N‑terminal truncated peroxisome proliferator‑activated receptor‑γ coactivator‑1α alleviates phenylephrine‑induced mitochondrial dysfunction and decreases lipid droplet accumulation in neonatal rat cardiomyocytes.

abstract：:microRNAs (miRNAs) are small non‑coding RNAs that regulate gene expression by binding to the untranslated regions (UTRs) of target mRNAs. Bioinformatic software predicted that MYCN, a gene overexpressed in aggressive neuroblastoma cells, is a target gene of miRNA‑202 (miR‑202) and that the promoter region of miR‑202 c...

journal_title：Molecular medicine reports

authors： Li YG,He JH,Yu L,Hang ZP,Li W,Shun WH,Huang GX

更新日期：2014-02-01 00:00:00

abstract：:Calcium dyshomeostasis is an important pathology of memory impairment. However, the mechanism of how calcium dyshomeostasis impairs neurons has remained elusive. The aim of the present study was to reveal the influence of calcium dyshomeostasis on the expression of calcium memory‑associated proteins and the ability of...

journal_title：Molecular medicine reports

authors： Zhou X,Yang Z,Han L,Li X,Feng M,Zhang T,Luo H,Zhu L,Zhang J,Zhang Q,Hu Q

更新日期：2015-10-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a disease associated with high mortality and morbidity. MicroRNAs (miRNAs) have been reported to be associated with the pathogenesis of numerous cerebrovascular diseases, including ICH. miR‑222 has been revealed to play important roles in various physiological and pathological process...

journal_title：Molecular medicine reports

authors： Bai YY,Niu JZ

更新日期：2020-03-01 00:00:00

abstract：:Ephrin type‑A receptor 2 (EphA2) is a receptor tyrosine kinase that is associated with cancer cell metastasis. There has been little investigation into its impact on the regulation of sensitivity to paclitaxel in nasopharyngeal carcinoma (NPC). In the present study, upregulation of EphA2 expression enhanced the surviv...

journal_title：Molecular medicine reports

authors： Wang Y,Liu Y,Li G,Su Z,Ren S,Tan P,Zhang X,Qiu Y,Tian Y

更新日期：2015-02-01 00:00:00

abstract：:Osteosarcoma, which is the most common type of primary bone tumor in adolescents, is characterized by complex genetic alterations and frequent resistance to conventional treatments. MicroRNAs (miRs) have emerged as fundamental regulators in gene expression through their ability to silence gene expression at post-trans...

journal_title：Molecular medicine reports

authors： Chen R,Li X,He B,Hu W

更新日期：2017-03-01 00:00:00

abstract：:Disruption of the intestinal mucosal barrier integrity is a pathogenic process in inflammatory bowel disease (IBD) development, and is therefore considered a drug discovery target for IBD. The well‑known traditional Chinese formulation Qing Hua Chang Yin (QHCY) has been suggested as a potential therapeutic agent for t...

journal_title：Molecular medicine reports

authors： Fang W,Zhao P,Shen A,Liu L,Chen H,Chen Y,Peng J,Sferra TJ,Sankararaman S,Luo Y,Ke X

更新日期：2021-03-01 00:00:00

abstract：:Lupus nephritis (LN) is a common complication of systemic lupus erythematosus. The present study aimed to elucidate the protective effect of magnolol (MG) on the progression of LN, via inhibition of key signaling pathways. The results of the present study demonstrated that administration of MG caused inhibition of the...

journal_title：Molecular medicine reports

authors： Huang F,Zhang RY,Song L

更新日期：2017-10-01 00:00:00

abstract：:Plesiomonas shigelloides (P. shigelloides) is implicated as an aetiological agent of human gastroenteritis in humans, for which reliable laboratory detection of P. shigelloides is clinically and epidemiologically desirable. A simple molecular method for rapid detection of P. shigelloides using cross‑priming amplificat...

journal_title：Molecular medicine reports

authors： Meng S,Wang Y,Wang Y,Ye C

更新日期：2016-12-01 00:00:00

abstract：:As the resident macrophages of the brain's innate immune system, microglial cells are key modulators in the neurodegenerative disease Alzheimer's disease (AD). In particular, the activation and accumulation of microglial cells around amyloid plaques is considered to result in chronic neuroinflammation. Although the pa...

journal_title：Molecular medicine reports

authors： Chen PL,Wang WJ,Rao YQ,Li J,Cheng MJ

更新日期：2018-04-01 00:00:00

abstract：:Fatty acid synthase (FASN) is a key anabolic enzyme for de novo fatty acid synthesis, which is important in the development of colon carcinoma. The high expression of FASN is considered a promising molecular target for colon cancer therapy. Emodin, a naturally occurring anthraquinone, exhibits an anticancer effect in ...

journal_title：Molecular medicine reports

authors： Lee KH,Lee MS,Cha EY,Sul JY,Lee JS,Kim JS,Park JB,Kim JY

更新日期：2017-04-01 00:00:00

abstract：:Although imatinib is effective in chronic myeloid leukemia treatment, imatinib resistance due to the T315I mutation and/or other mutations is a challenge to be overcome. However, how DNA mutation occurs, particularly the T315I mutation, remains unclear. In the current study, the mutagenesis of BCR‑ABL was analyzed via...

journal_title：Molecular medicine reports

authors： Dong Y,Gao X,Zhao Y,Wei M,Xu L,Yang G,Liu L

更新日期：2017-12-01 00:00:00

abstract：:The aim of the present study was to report on a complete synthetic approach, namely benzylation-hydrolysis-acylation‑hydrogenation, to the synthesis of regioselectively acylated quercetin analogues using low‑cost rutin as a starting material. Three quercetin analogues, quercetin‑3‑O‑propionate (Q‑pr), quercetin‑3‑O‑bu...

journal_title：Molecular medicine reports

authors： Duan Y,Sun N,Xue M,Wang X,Yang H

更新日期：2017-12-01 00:00:00

abstract：:Minoxidil and finasteride have been approved to treat hair loss by the Food and Drug Administration. However, the further elucidation of treatments for hair loss, including those using Chinese herbal medicine, remains important clinically. BeauTop (BT) is a health food supplement which contains Ginseng radix, Astragal...

journal_title：Molecular medicine reports

authors： Lee CY,Yang CY,Lin CC,Yu MC,Sheu SJ,Kuan YH

更新日期：2018-06-01 00:00:00

abstract：:In the present study, a novel polysaccharide, APS2-1, was isolated and purified from Astragalus membranaceus using DEAE-cellulose and Sephadex G-100 chromatography. The effect of APS2‑1 on the promotion of wound healing was evaluated and its preliminary mechanism was investigated. In vitro experiments showed that APS2...

journal_title：Molecular medicine reports

authors： Zhao B,Zhang X,Han W,Cheng J,Qin Y

更新日期：2017-06-01 00:00:00

abstract：:Vacquinol‑1 (Vacq), a quinolone derivative, has recently been reported to display potent antitumor effects in glioblastomas by inducing cellular massive vacuolization and cell death. However, whether Vacq induces cytotoxicities in other types of cancers, and the potential underlying mechanism, remain to be investigate...

journal_title：Molecular medicine reports

authors： Sun SL,Li X,Su N,Chen S,Gao X,Zhang G,Piao H

更新日期：2018-07-01 00:00:00

abstract：:Diabetic infected foot is the outcome of progressive vascular and neurological damage caused by persistent chronic hyperglycemia. Due to acute hypoxia and infection, the tissues develop extensive necrosis and gangrene, which often require amputation. The decision regarding the level of amputation relies mainly on the ...

journal_title：Molecular medicine reports

authors： Bekker-Méndez C,Guzmán-Aguilar RM,Hernández-Cueto MA,Huerta-Yepez S,Jarillo-Luna RA,González-Veyrand E,González-Bonilla CR

更新日期：2012-02-01 00:00:00

abstract：:Galectin‑3, a galactoside‑binding protein, is highly expressed in carotid plaques and plays an important role in the atherosclerotic lesions. The phenotype transformation of vascular smooth muscle cells is the basic pathological change of atherosclerosis. This study investigated the effects of exogenous galectin‑3 on ...

journal_title：Molecular medicine reports

authors： Tian L,Chen K,Cao J,Han Z,Wang Y,Gao L,Fan Y,Wang C

更新日期：2017-06-01 00:00:00

abstract：:The co-delivery of a drug and a target gene has become a primary strategy in cancer therapy. Based on our previous study, a synthesized star‑shaped co‑polymer consisting of β‑cyclodextrin (CD) and a poly(L‑lysine) dendron (PLLD) was used to co-deliver docetaxel (DOC) and matrix metalloproteinase 9 (MMP‑9) small interf...

journal_title：Molecular medicine reports

authors： Liu T,Wu X,Wang Y,Hou X,Jiang G,Wu T,Xie H,Xie M

更新日期：2017-08-01 00:00:00

abstract：:The present study aimed to investigate the effect of SOX2 on odontoblast differentiation of dental pulp stem cells (DPSCs), and to examine the potential application of DPSCs on dental restoration. SRY‑box 2 (SOX2) overexpression in human DPSCs (DPSCs‑SOX2) was established by retroviral infection. The empty vector‑infe...

journal_title：Molecular medicine reports

authors： Yang Y,Zhao Y,Liu X,Chen Y,Liu P,Zhao L

更新日期：2017-12-01 00:00:00

abstract：:Complement factor H‑related 3 (CFHR3) belongs to the human factor H protein family and is associated with various human diseases, including nephropathy, age‑related macular degeneration and atypical hemolytic uremic syndrome. However, to the best of our knowledge, the role of CFHR3 in hepatocellular carcinoma (HCC) re...

journal_title：Molecular medicine reports

authors： Liu H,Zhang L,Wang P

更新日期：2019-09-01 00:00:00

abstract：:Dermal papilla cells (DPCs) are located at the base of hair follicles, and are known to induce hair follicle regeneration. Platelet-rich plasma (PRP) functions in hair follicle regeneration. To investigate the influence of PRP on DPCs, the present study analyzed RNA‑seq data of human hair dermal papilla cells (HHDPCs)...

journal_title：Molecular medicine reports

authors： Shen H,Cheng H,Chen H,Zhang J

更新日期：2017-01-01 00:00:00

abstract：:Quercetin (a natural polyphenolic compound) is a polyphenolic flavonoid compound found in a variety of plants. It has been demonstrated to exert cytostatic activity against a variety of human cancer cell lines, including the human osteosarcoma cell line, MG-63. However, its effects on osteosarcoma cell apoptosis are s...

journal_title：Molecular medicine reports

authors： Liang W,Li X,Li C,Liao L,Gao B,Gan H,Yang Z,Liao L,Chen X

更新日期：2011-09-01 00:00:00

abstract：:Alzheimer's disease is one of the most common age‑associated diseases that frequently leads to memory disorders, cognitive decline and dementia. Evidence suggests that nicergoline serves an important role in the apoptosis of hippocampal cells, memory recovery, cognitive function and neuronal survival. However, the sig...

journal_title：Molecular medicine reports

authors： Zang G,Fang L,Chen L,Wang C

更新日期：2018-05-01 00:00:00

abstract：:Despite advances in the treatment of T‑cell acute lymphoblastic leukemia (T‑ALL), the outcome of T‑ALL treatment remains unsatisfactory, therefore, more effective treatment is urgently required. The present study examined the cytotoxicities of bortezomib in combination with daunorubicin against human Jurkat and Molt‑4...

journal_title：Molecular medicine reports

authors： Du X,Tong J,Lu H,He C,Du S,Jia P,Zhao W,Xu H,Li J,Shen Z,Wu Y,Tong J,Zhou L

更新日期：2017-07-01 00:00:00

abstract：:microRNAs (miRNAs) are small, highly conserved, non-coding RNAs that regulate gene expression at the post‑transcriptional level. The expression of these small RNA genes is tightly regulated during development, differentiation and apoptosis of normal cells, however, they are often deregulated in various types of cancer...

journal_title：Molecular medicine reports

authors： Liang G,Li G,Wang Y,Lei W,Xiao Z

更新日期：2014-03-01 00:00:00

abstract：:The use of non‑steroidal anti‑inflammatory drugs (NSAIDs) has been associated with a reduced risk of various types of cancer, including esophageal cancer. However, the mechanisms underlying the antineoplastic effects of NSAIDs in esophageal cancer remain to be elucidated. In the present study, a significant inhibition...

journal_title：Molecular medicine reports

authors： Qin S,Xu C,Li S,Yang C,Sun X,Wang X,Tang SC,Ren H

更新日期：2015-06-01 00:00:00

abstract：:Identification of novel risk factors that are critical to the initiation of lung cancer will be key for its prevention. Recently, it has been reported that glycine dehydrogenase (GLDC) can drive the formation of lung cancer initiating cells. However, there have been no perspective studies on the association between ci...

journal_title：Molecular medicine reports

authors： Wei HY,Feng R,Shao H,Feng B,Liu HQ,Men JL,Zou W

更新日期：2018-08-01 00:00:00

abstract：:In the past decade, a group of cases with persisting haemocytopenia were separated from those with idiopathic cytopenia of undetermined significance due to the optimal response of these patients to immunosuppression therapy and due to the detection of autoantibodies in the bone marrow of haemopoietic cells. This condi...

journal_title：Molecular medicine reports

authors： Chen J,Liu H,Li L,Wang H,Li Y,Wang Y,Ding K,Hao S,Shao Y,Li L,Song J,Wang G,Shao Z,Fu R

更新日期：2019-11-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of the eukaryotic initiation factor 6 (eIF6) gene on the secretion of M2 macrophage fibrosis‑associated factors and the expression levels of key proteases during scar repair. Male eIF6 wild‑type (eIF6+/+) and knockout (eIF6+/‑) C57BL/6 mice were intraperitoneall...

journal_title：Molecular medicine reports

authors： Bai YQ,Feng JK,Zhang QF,Wu HZ,Du YR,Wei W

更新日期：2016-07-01 00:00:00

abstract：:A few patients have been shown to develop severe abdominal pain and gastrointestinal dysmotility during treatment with gonadotropin‑releasing hormone (GnRH) analogs. A rat model of enteric neuropathy has been developed by administration of the GnRH analog buserelin to rats. Loss of enteric neurons and ganglioneuritis ...

journal_title：Molecular medicine reports

authors： Jönsson A,Sand E,Ekblad E,Ohlsson B

更新日期：2016-04-01 00:00:00