 times higher than that of the general population, There is currently little consensus regarding the cause of this discrepancy. As microRNAs are stabl...

journal_title：Molecular medicine reports

authors： Wang T,Liu Y,Yuan W,Zhang L,Zhang Y,Wang Z,Zhou X,Zhou H,Chu T,Hao Y,Liu B,Zhao X,Lu L,Feng S,Kong X

更新日期：2015-08-01 00:00:00

abstract：:The aim of the present study was to investigate the hypotheses that cytomegalovirus (CMV) may trigger idiopathic pulmonary fibrosis (IPF) in a susceptible host and/or that the presence of CMV may alter IPF in response to a well-defined trigger of pulmonary fibrosis. A mouse model of murine CMV (MCMV) infection was est...

journal_title：Molecular medicine reports

authors： Li Y,Gao J,Wang G,Fei G

更新日期：2016-08-01 00:00:00

abstract：:The present study aimed to investigate the effects of neuropeptide Y (NPY) on the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor glutamate receptor 2 (GluR2) subunit in epileptiform discharge hippocampal neurons. Hippocampal neurons were harvested from neonatal Sprague‑Dawley rats aged <24 h and ...

journal_title：Molecular medicine reports

authors： Bu W,Zhao WQ,Li WL,Dong CZ,Zhang Z,Li QJ

更新日期：2017-07-01 00:00:00

abstract：:The interaction between the host and human cytomegalovirus (HCMV) is important in determining the outcome of a viral infection. The HCMV RL13 gene product exerts independent, inhibitory effects on viral growth in fibroblasts and epithelial cells. At present, there are few reports on the interactions between the HCMV R...

journal_title：Molecular medicine reports

authors： Wang G,Ren G,Cui X,Lu Z,Ma Y,Qi Y,Huang Y,Liu Z,Sun Z,Ruan Q

更新日期：2016-03-01 00:00:00

abstract：:Dbl-family guanine nucleotide exchange factors (GEFs) are important activators of Rho GTPases, which are significantly associated with tumorigenesis and metastasis. The catalytic ability of the Dbl-family GEFs to activate Rho GTPases depends on their Dbl-homology domain followed by a pleckstrin-homology domain. In the...

journal_title：Molecular medicine reports

authors： Wang H,Li Y,Wang Y,Han ZG,Cai B

更新日期：2012-05-01 00:00:00

abstract：:The aim of this meta-analysis was to explore the association between the manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk, and to investigate the interaction of this gene polymorphism with known risk factors for breast cancer. Crude odds ratios (ORs) with 95% confidence intervals (CIs) f...

journal_title：Molecular medicine reports

authors： Liu G,Sun G,Wang Y,Wang D,Hu W,Zhang J

更新日期：2012-10-01 00:00:00

abstract：:Several environmental contaminants have been linked to the development of diabetes and increased diabetes‑associated mortality. Perfluorooctanoic acid (PFOA) is a widely used perfluoroalkane found in surfactants and lubricants, and in processing aids used in the production of polymers. Furthermore, PFOA has been detec...

journal_title：Molecular medicine reports

authors： Suh KS,Choi EM,Kim YJ,Hong SM,Park SY,Rhee SY,Oh S,Kim SW,Pak YK,Choe W,Chon S

更新日期：2017-06-01 00:00:00

abstract：:Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G protein-coupled receptor signaling pathways. RGS9‑2, a brain‑specific splice variant of the RGS9 gene, is highly expressed in the striatum but lowly expressed in the periaqueductal gray and spinal cord, which mediate various act...

journal_title：Molecular medicine reports

authors： Zhu Y,Zhang H

更新日期：2015-05-01 00:00:00

abstract：:Idiopathic normal pressure hydrocephalus (iNPH) is caused by the accumulation of cerebrospinal fluid (CSF) and is characterized by gait disturbance, urinary incontinence, and dementia. iNPH dementia is treatable by shunt operation; however, since the cognitive symptoms of iNPH are often similar to those of other demen...

journal_title：Molecular medicine reports

authors： Nagata Y,Bundo M,Sugiura S,Kamita M,Ono M,Hattori K,Yoshida S,Goto YI,Urakami K,Niida S

更新日期：2017-09-01 00:00:00

abstract：:Previous studies have demonstrated the effects of hyperuricemia on the damage to target organs, including the kidneys, joints and the heart. However, it is unclear whether hyperuricemia results in damage to the intestines. The aim of the present study was to investigate intestinal barrier dysfunction in a mouse model ...

journal_title：Molecular medicine reports

authors： Guo Y,Li H,Liu Z,Li C,Chen Y,Jiang C,Yu Y,Tian Z

更新日期：2019-10-01 00:00:00

abstract：:The tumorigenesis and maintenance of a cancer cells is dependent upon the collaboration of multiple signaling pathways. Signal transducer and activator of transcription 3 (STAT3) and β-catenin are at the center of multiple cancer-associated signaling pathways; therefore, simultaneously targeting STAT3 and β-catenin ma...

journal_title：Molecular medicine reports

authors： Wang XH,Liu MN,Huang P,Xu J,Liu AY,Chen J,Lv CQ,Xu RL

更新日期：2015-08-01 00:00:00

abstract：:The healing of diabetic wounds represents a formidable clinical challenge, and the molecular mechanisms involved in diabetic wound healing are far from clear. In this study, we investigated the expression of β-catenin and cyclin D1 in the epidermal stem cells (ESCs) of diabetic rats, and explored whether the reduction...

journal_title：Molecular medicine reports

authors： Zhong QL,Liu FR,Liu DW,Peng Y,Zhang XR

更新日期：2011-03-01 00:00:00

abstract：:Cobalt nanoparticles (CoNPs) released from metal‑on‑metal implants have caused considerable concern. Oxidative stress is associated with the mechanism underlying cobalt‑induced cytotoxicity and genotoxicity. The indolamine melatonin exhibits protective effects against damage induced by metals. The present study invest...

journal_title：Molecular medicine reports

authors： Liu Y,Yang X,Wang W,Wu X,Zhu H,Liu F

更新日期：2017-10-01 00:00:00

abstract：:Stroke is a leading cause of impairment and disability worldwide, and motor imagery (MI) has been used in stroke rehabilitation. Electroencephalography (EEG) has been used to study MI. However, the characteristic features of EEG during MI in stroke patients have not been established. The purpose of this study was to i...

journal_title：Molecular medicine reports

authors： Gong W,Zhang T,Shan L

更新日期：2013-12-01 00:00:00

abstract：:The purpose of the present study was to investigate the effect of bufadienolides on the A‑375 melanoma cell line, and to delineate the underlying mechanism. A Cell Counting Kit‑8 assay was used to determine the viability of the cells, and flow cytometry was used to evaluate apoptosis. Western blot analysis was used to...

journal_title：Molecular medicine reports

authors： Li H,Cao X,Chen X,Yi X,Xia J,Chen J,Yang L

更新日期：2019-09-01 00:00:00

abstract：:N‑terminal truncated peroxisome proliferator‑activated receptor‑γ coactivator‑1α (NT‑PGC‑1α) is an alternative splice variant of PGC‑1α. NT‑PGC‑1α exhibits stronger anti‑obesity effects in adipose tissue than PGC‑1α; however, NT‑PGC‑1α has not yet been investigated in neonatal rat cardiomyocytes (NRCMs). The present s...

journal_title：Molecular medicine reports

authors： Liu Z,Hua J,Cai W,Zhan Q,Lai W,Zeng Q,Ren H,Xu D

更新日期：2018-08-01 00:00:00

abstract：:Several lysosomal cathepsins have been implicated in a number of diseases, from arthritis to cancer. A recent member of the cathepsin family, cathepsin S (Cat S) has been associated with several types of cancer in humans. However, to date, no report has linked Cat S to human hepatocellular carcinoma (HCC). Here, we in...

journal_title：Molecular medicine reports

authors： Xu J,Li D,Ke Z,Liu R,Maubach G,Zhuo L

更新日期：2009-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been discovered to have pivotal roles in regulating the drug resistance of various types of human cancer, including cisplatin (DDP) resistance in non-small cell lung cancer (NSCLC). Fewer studies have explored the roles of miR-106a in NSCLC-cell resistance to DDP and its precise molecular mecha...

journal_title：Molecular medicine reports

authors： Ma Y,Li X,Cheng S,Wei W,Li Y

更新日期：2015-01-01 00:00:00

abstract：:We wish to retract our article entitled 'Clinical, pathological and genetic characteristics of autosomal dominant inherited dynamin 2 centronuclear myopathy' published in Molecular Medicine Reports 13: 4273-4278, 2016. The article was submitted by the first author, Xinhong Liu, without the prior knowledge of the corre...

journal_title：Molecular medicine reports

authors： Liu X,Wu H,Gong J,Wang T,Yan C

更新日期：2016-07-01 00:00:00

abstract：:While most cancer types are resistant to mammalian target of rapamycin complex 1 (mTORC1) inhibitor rapamycin, recent studies have identified mTORC2 as an important prospective therapeutic target for cancer. The present study assessed the effects of mTORC2 inhibitor PP242 on the proliferation and migration of bladder ...

journal_title：Molecular medicine reports

authors： Zhang Z,Zhang G,Kong C,Gong D

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present study was to explore the effects of co‑culturing bone marrow‑derived mesenchymal stem cells (BM-MSCs) cultured with hepatitis B virus (HBV)‑infected lymphocytes in vitro. BM‑MSCs and lymphocytes from Brown Norway rats were obtained from the bone marrow and spleen, respectively. Rats were divided...

journal_title：Molecular medicine reports

authors： Zheng WP,Zhang BY,Shen ZY,Yin ML,Cao Y,Song HL

更新日期：2017-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Although numerous studies have suggested the potentially oncogenic roles of wild‑type or mutant hepatitis B virus X (HBx) protein in hepatocarcinogenesis, their exact mechanism remains unclear. Increasing evidence suggests that microRNAs ...

journal_title：Molecular medicine reports

authors： Fu X,Tan D,Hou Z,Hu Z,Liu G,Ouyang Y,Liu F

更新日期：2013-02-01 00:00:00

abstract：:The aim of the present study was to investigate the combination of certain serological markers (Forns' index; FI), FibroScan® and acoustic radiation force impulse elastography (ARFI) in the assessment of liver fibrosis in patients with hepatitis B, and to explore the impact of inflammatory activity and steatosis on th...

journal_title：Molecular medicine reports

authors： Dong DR,Hao MN,Li C,Peng Z,Liu X,Wang GP,Ma AL

更新日期：2015-06-01 00:00:00

abstract：:Longdan Xiegan Tang (LXT) is a mixture of herbal extracts commonly used in traditional Chinese medicine that may exert immunomodulatory effects for the treatment of autoimmune diseases. However, the detailed mechanisms that mediate the actions of LXT are unclear. The present study induced an experimental autoimmune uv...

journal_title：Molecular medicine reports

authors： Tang K,Guo D,Zhang L,Guo J,Zheng F,Si J,Bi H

更新日期：2016-09-01 00:00:00

abstract：:Embryonic stem (ES) cells are pluripotent stem cells derived from a developmental stage of pre‑implanted embryos. The present study investigated the effect of female sex steroid hormones on the characteristics of human ES cells by using a feeder‑free culture protocol. In a feeder‑free condition without sex hormones, h...

journal_title：Molecular medicine reports

authors： Jeon SY,Hwang KA,Kim CW,Jeung EB,Choi KC

更新日期：2017-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancer types, and chemotherapy plays an important role in treatment of HCC. However, long‑term treatment with chemotherapeutic drugs such as 5‑fluorouracil (5‑FU) often results in chemoresistance, and the underlying mechanisms remain unclear. In this study, we s...

journal_title：Molecular medicine reports

authors： Wang C,Guo Y,Wang J,Min Z

更新日期：2015-03-01 00:00:00

abstract：:Macrophage cholesterol efflux is important in maintaining cellular lipid homeostasis and preventing the formation of lipid‑laden foam cells. Although radioactive [3H]‑cholesterol is widely used as a tracer in cholesterol efflux assays, the lengthy and labor‑intensive assay procedure, and the radioactivity disposal pro...

journal_title：Molecular medicine reports

authors： Song W,Wang W,Wang Y,Dou L,Chen L,Yan X

更新日期：2015-10-01 00:00:00